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Caboxymetylcellulose/Gelatin Blends Loaded with Piroxicam: Preparation, Characterization and Evaluation of in Vitro Release Profile

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Journal of Encapsulation and Adsorption Sciences 2013年第4期3卷 99-107页

作者： Vivia Buzzi Marli Brudner theodoro maciel wagner Giovana C. Bazzo Ana Paula Testa Pezzin Denise Abatti Kasper Silva Campus of Joinville Joinville-Brazil Campus Universitário University of Region of Joinville—UNIVILLE Joinville Brazil

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) exhibiting analgesic and antipiretic properties and widely used in the management of chronic diseases. Associated with these use, there are registers of adverse reactions. Microparticle formulations in hydrogel matrix can be used to form a semi-permeable barrier which enables their actions and can reduce the effects. This work presents a study on the effect of gelatin/carboxymethyl cellulose (Gel/CMC) semi-IPN matrix composition on the retention and kinetic behavior of releasing this drug. The microparticles were obtained through the emulsion-crosslinking method using 23 factorial planning and the piroxicam was added as solid particles. In order to characterize the interaction between matrix-active agent and quantification of the drug, the following techniques were applied: SEM, DSC and XRD. SEM micrographs revealed microparticles with regular and spherical shape and that in some compositions the drug is partially absorbed and not encapsulated. Beyond that DSC and XRD analyses indicate that the piroxicam remained in the matrixes, maintains the same crystalline form. The factorial planning analysis indicated that matrix obtained a maximum encapsulation efficiency (EE%) of 10.64% and became possible to create a response surface graph using a EE% as answer. In addition to this, release kinetics analyses demonstrated that the release process seems to be governed by distinctly kinetic models, considering the composition of the sample. In some samples the release can be driven by Fickinianan diffusion, others by anomalous transport or swelling.

关键词： Piroxicam Gelatin Carboxymethyl Cellulose

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