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Anti-tumor activity of rice bran hydrolysates on migration, invasion and angiogenesis

Asian Pacific Journal of Tropical Biomedicine 2021年第7期11卷 317-326页

作者： Suphanthip Phusrisom Laddawan Senggunprai Auemduan Prawan Sarinya Kongpetch Upa Kukongviriyapan Supawan Thawornchinsombut Sirithon Siriamornpun theeraphan chumroenphat Ronnachai Changsri Veerapol Kukongviriyapan Department of Pharmacology Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Physiology Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Department of Food Technology Faculty of TechnologyKhon Kaen UniversityKhon Kaen 40002Thailand Department of Food Technology and Nutrition Faculty of TechnologyMahasarakham UniversityMahasarakham44150Thailand Chumphae Rice Research Center Ministry of Agriculture and CooperativesKhon Kaen 40130Thailand

Objective:To investigate anti-tumor effect of rice bran hydrolysates(RBH)on proliferation,migration,invasion,and angiogenesis of cholangiocarcinoma(CCA)cells,and elucidate the underlying ***:RBH was prepared from Tubtim Chumprae rice(Oryza sativa L.)by hydrothermolysis followed by protease *** content in RBH was analyzed by high-performance liquid *** CCA cells,KKU-156,KKU-452,and KKU-100,were used to study the effects of RBH on proliferation,migration,invasion,and adhesion by wound healing,Transwell chamber,and fibronectin cell adhesion *** was evaluated using human umbilical vein endothelial *** associated with cancer progression were analyzed by immunobloting ***:RBH contained carbohydrates,proteins,lipids,and various phenolic compounds and *** did not inhibit CCA proliferation,but strongly suppressed migration,invasion,adhesion of CCA cells,and the formation of tube-like capillary structures of human umbilical vein endothelial ***,RBH downregulated phosphorylation of FAK,PI3K,and Akt,suppressed NF-κB nuclear translocation,decreased the expression of ICAM-1,vimentin and vascular endothelium growth factor(VEGF),and increased the expression of ***:RBH suppresses CCA cell migration and invasion and decreases expression of proteins involved in cancer *** is a potential food supplement for cancer prevention.

关键词： Rice bran hydrolysates Ferulic acid CCA cells Proliferation Migration Invasion Adhesion Metastasis Angiogenesis NF-κB

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