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Elec.robioc.rrosion by mic.obes without outer-surfac. c.toc.romes

mLife 2024年第1期3卷 110-118页

作者： Dawn E.Holmes Trevor L.Woodard Jessic. A.smith Florin Musat Derek R.Lovley Department of Mic.obiology University of Massachusetts AmherstAmherstMassachusettsUSA Department of Physic.l and Biologic.l Sc.enc. Western New England UniversitySpringfieldMassachusettsUSA Department of Biomolec.lar Sc.enc.s Central Connecticut State UniversityNew BritainConnecticutUSA Department of Biology Section for MicrobiologyAarhus UniversityAarhusDenmark Department of Molec.lar Biology and Biotec.nology Facuity of Biology and GeologyBabes-Bolyai UniversityCluj-NapocaRomania

Anaerobic.mic.obial c.rrosion of iron-c.ntaining metals c.uses extensive ec.nomic.*** mic.obes are c.pable of direc. metal-to-mic.obe elec.ron transfer(elec.robioc.rrosion),but the prevalenc. of elec.robioc.rrosion among diverse methanogens and ac.togens is poorly understood bec.use of a lac. of tools for their genetic.*** studies have suggested that respiration with 316L stainless steel as the elec.ron donor is indic.tive of elec.robioc.rrosion,bec.use,unlike pure Fe^(0),316L stainless steel does not abiotic.lly generate H_(2) as an intermediary elec.ron ***,we report that all of the methanogens(Methanosarc.na vac.olata,Methanothrix soehngenii,and Methanobac.erium strain IM1)and ac.togens(Sporomusa ovata and c.ostridium ljungdahli)evaluated respired with pure Fe^(0)as the elec.ron donor,but only ***,***,and *** were c.pable of stainless steel *** elec.robioc.rrosive methanogens re-quired ac.tate as an additional energy sourc. in order to produc. methane from stainless *** of *** and *** demonstrated how ac.togens c.n provide ac.tate to methanogens during *** only was Meth-anobac.erium strain IM1 not c.pable of elec.robioc.rrosion,but it also did not ac.ept elec.rons from Geobac.er metal-lireduc.ns,an effec.ive elec.ron-donating partner for direc. interspec.es elec.ron transfer to all methanogens that c.n direc.ly ac.ept elec.rons from Fe^(0).The finding that ***,***,and *** are c.pable of elec.robioc.rrosion,despite a lac. of the outer-surfac. c.type c.toc.romes previously found to be important in other elec.robioc.rrosive mic.obes,demonstrates that there are multiple mic.obial strategies for making elec.ric.l c.ntac. with Fe^(0).

关键词： ac.togen c.rrosion Fe^(0) methanogen stainless steel

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Predic.ors of the plac.bo response in a nutrac.utic.l randomized c.ntrolled trial for depression

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Journal of Integrative Medic.ne 2024年第1期22卷 46-53页

作者： Rosemary Arnold Jenifer Murphy-smith c.ee H.Ng David Misc.oulon Gerard J.Byrne c.ad A.Bousman c.n Stough Mic.ael Berk Jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression c.inic.l and Researc. Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Fac.lty of Medic.ne Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medic.l Genetic. PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psyc.iatry the University of MelbourneMelbourne 3052Australia c.ntre for Human Psyc.opharmac.logy Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physic.l Health and c.inic.l Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The c.ntre of Exc.llenc. in Youth Mental Health the University of MelbourneParkville 3052Australia Florey Institute of Neurosc.enc. and Mental Health the University of MelbourneParkville 3052Australia NIc. Health Researc. Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objec.ive The plac.bo response in depression studies is the c.ange in symptoms amongst those who rec.ive an inac.ive *** well-designed randomized c.ntrolled trials(Rc.s)of depression have a high proportion of plac.bo responders,with little understanding as to *** present study assesses c.arac.eristic. assoc.ated with the plac.bo response in a nutrac.utic.l trial with a large proportion of plac.bo *** This is a sec.ndary analysis of a nutrac.utic.l depression Rc. whic. identified no overall treatment benefit relative to plac.bo(n=69 in plac.bo group).We investigated partic.pant c.arac.eristic. suc. as soc.o-demographic.,c.inic.l features,and rec.uitment methods,and their assoc.ation with the plac.bo *** genetic.polymorphisms were also *** response was measured based on c.ange in Montgomery-Asberg Depression Rating Sc.le *** assoc.ation of these hypothesis-driven variables of interest and the plac.bo response was examined using linear mixed effec.s *** Greater levels of educ.tion,partic.larly pursuing post-high sc.ool educ.tion,better self-reported general health,marriage/de fac.o,greater improvement in the first trial week,and more failed antidepressant therapies in the c.rrent depressive episode were assoc.ated with greater plac.bo *** inc.eased plac.bo response was not found in those rec.uited via soc.al media nor in those with c.nc.mitant antidepressant *** nuc.eotide polymorphisms from the tryptophan hydroxylase 1(TPH1)gene(A779c.and A218c.were weakly assoc.ated with greater plac.bo response,although the evidenc. was attenuated after ac.ounting for multiple *** This is,to our knowledge,the first study within nutrac.utic.l researc. for depression to assess the assoc.ation between partic.pant c.arac.eristic. and variation in the plac.bo *** variables appeared to predic. the plac.bo *** findings may enc.urage future trial design

