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High rate of clinically relevant improvement following anatomical total shoulder arthroplasty for glenohumeral osteoarthritis

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World Journal of Orthopedics 2024年第2期15卷 156-162页

作者： Marc Randall Kristensen Nyring bo Sanderhoff Olsen Alexander Amundsen Jeppe Vejlgaard rasmussen Section for Shoulder and Elbow Surgery Department of Orthopaedic SurgeryHerlev and Gentofte University HospitalHellerup 2900Denmark

BACKGROUND The minimal clinically important difference(MCID)is defined as the smallest meaningful change in a health domain that a patient would identify as important.Thus,an improvement that exceeds the MCID can be used to define a successful treatment for the individual patient.AIM To quantify the rate of clinical improvement following anatomical total shoulder arthroplasty for glenohumeral osteoarthritis.METHODS Patients were treated with the Global Unite total shoulder platform arthroplasty between March 2017 and February 2019 at Herlev and Gentofte Hospital,Denmark.The patients were evaluated preoperatively and 3 months,6 months,12 months,and 24 months postoperatively using the Western Ontario Osteoarthritis of the Shoulder index(WOOS),Oxford Shoulder Score(OSS)and Constant-Murley Score(CMS).The rate of clinically relevant improvement was defined as the proportion of patients who had an improvement 24 months postoperatively that exceeded the MCID.Based on previous literature,MCID for WOOS,OSS,and CMS were defined as 12.3,4.3,and 12.8 respectively.RESULTS Forty-nine patients with a Global Unite total shoulder platform arthroplasty were included for the final analysis.Mean age at the time of surgery was 66 years(range 49.0-79.0,SD:8.3)and 65%were women.One patient was revised within the two years follow-up.The mean improvement from the preoperative assessment to the two-year follow-up was 46.1 points[95%confidence interval(95%CI):39.7-53.3,Pbout their prognosis.

关键词： Minimal clinically important difference Patient reported outcome measures Glenohumeral osteoarthritis Anatomical total shoulder arthroplasty Clinically relevant improvement

Effects of centralized and local PV plant control for voltage regulation in LV feeder based on cyber-physical simulations

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Journal of Modern Power Systems and Clean Energy 2018年第5期6卷 979-991页

作者： theis bo rasmussen Guangya YANG Arne Hejde NIELSEN Zhaoyang DONG Center for Electric Power and Energy Technical University of Denmark School of Electrical Engineering and Telecommunications University of New South Wales

In the modern power system, both local and centralized reactive power control strategies for photovoltaic(PV) plants, are proposed and compared. While local control improves the network security, it lacks the optimization benefits from centralized control strategies.Therefore, this paper considers the coordination of the two control strategies, depending on external impact from the weather system and consumer behavior, in a low voltage(LV) distribution feeder. Through modeling and simulation in an established real-time cyber-physical simulation platform, the LV network is evaluated with both local and centralized control. A set of boundaries for coordinating between the two strategies are identified, which can help network operators decide suitable control in different operating situations. Furthermore, the cyber-physical simulation platform, is used to study the impact of physical perturbations, i.e. changes in irradiance and consumption,and cyber disturbances, in form of communication channel noise, is evaluated for the control strategies. Results show how small and large disturbances in the cyber system affect the centralized control strategy optimizer performance.

关键词： Distribution Network Voltage regulation Photovoltaics Cyber-physical system

Low risk of postoperative ulnar nerve affection in surgically treated distal humeral fractures when the nerve is released in situ

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World Journal of Orthopedics 2023年第7期14卷 526-532页

作者： Mustafa Al-Gburi Ali Al-Hamdani Jeppe Vejlgaard rasmussen bo Sanderhoff Olsen Section for Shoulder and Elbow Surgery Department of Orthopaedic SurgeryHerlev and Gentofte University HospitalHellerup 2900GentofteDenmark

