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Surrogate markers of mucosal healing in inflammatory bowel disease:A systematic review

World Journal of Gastroenterology 2021年第16期27卷 1828-1840页

作者： Monica State Lucian Negreanu theodor voiosu Andrei voiosu Paul Balanescu Radu Bogdan Mateescu Department of Gastroenterology Colentina Clinical HospitalBucharest 020125Romania Department of Gastroenterology Emergency University HospitalBucharest 050098Romania Carol Davila University of Medicine and Pharmacy Bucharest 020021Romania Department of Internal Medicine and Research Methodology Colentina Clinical HospitalBucharest 020125Romania

Mucosal healing(MH)has emerged as a key therapeutic target in inflammatory bowel disease(IBD),and achievement of this goal is documented by endoscopy with ***,colonoscopy is burdensome and invasive,and substitution with an accurate noninvasive biomarker is *** To summarize published data regarding the performance of noninvasive biomarkers in assessing MH in IBD *** We conducted a systematic review of studies that reported the performance of biomarkers in diagnosing MH in patients with *** main outcome measure was to review the diagnostic accuracy of serum and fecal markers that showed promising utility in assessing *** We screened 1301 articles,retrieved 46 manuscripts and included 23 articles for full-text *** majority of the included manuscripts referred to fecal markers(12/23),followed by circulatory markers(8/23);only 3/23 of the included manuscripts investigated combined markers(serum and/or fecal markers).Fecal calprotectin(FC)was the most investigated fecal marker for assessing *** ulcerative colitis,for cutoff levels ranging between 58 mcg/g and 490 mcg/g,the sensitivity was 89.7%-100%and the specificity was 62%-93.3%.For Crohn’s disease,the cutoff levels of FC ranged from 71 mcg/g to 918 mcg/g(sensitivity 50%-95.9%and specificity 52.3%-100%).The best performance for a serum marker was observed for the endoscopic healing index,which showed a comparable accuracy to the measurement of FC and a higher accuracy than the measurement of serum C-reactive *** Several promising biomarkers of MH are emerging but cannot yet substitute for endoscopy with biopsy due to issues with reproducibility and standardization assessing *** ulcerative colitis,for cutoff levels ranging between 58 mcg/g and 490 mcg/g,the sensitivity was 89.7%-100%and the specificity was 62%-93.3%.For Crohn’s disease,the cutoff levels of FC ranged from 71 mcg/g to 918 mcg/g(sensitivity 50%-95.9%and specificity 52.3%-100%).The bes

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease Biomarkers Serum Fecal Mucosal healing

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Dispersal events of Triassic-Jurassic boundary faunas, and paleoenvironment of Tibetan Himalaya

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Science China Earth Sciences 2009年第12期52卷 1993-2000页

作者： YIN JiaRun Fü RSICH Franz theodor School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China Geozentrum Nordbayern Friedrich-Alexander Universitat ErlangenLoewenichstr.28D-91054ErlangenGermany

End-Triassic ammonoid and bivalve faunas of the Germig area, Tibetan Himalaya, lived in a tropical, shallow-water environment during the Triassic-Jurassic boundary interval. High stratigraphic resolution based on ammonite-biochrons allows to tracing the place of origin of several faunal elements. The bivalves Aguilerella and Ctenostreon occurred first in the Tibetan Himalaya and migrated from there to the eastern South Pacific, exhibiting a pantropic dispersal pattern. This dispersal route is supported by the distribution pattern of the ammonites Choristoceras, Discamphiceras, Pleuroacanthites, and Psiloceras calliphyllum. A few taxa, which went extinct everywhere else by the end of the Triassic, survived in the Tibetan Himalaya into early Early Jurassic times. They include the ammonites Choristoceras and Eopsiloceras, and the bivalves Newaagia, Terquemia, Persia, Ryderia guangdongensis, and Cultriopsis angusta. This suggests that the Tibetan Himalaya may have played a refugia role in the course of the end-Triassic mass extinction.

