检索结果-南通市图书馆

Mesenchymal stromal cells as potential immunomodulatory players in severe acute respiratory distress syndrome induced by SARSCoV- 2 infection

引用

World Journal of Stem Cells 2020年第8期12卷 731-751页

作者： Panagiotis Mallis Efstathios Michalopoulos theofanis chatzistamatiou Catherine Stavropoulos-Giokas Hellenic Cord Blood Bank Biomedical Research Foundation Academy of AthensAthens 11527Greece

Severe acute respiratory syndrome coronavirus-2 and the related coronavirus disease-19(COVID-19)is a worldwide emerging situation,which was initially reported in December 2019 in Wuhan,***,more than 7258842 new cases,and more than 411879 deaths have been reported *** new highly transmitted coronavirus is responsible for the development of severe acute respiratory distress *** to this disorder,a great number of patients are hospitalized in the intensive care unit followed by connection to extracorporeal membrane oxygenation for breath supporting and *** acute respiratory distress syndrome is mostly accompanied by the secretion of proinflammatory cytokines,including interleukin(IL)-2,IL-6,IL-7,granulocyte colony-stimulating factor(GSCF),interferon-inducible protein 10(IP10),monocyte chemotactic protein-1(MCP1),macrophage inflammatory protein 1A(MIP1A),and tumor necrosis factor alpha(TNF-α),an event which is known as“cytokine storm”.Further disease pathology involves a generalized modulation of immune responses,leading to fatal multiorgan ***,no specific treatment or vaccination against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has been *** stromal cells(MSCs),which are known for their immunosuppressive actions,could be applied as an alternative co-therapy in critically-ill COVID-19 ***,MSCs can regulate the immune responses through the conversion of Th1 to Th2,activation of M2 macrophages,and modulation of dendritic cells *** key immunoregulatory properties of MSCs may be exerted either by produced soluble factors or by cell-cell contact *** date,several clinical trials have been registered to assess the safety,efficacy,and therapeutic potential of MSCs in ***,MSC treatment may be effective for the reversion of ground-glass opacity of damaged lungs and reduce the tissue *** into account the multifunctional pro

关键词： SARS-CoV-2 COVID-19 Respiratory syndrome Cytokine storm Mesenchymal stromal cells Immunoregulation Lungs Th2 response Dendritic cells Natural killer cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mesenchymal stromal cell delivery as a potential therapeutic strategy against COVID-19:Promising evidence from in vitro results

引用

World Journal of Biological Chemistry 2022年第2期13卷 47-65页

作者： Panagiotis Mallis theofanis chatzistamatiou Zetta Dimou Eirini-Faidra Sarri Eleni Georgiou Maria Salagianni Vasiliki Triantafyllia Evangelos Andreakos Catherine Stavropoulos-Giokas Efstathios Michalopoulos Hellenic Cord Blood Bank Biomedical Research Foundation Academy of AthensAthens 11527Greece Laboratory of Immunobiology Center for ClinicalExperimental Surgery and Translational ResearchBiomedical Research Foundation Academy of AthensAthens 11527Greece

