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Fitness and health benefits of team handball training for young untrained women--A cross-disciplinary RCT on physiological adaptations and motivational aspects

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Journal of Sport and Health Science 2018年第2期7卷 139-148页

作者： therese Hornstrup Johan M.Wikman Bjorn Fristrup Susana Povoas Eva W.Helge Signe H.Nielsen Jorn W.Helge Jesper L.Andersen Lars Nybo Peter Krustrup Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen N 2200 Denmark Research Center in Sports Sciences Health Sciences and Human Development CIDESD University Institute of Maia ISMAI Maia 4475-690 Portugal Center of Healthy Aging Department of Biomedical Sciences University of Copenhagen Copenhagen N 2200 Denmark Institute of Sports Medicine Copenhagen Bispebjerg Hospital Copenhagen NV 2400 Denmark Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 3450 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The present study evaluated the effects of regular participation in small-sided team handball training on body composition, osteogenic response, physical performance, and cardiovascular risk factors, as well as well-being and motivation, in young untrained ***: Twenty-eight untrained 20- to 30-year-old women were randomized to a handball training group(HG; n = 14, height 170 ± 5 cm, weight 73 ± 11 kg, VO_(2peak) 37.7 ± 4.1 mL/min/kg) that trained 1.7 ± 0.3 times per week over 12 weeks(70 min 4 v 4 handball sessions) or an inactive control group(CG; n = 14, 169 ± 5 cm, 71 ± 12 kg, 38.1 ± 3.7 mL/min/kg). Physiological and psychological and motivational training adaptations were assessed pre-and post-intervention by dual-energy X-ray Absorptiometry(DXA) scans, blood sampling, physical tests, and ***: The average heart rate(HR) over all training sessions was equal to 85% ± 6% HR_(max). Between-group intervention effects were observed in favor of HG for muscle mass(2.1%, p = 0.024), proximal femur bone mineral density(0.8%, p = 0.041), Yo-Yo IE1 intermittent endurance test level 1(IE1) performance(35%, p < 0.001), and incremental treadmill test performance(11.5%, p = 0.003), but not total fat mass(p = 0.176),mean arterial blood pressure(p = 0.328), resting HR(p = 0.219), or blood lipids(p = 0.298—0.854). In CG, no changes were observed in any of the measured physiological variables after the training period. Compared to CG, HG had an increase in intrinsic motivation(p < 0.001) and in the well-being subscale "energy"(p = 0.010).Conclusion: Participation in regular recreational team handball training organized as small-sided games has marked beneficial effects on physical performance, musculoskeletal fitness, well-being, and motivation in untrained young women.

关键词： Bone mineral density (BMD) Intensity Intermittent Motivation Muscle mass Physical performance Recreational handball Well-being

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Purification and Characterisation of Xanthine Oxidoreductases from Local Bovids in Malta

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Advances in Enzyme Research 2014年第1期2卷 54-63页

作者： Marita Vella therese Hunter Claude Farrugia Arwen R. Pearson Gary Hunter Astbury Centre for Structural Molecular Biology University of Leeds Leeds UK Department of Chemistry University of Malta Msida Malta Department of Physiology and Biochemistry University of Malta Msida Malta

Xanthine oxidoreductase (XOR) is a molybdoflavoprotein mainly involved in purine catabolism. It exists in two forms, the oxidase (XO) and dehydrogenase (XDH) which are inter-convertible within mammalian cells. Although various researchers have reported the extraction of mammalian XOR, no extractions have yet been carried out in Malta and subsequently no characterizations are available. In this study, XOR was successfully purified from bovine, caprine and ovine milk through a multistep purification process involving both chemical and chromatographic techniques. The molecular weights of the native enzyme were found to be 295 kDa, 281 kDa and 275 kDa, representing the bovine, caprine and ovine XOR respectively. Western blot showed XOR to be represented on SDS-PAGE by a minimum of three major bands having molecular weights of 151 kDa, 131 kDa and 85 kDa. While all samples showed activity on native PAGE, spectrophotometric assays revealed the bovine XOR to be the most active. Surprisingly, the addition of NAD+ to the assay mixture inhibited enzyme activity of the bovine and caprine XOR whereas the ovine XOR doubled its activity in response to NAD+. The latter also showed a lower binding affinity to heparin. Following incubation with trypsin, XOR was irreversibly converted to its oxidase form in all samples as reflected by the observed increase in XO activity.

