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Estrogen receptor （α and β） but not androgen receptor expression is correlated with recurrence, progression and survival in post prostatectomy T3NOMO locally advanced prostate cancer in an urban Greek population

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Asian Journal of Andrology 2015年第1期17卷 98-105,I0009,I0010页

作者： Georgios Megas Michael Chrisofos Ioannis Anastasiou Aida Tsitlidou theodosia choreftaki Charalampos Deliveliotis Department of Urology General Hospital of Athens "G. Gennimatas" Greece Department of Urology Athens Medical School "Attiko" Hospital Athens Greece Department of Urology Athens Medical School "Laiko" Hospital Athens Greece Department of Pathology General Hospital of Athens "G. Gennimatas" Greece Department of Urology Athens Medical School "Sismanoglio" Hospital Athens Greece.

The objective of this study was to evaluate the expression of estrogen receptors （ER（（α ） and ER（β）） and androgen receptors （ARs） as prognostic factors for biochemical recurrence, disease progression and survival in patients with pT3NOMO prostate cancer （PCa） in an urban Greek population. A total of 100 consecutive patients with pT3NOMO PCa treated with radical prostatectomy participated in the study. The mean age and follow-up were 64.2 and 6 years, respectively. The HSCORE was used for semi-quantitative analysis of the immunoreactivity of the receptors. The prognostic value of the ER（（α） and ER（β） and AR was assessed in terms of recurrence, progression, and survival. AR expression was not associated with any of the above parameters; however, both ERs correlated with the prognosis. A univariate Cox regression analysis showed that ER（α） positive staining was significantly associated with a greater hazard for all outcomes. Increased ER（β） staining was significantly associated with a lower hazard for all outcomes in the univariate analysis. When both ER HSCORES were used for the analysis, it was found that patients with high ER（α） or low ER（β） HSCORES compared with patients with negatively stained ER（α） and 〉1.7 hSCORE ER（β） had 6.03, 10.93, and 10.53 times greater hazard for biochemical disease recurrence, progression of disease and death, respectively. Multiple Cox proportional hazard analyses showed that the age, preoperative prostate specific antigen, Gleason score and ERs were independent predictors of all outcomes. ER expression is an important prognosticator after radical prostatectomy in patients with pT3NOMO PCa. By contrast, AR expression has limited prognostic value.

关键词： androgen receptor estrogen receptor (α) estrogen receptor (β) locally advanced prostate cancer radical prostatectomy

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Perioperative blood management strategies for patients undergoing total knee replacement:Where do we stand now?

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World Journal of Orthopedics 2017年第6期8卷 441-454页

作者： Tzatzairis Themistoklis Vogiatzaki theodosia Kazakos Konstantinos Drosos I Georgios Department of Orthopaedic Surgery Medical SchoolDemocritus University of ThraceUniversity General Hospital of Alexandroupolis Department of Anaesthesia Medical SchoolDemocritus University of ThraceUniversity General Hospital of Alexandroupolis

Total knee replacement(TKR) is one of the most common surgeries over the last decade. Patients undergoing TKR are at high risk for postoperative anemia and furthermore for allogeneic blood transfusions(ABT). Complications associated with ABT including chills, rigor, fever, dyspnea, light-headedness should be early recognized in order to lead to a better prognosis. Therefore, perioperative blood management program should be adopted with main aim to reduce the risk of blood transfusion while maximizing hemoglobin simultaneously. Many blood conservation strategies have been attempted including preoperative autologous blood donation, acute normovolemic haemodilution, autologous blood transfusion, intraoperative cell saver, drain clamping, pneumatic tourniquet application, and the use of tranexamic acid. For practical and clinical reasons we will try to classify these strategies in three main stages/pillars: Pre-operative optimization, intra-operative and post-operative protocols. The aim of this work is review the strategies currently in use and reports our experience regarding the perioperative blood management strategies in TKR.

关键词： Total knee replacement Transfusion Total knee arthroplasty Blood loss Autologous blood donation Blood management Perioperative Tranexamic acid Tourniquet Haemodilution Anaemia Transfusion protocol

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Carbonation Resistance and Anticorrosive Properties of Organic Coatings for Concrete Structures

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Journal of Surface Engineered Materials and Advanced Technology 2013年第1期3卷 67-74页

作者： theodosia Zafeiropoulou Eleni Rakanta George Batis Department of Materials Science and Engineering School of Chemical Engineering National Technical University of Athens Athens Greece

The present study examines the behavior of three major categories of organic coatings which are applied on the surface of concrete structures and specifically conventional, high performance and nanotechnology paint systems. The comparison is achieved in the means of anticorrosion properties under the presence of chloride ions and carbonation resistance. The evaluation methods included electrochemical measurements in order to assess corrosion properties and the determination of steel’s mass loss after the end of the experimental procedure. Carbonation depth was measured using phenolphthalein as indicator after accelerated and physical exposure. From the results so far it can be shown nanocoatings gave promising results regarding induced chloride ion corrosion.