关键词： end-Triassic mass extinction paleobiogeography bivalves ammonites

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Sequence architecture of a Jurassic ramp succession from Gebel Maghara(North Sinai,Egypt):Implications for eustasy

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Journal of Palaeogeography 2015年第3期4卷 305-330页

作者： Ahmed Awad Abdelhady Franz theodor Fürsich Geology Department Faculty of ScienceMinia University FG Pal?oumwelt Geozentrum Nordbayern der Universit?t Erlangen

The Jurassic succession at Gebet Maghara, North Sinai, Egypt, represents a mixed carbonate-siticictastic sequence. Combining information from both fossits and rocks attowed a ptausibte reconstruction of the depositionat environments and of the basin evotution. The Ju- rassic succession of Gebel Maghara was deposited on a ramp, and the architecture of the ramp facies was strongty controtted not onty by sea-revel changes but atso by extensionat tectonics in connection with rifting of the Tethys, North Gondwana. Seven tectonicalty modified thirdorder sequences （DS 1-DS 7） have been recognized. The first three sequences （DS 1-DS 3）, ranging from the Toarcian to the Bajocian, record sea invasion （intertidat to shattow subtida[lconditions） across an intracratonic area as a resutt of eustatic sea-fever changes during a quiescent rift stage. The remaining sequences （DS 4-DS 7） reflect open marine mid to outer ramp settings. Non-marine conditions around the Bajocian-Bathonian boundary, documented by catiche, represent the maximum regression of the sea. During an active extensionat stage, horsts, which formerty acted as barriers separating the Maghara sub-basin from the main ocean, subsided. Subsequent rejuvenation and reactivation of fautts shifted the homoctinat physiography of the ramp to a distatty steepened ramp during the earty Bathonian, creating a 200-m-thick dettaic wedge. SimiLar processes during the earty Kimmeridgian created a catcirudite-catcarenite succession of stope origin. The diversity and the epifaunat/infaunat percentage of the macrofauna disptay a cyctic pattern which coincides more or tess with the sequence stratigraphic architecture.

关键词： facies sequence stratigraphy ramp extensional basin Jurassic Gebel Maghara Egypt

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Interbasinal marker intervals——A case study from the Jurassic basins of Kachchh and Jaisalmer, western India

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Science China Earth Sciences 2009年第12期52卷 1924-1931页

作者： PANDEY Dhirendra Kumar FüRSICH Franz theodor Department of Geology University of Rajasthan Jaipur 302004 India Institut für Geologie und Palontologie der Universitt Würzburg Pleicherwall 1 D-97070 Würzburg Germany GeoZentrum Nordbayern der Universitt Erlangen Loewenichstr. 28 D-91054 Erlangen Germany

The Kachchh Basin and the Jaisalmer Basin are two neighboring Mesozoic sedimentary basins at the western margin of the Indian craton. The Jurassic succession of the Kachchh Basin is more complete and more fossiliferous than that of the Jaisalmer Basin. Consequently, intrabasinal correlation of the sedimentary units has been possible in the Kachchh Basin, but not in the Jaisalmer Basin. However, some marker beds existing in the Kachchh Basin can be recognized also in the Jaisalmer Basin. Ammonite evidence shows that they are time-equivalent. The following four units form marker intervals in both basins: (1) the pebbly rudstone unit with Isastrea bernardiana and Leptosphinctes of the Kaladongar Formation (Kachchh Basin) and the Isastrea bernardiana-bearing rudstone of the Jaisalmer Formation (Jaisalmer Basin) both represent transgressive systems tract deposits dated as Late Bajocian; (2) bioturbated micrites with anomalodesmatan bivalves within the Goradongar Yellow Flagstone Member (Kachchh Basin) and bioturbated units in the Fort Member (Jaisalmer Basin) represent maximum flooding zone deposits of the Middle to Late Bathonian; (3) trough-crossbedded, sandy packto grainstones of the Raimalro Limestone Member (Kachchh Basin) and the basal limestone-sandstone unit of the Kuldhar section of the Jaisalmer Formation (Jaisalmer Basin) correspond to Late Bathonain transgressive systems tract deposits; and (4) ferruginous ooid-bearing carbonates with hardgrounds of the Dhosa Oolite member (Kachchh Basin) and the middle part of the Jajiya Member (Jaisalmer Basin) are Oxfordian transgressive systems tract deposits. The fact that in both basins similar biofacies prevailed during certain time intervals demonstrates a common control of their depositional history. As the two basins represent different tectonic settings, the most likely controlling factors were the relative sea-level changes produced by eustatic processes, a common subsidence history of the northwestern margin of t

关键词： Jurassic interbasinal correlation marker beds sequence stratigraphy India

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Intelligent Manufacturing Systems in COVID‑19 Pandemic and Beyond:Framework and Impact Assessment

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Chinese Journal of Mechanical Engineering 2020年第4期33卷 1-5页

作者： Xingyu Li Baicun Wang Chao Liu theodor Freiheit Bogdan I.Epureanu Department of Mechanical Engineering University of MichiganAnn ArborMI 48109USA School of Engineering Cardiff UniversityCardiff CF243AAUK

Pandemics like COVID-19 have created a spreading and ever-higher healthy threat to the humans in the manufacturing system which incurs severe disruptions and complex issues to industrial *** intelligent manufacturing(IM)systems are promising to create a safe working environment by using the automated manufacturing assets which are monitored by the networked sensors and controlled by the intelligent decision-making *** relief of the production disruption by IM technologies facilitates the reconnection of the good and service flows in the network,which mitigates the severity of industrial chain *** this study,we create a novel intelligent manufacturing framework for the production recovery under the pandemic and build an assessment model to evaluate the impacts of the IM technologies on industrial *** the constraints of the IM resources,we formulate an optimization model to schedule the allocation of IM resources according to the mutual market demands and the severity of the pandemic.