BACKGROUND Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for the coronavirus disease 2019(COVID-19)pandemic,which was initiated in December ***-19 is characterized by a low mortality rate(<6%);however,this percentage is higher in elderly people and patients with underlying ***-19 is characterized by mild to severe ***,several therapeutic strategies are evaluated,such as the use of anti-viral drugs,prophylactic treatment,monoclonal antibodies,and *** cellular therapies are also investigated,thus representing an additional therapeutic tool for *** stromal cells(MSCs),which are known for their immunoregulatory properties,may halt the induced cytokine release syndrome mediated by SARS-CoV-2,and can be considered as a potential stem cell *** To evaluate the immunoregulatory properties of MSCs,upon stimulation with COVID-19 patient *** MSCs derived from the human Wharton’s Jelly(WJ)tissue and bone marrow(BM)were isolated,cryopreserved,expanded,and defined according to the criteria outlined by the International Society for Cellular ***,WJ and BM-MSCs were stimulated with a culture medium containing 15%COVID-19 patient serum,1%penicillin-streptomycin,and 1%L-glutamine for 48 *** quantification of interleukin(IL)-1 receptor a(Ra),IL-6,IL-10,IL-13,transforming growth factor(TGF)-β1,vascular endothelial growth factor(VEGF)-a,fibroblast growth factor(FGF),platelet-derived growth factor(PDGF),and indoleamine-2,3-dioxygenase(IDO)was performed using commercial ELISA *** expression of HLA-G1,G5,and G7 was evaluated in unstimulated and stimulated WJ and ***,the interactions between MSCs and patients’macrophages were established using co-culture *** Thawed WJ and BM-MSCs exhibited a spindle-shaped morphology,successfully differentiated to“osteocytes”,“adipocytes”,and“chondrocytes”,and in flow cytometric analysis were characte

关键词： SARS-CoV-2 COVID-19 MSCs Stem cell therapy Cytokine storm Immunomodulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Effect of Trace Elements Accumulation on the Levels of Secondary Metabolites and Antioxidant Activity in Carrots, Onions and Potatoes

引用

Food and Nutrition Sciences 2011年第10期2卷 1071-1076页

作者： Evangelia Flemotomou theofanis Molyviatis Ioannis Zabetakis 不详

The objective of this work is to correlate the accumulation of trace elements in food tubers with possible alterations of the secondary plant metabolism. Samples of carrots, onions and potatoes grown in the environmentally polluted area of Asopos river in Viotia, Greece and other Greek areas (control) were analysed for carotenoids by HPLC-UV and DPPH antioxidant activity. In carrots, the levels of α-carotene, β-carotene and lutein were quantified and it was found that Asopos samples had statistically significantly lower levels of β-carotene compared to control ones. Also, in potatoes, the levels of lutein in Asopos samples were statistically significantly lower than control ones. However, in onions, the levels of lutein between Asopos and control samples were not found statistically different. In all samples, no statistically significant differences in the levels of DPPH activity (measured as ΙC50: sample levels that cause 50% inhibition of DPPH scavenging activity) were observed. In conclusion, the presence of heavy metals in carrots and potatoes has affected the levels of carotenoids.

关键词： Asopos Carotenoids Tuber Foods Nickel Chromium DPPH

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Violence against health care staff by patient’s visitor in general hospital in Greece: Possible causes and economic crisis

引用

Open Journal of Nursing 2013年第8期3卷 21-27页

作者： Evmorfia Koukia Polyxeni Mangoulia Nikolaos Gonis theofanis Katostaras Faculty of Nursing University of Athens Greece

This study examined the types of violence experienced by physicians, nurses and nurse assistants in various departments by patients’ visitors. Few studies have focused on patients’ visitors’ violence against nurses or physicians in general hospitals and various departments in the beginning of economic crisis in Greece. A total of 250 health care staff—physicians, nurses, nurses’ assistants—took part in a questionnaire-based study. A majority of respondents had experienced some forms of violence (verbal, psychological, physical and sexual). The most frequently reported incident was verbal violence followed by psychological violence. Violation of visiting hours and long waiting periods were among the most common causes of violence. Associations were found between workplace violence and demographics and types of wards. Nurses identified economic crisis to be the major cause of violence. The most significant finding is the high rate of workplace violence caused by patients’ visitors due to economic crisis and the fact that we found no statistically significant differences in the prevalence of violence among different health professionals.

