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Rec.mbinant streptokinase vs hydroc.rtisone suppositories in ac.te hemorrhoids:A randomized c.ntrolled trial

World Journal of Gastroenterology 2015年第23期21卷 7305-7312页

作者： Franc.sc. Hernández-Bernal Georgina c.stellanos-Sierra c.rmen M Valenzuela-Silva Karem M c.tasús-Alvarez Osmany Martínez-Serrano Odalys c.Lazo-Diago c.mara H Bermúdez-Badell José R c.usa-Garc.a Juan E Domínguez-Suárez Pedro A López-Saura 无 c.inic.l Researc. Direc.ion Center for Genetic Engineering and Biotechnology Juan B.Zayas Hospital Ernesto Guevara Hospital c.lia Sánc.ez Hospital Manzanillo Gustavo Aldereguía Hospital theresa-4(Treatment of HEmorrhoids with REc.mbinant Streptokinase Applic.tion)Group of Investigators

AIM: To c.mpare the effic.c. and safety of rec.mbinant streptokinase(rSK) vs hydroc.rtisone ac.tate-based suppositories in ac.te hemorrhoidal ***: A multic.nter(11 sites), randomized(1:1:1), open, c.ntrolled trial with parallel groups was performed. All partic.pating patients gave their written,informed c.nsent. After inc.usion, patients with ac.te symptoms of hemorrhoids were c.ntrally randomized to rec.ive, as outpatients, by the rec.al route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were c.mpleted(sc.edule A), one unit every 8 h until 6 units were c.mpleted(sc.edule B), or 25 mg hydroc.rtisone ac.tate onc. every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inc.usion. The main end-point was the 5thday response(disappearanc. of pain and bleeding, and≥ 70% reduc.ion of the lesion size). Time to response and need for thrombec.omy were sec.ndary effic.c. variables. Adverse events were also ***: Groups were homogeneous with regards to demographic.and baseline c.arac.eristic.. Fifth day c.mplete response rates were 156/170(91.8%; 95%c.:87.3-96.2), 155/170(91.2%; 95%c.: 86.6%-95.7%),and 46/170(27.1%; 95%c.: 20.1%-34.0%) with rSK(sc.edule A and B) and hydroc.rtisone ac.tate suppositories, respec.ively. These 64.6% and 63.9%differenc.s(95%c.: 56.7%-72.2% and 55.7%-72.0%)were highly signific.nt(P c.ed sinc. the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and ac.ive c.ntrol groups,respec.ively; P c.rtisone ac.tate, respec.ively;P c.: 2.9-3.1)for both rSK groups and 10 d(95%c.: 9.3-10.7) in the hydroc.rtisone ac.tate group. This differenc. was highly signific.nt(P < 0.001). All subgroup stratified analyses(with or without thrombosis and he

关键词： Streptokinase Suppository Hydroc.rtisoneac.tate Thrombolysis Hemorrhoids Randomizedc.inic.l trial

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基于辣椒基因组测序探究辣味在种群中的进化

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辣椒杂志 2014年第2期12卷 40-50页

作者： Seungill Kim Minkyu Park Seon-In Yeom Yong-Min Kim Je Min Lee Hyun-Ah Lee Eunyoung Seo Jaeyoung c.oi Kyeongc.ae c.eong Ki-Tae Kim Kyongyong Jung Gir-Won Lee Sang-Keun Oh c.ungyun Bae Saet-Byul Kim Hye-Young Lee Shin-Young Kim Myung-Shin Kim Byoung-c.eorl Kang Yeong Deuk Jo Hee-Bum Yang Hee-Jin Jeong Won-Hee Kang Jin-Kyung Kwon c.anseok Shin Jae Yun Lim June Hyun Park Jin Hoe Huh June-Sik Kim Byung-Dong Kim Oded c.hen Ilan Paran Mi c.ung Suh Saet Buyl Lee Yeon-Ki Kim Younhee Shin Seung-Jae Noh Junhyung Park Young Sam Seo Suk-Yoon Kwon Hyun A Kim Jeong Mee Park Hyun-Jin Kim Sang-Bong c.oi Paul W Bosland Gregory Reeves Sung-Hwan Jo Bong-Woo Lee Hyung-Taeg c.o Hee-Seung c.oi Min-Soo Lee Yeisoo Yu Yang Do c.oi Beom-Seok Park Allen van Deynze Hamid Ashrafi theresa Hill Woo Taek Kim Hyun-Sook Pai Hee Kyung Ahn Inhwa Yeam James J Giovannoni Joc.lyn K c.Rose Iben Sφrensen Sang-Jik Lee Ryan W Kim Ik-Young c.oi Beom-Soon c.oi Jong-Sung Lim Yong-Hwan Lee Doil c.oi 刘峰张西露 Department of Plant Sc.enc. Seoul National University Plant Genomic. and Breeding Institute Seoul National University Department of Agric.ltural Biotec.nology Seoul National University Department of Bioinformatic. and Life Sc.enc. Soongsil University Vegetable Breeding Researc. c.nter Seoul National University Agric.ltural Researc. Organization Institute of Plant Science Volcani Center Bet DaganIsrael. Agric.ltural Researc. Organization Institute of Plant Science Volcani Center Bet DaganIsrael Department of Bioenergy Sc.enc. and Tec.nology Chonnam National University Genomic. Genetic. Institute GreenGene BioTech Inc. c.des Division Insilicogen Inc. Ginseng Resourc.s Researc. Laboratory Korea Ginseng Corporation Korea Researc. Institute of Biosc.enc. and Biotec.nology Division of Biosc.enc. and Bioinformatic. Myongji University Department of Plant and Environmental Sc.enc.s New Mexico State University c.ile Pepper Institute New Mexico State University Seeders Inc. Department of Biologic.l Sc.enc.s Seoul National University Arizona Genomic. Institute University of Arizona Agric.ltural Genome c.nter National Academy of Agricultural Science Rural Development Administration Seed Biotec.nology c.nter University of California Davis Davis California USA Department of Systems Biology Yonsei University Department of Hortic.lture and Breeding Andong National University US Department of Agric.lture-Agric.ltural Researc. Servic. Robert W. Holley Center Ithaca New York USA Boyc. Thompson Institute for Plant Researc. Cornell University Ithaca New York USA Department of Plant Biology Cornell University Ithaca New York USA Biotec.nology Institute Nongwoo Bio Yeoju Korea Genome c.nter University of California Davis Davis California USA National Instrumentation c.nter for Environmental Management Seoul National University Seoul Korea 湖南省蔬菜研究所

辣椒(c.psic.m annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对c.334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表... 详细信息

辣椒(c.psic.m annuum)是美洲最古老的驯化作物之一,在全世界被广泛种植。本研究对c.334(墨西哥地方品种)进行了全基因组测序和组装(覆盖度为186.6×),同时还对另外两个栽培种和一个野生种分别进行了重测序和从头(de novo)测序。结果表明辣椒基因组大小约为番茄的4倍,辣椒基因组上存在大量gypsy转座子和花椰菜病毒家族元件的积累。结合转录组综合分析认为,辣椒素合成酶基因表达模式的改变及新功能化是导致辣椒素生物合成的原因,研究还发现辣椒与番茄在乙烯合成及果实成熟调控方面存在明显不同的分子模式。辣椒参考基因组的发布为辣椒营养品质和药用价值的改善提供了重要平台。

关键词：基因组测序辣椒素参考基因 c.psic.m 转座子辣椒果实分子模式生物合成基因表达模式基因组大小

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