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A Novel Heuristic Algorithm for theModeling and Risk Assessment of the COVID-19 Pandemic Phenomenon

Computer Modeling in engineering & Sciences 2020年第11期125卷 815-828页

作者： Panagiotis G.Asteris Maria G.Douvika Chrysoula A.Karamani Athanasia D.Skentou Katerina Chlichlia Liborio Cavaleri Tryfon Daras Danial J.Armaghani theoklis e.zaoutis Computational Mechanics Laboratory School of Pedagogical and Technological EducationAthens15122Greece Laboratory of Molecular Immunology Department of Molecular Biology and GeneticsDemocritus University of ThraceAlexandroupolisGreece Department of Civil EnvironmentalAerospace and Materials EngineeringUniversity of PalermoPalermoItaly School of environmental engineering Technical University of CreteChaniaGreece Department of Civil engineering Faculty of EngineeringUniversity of MalayaKuala LumpurMalaysia Division of Infectious Diseases The Children’s Hospital of PhiladelphiaPerelman School of MedicineUniversity of PennsylvaniaPHLUSA

Themodeling and risk assessment of a pandemic phenomenon such as COVID-19 is an important and complicated issue in epidemiology,and such an attempt is of great interest for public health *** this end,in the present study,based on a recent heuristic algorithm proposed by the authors,the time evolution of COVID-19 is investigated for six different countries/states,namely New York,California,USA,Iran,Sweden and *** number of COVID-19-related deaths is used to develop the proposed heuristic model as it is believed that the predicted number of daily deaths in each country/state includes information about the quality of the health system in each area,the age distribution of population,geographical and environmental factors as well as other *** on derived predicted epidemic curves,a new 3D-epidemic surface is proposed to assess the epidemic phenomenon at any time of its *** research highlights the potential of the proposed model as a tool which can assist in the risk assessment of the *** its development through 3D-epidemic surface can assist in revealing its dynamic nature as well as differences and similarities among different districts.

关键词： Algorithm COVID-19 Gaussian-function heuristic model pandemic trend prediction SARS-CoV-2

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Willingness of Greek general population to get a COVID-19 vaccine

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Global Health Research and Policy 2021年第1期6卷 478-487页

作者： Georgia Kourlaba eleni Kourkouni Stefania Maistreli Christina-Grammatiki Tsopela Nafsika-Maria Molocha Christos Triantafyllou Markela Koniordou Ioannis Kopsidas evangelia Chorianopoulou Stefania Maroudi-Manta Dimitrios Filippou theoklis e.zaoutis Center for Clinical epidemiology and Outcomes Research(CLeO) AthensGreece eCONCARe LP AthensGreece Department of Anatomy and Surgical Anatomy Medical SchoolNational and Kapodistrian University of AthensAthensGreece Division of Infectious Diseases The Children’s Hospital of PhiladelphiaPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaUSA

Background:epidemiological data indicate that a large part of population needs to be vaccinated to achieve herd ***,it is of high importance for public health officials to know whether people are going to get vaccinated for *** objective of the present study was to examine the willingness of adult residents in Greece to receive a COVID-19 ***:A cross-sectional was survey conducted among the adult general population of Greece between April 28,2020 to May 03,2020(last week of lockdown),using a mixed methodology for data collection:Computer Assisted Telephone Interviewing(CATI)and Computer Assisted web Interviewing(CAWI).Using a sample size calculator,the target sample size was found to be around 1000 *** ensure a nationally representative sample of the urban/rural population according to the Greek census 2011,a proportionate stratified by region systematic sampling procedure was used to recruit *** collection was guided through a structured *** willingness to COVID-19 vaccination,participants were asked to answer the following question:“If there was a vaccine available for the novel coronavirus,would you do it?”Results:Of 1004 respondents only 57.7%stated that they are going to get vaccinated for *** aged>65 years old,those who either themselves or a member of their household belonged to a vulnerable group,those believing that the COVID-19 virus was not developed in laboratories by humans,those believing that coronavirus is far more contagious and lethal compared to the H1N1 virus,and those believing that next waves are coming were statistically significantly more likely to be willing to get a COVID-19 *** knowledge score regarding symptoms,transmission routes and prevention and control measures against COVID-19 was significantly associated with higher willingness of respondents to get ***:A significant proportion of individuals in the general popu