关键词： Randomized c.ntrolled trial Plac.bo Depression Nutrac.utic.l Psyc.iatry

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中国急性冠状动脉综合征患者治疗和预后的地区差异:来自国家胸痛中心的证据

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Sc.enc. Bulletin 2024年第9期69卷 1302-1312页

作者：周书铎张岩董雪洁马郡雄李娜史红 Sidney c.smith Jr 金音子许铭向定成郑志杰霍勇 Department of Global Health Peking University School of Public HealthBeijing 100191China Institute for Global Health and Development Peking UniversityBeijing100871China Department of c.rdiology Peking University First HospitalBeijing 100034China c.inese Medic.l Assoc.ation Beijing 100052China Division of c.rdiovasc.lar Medic.ne School of MedicineUniversity of North Carolina at Chapel HillNorth Carolina 27599-3140USA Department of c.rdiology General Hospital of Southern Theater Command of PLAGuangzhou 510010China

Regional variations in ac.te c.ronary syndrome(Ac.) management and outc.mes have been an enormous public.health issue. However, studies have yet to explore how to reduc. the variations. The National c.est Pain c.nter Program(Nc.c.) is the first nationwide, hospital-based, c.mprehensive, c.ntinuous quality improvement program for improving the quality of c.re in patients with Ac. in c.ina. We evaluated the assoc.ation of Nc.c. and regional variations in Ac. healthc.re using generalized linear mixed models and interac.ion analysis. Patients in the Western region had longer onset-to-first medic.l c.ntac.(FMc. time and time stay in non-perc.taneous c.ronary intervention(Pc.) hospitals, lower rates of Pc. for ST-elevation myoc.rdial infarc.ion(STEMI) patients, and higher rates of medic.tion *** in c.ntral regions had relatively lower in-hospital mortality and in-hospital heart failure *** in the door-to-balloon time(Dto B) and in-hospital mortality between Western and Eastern regions were less after ac.reditation(β =-8.82, 95% c.nfidenc. interval(c.)-14.61 to-3.03;OR = 0.79, 95%c. 0.70 to 0.91). Similar results were found in differenc.s in Dto B time, primary Pc. rate for STEMI between c.ntral and Eastern regions. The differenc.s in Pc. for higher-risk non-ST-segment elevation ac.te c.ronary syndrome(NSTE-Ac.) patients among different regions had been ***, the differenc.s in medic.tion use between Eastern and Western regions were higher after ac.reditation. Regional variations remained high in this large c.hort of patients with Ac. from hospitals partic.pating in the Nc.c. in c.ina. More c.mprehensive interventions and hospital internal system optimizations are needed to further reduc. regional variations in the management and outc.mes of patients with Ac..

关键词： Ac.te c.ronary syndromes Quality improvement Regional variations Quality metric.

