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Clock genes:Their role in colorectal cancer

World Journal of Gastroenterology 2014年第8期20卷 1986-1992页

作者： theodoros karantanos George Theodoropoulos Dimitrios Pektasides Maria Gazouli First Department of Propaedeutic Surgery School of MedicineUniversity of Athens11725 AthensGreece Second Pathology Department School of MedicineUniversity of Athens11725 AthensGreece Department of Basic Medical Science Laboratory of BiologySchool of MedicineUniversity of Athens11725 AthensGreece

Clock genes create a complicated molecular time-keeping system consisting of multiple positive and negative feedback loops at transcriptional and translational levels. This circadian system coordinates and regulates multiple cellular procedures implicated in cancer development such as metabolism, cell cycle and DNA damage response. Recent data support that molecules such as CLOCK1, BMAL1 and PER and CRY proteins have various effects on c-Myc/p21 and Wnt/β-catenin pathways and influence multiple steps of DNA damage response playing a critical role in the preservation of genomic integrity in normal and cancer cells. Notably, all these events have already been related to the development and progression of colorectal cancer (CRC). Recent data highlight critical correlations between clock genes’ expression and pathogenesis, progression, aggressiveness and prognosis of CRC. Increased expression of positive regulators of this circadian system such as BMAL1 has been related to decrease overall survival while decreased expression of negative regulators such as PER2 and PER3 is connected with poorer differentiation, increased aggressiveness and worse prognosis. The implications of these molecules in DNA repair systems explain their involvement in the development of CRC but at the same time provide us with novel targets for modern therapeutic approaches for patients with advanced CRC.

关键词： Clock genes Colorectal cancer Development Prognosis

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Association of rs1568885, rs1813443 and rs4411591 polymorphisms with anti-TNF medication response in Greek patients with Crohn's disease

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World Journal of Gastroenterology 2014年第13期20卷 3609-3614页

作者： Diamantis Thomas Maria Gazouli theodoros karantanos Stella Rigoglou Georgios Karamanolis Konstantinos Bramis George Zografos George E Theodoropoulos Colorectal Unit 1st Department of Propaedeutic Surgery"Hippokrateio" HospitalSchool of MedicineUniversity of Athens11527 AthensGreece Department of Basic Medical Science Laboratory of BiologySchool of MedicineUniversity of Athens11527 AthensGreece Gastroenterology Unit 2nd Department of Surgery"Aretaieio" HospitalUniversity of AthensAthens 11527Greece

AIM: To investigate the correlation between rs1568885, rs1813443 and rs4411591 polymorphisms and response to infliximab in a cohort of Greek patients with Crohn’s disease (CD).

关键词： Crohn’ s disease, Treatment response, Infliximab, Polymorphisms

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Novel anti-androgen receptor signaling agents:Understanding the mechanisms of resistance

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Asian Journal of Urology 2014年第1期1卷 30-39页

作者： Styliani Karanika theodoros karantanos Jianhua Yin Likun Li Timothy C.Thompson Department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Epidemiology Second Military Medical UniversityShanghaiChina

Prostate cancer remains an intractable threat to the lives of men *** deaths from prostate cancer(PCa)in the United States have declined in recent years,in other parts of the world Pca mortality is *** introduction of 2nd generation antiandrogen receptor agents into the therapeutic armamentarium for metastatic castrationresistant prostate cancer(mCRPC)has resulted in modestly increased survival advantages as demonstrated by initial clinical ***,analysis of the molecular pathways affected by these agents may lead to new insight into mechanisms of resistance that drive mCRPC,including proliferation and survival signaling pathways that are derepressed by maximum repression of androgen *** therapies that involve anti-AR signaling agents together with agents that target these pathways establish a paradigm for the development of more effective treatment of *** this review,we briefly summarize the current clinical trial literature with regard to novel anti-AR signaling agents such as abiraterone acetate and *** discuss observational data that point to mechanisms of resistance that emerged from these *** further present and discuss recent experimental studies that address the mechanisms of resistance to these ***,we discuss novel and rational therapeutic approaches,including combination therapy,for patients with mCRPC.

关键词： Prostate cancer Castration-resistant prostate cancer Anti-androgen receptor agents Combination therapies

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Immune response after laparoscopic colectomy for cancer:a review

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Gastroenterology Report 2013年第2期1卷 85-94页

作者： Styliani Karanika theodoros karantanos George E.Theodoropoulos Colorectal Unit First Department of Propaedeutic SurgeryAthens Medical SchoolAthensGreece

Background and aim:Colorectal cancer(CRC)is the third leading cause of cancer mortality worldwide and laparoscopic colectomy has been established as equivalent to the open approach in terms of oncological results and patients’*** benefits have been reported in favor of laparoscopic colectomy(LC)in stage III CRC *** immune responses after surgery,in terms of innate and cellular immunity,may potentially explain some of the reported *** review summarizes the literature on differences in immune response after the laparoscopic and the open approach for *** and Methods:A literature search of electronic databases was conducted and all studies published on‘colorectal cancer’,‘laparoscopic and open colectomy’‘immune response’and‘surgical stress laparoscopy versus open’were *** these,the ones referring to CRC and those that had any clinical relevance offering information on perioperative parameters were ***:Despite the heterogeneity of studies,they support the view that innate immune response is activated to a greater degree in open colectomy(OC),which may be related to the more extensive trauma and surgical *** the other hand,cellular immunity is better preserved after *** differences are more pronounced in the immediate postoperative ***:LC has been related to decreased up-regulation of innate immunity and better-preserved cellular *** latter may be related to better anti-tumor activity and may be beneficial in terms of oncological survival in a subgroup of LC patients.

关键词： colorectal cancer laparoscopic colectomy immune response innate immunity cellular immunity

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