关键词： Vaccine hesitancy COVID-19 europe Vaccine coverage

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Advanced optimization of gas turbine aero-engine transient performance using linkage-learning genetic algorithm:PartⅡ,optimization in flight mission and controller gains correlation development

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Chinese Journal of Aeronautics 2021年第4期34卷 568-588页

作者： Yinfeng LIU Soheil JAFARI theoklis NIKOLAIDIS Aero engine Test Department of Hunan Aviation Powerplant Research Institute AECCZhuzhou 412002China Centre for Propulsion engineering School of Aerospace Transport and Manufacturing(SATM)Cranfield UniversityCranfield MK430ALUK

PartⅠhas illustrated the procedures to apply the Linkage Learning Genetic Algorithm(LLGA)in Gas Turbine engine(GTe)controller gains tuning and generated the optimization results for runway conditions from idle to ***,the total pressure and temperature of the engine inlet vary as the changing of altitude and Mach number,which would lead to the variation in fuel flow supply *** a result,the optimized gains in runway might not be suitable for other flight *** order to maintain the optimal control performance,the GTe controller gains should be adjusted according to the flight *** paper extends the application of the LLGA method to other flight conditions and then simulates a complete flight mission with different gains and weather condition *** this purpose,the control parameters in the Simulink model of the GTe controller are first corrected by the weather condition in ***,a typical flight mission is defined and divided into different flight segments based on the altitude and Mach number *** representative point is selected from each segment as the datum point for optimization *** this step,the LLGA method is used to find the best gains combinations for different flight conditions and the differences in optimization effects for different flight conditions are analyzed *** simulation results show that the optimization effect of the control performance of each flight condition is dependent on the value of(θδ)~(1/2)and the optimal K_(pla)in some flight conditions is approximately equal to p hd times of the Kplavalue in sea level standard ***,the complete flight mission is simulated with different gains and weather condition *** simulation results show that the engine performance has been greatly improved after optimization by LLGA in the transient state and the high altitude *** other steady states,the optimization effect is not

关键词： Aeroengine control Control optimization Flight condition Flight mission simulation GA GTe LLGA Min-Max controller Robustness

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Advances and challenges in diagnosing and managing adult autoimmune enteropathy

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World Journal of Gastroenterology 2025年第2期31卷 128-131页

作者： Grigorios Christodoulidis Sara e Agko Marina N Kouliou Konstantinos e Koumarelas Dimitris Zacharoulis Department of General Surgery University Hospital of LarissaLarissa 41110Greece Department of Intensive Care Unit Asklepios Paulinen Clinic WiesbadenWiesbaden 65197Germany Department of emergency Medicine General Hospital of LarissaLarissa 41221Greece Department of Surgery University Hospital of LarissaLarissa 41334Greece

Autoimmune enteropathy(AIe)is a rare immune mediated disorder primarily affecting children,characterized by chronic diarrhea,malabsorption,vomiting,weight loss and villous *** has also been observed in adults presenting diagnostic and treatment challenges due to its overlap with other gastrointestinal disorders such as celiac *** diagnostic criteria for AIe include small bowel villous atrophy,lack of response to dietary restrictions,presence of anti-enterocyte antibodies,and predisposition to autoimmunity without severe *** criteria emphasize characteristic histological findings and exclusion of other causes of villous *** is associated with various autoimmune disorders and can present with overlapping features with Celiac disease,including villous atrophy but without significant intraepithelial *** primarily involves immunosuppression using corticosteroids,calcineurin inhibitors,and anti-tumor necrosis factor therapy,alongside nutri-tional *** the challenges,understanding AIe’s diverse manifest-ations and improving diagnostic criteria are essential for effective management and improved patient *** research is needed to elucidate the pathogenesis,disease progression and long-term outcomes of AIe.

