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Probability parametric imaging with DCE-MRI data to identify prostate cancer in the peripheral zone

Progress in Natural Science:Materials International 2006年第9期16卷 948-953页

作者： HUANG Xinrui, WANG Qiang, XU Yufeng, WANG Xiaoying and BAO Shanglian ( The Key Laboratory of medical Physics and Engineering, peking university, beijing 100871, china the medical school of peking university, beijing 100083, china 3. The First Hospital of peking university, beijing 100034, china) The Key Laboratory of medical Physics and Engineering Peking University Beijing 100871 China the medical school of peking university Beijing 100083 China The First Hospital of peking university Beijing 100034 China

To quantitatively analyze prostate dynamic contrast-enhanced magnetic resonance images (DCE-MRI), a retrospective study was carried out to construct a mathematical model to predict whether a lesion is cancerous or not. With known diagnosis of 52 re-gions-of-interest (10 malignant, 26 benign and 16 normal) in peripheral zone (PZ) of prostate from 18 patients undergoing needle biopsy and 8 normal volunteers, we combined feature parameters (k1, k2 and tp) from the linear-slope model with logistic regression to determine the statistical probability model. Prostate cancerous probability maps were derived using the model on each subject to examine the correlation between the model-based prediction and the known diagnosis. Compared the model prediction results of 52 regions-of-interest with the histopathologic results, the total agreement rate was 90.4 % ; the agreement rate was 60 % for the malignant and 97. 6 % for the nonmalignant. The diagnostic results only referencing the probability maps by two radiologists showed a high agreement in tissue characteristics and lesion location with the combining results from other diagnostic techniques such as PSA (prostate specific antigen) level and MRS (magnetic resonance spectroscopy) .

关键词： time-intensity curve prostate DCE-MRI logistic regression probability parametric image.

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灵光独耀:沈宗灵与中国法理学

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中国法律评论 2024年第4期 149-154页

作者： peking university Law school 北京大学法学院

在其诸多弟子的追忆中,沈宗灵先生一生专心治学、淡泊名利,由此常常对世事保持一种有意的疏离。“灵光独耀,迥脱根尘”,或许便是这位法理学大家的灵魂写照。壹“经国济民”:沈宗灵的早年岁月1923年2月24日,沈宗灵出生于浙江杭州的一个... 详细信息

在其诸多弟子的追忆中,沈宗灵先生一生专心治学、淡泊名利,由此常常对世事保持一种有意的疏离。“灵光独耀,迥脱根尘”,或许便是这位法理学大家的灵魂写照。壹“经国济民”:沈宗灵的早年岁月1923年2月24日,沈宗灵出生于浙江杭州的一个商人家庭,后随家人迁居上海。

关键词：沈宗灵淡泊名利法理学浙江杭州灵光

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CFU-E和其分化细胞的生物物理特性

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生物物理学报 2003年第4期19卷 367-371页

作者：王金华岳黎敏唐军民孙大公文宗曜北京大学医学部基础医学院物理教研室北京100083 北京大学医学部人体解剖与组织胚胎学系北京100083

用可诱发小鼠贫血的病毒(anemia-inducing strain friend’s virus,FVA)感染BALB/c小鼠,13 d后取其脾脏,用Ficoll-Urografin分层液(1.070)分离出红系集落形成单位(colony forming ***-E)细胞,用Wright-Giemsa染液染色并用透射电镜进行形态学观察,在培养液加细胞因子,如促红细胞生成素(erythropoietin,EPO)、白介素3(interleukin-3,IL-3)、干细胞刺激因子(stem cell factor,SCF),诱导其分化的情况下培养12、24和36h,分别对0、12、24和36 h的细胞进行电泳率、膜的流动性和变形性的测量及红系特异转录因子GATA-1表达(0、12、24和48 h)的检测,发现CFU-E细胞随着分化培养时间增加,其电泳率不断减少,膜的流动性不断增大,细胞的变形性和取向性逐渐变好;CFU-E在0、12和24 h GATA持续高水平表达,而48 h后,其表达明显降低。

关键词：分化细胞生物物理特性电泳率膜流动性变形性 CFU-E

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GDNF、GFAP和NGFRp75在成年大鼠和金黄地鼠嗅球成鞘细胞的免疫组织化学研究

