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Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a delphi consensus project

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Asian Journal of Urology 2024年第2期11卷 271-279页

作者： Andrea Cocci marta Pezzoli Fernando Bianco Franco Blefari Pierluigi Bove Francois Cornud Gaetano de Rienzo Paolo destefanis Danilo Di Trapani Alessandro Giacobbe Luca Giovanessi Antonino Laganà Giovanni Lughezzani Guglielmo manenti Gianluca muto Gianluigi Patelli Novello Pinzi Stefano Regusci Giorgio I.Russo Juan I.m.Salamanca matteo Salvi Luigi Silvestri Fabrizio Verweij Eric Walser Riccardo GBertolo Valerio Iacovelli Alessandro Bertaccini debora marchiori Hugo Davila Pasquale Ditonno Paolo Gontero Gennaro Iapicca theo m de reijke Vito Ricapito Pierluca Pellegrini Andrea minervini Sergio Serni Francesco Sessa department of Urology Careggi HospitalUniversity of FlorenceFlorenceItaly Urology Section University of FlorenceFlorenceItaly Urological Research Network MiamiFLUSA Urology Section Prato HospitalPratoItaly Torvergata Oncoscience Research Centre of Excellence TORDepartment of Experimental MedicineUniversity of Rome Tor VergataRomeItaly department of Urology San Carlo di Nancy HospitalRomeItaly department of Radiology Hôpital CochinParis Descartes UniversityParisFrance Urology and Andrology Unit II Department of Emergency and Organ TransplantationUniversity of BariBariItaly Unit of Urology Cittàdella Salute e della Scienza HospitalUniversity of TurinTurinItaly Urology Unit Buccheri La Ferla Fatebenefratelli HospitalPalermoItaly department of Urology Humanitas Gradenigo HospitalTurinItaly Urology Unit Surgical DepartmentFondazione Poliambulanza Istituto OspedalieroBresciaItaly departement of Urology “S.Giovanni Evangelista”HospitalTivoliItaly Humanitas Clinical and Research CentereIRCCS Department of UrologyRozzanoItaly department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly department of Biomedicine and Prevention University of Rome“Tor Vergata”RomeItaly department of Diagnostic Imaging and Interventional Radiology University of Rome“Tor Vergata”RomeItaly department of Interventional Radiology Pesenti-Fenaroli Hospital-ASST Bergamo EstAlzano LombardoItaly department of Urology University of SienaSienaItaly Swiss International Prostate Center GenevaSwitzerland Clinique Générale Beaulieu GenevaSwitzerland department of Urology University of CataniaItaly department of Urology Puerta de Hierro-Majadahonda University HospitalMadridSpain Lyx Institute of Urology Universidad Francisco de VitoriaMadridSpain department of medico-Surgical Sciences and Biotechnologies Sapienza University of RomeFaculty of Pharmacy and MedicineUrology Unit ICOTLatinaItaly department of Urology European Institute of Oncology(IEO)IRCCSMilanItaly department of Radiology D

Objective: To evaluate transperineal laser ablation (TPLA) with Echolaser® (Echolaser® TPLA, Elesta S.p.A., Calenzano, Italy) as a treatment for benign prostatic hyperplasia (BPH) and prostate cancer (PCa) using the delphi consensus ***: Italian and international experts on BPH and PCa participated in a collaborative consensus project. During two rounds, they expressed their opinions on Echolaser® TPLA for the treatment of BPH and PCa answering online questionnaires on indications, methodology, and potential complications of this technology. Level of agreement or disagreement to reach consensus was set at 75%. If the consensus was not achieved, questions were modified after each round. A final round was performed during an online meeting, in which results were discussed and ***: Thirty-two out of forty invited experts participated and consensus was reached on all topics. Agreement was achieved on recommending Echolaser® TPLA as a treatment of BPH in patients with ample range of prostate volume, from mL (80%) to >80 mL (80%), comorbidities (100%), antiplatelet or anticoagulant treatment (96%), indwelling catheter (77%), and strong will of preserving ejaculatory function (100%). majority of respondents agreed that Echolaser® TPLA is a potential option for the treatment of localized PCa (78%) and recommended it for low-risk PCa (90%). During the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. Almost all participants agreed that the transperineal approach of this organ-sparing technique is safer than transrectal and transurethral approaches typical of other techniques (97% of agreement among experts). Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading t

关键词： Transperineal laser ablation Prostatecancer Benignprostatic hyperplasia delphi consensus

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metastatic prostate cancer remains incurable, why?