BACKGROUND Adult distal humeral fractures(DHF)comprise 2%-5%of all fractures and 30%of all elbow fractures.Treatment of DHF may be technically demanding due to fracture complexity and proximity of neurovascular structures.Open reduction and internal fixation(ORIF)are often the treatment of choice,but arthroplasty is considered in case of severe comminution or in elderly patients with poor bone quality.Ulnar nerve affection following surgical treatment of distal humerus fractures is a well-recognized complication.AIM To report the risk of ulnar nerve affection after surgery for acute DHFs.METHODS We retrospectively identified 239 consecutive adult patients with acute DHFs who underwent surgery with ORIF,elbow hemiarthroplasty(EHA)or total elbow arthroplasty(TEA)between January 2011 and December 2019.In all cases,the ulnar nerve was released in situ without anterior transposition.We used our institutional database to review patients’medical records for demographics,fracture morphology,type of surgery and ulnar nerve affection immediately;records were reviewed after surgery and at 2 wk and 12 wk of routine clinical outpatient follow-up.Twenty-nine percent patients were excluded due to pre-or postoperative conditions.Final follow-up examination was a telephone interview in which ulnar nerve affection was reported according to the McGowen Classification Score.A total of 210 patients were eligible for interview,but 13 patients declined participation and 17 patients failed to respond.Thus,180 patients were included.RESULTS Mean age at surgery was 64 years(range 18-88 years);121(67.3%)patients were women;59(32.7%)were men.According to the AO/OTA classification system,we recorded 47 patients with type A3,55 patients with type B and 78 patients with type C fractures.According to the McGowen Classification Score,mild ulnar nerve affection was reported in nine patients;severe affection,in two.A total of 69 patients were treated with ORIF of whom three had mild temporary ulnar nerve affection and one had severe ulnar nerve af

关键词： Humeral fracture Arthroplasties Internal fixation Ulnar nerve affection In situ release

Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2

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Acta Pharmaceutica Sinica B 2019年第4期9卷 659-674页

作者： Liming Chen Jose E.Manautou Theodore P.rasmussen Xiao-bo Zhong Department of Pharmaceutical Sciences School of Pharmacy University of Connecticut

Precision medicine is a rapidly-developing modality of medicine in human healthcare.Based on each patient’s unique characteristics, more accurate dosages and drug selection can be made to achieve better therapeutic efficacy and less adverse reactions in precision medicine. A patient’s individual parameters that affect drug transporter action can be used to develop a precision medicine guidance, due to the fact that therapeutic efficacy and adverse reactions of drugs can both be affected by expression and function of drug transporters on the cell membrane surface. The purpose of this review is to summarize unique characteristics of human breast cancer resistant protein(BCRP) and the genetic variability in the BCRP encoded gene ABCG2 in the development of precision medicine. Inter-individual variability of BCRP/ABCG2 can impact choices and outcomes of drug treatment for several diseases, including cancer chemotherapy. Several factors have been implicated in expression and function of BCRP, including genetic, epigenetic, physiologic,pathologic, and environmental factors. Understanding the roles of these factors in controlling expression and function of BCRP is critical for the development of precision medicine based on BCRP-mediated drug transport.

关键词： BCRP Epigenetics Gene polymorphisms Physiologic factors Precision medicine

Integrative taxonomy of the Russet Bush Warbler Locustella mandelli complex reveals a new species from central China

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Chinese Birds 2015年第2期6卷 60-91页

作者： Per Alstrom Canwei Xia Pamela C rasmussen Urban Olsson bo Dai Jian Zhao Paul J Leader Geoff J Carey Lu Dong Tianlong Cai Paul I Holt Hung Le Manh Gang Song Yang Liu Yanyun Zhang Fumin Lei Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of Sciences Swedish Species Information Centre Swedish University of Agricultural Sciences Ministry of Education Key Laboratory for Biodiversity and Ecological Engineering College of Life SciencesBeijing Normal University Department of Integrative Biology and MSU Museum Michigan State University Bird Group The Natural History Museum at Tring Department of Biology and Environmental Sciences Systematics and BiodiversityUniversity of Gothenburg College of Life Sciences Leshan Normal University State Key Laboratory of Biocontrol and College of Ecology and Evolution Sun Yat-sen University c/o AEC Ltd 121–127 Commercial CentrePalm SpringsYuen LongHong Kong College of Life Sciences University of Chinese Academy of Sciences Bracken Dean PendletonClitheroeLancashire BB7 1PTUK Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology