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解剖学报 2002年第4期33卷 366-369页

作者：杨磊周长满买鸿宴于恩华北京大学基础医学院解剖学系北京100083

目的　研究GDNF在成年大鼠和金黄地鼠嗅球成鞘细胞的表达 ,探索成鞘细胞在中枢神经再生中的作用。　方法　用免疫组织化学ABC法 ,显示GDNF在成年大鼠和金黄地鼠嗅球成鞘细胞的表达和分布 ,同时用NGFRp75和GFAP染色作为阳性对照。　结果... 详细信息

目的　研究GDNF在成年大鼠和金黄地鼠嗅球成鞘细胞的表达 ,探索成鞘细胞在中枢神经再生中的作用。　方法　用免疫组织化学ABC法 ,显示GDNF在成年大鼠和金黄地鼠嗅球成鞘细胞的表达和分布 ,同时用NGFRp75和GFAP染色作为阳性对照。　结果　在成年大鼠和金黄地鼠嗅球的纤维层和小球层内均可见深棕色的GDNF免疫组织化学反应的成鞘细胞。在小球层与纤维层分界处和小球层与分子层分界处及嗅小球之间密集分布 ,在嗅小球之内较稀疏。同时在同一嗅球组织的另两组切片的相同部位 ,分别出现GFAP和NGFRp75免疫反应性细胞 ,间接说明GDNF免疫反应的结构是嗅球成鞘细胞。

关键词：嗅神经成鞘细胞胶质细胞源性神经营养因子免疫组织化学

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人白细胞抗原G3在稳定转染细胞细胞膜上的表达

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中国生物化学与分子生物学报 2002年第4期18卷 482-485页

作者：石春林马康涛周春燕北京大学基础医学院生物化学与分子生物学系北京100083

人白细胞抗原G(HLA G)是一种在母婴耐受中起主要作用的非经典的HLA Ⅰ类分子 .其中HLA G3结构简单 ,仅具有α1结构域、穿膜区及胞浆区 ,其是否在细胞表面表达尚存在争议 .为了建立HLA G3稳定转染细胞株并确定其在细胞内的定位 ,采用RT ... 详细信息

人白细胞抗原G(HLA G)是一种在母婴耐受中起主要作用的非经典的HLA Ⅰ类分子 .其中HLA G3结构简单 ,仅具有α1结构域、穿膜区及胞浆区 ,其是否在细胞表面表达尚存在争议 .为了建立HLA G3稳定转染细胞株并确定其在细胞内的定位 ,采用RT PCR法从 9周人胎盘组织中获得了HLA G3的cDNA ,并构建到真核表达载体pcDNA3中 ,将所获得的真核表达质粒pcDNA G3转染至HLA Ⅰ (- )细胞株K5 6 2 ,经G4 18筛选后获得稳定转染的细胞株K5 6 2 G3.利用RT PCR、Western印迹检测方法证明在K5 6 2 G3细胞株中 ,HLA G3在mRNA水平和蛋白水平上均有表达 .进一步利用免疫荧光标记技术 ,证明HLA G3能够在转染细胞细胞膜上表达 .结果表明 ,稳定转染细胞株中HLA

关键词：人白细胞抗原G3 稳定转染细胞细胞膜表达 HLA-G3 K562细胞

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Expert consensus on radiotherapy combined with immunotherapy for esophageal cancer(2024 edition)

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Radiation Medicine and Protection 2024年第2期5卷 59-67页

作者： Professional Committee of Radiation Oncology china Anti-Cancer Association Branch ofRadiation Oncology Chinese medical Association Branch of Radiation Oncology TreatmentPhysician Chinese medical Doctor Association Qingsong Pang Jun Wang Zhouguang Hui 不详 Tianjin medical university Cancer Institute&Hospital Tianjin 300060China the Fourth Hospital of Hebei medical university Shijiazhuang 050011China National Cancer Center National Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China.