关键词： Xanthine Xanthine Dehydrogenase Xanthine Oxidase Milk Bovid Malta

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Pharmacogenetic Treatments for Alcohol and Stimulants

Pharmacogenetic Treatments for Alcohol and Stimulants

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自主创新与持续增长第十一届中国科协年会

作者： Thomas R.Kosten therese Kosten Colin Haile Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine

Pharmacogenetics uses genetic tests to predict the effectiveness of medication treatments for individual patients with drug dependence such as alcohol and opiates. An important shared neurobiological component of the reinforcement and dependence on alcohol and opiates is alcohol’s enhancement of β- endorphin release. The physiological and subjective effects of both alcohol and opiates are associated with β-endorphin and the mu opiate system. A pharmacotherapy that has been effective for both disorders is naltrexone, which increases baseline β-endorphin release blocking further release by alcohol. Naltrexone’s action as an alcohol pharmacotherapy is facilitated by a putative functional single nucleotide polymorphism (SNP) in the opioid mu receptor gene (Al18G) which alters its receptor function. Patients with this SNP have significantly lower relapse rates to alcoholism when treated with naltrexone. This SNP is particularly common among northern Chinese suggesting an important role for naltrexone treatment of alcoholism in China. Another important genetic polymorphism related to stimulant and perhaps other types of dependence frequently occurs (about 40% of the population) in the promoter region of the gene coding for dopamine beta hydroxylase (DβH). This polymorphism leads to 10 to 100 times lower levels of the DβH enzyme, which converts dopamine to norepinephrine in neurons. Stimulant abusers with normal levels of this enzyme show significant reductions in stimulant abuse when treated with DβH inhibitors, while those with the polymorphism for low DβH levels show no treatment efficacy with these medications. Pharmacogenetics has great potential for improving treatment outcome as we identify gene variants that affect pharmacodynamic as well as the more commonly studied pharmacokinetic factors. These mutations can guide pharmacotherapeutic agent choice for optimum treatment of alcohol and stimulant abuse and reduce relapse after successful initial abstinence.

关键词： pharmacogenetic treatments alcohol stimulants

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变革的“清单”

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董事会 2014年第6期 90-92页

作者： therese Kinal

长达一个世纪里,管理者一直在试图更好地控制人、流程和信息,而今转折点到来,公司需要认清过去起作用的思想和手段已经不再足以应付现在的新情况。如果公司想要的是顺从,那么传统的管理就很好;而如果想要创新和成长。

关键词：清单变革管理者控制人公司流程

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Procedural results and 30-day clinical events analysis following Edwards transcatheter aortic valve implantation in 48 consecutive patients： initial experience

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Chinese Medical Journal 2012年第16期125卷 2807-2810页

作者： ZHAO Quan-ming therese Lognone Calin Ivascau Remi Sabatier Vincent Roule Ziad Dahdouh Massimo Massetti Gilles Grollier Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing 100029 China

Background Transcatheter aortic valve implantation （TAVI） is a rapidly evolving strategy for therapy of aortic stenosis. We presented the procedural results and analyzed the death causes of 30-day mortality and clinical events in patients who underwent TAVI with Edwards prosthetic valves in University Hospital of Caen, France. Methods The patients with severe aortic stenosis but at high surgical risk or inoperable were considered as candidates for TAVI. Forty-eight patients undergoing TAVI from July 2010 to September 2011 were enrolled in this registry. The Edwards prosthetic valves were solely used in this clinical trial. Results Overall 48 patients underwent TAVI, 28 of which accepted TAVI by trans-femoral （TF） approaches, 20 by trans-apical approaches （TA）. The aortic valve area （AVA） was （0.70±0.23） cm2, left ventricular ejection fraction （LVEF） was （57.4±17.6）%, Log EuroSCORE was （19.2±15.8）%, mean gradient was （47.0±16.6） mmHg. There were no significant differences between TF and TA groups in all these baseline parameters. Device success rate was 95.8%, and procedural success rate was 93.7% in total. Procedural mortality was 6.7% （3/48）： two deaths in TA group （10%）, and one death in TF group （3.6%）. Forty-six Edwards valves were implanted： 10 Edwards Sapien and 36 Edwards XT. Procedure-related complications included cardiac tamponade in 2 cases （4.2%）, acute myocardial infarction （AMI） in 1 case （2.1%）, permanent pacemaker implantation in 1 case （2.1%）, life-threatening and major bleeding in 3 cases; access site related major complication in 1 case, AKI stage 3 in 3 cases （6.3%）, minor stroke in 1 case （2.1%）. Thirty-day survival rate was 89.6%. There were 5 deaths in total （10.4%）： 4 in TA group （20%） and 1 in TF group （3.6%）. Conclusion The procedural success rate and 30-day mortality were acceptable in these high risk patients withpatients withEdwards prosthetic valves in the first 48 TAVI.

