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Innovation Portfolio Management for Small-medium Enterprises

Journal of Systems Science and Systems Engineering 2020年第5期29卷 507-524页

作者： Daniel Pashley theo tryfonas Andy Crossley Chris Setchell Stylianos Karatzas iMETRUM Ltd. BristolUK Civil Engineering Department University of BristolUK Civil Engineering Department University of PatrasGreece

For small and medium sized enterprises,portfolio management can be a difficult exercise;especially when the available paths forwards are shrouded in *** overcome this,they are required to research and decide upon the path to follow,but this can be difficult when the information to gather is unclear,leading to ad-hoc processes and *** motivation for this project originated from a small and medium sized enterprise experiencing this problem of unknown critical information and a technological portfolio with significant *** no procedure or method in place,they conducted the research in an ad-hoc way resulting in uncertainty and low repeatability of *** tackle this problem,innovation structuring frameworks were synthesised with appropriate risks and context to pose a new structure for information *** resulting structure was tested within the small and medium sized enterprise to investigate the repeatability of the information capture and the subsequent *** proposed structure was also analysed by-process experts for its wider *** the small and medium sized enterprise,this led to a consistent and repeatable method that delivered increased confidence about selecting a path forwards for its *** addition,it was found to be applicable to external organisations increasing the moders worth and *** implications of this work have led to a change in the operational procedure of the small and medium sized enterprise to utilise the defined process for researching new ideas for their portfolio which can lead to repeatable and trustworthy *** also has applicability to other similar companies and could lead them through a repeatable process as presented here.

关键词： Portfolio management directed research decision support small-medium enterprise

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WNT/β-catenin-M2 macrophage interplay as a target for therapy against hepatocellular carcinoma:Role of Calculus bovis

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World Journal of Gastroenterology 2025年第3期31卷 130-133页

作者： tryfonas Mpektsis Anastasios Manolakis Andreas Kapsoritakis Department of Gastroenterology University Hospital of LarisaLarisa 41100Greece

Liver cancer,and in particular hepatocellular carcinoma(HCC)is a disease of rising prevalence and *** date,definitive treatment options include either surgical excision or ablation of the affected *** increasing research on several pathways that could be involved in the progression of HCC,new elements within these pathways emerge as potential targets for novel *** WNT/β-catenin pathway favors the presence of M2 tumor-associated macrophages which in turn promote tumor growth and *** inhibition of this pathway is considered a good candidate for such targeted therapeutic ***,as Huang et al show in their recently published article,Calculus bovis which is used in traditional Chinese medicine can exert an inhibitory effect on theβ-catenin pathway and become a potential candidate for targeted pharmacotherapy against liver cancer.

关键词： Hepatocellular carcinoma Calculus bovis WNT/β-catenin pathway Tumorassociated macrophages

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