关键词： Intelligent manufacturing system COVID-19 pandemic Industrial network Supply chain disruption Optimization

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Smart Manufacturing and Intelligent Manufacturing:A Comparative Review

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Engineering 2021年第6期7卷 738-757页

作者： Baicun Wang Fei Tao Xudong Fang Chao Liu Yufei Liu theodor Freiheit State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Department of Mechanical Engineering University of MichiganAnn ArborMI 48109USA Chinese Academy of Engineering Beijing 100088China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China School of Engineering Cardiff UniversityCardiff CF243AAUK

The application of intelligence to manufacturing has emerged as a compelling topic for researchers and industries around the ***,different terminologies,namely smart manufacturing(SM)and intelligent manufacturing(IM),have been applied to what may be broadly characterized as a similar paradigm by some researchers and *** SM and IM are similar,they are not *** an evolutionary perspective,there has been little consideration on whether the definition,thought,connotation,and technical development of the concepts of SM or IM are consistent in the *** address this gap,the work performs a qualitative and quantitative investigation of research literature to systematically compare inherent differences of SM and IM and clarify the relationship between SM and IM.A bibliometric analysis of publication sources,annual publication numbers,keyword frequency,and top regions of research and development establishes the scope and trends of the currently presented *** topics discussed include origin,definitions,evolutionary path,and key technologies of SM and *** implementation architecture,standards,and national focus are also *** this work,a basis to understand SM and IM is provided,which is increasingly important because the trend to merge both terminologies rises in Industry 4.0 as intelligence is being rapidly applied to modern manufacturing and human–cyber–physical systems.

关键词： Smart manufacturing Intelligent manufacturing Industry 4.0 Human–cyber–physical system(HCPS)

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Maximal Coupling of Euclidean Brownian Motions

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Communications in Mathematics and Statistics 2013年第1期1卷 93-104页

作者： Elton P.Hsu Karl-theodor Sturm Department of Mathematics Northwestern UniversityEvanstonIL 60208USA Institute for Applied Mathematics University of BonnEndenicher Allee53115 BonnGermany

We prove that the mirror coupling is the unique maximal Markovian coupling of two Euclidean Brownian motions starting from single points and discuss the connection between the uniqueness of maximalMarkovian coupling o... 详细信息

关键词： Euclidean Brownian motion Mirror coupling Maximal coupling

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Current status of adoption of no-till farming in the world and some of its main benefits

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International Journal of Agricultural and Biological Engineering 2010年第1期3卷 1-25页

作者： Rolf Derpsch theodor Friedrich Amir Kassam Li Hongwen Rolf Derpsch Freelance ConsultantAsunciónParaguay Food and Agriculture Organization(FAO) United NationsRomeItaly School of Agriculture Policy and DevelopmentUniversity of ReadingReadingBerkshireRG66AHUnited Kingdom Conservation Tillage Research Center under Ministry of Agriculture College of EngineeringChina Agricultural UniversityBeijing 100083China

In 1999 no-tillage farming,synonymous of zero tillage farming or conservation agriculture,was adopted on about 45 million ha world wide,growing to 72 million ha in 2003 and to 111 million ha in 2009,corresponding to an growth rate of 6 million ha per *** adoption rates have been experienced in South America where some countries are using no-tillage farming on about 70%of the total cultivated *** to countries like the USA where often fields under no-tillage farming are tilled every now and then,more than two thirds of the area under no-tillage systems in South America is permanently not tilled;in other words once adopted,the soil is never tilled *** spread of no-tillage systems on more than 110 million ha world-wide shows the great adaptability of the systems to all kinds of climates,soils and cropping ***-tillage is now being practiced from the artic circle over the tropics to about 50ºlatitude south,from sea level to 3,000 m altitude,from extremely rainy areas with 2,500 mm a year to extremely dry conditions with 250 mm a ***-till farming offers a way of optimizing productivity and ecosystem services,offering a wide range of economic,environmental and social benefits to the producer and to the *** the same time,no-till farming is enabling agriculture to respond to some of the global challenges associated with climate change,land and environmental degradation,and increasing cost of food,energy and production *** wide recognition of no-till farming as a truly sustainable system should ensure the spread of the no-till technology and the associated practices of organic soil cover and crop rotation,as soon as the barriers to its adoption have been overcome,to areas where adoption is currently still *** widespread adoption globally also shows that no-tillage farming cannot any more be considered a temporary fashion or a craze;instead largely through farmers’own effort,the system has established itself as a farming