关键词： aortic stenosis transcatheter aortic valve implantation, registry

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有针对性的代谢组学方法为个性化医疗提供新途径

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实验与分析 2017年第2期 36-38页

作者： therese Koal

如今，人类代谢物组学的研究为人们提供了利用代谢谱（代谢组）构成的代谢组全谱、利用最小量患者血液通过生物标记物标志确定各个患者健康状况的可能性——甚至可以在常规临床标准情况下确定患者健康状况。

关键词：代谢组学个性化医疗健康状况生物标记代谢物组学患者利用血液

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Behavioral Evidence for Cognitive Dysfunctions in the(BALB/cByJ-Kv1.1mceph/mceph)Mouse Model for Epilepsy

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Journal of Behavioral and Brain Science 2011年第4期1卷 210-228页

作者： Sarah Holst Elin Aberg therese M.Eriksson Catharina Lavebratt Sven Ove Ogren Department of Neuroscience Karolinska InstituteStockholmSweden Department of Molecular Medicine and Surgery Karolinska University HospitalStockholmSweden Center of Molecular Medicine Department of Physiology and PharmacologyKarolinska InstituteStockholmSweden Department of Clinical Neuroscience Karolinska InstituteStockholmSweden

The epileptic mouse model BALB/cByJ-Kv1.1mceph/mceph (mceph/mceph) is homozygous for a spontaneous mutation truncating the Shaker-like voltage gated potassium channel, Kv1.1 (Kcna1). The mceph/mceph mice are asymptomatic at birth, but develop from 3 weeks of age epileptic seizures, overgrowth and neuronal hyperplasia of the hippocampus. Hippocampal cognitive function of the mice was examined by investigating emotional memory using the aversive Passive Avoidance (PA) task combined with studies of explorative behavior using the non-aversive Novel Cage test (NCT). The behavioural results were examined by multivariate analysis. Compared to wild type and heterozygous mice, the mceph/mceph mice displayed lower exploratory and safety assessment behavior in the NCT and impairment in PA retention 24 hours after training, indicating an impairment in cognitive functions. In conclusion, the epileptic mouse model BALB/cByJ-Kv1.1mceph/mceph, with chronic epilepsy related to potassium-channelopathy, display a behavioural phenotype characterized by impairments in emotional memory and defensive motivational responses probably related to hippocampal dysfunctions.

关键词： Epilepsy Potassium Ion-Channelopathy Hippocampus Passive Avoidance Novel Cage Test Principal Component Analysis

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Variability in Spatial Distribution of Precipitation Overall Rugged Topography of Lebanon, Using TRMM Images

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Atmospheric and Climate Sciences 2019年第3期9卷 369-380页

作者： Ihab Jomaa Marie therese Abi Saab Sleiman Skaf Nisrine El Haj Randa Massaad Lebanese Agricultural Research Institute Tal Amara Lebanon Lebanese Agricultural Research Institute Fanar Lebanon