Background: The Russet Bush Warbler Locustella(previously Bradypterus) mandelli complex occurs in mountains in the eastern Himalayas, southern China, Vietnam, the Philippines, and Indonesia. The taxonomy has been debated,with one(L. seebohmi) to four(L. seebohmi, L. mandelli, L. montis and L. timorensis) species having been recognised.Methods: We used an integrative approach, incorporating analyses of morphology, vocalizations and a molecular marker, to re-evaluate species limits in the L. mandelli complex.Results: We found that central Chinese L. mandelli differed from those from India through northern Southeast Asia to southeast China in plumage, morphometrics and song. All were easily classified by song, and(wing + culmen)/tail ratio overlapped only marginally. both groups were reciprocally monophyletic in a mitochondrial cytochrome b(cytb) gene tree, with a mean divergence of 1.0 ± 0.2%. They were sympatric and mostly altitudinally segregated in the breeding season in southern Sichuan province. We found that the Mt Victoria(western Myanmar) population differed vocally from other L. mandelli, but no specimens are available. Taiwan Bush Warbler L. alishanensis was sister to the L. mandelli complex, with the most divergent song. Plumage, vocal and cytb evidence supported the distinctness of the south Vietnamese L. mandelli idonea. The Timor Bush Warbler L. timorensis, Javan Bush Warbler L.montis and Benguet Bush Warbler L. seebohmi differed distinctly in plumage, but among-population song variation in L. montis exceeded the differences between some populations of these taxa, and mean pairwise cytb divergences were only 0.5–0.9%. We also found that some L. montis populations differed morphologically.Conclusions: We conclude that the central Chinese population of Russet Bush Warbler represents a new species,which we describe herein, breeding at mid elevations in Sichuan, Shaanxi, Hubei, Hunan and Guizhou provinces.The taxonomic status of the other allopatric populations is less clear. However, as they differ to a

关键词： Bradypterus Cryptic species Locustella seebohmi Locustella mandelli Locustella montis Locustella timorensis Locustella alishanen

3D打印技术在腓骨头上入路治疗复杂胫骨平台后外侧骨折中的临床应用

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实用临床医药杂志 2024年第5期28卷 17-20,58页

作者：刘波曹光华张文玺杨栋姜辉乔之军江苏省溧阳市人民医院骨科江苏溧阳213300

目的探讨3D打印技术在腓骨头上入路治疗复杂胫骨平台后外侧骨折中的临床应用价值。方法回顾性分析67例接受腓骨头上入路治疗的复杂胫骨平台后外侧骨折患者的临床资料,根据术前是否采用3D打印模拟手术将患者分为3D打印组35例和常规组32... 详细信息

目的探讨3D打印技术在腓骨头上入路治疗复杂胫骨平台后外侧骨折中的临床应用价值。方法回顾性分析67例接受腓骨头上入路治疗的复杂胫骨平台后外侧骨折患者的临床资料,根据术前是否采用3D打印模拟手术将患者分为3D打印组35例和常规组32例。比较2组患者的手术时间、术中出血量、术中透视次数,观察术后切口感染、腘血管损伤、腓总神经损伤等并发症发生情况。随访骨折愈合时间,术后6个月评估rasmussen评分,末次随访时评估美国特种外科医院(HSS)膝关节功能评分。结果67例患者随访时间为14~22个月;2组各有1例患者发生术后切口感染,均未发生腘血管损伤、腓总神经损伤、下肢深静脉血栓等并发症;3D打印组患者手术时间、术中出血量、术中透视次数均短于或少于常规组,差异有统计学意义(Prasmussen评分、末次随访时HSS评分比较,差异无统计学意义(P>0.05)。结论3D打印技术应用于复杂胫骨平台后外侧骨折患者的腓骨头上入路治疗中,可以优化手术方案,缩短手术时间,减少术中出血量和透视次数。

关键词： 3D打印骨折胫骨平台腓骨头上入路内固定

Valuable Biomolecules from Nine North Atlantic Red Macroalgae: Amino Acids, Fatty Acids, Carotenoids, Minerals and Metals

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Natural Resources 2016年第4期7卷 157-183页

作者： Behnaz Razi Parjikolaei Annette Bruhn Karin Loft Eybye Martin Mørk Larsen Michael bo rasmussen Knud Villy Christensen Xavier C. Fretté Department of Chemical Engineering Biotechnology and Environmental Technology University of Southern Denmark Odense Denmark Department of Bioscience Aarhus University Silkeborg Denmark Food Technology Department Life Science Division Danish Technological Institute Aarhus Denmark Department of Bioscience Aarhus University Roskilde Denmark