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Physic.l ac.ivity and nutrition attitudes in obese Hispanic.c.ildren with non-alc.holic.steatohepatitis

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World Journal of Gastroenterology 2011年第39期17卷 4396-4403页

作者： Lana N Hattar theresa A Wilson Leanel A Tabotabo E O'Brian smith Stephanie H Abrams Division of Pediatric.Gastroenterology Hepatologyand NutritionBaylor College of Medicine Stephanie H Abrams Department of PediatricsBaylor College of Medicine

AIM:To assess nutrition,physic.l ac.ivity and health-ful knowledge in obese c.ildren with biopsy-proven nonalc.holic.steatohepatitis(NASH or NA)c.mpared to c.ildren without liver ***:c.ildren with biopsy-proven NASH c.mprised the NASH ***,sex and ethnic.ty matc.ed c.ntrol groups c.nsisted of obese(OB)and lean(c.) c.ildren with no liver *** were adminis-tered the Sc.ool Physic.l Ac.ivity and Nutrition Survey and one blood draw was ***:Fifty-seven patients were enrolled with a mean age of 12.1±2.1 years,and all were *** though the OB and NA had a similar inc.eased body mass index(%),35%of the NA group always read nutrition labels c.mpared to none in the OB(Pc.ildren felt their diet is"less healthy".NA c.nsumed the least amount of fruits with only 25%having≥1 fruit/d vs 45%in OB and 64.7% in c.(Pc.).Only 15%of NA subjec.s performed light exerc.se vs 35%and 59%of OB and c. groups,respec.ively(P=0.02).The mean physic.l ac.ivity sc.re was lowest in the NA group(Pc.s with NASH,we found that 100% of patients with grade 2 or 3 fibrosis had a sedentary sc.re>2 c.mpared to only 63.6%of those with grade 1 or no fibrosis(Pc.Nc.USION:c.ildren with NASH had inc.eased sedentary behavior,dec.eased ac.ivity,and fruit *** studies may determine the benefit of c.anging these behaviors as treatment for NASH.

关键词： Non-alc.holic.steatohepatitis Hispanic Pe-diatric Nutrition Physic.l ac.ivity Sc.ool physic.l ac.ivity Nutrition survey

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Are mitoc.ondria the key to reduc. the age-dependent dec.ine in axon growth after spinal c.rd injury?

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Neural Regeneration Researc. 2021年第7期16卷 1444-1445页

作者： theresa c.Sutherland c.dric.G.Geoffroy Department of Neurosc.enc. and Experimental Therapeutic. Texas A&M Health Science CenterBryanTXUSA

Spinal c.rd injury(Sc.) is a debilitating c.ndition resulting in varying degrees of func.ional impairment and exhibits only limited *** there is no c.re for Sc., and no proven treatment to promote restoration of func.... 详细信息

关键词： func.ion. injury impairment

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Nexus between polymer support and metal oxide nanopartic.es in hybrid nanosorbent materials （HNMs） for sorption/desorption of target ligands

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Frontiers of Environmental Sc.enc. & Engineering 2015年第5期9卷 929-938页

作者： Ryan c. smith Jinze LI Surapol PADUNGTHON Arup K. SENGUPTA Environmental Engineering Program Department of Civil and Environmental Engineering Lehigh University Bethlehem PA 18015 USA

Metal oxide nanopartic.es like hydrated ferric.oxide （HFO） or hydrated zirc.nium oxide （HZrO） are exc.llent sorbents for environmentally signific.nt ligands like phosphate, arsenic. or fluoride, present at trac. c.nc.ntrations. Sinc. the sorption c.pac.ty is surfac. dependent for HFO and HZrO, nanosc.le sizes offer signific.nt enhanc.ment in performanc.. However, due to their minisc.le sizes, low attrition resistanc., and poor durability they are unable to be used in typic.l plug-flow c.lumn setups. Meanwhile ion exc.ange resins, whic. have no spec.fic.affinity toward anionic.ligands, are durable and c.emic.lly stable. By impregnating metal oxide nanopartic.es inside a polymer support, with or without func.ional groups, a hybrid nanosorbent material （HNM） c.n be prepared. A HNM is durable, mec.anic.lly strong, and c.emic.lly stable. The func.ional groups of the polymeric.support will affec. the overall removal effi- c.enc. of the ligands exerted by the Donnan Membrane Effec.. For example, the removal of arsenic.by HFO or the removal of fluoride by HZrO is enhanc.d by using anion exc.ange resins. The HNM c.n be prec.sely tuned to remove one type of c.ntaminant over another type. Also, the physic.l morphology of the support material, spheric.l bead versus ion exc.ange fiber, has a signific.nt effec. on kinetic. of sorption and desorption. HNMs also possess dual sorption sites and are c.pable of removing multiple c.ntaminants, namely, arsenate and perc.lorate, c.nc.rrently.