Rain gages data represents limited spatial coverage, especially in rugged terrains like Lebanon. Other precipitation data sources are the developing satellite and radar technologies. In this study, Tropical Rain Measurement Mission (TRMM) monthly rainfall data of 18 years (1998-2014 and 2017) was used to understand monthly and yearly precipitation spatial distribution overall Lebanon. Topographic effect of rainfall spatial distribution was investigated in comparison to Plassard’s map of 1971. The annual precipitation over the country ranged between 850 mm and 200 mm that differs than the existing historical map. The maximum rainfall rate decreased by about 700 mm between the derived TRMM rainfall map and Plassard’s one. Spatial distribution of maximum precipitation rates does not coincide between maps. TRMM map of elevated terrains did not show similar trends of rainfall distribution as Plassard’s. Pixels (Lebanon was divided into 27 pixels) of lower rainfall rates was found toward the eastern side of Lebanon, in contrast to Plassard’s results. Anti-Lebanon did not show an increase in precipitation in accordance to altitude. Spatial variability of precipitation was about 50 mm between pixels which reveals the importance of considering topography while implemented rain gages as observation points. TRMM and satellite rainfall data aid in investigating complete spatial distribution of rainfall over continuous periods. Accumulating knowledge of spatial rainfall distribution on timely basis will lead to better future modelling on floods and drought conditions in Lebanon.

关键词： TRMM Data Rainfall Plassard’s Map Lebanon Topography

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Neonatal Outcome of Induced Prematurity for Severe Preeclampsia in Four Great Kinshasa Maternities

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Open Journal of Obstetrics and Gynecology 2020年第11期10卷 1637-1643页

作者： Olive Yalala Ambambula Andy Muela Mbangama therese Biselele Rashid Rahma Tozin Dieudonné Mushengezi Sengeyi Department of Obstetrics and Gynecology University Clinics of Kinshasa Kinshasa DR Congo Department of Pediatrics University Clinics of Kinshasa Kinshasa DR Congo

Severe preeclampsia (SPE) is associated with fetal complications including intrauterine growth retardation (IUGR), prematurity and in utero fetal death. Its treatment remains child birth that often is planned before term. However, this attitude can lead to fetal complications related to prematurity. Several studies on preeclampsia have already been studied in the DRC and several aspects have already been realized, but to date, the neonatal outcome has not yet been addressed. Methods: This is cross-sectional study performed in four public hospitals in Kinshasa (Democratic Republic of Congo). We included 400 cases of induced prematurity (IP) for SPE;the analysis compared pregnant women who gave birth before 34 weeks of amenorrhea (WA) and those after 34 WA. The comparison of the proportions was made by the Chi-square test and the calculation of Means by the Student’s test. The significance level was set at P Objective: To determine the frequency of induced prematurity for severe preeclampsia (SPE), to identify the indications and to evaluate neonatal outcome. Results: The IP frequency for SPE was 46.2%. The retro placental hematoma was the most indication in pregnancies before 34 WA 24.9%, while high blood pressure 54.5% in the after 34 WA group. In utero death was more common in pregnant women who gave birth before 34 weeks 25.4%;chroni

关键词： Preeclampsia Induced Prematurity Neonatal Outcome

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中国高龄老人健康状况和死亡率变动趋势

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人口研究 2017年第4期41卷 22-32页

作者：曾毅冯秋石 therese Hesketh Kaare Christensen James W.Vaupel 北京大学国家发展研究院健康老龄与发展研究中心北京大学瑞意高等研究院美国杜克大学医学院老龄与人类发展研究中心美国杜克大学医学院老年医学部新加坡国立大学社会学系英国伦敦大学学院全球健康研究所浙江大学公共卫生学院全球健康研究所南丹麦大学公共健康研究所德国马普人口研究所

文章对"中国老年健康影响因素跟踪调查"近两万名80~105岁高龄老人的数据分析发现,社会经济发展使得2008年高龄老人存活概率和自评日常生活自理能力比1998年有显著改善。医疗条件进步使健康较差高龄老人被"救"存活率提高,使2008年高龄老... 详细信息

文章对"中国老年健康影响因素跟踪调查"近两万名80~105岁高龄老人的数据分析发现,社会经济发展使得2008年高龄老人存活概率和自评日常生活自理能力比1998年有显著改善。医疗条件进步使健康较差高龄老人被"救"存活率提高,使2008年高龄老人客观量测的躯体功能和认知功能比10年前显著下降;这给社会和亿万家庭带来严峻挑战。研究表明,经济社会发展和人类寿命提高带来效益的同时,也会产生一定成本;但它不是以往不少国际文献解释这一现象时所称的"胜利的失败",所以没有必要为此恐慌,而需要全社会积极应对,努力实现人口健康老龄化。

关键词：高龄老人生活自理能力躯体功能认知功能健康老龄化

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