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Direct adaptive regulation of unknown nonlinear systems with analysis of the model order problem

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第1期12卷 1-16页

作者： Dimitrios theodoridis Yiannis BOUTALIS Manolis CHRISTODOULOU Department of Electrical and Computer Engineering Democritus University of Thrace Department of Industrial Informatics Technological Education Institute of Kavala Chair of Automatic Control University of Erlangen-Nuremberg Department of Electronic and Computer Engineering Technical University of Crete Dipartimento di Automatica et Informatica Politecnico di Torino

A new method for the direct adaptive regulation of unknown nonlinear dynamical systems is proposed in this paper,paying special attention to the analysis of the model order *** method uses a neurofuzzy (NF) modeling of the unknown system,which combines fuzzy systems (FSs) with high order neural networks (HONNs).We propose the approximation of the unknown system by a special form of an NF-dynamical system (NFDS),which,however,may assume a smaller number of states than the original unknown *** omission of states,referred to as a model order problem,is modeled by introducing a disturbance term in the approximating *** development is combined with a sensitivity analysis of the closed loop and provides a comprehensive and rigorous analysis of the stability *** adaptive modification method,termed ‘parameter hopping’,is incorporated into the weight estimation algorithm so that the existence and boundedness of the control signal are always *** applicability and potency of the method are tested by simulations on well known benchmarks such as ‘DC motor’ and ‘Lorenz system’,where it is shown that it performs quite well under a reduced model order ***,the proposed NF approach is shown to outperform simple recurrent high order neural networks (RHONNs).

关键词： Neuro-fuzzy systems Direct adaptive regulation Model order problems Parameter hopping

GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2)drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine

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Journal of Pharmaceutical Analysis 2020年第1期10卷 49-59页

作者： Olga Begou Kathrin Drabert Georgios theodoridis Dimitrios Tsikas Institute of Toxicology Core Unit ProteomicsHannover Medical SchoolCarl-Neuberg-Strasse 1D-30625HannoverGermany Department of Chemistry Aristotle University of Thessaloniki54124ThessalonikiGreece BIOMIC_AUTh Center for Interdisciplinary Research and Innovation(CIRI-AUTH)Balkan Center10th Km Thessaloniki-Thermi RdP.O.Box 8318GR 57001ThessalonikiGreece

Acetazolamide(molecular mass(MM),222)belongs to the class of sulfonamides(R-SO2-NH2)and is one of the strongest pharmacological inhibitors of carbonic anhydrase *** is excreted unchanged in the ***,we report on the development,validation and biomedical application of a stable-isotope dilution GC-MS method for the reliable quantitative determination of acetazolamide in human *** method is based on evaporation to dryness of 50 mL urine aliquots,base-catalyzed derivatization of acetazolamide(d0-AZM)and its internal standard[acetylo-2H3]acetazolamide(d3-AZM)in 30 vol%pentafluorobenzyl(PFB)bromide in acetonitrile(60 min,30C),reconstitution in toluene(200 mL)and injection of 1-mL *** negative-ion chemical ionization(NICI)mass spectra(methane)of the PFB derivatives contained several intense ions including[M]‒at m/z 581 for d0-AZM and m/z 584 for d3-AZM,suggesting derivatization of their sulfonamide groups to form N,N-dipentafluorobenzyl derivatives(R-SO2-N(PFB)2),i.e.,d0-AZM-(PFB)2 and d3-AZM-(PFB)2,*** was performed by selected-ion monitoring of m/z 581 and 83 for d0-AZM-(PFB)2 and m/z 584 and 86 for d3-AZM-(PFB)*** limits of detection and quantitation of the method were determined to be 300 fmol(67 pg)and 1 mM of acetazolamide,***-and inter-assay precision and accuracy for acetazolamide in human urine samples in pharmacologically relevant concentration ranges were determined to be 0.3%e4.2%and 95.3%e109%,*** method was applied to measure urinary acetazolamide excretion after ingestion of a 250 mg acetazolamide-containing tablet(Acemit®)by a healthy *** other tested sulfonamide drugs,methazolamide(MM,236)was also found to form a N,N-dipentafluorobenzyl derivative,whereas dorzolamide(MM,324)was hardly *** GC-MS peaks were obtained from the PFB bromide derivatization of hydrochlorothiazide(MM,298),xipamide(MM,355),indapamide and metholazone(MM,366 each)or br

关键词： Acetazolamide Derivatization Quantification Sulfonamides Validation

Humanin and diabetes mellitus: A review of in vitro and in vivo studies

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World Journal of Diabetes 2022年第3期13卷 213-223页

作者： Chrysoula Boutari Panagiotis D Pappas theodoros D theodoridis Dimitrios Vavilis Second Propedeutic Department of Internal Medicine Hippocration HospitalAristotle University of ThessalonikiThessaloniki 54642Greece First Department of Obstetrics and Gynaecology Papageorgiou HospitalAristotle University of ThessalonikiThessaloniki 56429Greece Medical School University of CyprusNicosiaCyprus 205371678Cyprus

Humanin(HN)is a 24-amino acid mitochondrial-derived polypeptide with cytoprotective and anti-apoptotic effects that regulates the mitochondrial functions under stress *** evidence suggests the role of HN against age-related diseases,such as Alzheimer’s *** decline in insulin action is a metabolic feature of aging and thus,type 2 diabetes mellitus is considered an agerelated disease,as *** has been suggested that HN increases insulin sensitivity,improves the survival of pancreatic beta cells,and delays the onset of diabetes,actions that could be deployed in the treatment of *** aim of this review is to present the in vitro and in vivo studies that examined the role of HN in insulin resistance and diabetes and to discuss its newly emerging role as a therapeutic option against those conditions.