关键词： Workplace Violence Health Care Professionals Visitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applications of Slice Imaging to Physics and Chemistry

Applications of Slice Imaging to Physics and Chemistry

引用

第九届全国化学动力学会议

作者： theofanis N．Kitsopoulos Institute of Electronic Structure and Laser-Foundation for Research and Technology-Hellas and University of Crete 71110 Heraklion Greece

＜正＞In the first part I will present a new approach to the already popular methods of ion imaging and velocity mapping. The novelty of this approach is that the speed and angular distributions are measured directly from the ullages without the need of inverse Abel transformation as in the conventional approaches. This is achieved by using delayed pulsed extraction of the ions following photodissociation and positioning of the nascent products.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Percutaneous antegrade management of large proximal ureteral stones using non-papillary puncture

引用

Asian Journal of Urology 2024年第1期11卷 110-114页

作者： Arman Tsaturyan Angelis Peteinaris Constantinos Adamou Konstantinos Pagonis Lusine Musheghyan Anastasios Natsos theofanis Vrettos Evangelos Liatsikos Panagiotis Kallidonisa Department of Urology University of PatrasPatrasGreece Gerald and Patricia Turpanjian School of Public Health American University of ArmeniaYerevanArmenia Department of Anesthesiology and ICU University of PatrasPatrasGreece Department of Urology Medical University of ViennaViennaAustria

Objective:To evaluate the feasibility and the safety of medial non-papillary percutaneous nephrolithotomy(npPCNL)for the management of large proximal ureteral ***:We evaluated prospectively collected data of 37 patients with large proximal ureteral stones more than 1.5 cm in diameter treated by prone *** on stone size,in-toto stone removal or lithotripsy using the Lithoclast®Trilogy(EMS Medical,Nyon,Switzerland)was *** parameters including operative time(from start of puncture to the skin suturing),stone extraction time(from the first insertion of the nephroscope to the extraction of all stone fragments),and the stone-free rate were ***:Twenty-one males and 16 females underwent npPCNL for the management of large upper ureteral *** median age and stone size of treated patients were 58(interquartile range[IQR]:51-69)years and 19.3(IQR:18.0-22.0)mm,*** median operative time and stone extraction time were 25(IQR:21-29)min and 8(IQR:7-10)min,*** case(2.7%)of postoperative bleeding and two cases(5.4%)of prolonged fever were managed *** stone-free rate at a 1-month follow-up was 94.6%.Conclusion:The npPCNL provides a straight route to the ureteropelvic junction and proximal *** from a dilated portion of the ureter under low irrigation pressure with larger diameter instruments results in effective and safe stone extraction within a few minutes.

关键词： Antegrade percutaneous nephrolithotomy Proximal ureteral stone Non-papillary puncture Large ureteral stone Prone percutaneous nephrolithotomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Verifying a Finite Element Analysis Methodology with Reinforced Concrete Beam Experiments

引用

Journal of Applied Mathematics and Physics 2020年第11期8卷 2549-2556页

作者： Naveen Revanna Charles K. S. Moy theofanis Krevaikas Department of Civil Engineering Xi’an Jiaotong-Liverpool University Suzhou China

This paper verifies the accuracy of a methodology recently proposed on reinforced concrete beam tested in flexure available from literature. This was implemented using the general purpose FEA software Abaqus. A very good agreement between numerical and experimental study was obtained. The compression failure, tension failure matched with experimental findings which shows the applicability of the methodology.

关键词： Numerical Abaqus CDP

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Verifying a Finite Element Analysis Methodology with Reinforced Concrete Beam Experiments

Verifying a Finite Element Analysis Methodology with Reinfor...

引用

作者： Naveen Revanna Charles K.S.Moy theofanis Krevaikas Department of Civil Engineering Xi’an Jiaotong-Liverpool University

关键词： Numerical Abaqus CDP

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

新冠疫情后菏泽市基础设施建设推动制造业发展方案研究

引用

特区经济 2021年第4期 29-38页

作者：宇宸尹琴 theofanis Mamuneas 菏泽学院商学院山东菏泽274015 菏泽学院外国语学院山东菏泽274015 塞浦路斯大学经济系塞浦路斯尼科西亚20357

本文采集了菏泽市9个区县制造业2001年到2018年的时间序列和横截面数据,使用计量经济学的方法定量研究基础设施建设对菏泽市各区县制造业经济表现的影响。本文发现:第一,基础设施投资降低生产成本,基础设施是劳动力和企业资本投入的互补... 详细信息