关键词： Autoimmune enteropathy Diagnosis Prognosis Adult autoimmune enter-opathy and challenges Autoimmune enteropathy and treatment Autoimmune enteropathy and diagnostic criteria Pathophysiology of autoimmune enteropathy

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Impact of rotavirus vaccine on acute gastroenteritis emergency department visits and hospitalizations in a highly-vaccinated urban cohort

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Open Journal of Pediatrics 2011年第4期1卷 41-44页

作者： Sheila M. Nolan Priya Prasad Alexander G. Fiks theoklis e. zaoutis Thomas R. TenHave Susan e. Coffin 不详

Background: Rotavirus vaccines (RVV) have significantly reduced rotavirus disease in children over the past 4 years in the United States. In this study, we describe the impact of RVV in preventing acute gastroenteritis (AGe) hospital encounters in a highly-vaccinated urban pediatric network during the 2007 and 2008 rotavirus seasons. Methods: We used 5 urban practices from a practice-based network to conduct a retrospective cohort study comparing the numbers of AGe emergency department (eD) visits and hospitalizations in RVV-immunized (exposed) and non-immunized (unexposed) children during the first 2 full seasons following RVV introduction. We determined incident rate ratios (IRR), using Poisson regression, and vaccine effectiveness for each outcome. Results: The 2007 and 2008 cohorts were analyzed separately. 62% of the 2007 cohort was vaccinated and 88% of the 2008 cohort. AGe hospitalizations were significantly reduced among RVV-immunized children from the 2007 cohort in the 2008 season with vaccine effectiveness of 67%. Sub-analysis of this cohort by age revealed that RVV was most protective against hospitalizations in the youngest age group (IRR = 0.21, 95% CI (0.06, 0.82). A trend toward protection against hospitalization was detected for both cohorts in the first season following immunization that did not reach a statistically significant level. For AGe eD visits, no significant difference was seen between RVV-immunized and non-immunized children in either cohort, although there was a trend toward protection (IRR’s: 0.67 - 0.7). Conclusions: RVV was highly effective in preventing AGe hospitalizations for a subset of our cohort in 2008. Given reports of RVV effectiveness, we hypothesize that herd immunity is responsible for the inability to detect a significant difference between RVV-immunized and non-immunized children in our highly- vaccinated cohort.

关键词： Rotavirus Pediatrics Acute Gastroenteritis

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enhancing perianal disease management with integrated physical and psychological approaches

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World Journal of Clinical Cases 2025年第2期13卷 59-63页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This article provides a comprehensive analysis of the study by Hou et al,focusing on the complex interplay between psychological and physical factors in the postoperative recovery(POR)of patients with perianal *** study sheds light on how illness perception,anxiety,and depression significantly influence recovery *** et al developed a predictive model that demonstrated high accuracy in identifying patients at risk of poor *** article explores the critical role of pre-operative psychological assessment,highlighting the need for mental health support and personalized recovery plans in enhancing POR quality.A multidisciplinary approach,integrating mental health professionals with surgeons,anesthesiologists,and other specialists,is emphasized to ensure comprehensive care for *** study’s findings serve as a call to integrate psychological care into surgical practice to optimize outcomes for patients with perianal diseases.

关键词： Perianal disease Post-operative recovery Anxiety Depression Pain management emotional well-being Multidisciplinary approach

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Brain-derived neurotrophic factor alterations and cognitive decline in schizophrenia:Implications for early intervention

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World Journal of Psychiatry 2025年第1期15卷 189-193页

作者： Uchenna e Okpete Haewon Byeon Department of Digital Anti-aging Healthcare(BK21) Inje UniversityGimhae 50834South Korea

This manuscript explores the recent study by Cui et al which assessed the interplay between inflammatory cytokines and brain-derived neurotrophic factor(BDNF)levels in first-episode schizophrenia *** study revealed that higher levels of interleukin-6 and tumor necrosis factor-αcorrelated with reduced BDNF levels and poorer cognitive *** is a severe psy-chiatric disorder impacting approximately 1%of the global population,charac-terized by positive symptoms(hallucinations and delusions),negative symptoms(diminished motivation and cognitive impairments)and disorganized thoughts and *** research highlights the role of BDNF as a potential biomarker for early diagnosis and therapeutic *** findings from Cui et al’s study suggest that targeting neuroinflammation and enhancing BDNF levels may improve cognitive *** treatment approaches involve a com-bination of pharmacological and non-pharmacological interventions tailored to individual patient ***,monitoring cognitive and neuroinflammatory markers is essential for improving patient outcomes and quality of ***-quently,this manuscript highlights the need for an integrated approach to schizo-phrenia management,considering both clinical symptoms and underlying neuro-biological changes.