关键词： Diabetes mellitus Insulin resistance Humanin Aging Apoptosis Oxidative stress

i4sea:a big data platform for sea area monitoring and analysis of fishing vessels activity

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Geo-Spatial Information Science 2022年第2期25卷 132-154页

作者： Panagiotis Tampakis Eva Chondrodima Andreas Tritsarolis Aggelos Pikrakis Yannis theodoridis Kostis Pristouris Harry Nakos Panagiotis Kalampokis theodore Dalamagas Data Science Lab University of PiraeusPiraeusGreece Institute of Mathematics and Computer Science University of Southern DenmarkOdenseDenmark ATHENA Research Center Information Management Systems InstituteMarousiGreece

The i4sea research project provides effective and efficient big data integration,processing,and analysis technologies to deliver both real-time and historical operational snapshots of fishing vessels activity in national sea *** paper presents the architecture of the i4sea big data platform for sea area monitoring and analysis of fishing vessels activity and demonstrates the operation of some use-case pilot scenarios.

关键词： Big data fishing vessel activity machine learning

The Radical Character of Art and the Pedagogical and Political Value of the ＂Sublime＂ in Adorno＇s Aesthetic theory

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Journal of Philosophy Study 2016年第1期6卷 1-19页

作者： Alexandros theodoridis Democritus University of Thrace

The critical nature of artwork is owed, according to Adorno, to the fact that it opposes its assimilation by reason and that it does not yield to the imposition of its established principles. This character which Heidegger, too, through a paradoxical convergence with Adorno, and in opposition to Lukacs, recognizes as its ontological component, permits the work of art to represent a force of resistance to dominance in general, in the prospect of the salvation of a humanized society. As such, it makes possible the radical rejection of political and, pertinent to it, pedagogical activity, when converted into primarily authoritiarian activity. Such a responsibility does art assume, according to Adorno, when it represents a spirituality, which is embodied in exemplary fashion both in the work of art itself, making the experience of the sublime possible, and in the aesthetic of the sublime, which is concentrated intensively on whatever remains unapproachable through concepts. In this way, we could say that the aesthetic of the sublime is converted into ＂first philosophy,＂ in the sense that it provides the rule for every theoretical approach. Concurring with this reading of Adorno, we consider how the sublime, as shown in the context of his aesthetic theory, is governed, furthermore, by a paideutic principle of exceptional significance, which we must necessarily activate through aesthetic education, so that western man may understand that he must uproot himself from the nihilistic social context in which he lives, rupturing the delusion of his omnipotence. In a world governed by a permanent crisis of democracy in public and private life, since the weakening of political imagination unites with the retreat from political ethos and an generalization of the unprecedented will for dominance, we consider this aesthetic theory to be exceptionally essential and useful to us both as pedagogical theory and as political theory, since it allows us to understand that the experience of

关键词： art sublime paideutic value nihilism opposition to destruction

The ＂Sacred Marriage＂ of Beauty and Eros and Its Anthropological Condition

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Journal of Philosophy Study 2015年第7期5卷 372-381页

作者： Alexandros theodoridis Panagiotis Karakatsanis Democritus University of Thrace

Art composed of categories of the scale of beauty transmutes the aesthetic into eroticism, such that as an element of life it may be displayed as a love relationship between beauty and eros, the knowledge of which is referenced as early as Plato＇s philosophical contemplations. Plato characterizes eros in the Symposium and the Phaedrus as an invincible psychic force, capable, taking into account the fallibility of man, of compelling him toward the acquisition of that which will entail his completion. Eros, considered thusly, contributes to human ontogeny. Plotinus, who experiences beauty as eros and terror accompanied by pleasure, to the same degree will characterize it as the outcome and consequence of an intellectually and morally superior human soul. By this definition, the greatness of art lies in the fact that it compels the souls of men to eros for its spiritual content, the true nature of a work of art being the idea. As such, as long as it is not easy to know if this beauty exists as an ontologically, gnoseologically, and aesthetically idealized entity, so much the more we consider that we cannot entirely prove Freud＇s erotic theory of primordial and desirable phantasms, which seems to differ only slightly from the Platonic theory, or from Jung＇s theory of archetypes, as it seems not to recognize to an appropriate degree individual human experience. On the contrary and in agreement with the Lacanian theory on eros, in the environment of which eros is directed towards the other, so like it, it emerges in the life of the other, rupturing and reformulating it, we consider that each of us, in reality, in the erotic phenomenon, meets the other, and, behind him, our own self, which, enchanted by all that we sense that the other represents, rates all his characteristics as charmingly beautiful, because they have the privilege of coinciding, or at least of converging towards the aesthetic, entirely unique foundation of our self.