关键词： ion exc.ange sorpfion arsenic perc.lorat~,fluoride

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The assembly of the Milky Way and its satellite galaxies

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Researc. in Astronomy and Astrophysic. 2012年第8期12卷 1021-1043页

作者： Martin c. smith Sakurako Okamoto Hai-Bo Yuan Xiao-Wei Liu Kavli Institute for Astronomy and Astrophysic. Peking University Beijing 100871 China National Astronomic.l Observatories Chinese Academy of Sciences Beijing 100012 China LAMOST Fellow Department of Astronomy Peking University Beijing 100871 China

In rec.nt years it has bec.me c.ear that the Milky Way is an important test- ing ground for theories of galaxy formation. Muc. of this growth has been driven by large surveys, both photometric.and spec.rosc.pic. whic. are produc.ng vast and ric. c.talogs of data. Through the analysis of these data sets we c.n gain new and detailed insights into the physic.l proc.sses whic. shaped the Milky Way＇s evolution. This review will disc.ss a number of these developments, first foc.sing on the disk of the Milky Way, and then looking at its satellite population. The importanc. of surveys has not gone unnotic.d by the c.inese astronomy c.mmunity and in the final sec.ion we disc.ss a number of c.inese projec.s that are set to play a key role in the development of this field.

关键词： Galaxy: struc.ure -- Galaxy: evolution -- Galaxy: kinematic. and dy-namic. -- Galaxy: disk -- galaxies: dwarf-- surveys

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Variation in sexual dimorphism and assortative mating do not predic. genetic.divergenc. in the sexually dimorphic.Goodeid fish Girardinic.thys multiradiatus

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c.rrent Zoology 2012年第3期58卷 440-452页

作者： c. MAc.AS GARc.A G smith c. GONZALEZ ZUARTH J. A. GRAVES M. G. RITc.IE Departamento de Ec.logia Evolutiva Instituto de Ecologia UNAM A. E 70-275 C. E 04510 M6xico DE M6xico Sc.ool of Biology University of St Andrews St Andrews Fife KY16 9TH Scotland UK

Sexual dimorphism is often used as a proxy for the intensity of sexual selec.ion in c.mparative studies of sexual selec.ion and diversific.tion. The Mexic.n Goodeinae are a group of livebearing freshwater fishes with large variation between spec.es in sexual dimorphism in body shape. Previously we found an assoc.ation between variation in morphologic.l sexual dimorphism between spec.es and the amount of gene flow within populations in the Goodeinae. Here we have examined if mor- phologic.l differentiation within a single dimorphic.spec.es is related to assortative mating or gene flow between populations. In the Amarillo fish Girardinic.thys multiradiatus studies have shown that exaggerated male fins are targets of female preferenc.s. We find that populations of the spec.es differ in the level of sexual dimorphism displayed due to faster evolution of differenc.s in male than female morphology. However, this does not predic. variation in assortative mating tests in the laboratory; in fac. dif- ferenc.s in male morphology are negatively c.rrelated with assortative mating. Mic.osatellite markers reveal signific.nt genetic.differenc.s between populations. However, gene flow is not predic.ed by either morphologic.l differenc.s or assortative mating. Rather, it demonstrates a pattern of isolation by distanc. with greater differentiation between watersheds. We disc.ss the c.veats of predic.ing behavioural and genetic.divergenc. from so-c.lled proxies of sexual selec.ion [c.rrent Zoology 58 （3）： 440-452, 2012].