关键词： world-wide no-till adoption zero tillage adoption conservation agriculture soil health climate change ecosystem services

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Mid-infrared dual-comb spectroscopy with electro-optic modulators

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Light(Science & Applications) 2017年第1期6卷 450-457页

作者： Ming Yan Pei-Ling Luo Kana Iwakuni Guy Millot theodor W Hänsch Nathalie Picqué Max-Planck-Institut für Quantenoptik 85748 GarchingGermany Fakultät für Physik Ludwig-Maximilians-Universität München80799 MünchenGermany Laboratoire Interdisciplinaire Carnot de Bourgogne UMR 6303 CNRS-Univ.Bourgogne Franche-ComtéF-21078 DijonFrance Institut des Sciences Moléculaires d’Orsay(ISMO) CNRSUniv.Paris-SudUniversitéParis-SaclayF-91405 OrsayFrance

Absorption spectroscopy of fundamental ro-vibrational transitions in the mid-infrared region provides a powerful tool for studying the structure and dynamics of molecules in the gas phase and for sensitive and quantitative gas *** frequency combs permit novel approaches to perform broadband molecular *** dual-comb spectroscopy without moving parts can achieve particularly high speed,sensitivity and ***,achieving Doppler-limited resolution in the mid-infrared still requires overcoming instrumental *** we demonstrate a new approach based on difference-frequency generation of frequency-agile near-infrared frequency combs that are produced using electro-optic *** combs have a remarkably flat intensity distribution,and their positions and line spacings can be freely selected by simply dialing a *** the proposed technique,we record,in the 3-μm region,Doppler-limited absorption spectra with resolved comb lines within milliseconds,and precise molecular line parameters are *** technique holds promise for fast and sensitive time-resolved studies of,for example,trace gases.

关键词： Fourier transform spectroscopy frequency comb mid-infrared molecular spectroscopy

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Risk of conduction disturbances following different transcatheter aortic valve prostheses:the role of aortic valve calcifications

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Journal of Geriatric Cardiology 2022年第3期19卷 167-176页

作者： Francesco Pollari Ferdinand Vogt Irena Großmann Jill Marianowicz Marie Claes Steffen Pfeiffer Johannes Schwab theodor Fischlein Cardiac Surgery Cardiovascular CenterKlinikum NürnbergParacelsus Medical UniversityNurembergGermany Cardiology Cardiovascular CenterKlinikum NürnbergParacelsus Medical UniversityNurembergGermany Radiology Klinikum NürnbergParacelsus Medical UniversityNurembergGermany

OBJECTIVES To assess the impact of prosthesis choice and aortic valve calcifications on the occurrence of conduction disturb-ances after transcatheter aortic valve implantation(TAVI).METHODS We retrospectively analyzed the preoperative clinical characteristics,electrocardiograms,contrast-enhanced mul-tidetector computed tomography scans and procedural strategies of patients who underwent TAVI in our center between January 2012 and June *** of calcium volume was performed for each aortic cusp above(aortic valve)and below(left ventricular outflow tract,LVOT)the basal *** analysis was performed to evaluate risk factors for the onset of new bundle branch block(BBB),transient and permanent atrioventricular block(tAVB,pAVB).RESULTS A total of 569 patients were included in the *** different prostheses were implanted(Edwards Sapien XT,n=162;Edwards Sapien 3,n=240;Medtronic CoreValve,n=27;Medtronic CoreValve Evolut R,n=21;Symetis Acurate,n=56;Sy-metis Acurate neo,n=63).The logistic regression analysis for BBB showed association with baseline left anterior *** logistic regression for tAVB,found the prior valvuloplasty and the balloon post-dilatation associated with the *** left and right BBB,degree of oversizing,and LVOT calcification beneath the non-coronary cusp were associated with *** the prosthesis model,nor the use of a self-expandable prosthesis showed statistical significance with the above-men-tioned outcomes on univariate *** LVOT calcification beneath the non-coronary cusp,baseline left anterior hemiblock,right BBB,balloon post-dilatation,prior valvuloplasty and oversizing are independently associated with postprocedural conduction disturbances after *** of a self-expandable prosthesis may show a lower incidence of AVB,if applied in lower calcified aortic valves.

关键词： aortic balloon conduction

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