关键词： man soul eros beauty art anthropology

Diagnostic and clinical significance of antigen-specific pancreatic antibodies in inflammatory bowel diseases: A meta-analysis

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World Journal of Gastroenterology 2020年第2期26卷 246-265页

作者： Konstantinos Gkiouras Maria G Grammatikopoulou Xenophon theodoridis Eirini Pagkalidou Evangelia Chatzikyriakou Anna G Apostolidou Eirini I Rigopoulou Lazaros I Sakkas Dimitrios Petrou Bogdanos Department of Rheumatology and Clinical Immunology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyBiopolisLarissa GR41110Greece Faculty of Medicine School of Health SciencesAristotle University of ThessalonikiUniversity CampusThessaloniki GR54124Greece Department of Nutritional Sciences and Dietetics School of Health SciencesInternational Hellenic UniversitySindos CampusThessaloniki GR57400Greece Laboratory of Hygiene Social and Preventive Medicine and Medical StatisticsFaculty of MedicineSchool of Health SciencesAristotle University of ThessalonikiUniversity CampusThessaloniki GR54124Greece Laboratory of Clinical Neurophysiology AHEPA University HospitalFaculty of MedicineAristotle University of ThessalonikiUniversity CampusThessaloniki GR54124Greece Department of Medicine and Research Laboratory of Internal Medicine University Hospital of LarissaBiopolisLarissa GR41110Greece Division of Transplantation Immunology and Mucosal BiologyMRC Centre for TransplantationKing's College London Medical SchoolLondon GR41110United Kingdom

BACKGROUND Non-invasive criteria are needed for Crohn’s disease(CD)diagnosis,with several biomarkers being *** of individual diagnostic test accuracy studies assessing the diagnostic value of pancreatic autoantibodies-to-glycoprotein-2(anti-GP2)tests for the diagnosis of CD appear *** To systematically review and meta-analyze evidence on the diagnostic accuracy of anti-GP2 tests in patients with suspected/confirmed *** An electronic search was conducted on PubMed,Cochrane-CENTRAL and grey literature(CRD42019125947).The structured research question in PICPTR format was“Population”including patients with symptoms akin to CD,the“Index test”being anti-GP2 testing,the“Comparator”involved standard CD diagnosis,the“Purpose of test”being diagnostic,“Target disorder”was CD,and the“Reference standard”included standard clinical,radiological,endoscopical,and histological CD diagnostic *** was assessed with the Quality Assessment of Diagnostic Accuracy Studies-2 tool and hierarchical models were employed to synthesize the *** Out of 722 studies retrieved,15 were *** studies had industry-related conflicts-of-interest,and most included healthy donors as controls(spectrum bias).For the combination of IgA and/or IgG anti-GP2 test,the summary sensitivity was 20%(95%confidence interval:10%-29%)at a median specificity of 97%.If the test was applied in 10000 suspected patients,9669 would be true negatives and in 26,the diagnosis would be *** this hypothetical cohort,the anti-GP2 would fail to produce a diagnosis for 81.3%of the positive *** summary points of sensitivity and high specificity were estimated for the IgG or IgA anti-GP2 *** results were observed when the analyses were restricted using specific cut-offs,or when ulcerative colitis patients were used as *** Anti-GP2 tests demonstrate low sensitivity and high *** results indicate that caution is required

关键词： Inflammatory bowel disease Gastrointestinal disease Evidence-based diagnosis Sensitivity Specificity Ulcerative colitis Conflicts of interest Metaregression Industry bias

Economic Appraisal of Damages Caused by Forest Fires Adopting a New Prevention and Suppression System： The Case of Rhodes Island, Greece

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Journal of Environmental Science and Engineering 2011年第4期5卷 475-482页

作者： A.S. Christodoulou N. theodoridis K. Papastergiou Laboratory of Forest Economics Faculty of Forestry and Natural Environment Thessalonik 54124i Greece Forest Inspection of South Aegean Region Rhodes 85100 Greece Technical and Environmental Services of the Municipality of Kameiros Rhodes 85106 Greece

Rhodes is one of the most forested islands of Greece, in the Prefecture of Dodecanese, in southeast of Aegean Sea. The island in recent times has been struck by big and devastating fires. After 1993, the local Forest Service and the local political authority have adopted a new prevention and suppression system relied on the fast fire detection and suppression at its initial stages. By the present research, comparing the results of 1993-2006 （a time span when the above method was applied） with the results of the immediately precedent equal time of 1978-1992, was made certain that the firefighting system applied after 1993 had very good results irrespective from the primary agency in charge of extinguishing the forest fires. Among others, it was made clear that, during the period that this method was applied, a much less area was burnt per year than the period before the application in spite of the fact that in the same period （1993-2006） there has been a significant increase of forest fires. It is also estimated that the economic damage occurred in the first period （1978-1992） on average was 12.4 times per year higher compared to the second period （1993-2006）.

关键词： Forest fires fire detection economic impacts Rhodes island-Greece.

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