In modern society, novel marine resources are scrutinized pursuing compounds of use in the medical, pharmaceutical, biotech, food or feed industry. Few of the numerous marine macroalgae are currently exploited. In this study, the contents of nutritional compounds from nine common North Atlantic red macroalgae were compared: the lipid content was low and constant among the species, whereas the fatty acid profiles indicated that these species constitute interesting sources of polyunsaturated fatty acids (PUFA). The dominating essential and non-essential amino acids were lysine and leucine, aspartic acid, glutamic acid, and arginine, respectively. The amino acid score of the nine algae varied from 44% to 92%, the most commonly first limiting amino acid being histidine. Lutein, β-carotene, and zeaxanthin were the identified carotenoids. Contents of all macro and trace minerals, with the exception of phosphorus, were higher than those described for conventional food. Low sodium/potassium ratios (0.08 - 2.54) suggested a potential for using the ash fraction for sodium salt replacement. The algae constituted rich sources of carbohydrates (40% to 71% of DM) which show their potential for a broader commercial exploitation. In some species, the concentrations of arsenic, cadmium, and lead exceeded limit values for application in food or feed. In conclusion, the nine algae represent promising potential sources of health promoting additives for human and animal diets, in whole or in a biorefinery concept.

关键词： Protein Lipid Carotenoids Dry Matter Arsenic

双切口金属植入物内固定修复SchatzkerⅤ、Ⅵ型胫骨平台双髁骨折

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中国组织工程研究 2015年第15期19卷 2330-2335页

作者：黄波北京市昌平区医院北京市102200

背景:胫骨平台骨折治疗的内固定修复方法有很多种,各有优缺点,有研究报道膝关节内固定修复SchatzkerⅤ、Ⅵ型胫骨平台双髁骨折效果较好,具体此2种骨折修复效果的差异尚不确定。目的:观察采用膝关节前外侧和后内侧联合入路双切口金属植... 详细信息

背景:胫骨平台骨折治疗的内固定修复方法有很多种,各有优缺点,有研究报道膝关节内固定修复SchatzkerⅤ、Ⅵ型胫骨平台双髁骨折效果较好,具体此2种骨折修复效果的差异尚不确定。目的:观察采用膝关节前外侧和后内侧联合入路双切口金属植入物内固定法修复SchatzkerⅤ、Ⅵ型胫骨平台双髁骨折的修复效果。方法:自2009年1月至2012年12月北京市昌平区医院骨科共收治SchatzkerⅤ、Ⅵ型胫骨平台双髁骨折患者67例,其中SchatzkerⅤ型38例、SchatzkerⅥ型29例,均采用膝关节前外侧和后内侧联合入路双切口金属植入物内固定修复,对两种分型患者进行随访观察比较骨折愈合情况、功能恢复情况的差异。结果与结论:两组患者的伤口经过积极治疗均愈合。末次随访结果显示,SchatzkerⅤ型患者的内外翻评分、rasmussen放射学总评分、rasmussen膝关节功能评分的屈、伸评分、关节活动度、关节稳定性评分和膝关节功能优良率均显著高于SchatzkerⅥ型患者(P0.05),SchatzkerⅤ型患者关节面恢复良好,内固定稳定可靠。结果证实,膝关节前外侧和后内侧联合内固定修复SchatzkerⅤ型胫骨平台双髁骨折及膝关节功能恢复情况均优于SchatzkerⅥ型骨折。

关键词：组织工程骨折膝关节胫骨组织构建骨组织工程前外侧入路后内侧入路 SchatzkerⅤ型 SchatzkerⅥ型胫骨平台双髁骨折

^(146)Ce核的八级形变带和准γ带(英文)

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高能物理与核物理 2006年第8期30卷 740-744页

作者：陈永静朱胜江 J. H. Hamilton A. V. Ramayya J. K. Hwang Y. X. Luo J. O. rasmussen 车兴来丁怀博李明亮清华大学物理系北京100084 Department of Physics Vanderbilt University Nashville Tennessee 37235 USA Lawrence Berkeley National Laboratory Berkeley California 94720 USA

通过测量252Cf自发裂变所产生的瞬发γ射线,对146Ce核的高自旋结构进行了重新研究,结果更新了以前报道的能级纲图,把八级形变集体带扩展到更高的自旋,并且重新构建了可能的准γ带结构．此外,用反射不对称壳模型(RASM)对146Ce核的八级形... 详细信息

通过测量252Cf自发裂变所产生的瞬发γ射线,对146Ce核的高自旋结构进行了重新研究,结果更新了以前报道的能级纲图,把八级形变集体带扩展到更高的自旋,并且重新构建了可能的准γ带结构．此外,用反射不对称壳模型(RASM)对146Ce核的八级形变带进行了计算,低自旋处的计算结果与实验数据符合得很好．

关键词：高自旋态八级形变带准γ带壳模型