Radiotherapy represents an essential treatment approach for esophageal *** recent years,immunotherapy combined with chemotherapy has become the first-line standard treatment for patients with advanced esophageal *** phase III studies on immunotherapy combined with radiotherapy for locally advanced esophageal cancer are currently *** evidence-based medical data are urgently needed to support the integration of immunotherapy and chemoradiotherapy as a new treatment strategy for patients with locally advanced esophageal *** consensus,formulated based on the latest study results,in-depth research,and thorough discussions,provides a comprehensive set of *** document extensively covers treatment strategies and evaluation methods for radiotherapy combined with immunotherapy across patients with operable esophageal cancer,inoperable locally advanced esophageal cancer,and advanced esophageal ***,common complications and radiation-related issues associated with radiotherapy combined with immunotherapy are discussed,serving as clinical *** expert group comprised members from the Professional Committee of Radiation Oncology,china Anti-Cancer Association,the Branch of Radiation Oncology,Chinese medical Association,and the Branch of Radiation Oncology Treatment Physician,Chinese medical Doctor Association.

关键词： Esophageal squamous cell carcinoma Esophageal adenocarcinoma Immunotherapy Chemoradiotherapy Radiotherapy Expert consensus

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传染病多点触发智慧化监测预警系统关键技术专家共识

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中华医学杂志 2024年第32期104卷 1-15页

作者：中国医学科学院北京协和医学院群医学及公共卫生学院北京大学公共卫生学院中国疾病预防控制中心传染病管理处四川大学华西公共卫生学院中国科学院地理科学与资源研究所首都医科大学附属北京地坛医院中华医学会公共卫生分会

有效的传染病监测预警系统是公共卫生安全体系的重要组成部分, 对预防与控制传染病暴发流行至关重要, 提升监测预警能力是推动疾病预防控制事业高质量发展的当务之急。专家组结合公共卫生与预防医学、临床医学、管理学、数据科学、计算... 详细信息

有效的传染病监测预警系统是公共卫生安全体系的重要组成部分, 对预防与控制传染病暴发流行至关重要, 提升监测预警能力是推动疾病预防控制事业高质量发展的当务之急。专家组结合公共卫生与预防医学、临床医学、管理学、数据科学、计算机科学等多学科专家的研究成果与实践经验, 经过反复多轮专家研讨, 形成了传染病多点触发智慧化监测预警系统关键技术专家共识。本共识内容主要包括传染病多点触发智慧化监测预警系统的相关概念和定义, 关键技术框架, 多渠道监测预警数据来源、获取与治理, 预警方法分类, 多点触发智慧化监测预警关键流程及路径, 多点触发预警及综合研判, 预警信号响应以及预警效果评价等方面, 以期为传染病多点触发智慧化监测预警系统建设及应用提供技术参考。

关键词：传染病监测预警多点触发智慧化

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Recommendation Method for Contrastive Enhancement of Neighborhood Information

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Computers, Materials & Continua 2024年第1期78卷 453-472页

作者： Hairong Wang beijing Zhou Lisi Zhang He Ma school of Computer Science and Engineering North Minzu UniversityNingxia750021China

Knowledge graph can assist in improving recommendation performance and is widely applied in various person-alized recommendation ***,existing knowledge-aware recommendation methods face challenges such as weak user-item interaction supervisory signals and noise in the knowledge *** tackle these issues,this paper proposes a neighbor information contrast-enhanced recommendation method by adding subtle noise to construct contrast views and employing contrastive learning to strengthen supervisory signals and reduce knowledge ***,first,this paper adopts heterogeneous propagation and knowledge-aware attention networks to obtain multi-order neighbor embedding of users and items,mining the high-order neighbor informa-tion of users and ***,in the neighbor information,this paper introduces weak noise following a uniform distribution to construct neighbor contrast views,effectively reducing the time overhead of view *** paper then performs contrastive learning between neighbor views to promote the uniformity of view information,adjusting the neighbor structure,and achieving the goal of reducing the knowledge noise in the knowledge ***,this paper introduces multi-task learning to mitigate the problem of weak supervisory *** validate the effectiveness of our method,experiments are conducted on theMovieLens-1M,MovieLens-20M,Book-Crossing,and Last-FM *** results showthat compared to the best baselines,our method shows significant improvements in AUC and F1.