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Asian Journal of Urology 2019年第1期6卷 26-41页

作者： Liang Dong Richard C.Zieren Wei Xue theo m.de reijke Kenneth J.Pienta The Brady Urological Institute Johns Hopkins School of MedicineBaltimoreMDUSA department of Urology Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Urology Amsterdam UMCUniversity of AmsterdamAmsterdamthe Netherlands

metastatic prostate cancer patients present in two waysdwith already disseminated disease at the time of presentation or with disease recurrence after definitive local *** deprivation therapy is given as the most effective initial treatment to ***,after the initial response,almost all patients will eventually progress despite the low levels of *** at this stage is termed castration resistant prostate cancer(CRPC).Before 2010,the taxane docetaxel was the first and only life prolonging agent for metastatic CRPC(mCRPC).The last decade has witnessed robust progress in CRPC therapeutics ***,enzalutamide,apalutamide and sipuleucel-T have been evaluated as first-and second-line agents in mCRPC patients,while cabazitaxel was approved as a second-line ***-223 dichloride was approved in symptomatic patients with bone metastases and no known visceral metastases pre-and ***,despite significant advances,mCRPC remains a lethal *** primary and acquired resistance have been observed in CRPC patients treated by these new *** could be solely cell intrinsic or it is possible that the clonal heterogeneity in treated tumors may result from the adaptive responses to the selective pressures within the tumor *** aim of this review is to list current treatment agents of CRPC and summarize recent findings in therapeutic resistance mechanisms.

关键词： Prostate cancer Heterogeneity Drug resistance Novel treatment

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人体前列腺特异性抗原携带含酮基-脱氧壬酮糖酸的N-聚糖

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Engineering 2023年第7期26卷 119-131,I0005,I0006页

作者： Wei Wang Tao Zhang Jan Nouta Peter Avan Veelen Noortje de Haan theo m.de reijke manfred Wuhrer Guinevere S.m.Lageveen-Kammeijer Center for Proteomics and metabolomics Leiden University Medical CenterLeiden 2333 ZANetherlands Copenhagen Center for Glycomics Department of Cellular and Molecular MedicineUniversity of CopenhagenCopenhagen DK-2200Denmark department of Urology Amsterdam University Medical CentersLocation Academic Medical CenterUniversity of AmsterdamAmsterdam 1105 AZNetherlands Analytical Biochemistry Groningen Research Institute of PharmacyFaculty of Science and EngineeringUniversity of GroningenGroningen 9747 AGNetherlands

Ketodeoxynononic acid(Kdn)is a rather uncommon class of sialic acid in ***,associations have been found between elevated concentrations of free or conjugated Kdn in relation to human cancer ***,there has been a lack of conclusive evidence that Kdn occurs on(specific)human glycoproteins(conjugated Kdn).Here,we report for the first time that Kdn is expressed on prostate-specific antigen(PSA)N-linked glycans derived from human seminal plasma and ***,Kdn was found only in an a2,3-linkage configuration on an antennary galactose,indicating a highly specific *** unusual glycosylation feature was also identified in a urinary PSA cohort in relation to prostate cancer(PCa),although no differences were found between PCa and nonPCa *** research is needed to investigate the occurrence,biosynthesis,biological role,and biomarker potential of both free and conjugated Kdn in humans.

关键词： Ketodeoxynononic acid Glycosylation Prostate cancer Prostate-specific antigen

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