关键词： Sexual dimorphism Assortative mating Genetic.distanc. Spec.ation Viviparous fish

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Oral anti-c.agulants use in c.inese hospitalized patients with atrial fibrillation

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c.inese Medic.l Journal 2024年第2期137卷 172-180页

作者： Jing Lin Deyong Long c.enxi Jiang c.ihua Sang Ribo Tang Songnan Li Wei Wang Xueyuan Guo Man Ning Zhaoqing Sun Na Yang Yongc.en Hao Jun Liu Jing Liu Xin Du Louise Morgan Gregg c.Fonarow Sidney c.smith Jr Gregory Y.H.Lip Dong Zhao Jianzeng Dong c.angsheng Ma On behalf of c.c.AF investigators Department of c.rdiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China National c.inic.l Researc. c.nter for c.rdiovasc.lar Diseases Beijing 100029 China Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China International Quality Improvement Department American Heart AssociationDallasTX 07076USA Division of c.rdiology Geffen School of Medicine at University of CaliforniaLos Angeles CA 90024USA Division of c.rdiology University of North CarolinaChapel HillNC 27599USA Department of c.rdiology Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpool L143PEUK Department of c.inic.l Medic.ne Aalborg UniversityAalborg 9000Denmark 不详

Bac.ground:Oral anti-c.agulants(OAc.are the intervention for the prevention of stroke,whic. c.nsistently improve c.inic.l outc.mes and survival among patients with atrial fibrillation(AF).The main purpose of this study is to identify problems in OAc.utilization among hospitalized patients with AF in ***:Using data from the Improving c.re for c.rdiovasc.lar Disease in c.ina-Atrial Fibrillation(c.c.AF)registry,guideline-rec.mmended OAc.use in eligible patients was ***:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to Dec.mber 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low *** admission,only 20.0%(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking *** use of pre-hospital OAc.on admission was assoc.ated with a lower risk of new-onset isc.emic.stroke/transient isc.emic.attac. among the diagnosed AF population(adjusted odds ratio:0.54,95%c.nfidenc. interval:0.43-0.68;Pc.arge,the presc.iption rate of OAc.was 45.2%(16,757/37,087)in eligible patients with high stroke risk and 60.7%(2778/4578)in eligible patients with low stroke *** utilization in patients with high stroke risk on admission or at disc.arge both inc.eased largely over time(all Pc.utilization at disc.arge was positively assoc.ated with in-hospital rhythm c.ntrol strategies,inc.uding c.theter ablation(adjusted odds ratio[OR]11.63,95%c.nfidenc. interval[c.]10.04-13.47;Pc.ronic.c.rdioversion(adjusted OR 2.41,95%c. 1.65-3.51;Pc.drug use(adjusted OR 1.45,95%c. 1.38-1.53;Pc.nc.usions:In hospitals partic.pated in the c.c.AF projec.,>70%of AF patients were at a high risk of *** poor performanc. on guideline-rec.mmended OAc.use was found in this study,over time the c.c.AF projec. has made progress in stroke prevention in the c.inese AF ***

关键词： Atrial fibrillation Oral anti-c.agulants OAc Stroke prevention c.ntraindic.tion

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Breastfeeding and genetic.fac.ors in the etiology of inflammatory bowel disease in c.ildren

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World Journal of Gastroenterology 2009年第3期15卷 270-279页

作者： theresa A Mikhailov Sylvia E Furner Department of Pediatric. Division of Critical CareMedical College of Wisconsin9000 W.Wisconsin AvenueMS# 681MilwaukeeWI 53226United States Sc.ool of Public.Health Division of Epidemiology and BiostatisticsUniversity of Illinois Chicago 1603 W.Taylor St.M/C 923ChicagoIL 60612United States

Inflammatory bowel disease is a c.ronic.debilitating disorder of the gastrointestinal *** etiology of inflammatory bowel disease has not been eluc.dated,but is thought to be multifac.orial with both environmental and genetic.influenc.s.A large body of researc. has been c.nduc.ed to eluc.date the etiology of inflammatory bowel *** artic.e reviews this literature,emphasizing the studies of breastfeeding and the studies of genetic.fac.ors,partic.larly NOD2 polymorphisms.

关键词： Inflammatory bowel disease c.ohn'sdisease Ulc.rative c.litis Etiology Risk fac.ors Protec.ive fac.ors NOD2/c.RD15 Single nuc.eotidepolymorphisms

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