关键词： Contrastive learning knowledge graph recommendation method

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Expert Consensus on the Prevention and Treatment of Chronic Hepatitis B in Children

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Infectious Diseases & Immunity 2024年第3期4卷 106-120页

作者： Chinese Society of Infectious Diseases Chinese medical Association Chinese Society of Hepatology Chinese medical Association Group of Infectious Diseases Chinese Pediatric Society Chinese medical Association National Clinical Research Center for Infectious Diseases(beijing) Fu-Sheng Wang Shishu Zhu Min Zhang Jianshe Wang Shuangjie Li Junliang Fu Yuanyuan Li Yuming Guo Jing Li Hongmei Xu Wenxian Ouyang Yuemin Nan Sainan Shu Shuangsuo Dang Xiaoyuan Xu Taisheng Li Jinlin Hou 不详 The Fifth medical Center of PLA General Hospital Beijing 100039China Fudan university Children’s Hospital Hunan Children’s Hospital Children’s Hospital of Chongqing medical university Third Hospital Hebei Medical University Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology The Second Affiliated Hospital of Xi’an Jiaotong university peking university First Hospital peking Union medical College Hospital Chinese Academy of Medical Sciences&Peking Union Medical College Nanfang Hospital Southern Medical University

The aim of this consensus is to standardize the prevention, diagnosis, and treatment of chronic hepatitis B in children and to achieve the goal of “eliminating viral hepatitis as a major public health threat by 2030” issued by the World Health Organization. Formulated by organized experts of the Chinese Society of Infectious Diseases and Chinese Society of Hepatology, Chinese medical Association;Group of Infectious Diseases, Chinese Pediatric Society, Chinese medical Association;and the National Clinical Research Center for Infectious Diseases (beijing), the consensus provides the latest evidence and recommendations for the prevention, diagnosis, and treatment of chronic hepatitis B in children.

关键词： Chronic hepatitis B Children Treatment Prevention Consensus

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Chinese expert consensus on refined diagnosis,treatment,and management of advanced primary liver cancer(2023 edition)

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肝脏研究（英文） 2024年第2期8卷 61-71页

作者： Xiufeng Liu Feng Xia Yue Chen Huichuan Sun Zhengqiang Yang Bo Chen Ming Zhao Xinyu Bi Tao Peng Aizier Ainiwaer Zhiwen Luo Fusheng Wang Yinying Lu National Clinical Research Center for Infectious Diseases Society of Hepatology,beijing medical Association Translational Medicine Branch,china Association of Gerontology and Geriatrics Department of medical Oncology Bayi Hospital Affiliated to Nanjing Chinese Medical University NanjingJiangsuChina Department of Hepatobiliary Surgery Southwest HospitalArmy Medical University ChongqingChina Senior Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijingChina Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Department of Interventional Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Minimally Invasive Interventional Therapy Liver Cancer Study and Service GroupSun Yat-sen University Cancer CenterGuangzhouGuangdongChina Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxiChina Senior Department of Infectious Diseases The Fifth Medical Center of PLA General HospitalBeijingChina Comprehensive Liver Cancer Center The Fifth Medical Center of PLA General HospitalBeijingChina

Hepatocellular carcinoma(HCC),commonly known as primary liver cancer,is a major cause of malignant tumors and cancer-related deaths in china,accounting for approximately 85％of all cancer cases in the *** guidelines have been used to diagnose and treat liver ***,these guidelines provide a broad definition for classifying advanced liver cancer,with an emphasis on a singular approach,without considering treatment options for individual ***,it is necessary to establish a comprehensive and practical expert consensus,specifically for china,to enhance the diagnosis and treatment of HCC using the Delphi *** classification criteria were refined for Chinese patients with HCC,and the corresponding optimal treatment regimen recommendations were *** recommendations took into account various factors,including tumor characteristics,vascular tumor thrombus grade,distant metastasis,liver function status,portal hypertension,and the hepatitis B virus replication status of patients with primary HCC,along with treatment *** findings and rec-ommendations provide detailed,scientific,and reasonable individualized diagnosis and treatment strategies for clinicians.

关键词： Hepatocellular carcinoma (HCC) Targeted therapy Immunotherapy Refined diagnosis and treatment Expert consensus

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