本文采集了菏泽市9个区县制造业2001年到2018年的时间序列和横截面数据,使用计量经济学的方法定量研究基础设施建设对菏泽市各区县制造业经济表现的影响。本文发现:第一,基础设施投资降低生产成本,基础设施是劳动力和企业资本投入的互补品,是中间投入的替代品;第二,菏泽市8个区县的基础设施投资回报率大于银行平均长期贷款利率,说明基础设施投资对制造业发展是有利的;第三,基础设施对劳动生产率的增长有积极的影响。在疫情常态化的背景下,为了发展菏泽制造业,从而提振经济,本文建议:在对已有的基础设施进行维护、保养和修理的基础上,加大菏泽市各区县交通、邮电通信、信息服务和能源供应基础设施建设力度,从而降低制造业的运营成本,提高劳动生产率,提升企业利润,促进就业和资本积累,扩大企业生产规模,提高制造业产量和增加值。

关键词：疫情常态化基础设施建设制造业成本回报率劳动生产率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Smoking and genital human papilloma virus infection in women attending cervical cancer screening in Greece

引用

World Journal of Obstetrics and Gynecology 2013年第3期2卷 53-61页

作者： Kimon chatzistamatiou Taxiarchis Katsamagas Menelaos Zafrakas Konstantia Zachou Anastasia Orologa Fani Fitsiou Thomas Theodoridis Theocharis Konstantinidis Theodoros C Konstantinidis Theodoros Agorastos 4th Department of Obstetrics and Gynecology Hippokrateio Hospital Aristotle University of Thessaloniki 54642 Thessaloniki Greece School of Health and Medical Care Alexander Technological Educational Institute of Thessaloniki 55134 Thessaloniki Greece Laboratory of Cytology Hippokrateio Hospital54642 ThessalonikiGreece Center for Family Planning Hippokrateio Hospital 54642 Thessaloniki Greece Peripheral Laboratory of Public Health Hellenic Center for Disease Control and Prevention Ministry of Health 68100 Alexandroupoli Greece Laboratory of Hygiene and Environmental Protection and Laboratory of Microbiology Democritus University of Thrace 68100 Alexandroupoli Greece

AIM: To investigate whether smoking is associated with human papilloma virus(HPV) infection. METHODS: HPV infection is considered to be a neces-sary condition for cervical cancer development. The study population included 1291 women, aged 25-55 years, attending cervical cancer screening. All women had a Papanicolaou(Pap) test, with liquid-based cytology(Thinprep), an HPV-DNA test and an evaluation of smoking habits. The COBAS 4800 system was used for HPV-DNA testing, enabling identifi cation of the following high-risk HPV(hr HPV)-types: each of HPVs 16 and 18 separately, and HPVs 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68 as a cocktail. The evaluation of smoking habits was assessed using the smoking intensity index(SII), a variable formed as the product of cigarettes consumed per day by the days(years × 365) that a woman was a smoker, divided by 1000. RESULTS: There were 136 smokers among 238 women tested positive for hr HPV-types(HPVs 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and/or 68), and 463 smokers among 1053 hr HPV-negative women(OR = 1.7, P < 0.001). This association was attributed to the youngest age group of women, aged 25-34 years(OR = 2.3, P < 0.001), while there was no association in other age groups. The intensity of smoking(increasing SII) showed no statistically signifi cant association with hr HPV infection. Cervical infection with HPV 16 and/or HPV 18 was also not associated with age or smoking habits. Finally, no association was found between Pap test status and smoking habits or smoking intensity. CONCLUSION: Smoking appears to be associated with hr HPV infection of the uterine cervix, particularly in younger women. Further studies should investigate whether this association is based on causality and evaluate the role of other possible co-factors.

关键词： Human papilloma virus High-risk human papilloma virus Human papilloma virus-DNA test Smok-ing Cervical cancer Screening

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：