关键词： Chloride Induced Corrosion Electrochemical Measurements Carbonation Concrete

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Efficiency of Amino Alcohols as Corrosion Inhibitors in Reinforced Concrete

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Open Journal of Civil Engineering 2013年第2期3卷 1-8页

作者： Ioannis Vyrides Eleni Rakanta theodosia Zafeiropoulou George Batis Department of Chemical Engineering and Chemical Technology Imperial College London UK School of Chemical Engineering National Technical University of Athens Athens Greece

The objective of this paper is to investigate the behaviour of amino alcohol corrosion inhibitors when they are used in reinforced cement mortars either as admixtures in the cement paste or as coating applications on the surface of the rebars. The reinforced cement mortars were exposed to both partial and full immersion in 3.5 wt% NaCl solution. Electrochemical measurements such as half-cell potential and linear polarization technique, as well as weight loss of the embedded rebars were performed in order to obtain information on the corrosion behaviour of the reinforcing steel in cement mortar. Results demonstrate that the amino alcohol corrosion inhibitors offer protection against rebar corrosion in cement mortars.

关键词： Steel Corrosion Concrete Durability Amino Alcohols Corrosion Inhibitors Cement Mortars

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Double Burden of Malnutrition: Toxic Metals in Breast Milk May Limit the Amounts of Micronutrients Available to Infants through Breast Milk

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Food and Nutrition Sciences 2019年第3期10卷 298-314页

作者： Adolf Kofi Awua Rose Boatin theodosia Adom Edward Christian Brown-Appiah Akusika M. Diaba Dominic Datohe David Kwaku Bansa Cellular and Clinical Research Centre Radiological and Medical Sciences Research Institute of the Ghana Atomic Energy Commission Accra Ghana Nutrition Research Centre Radiological and Medical Sciences Research Institute of the Ghana Atomic Energy Commission Accra Ghana

Background: The amounts of micronutrients in the diets of infants, and the factors that influence them needs to be monitored at the population level in order to avert detrimental developmental defects that impose lifetime-limitations on an infant’s regulatory and defense systems. This study therefore, sought to evaluate if increasing levels of the toxic metals, Hg, Pb and Cd in breast milk will result in reducing amounts of the micronutrients Zn, Se and Cu in breast milk. Methods: Breast milk samples of 114 women living in two mining areas (57 women each) in Ghana, whose babies’ amounts of breast milk intake at three months postpartum, and amounts of toxic metals had previously been determined in a prospective study, were analyzed for micronutrients by a combination of acid and microwave digestion, and quantifications were by two different modes (hydrogen and helium) of Octapole Reaction System Inductively Coupled Plasma Mass Spectrometer (7500 ce. Agilent), equipped with an ASX-510 Auto-sampler (Cetac). Results: All the breast milk specimen collected contained detectable amounts of Cu, Zn, both at levels less than have been previously reported, and Se. For specimen that did not contain Pb the amount of Se ranged from about 110 to 245 ng/g of milk, however, as the amount of Pb increased, the corresponding highest detected amount of Se reduced steeply, resulting in a right-angle triangle-shaped scatter plot. Similar relationships were observed between other toxic metals and micronutrients studied. A curve fitting regression analysis showed significant quadratic and cubic relationships between the amounts of Hg and Se, as well as between Pb, As and Cu. Conclusion: The results clearly suggest a double burden of malnutrition in these mining areas, where high loads of maternal toxic metals in breast milk, related significantly with a progressive reduction in the amounts of the micronutrients Cu and Se in breast milk, potentially reducing in infants’ intake of these micro

关键词： Toxic Metals Micronutrients Breastmilk Mining Infant Nutrition

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Persistent post-surgical pain and neuropathic pain after total knee replacement

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World Journal of Orthopedics 2015年第7期6卷 528-536页

作者： Georgios I Drosos Triantafilia Triantafilidou Athanasios Ververidis Cristina Agelopoulou theodosia Vogiatzaki Konstantinos Kazakos Department of Orthopaedic Surgery Medical School Democritus University of Thrace University General Hospital of Alexandroupolis Department of Neurology Medical School Democritus University of Thrace University General Hospital of Alexandroupolis Department of Anaesthesia Medical School Democritus University of Thrace University General Hospital of Alexandroupolis

AIM: To study the prevalence of persistent post-surgical pain(PPSP) and neuropathic pain(NP) after total knee replacement(TKR).METHODS: MEDLINE and Embase databases were searched for articles published until December 2014 in English language. Published articles were included if they referred to pain that lasts at least 3 mo after primary TKR for knee osteoarthritis, and measured pain with pain specific instruments. Studies that referred to pain caused by septic reasons and implant malalignment were excluded. Both prospective and retrospective studies were included and only 14 studies that match the inclusion criteria were selected for this ***: The included studies were characterized by the heterogeneity on the scales used to measure pain and pre-operative factors related to PPSP and NP. The reported prevalence of PPSP and NP seems to be relatively high, but it varies among different studies. There is also evidence that the prevalence of post-surgical pain is related to the scale used for pain measurement. The prevalence of PPSP is ranging at 6 mo from 16% to 39% and at 12 mo from 13.1% to 23% and even 38% of the patients. The prevalence of NP at 6 mo post-operatively is ranging from 5.2% to13%. Pre-operative factors related to the development of PPSP also differ, including emotional functioning, such as depression and pain catastrophizing, number of comorbidities, pain problems elsewhere and operations in knees with early grade of ***: No firm conclusions can be reached regarding the prevalence of PPSP and NP and the related factors due to the heterogeneity of the studies.

关键词： Total knee replacement Pain Chronic pain Neuropathic pain Post-operative pain Persistent postsurgical pain

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