关键词： Schizophrenia Cognitive impairment Neuroinflammatory markers Brain-derived neurotrophic factor Interleukin Personalized treatment

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NeCAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Forging an easier path through graduation:Improving the patient transition from paediatric to adult critical care

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World Journal of Critical Care Medicine 2025年第1期14卷 82-90页

作者： Stephen Warrillow Ben Gelbart Jess Stevens Gordon Baikie Mark e Howard Department of Intensive Care Austin HealthHeidelberg 3084VictoriaAustralia Department of Critical Care The University of MelbourneParkville 3010VictoriaAustralia Department of Intensive Care Royal Children’s HospitalParkville 3010VictoriaAustralia Living with Disability Research Centre La Trobe UniversityBundoora 3086VictoriaAustralia Department of Neurodevelopment&Disability Royal Children’s HospitalParkville 3010VictoriaAustralia Department of Paediatrics The University of MelbourneParkville 3010VictoriaAustralia Department of Respiratory and Sleep Medicine Austin HealthHeidelberg 3084VictoriaAustralia Department of Medicine Austin HealthThe University of MelbourneHeidelberg 3084VictoriaAustralia

Adolescence and the journey to adulthood involves exciting opportunities as well as psychosocial stress for young people growing *** normal experiences are potentially magnified for teenagers living with chronic illness or disability and their *** in care have improved survival for children with a variety of serious chronic medical conditions such that many who may once have died in childhood now survive well into adulthood with ongoing *** those with highly complex needs,care is often provided at major paediatric hospitals with expertise,specially trained personnel,and resources to support young people and their families for the first decades of *** the end of adolescence,however,it is generally appropriate and necessary for young adults and their caregivers to transition to the care of clinicians trained in the care of adults at general *** there are some well-managed models to support this journey of transition,these are often specific to certain conditions and usually do not involve intensive *** patients may encounter considerable challenges during this *** may include the loss of established therapeutic relationships,a perception of austerity and reduced amenity in facilities oriented to caring for adult patients,and care by clinicians with less experience with more common paediatric *** addition,there is a risk of potential conflict between clinicians and families regarding goals of care in the event of a critical illness when it occurs in a young adult with major disability and long-term health *** challenges present genuine opportunities to better understand the transition from paediatric to adult-based care and to improve processes that assist clinicians who support patients and families as they shift between healthcare settings.

关键词： Paediatric intensive care Disability Adult intensive care Transition Critical care

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Current and future perspectives in the management and treatment of colorectal cancer

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World Journal of Clinical Oncology 2025年第2期16卷 9-17页

作者： Sigfredo e Romero-Zoghbi evita Krumina Fernando López-Campos Felipe Couñago Department of Radiation Oncology GenesisCare Talavera de la ReinaToledo 45600Spain Department of Radiation Oncology GenesisCare GuadalajaraGuadalajara 19004Spain Department of Radiation Oncology Hospital Universitario Ramón Y CajalMadrid 28034Spain Department of Radiation Oncology GenesisCare-Hospital Universitario Vithas Madrid La MilagrosaMadrid 28010Spain

In this editorial,we reviewed the article by Fadlallah et al that was recently published in the World Journal of Clinical *** article provided a comprehensive and in-depth view of the management and treatment of colorectal cancer(CRC),one of the leading causes of cancer-related morbidity and mortality *** article analyzed the therapeutic modalities and their sequencing,focusing on total neoadjuvant therapy for locally advanced rectal *** highlighted the role of immunotherapy in tumors with high microsatellite instability or deficient mismatch repair,addressing recent advances that have improved prognosis and therapeutic response in localized and metastatic *** in surgical techniques,advanced radiotherapy,and systemic agents targeting specific mutational profiles are also discussed,reflecting on how they revolutionized clinical *** tumor DNA has emerged as a promising tool for detecting minimal residual disease,prognosis,and therapeutic monitoring,solidifying its role in precision *** review emphasized the importance of technological and therapeutic advancements in improving clinical outcomes and personalizing CRC treatment.

关键词： Colorectal cancer Metastatic colorectal cancer Total neoadjuvant therapy Chemoradiotherapy Colon surgery Rectal surgery Chemotherapy Immunotherapy

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