检索结果-南通市图书馆

Convergent adaptation of the genomes of woody plants at the land–sea interface

National Science Review 2020年第6期7卷 978-993页

作者： Ziwen He Shaohua Xu Zhang Zhang Wuxia Guo Haomin Lyu Cairong Zhong David E.Boufford Norman C.Duke the international m.ngrove consortium.suhua shi State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory of Plant Resources Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes School of Life Sciences Sun Yat-Sen University Hainan Dongzhai Harbor National Nature Reserve Administration Harvard University Herbaria Centre for Tropical Water and Aquatic Ecosystem Research James Cook University the consortium of 26 Institutions

Sequencing multiple species that share the same ecological niche may be a new frontier for genomic *** such studies should shed light on molecular convergence, genomic-level analyses have been unsuccessful, due mainly to the absence of empirical controls. Woody plant species that colonized the global tropical coasts, collectively referred to as m.ngroves, are ideal for convergence studies. Here, we sequenced the genomes/transcriptomes of 16 species belonging in three major m.ngrove clades. To detect convergence in a large phylogeny, a CCS+ model is implemented, extending the more limited CCS method(convergence at conservative sites). Using the empirical control for reference, the CCS+ model reduces the noises drastically, thus permitting the identification of 73 convergent genes with Ptrue(probability of true convergence) > 0.9. Products of the convergent genes tend to be on the plasma membrane associated with salinity tolerance. Importantly, convergence is more often manifested at a higher level than at amino-acid(AA) sites. Relative to >50 plant species, m.ngroves strongly prefer 4 AAs and avoid 5 others across the genome. AA substitutions between m.ngrove species strongly reflect these tendencies. In conclusion, the selection of taxa, the number of species and, in particular, the empirical control are all crucial for detecting genome-wide convergence. We believe this large study of m.ngroves is the first successful attempt at detecting genome-wide site convergence.

关键词： convergent evolution genome m.ngrove adaptive evolution woody plants

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The origin,diversification and adaptation of a major m.ngrove clade(Rhizophoreae) revealed by whole-genome sequencing

引用

National Science Review 2017年第5期4卷 721-734页

作者： Shaohua Xu Ziwen He Zhang Zhang Zixiao Guo Wuxia Guo Haomin Lyu Jianfang Li ming Yang Zhenglin Du Yelin Huang Renchao Zhou Cairong Zhong David E.Boufford manuel Lerdau Chung-I Wu Norman C.Duke suhua shi State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory of Plant ResourcesKey Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes School of Life Sciences Sun Yat-Sen University Core Genomic Facility Beijing Institute of Genomics Chinese Academy of Sciences Hainan Dongzhai Harbor National Nature Reserve Harvard University Herbaria Departments of Environmental Sciences and of Biology University of Virginia Department of Ecology and Evolution University of Chicago Centre for Tropical Water and Aquatic Ecosystem Research James Cook University The international m.ngrove consortium

m.ngroves invade some very marginal habitats for woody plants—at the interface between land and *** m.ngroves anchor tropical coastal communities globally, their origin, diversification and adaptation are of scientific significance, particularly at a time of global climate change. In this study, a combination of single-molecule long reads and the more conventional short reads are generated from Rhizophora apiculata for the de novo assembly of its genome to a near chromosome level. The longest scaffold, N50 and N90 for the R. apiculata genome, are 13.3 mb, 5.4 mb and 1.0 mb, respectively. Short reads for the genomes and transcriptomes of eight related species are also generated. We find that the ancestor of Rhizophoreae experienced a whole-genome duplication70 myrs ago, which is followed rather quickly by colonization and species diversification. m.ngroves exhibit pan-exome modifications of amino acid（AA） usage as well as unusual AA substitutions among closely related species. The usage and substitution of AAs, unique among plants surveyed, is correlated with the rapid evolution of proteins in m.ngroves. A small subset of these substitutions is associated with m.ngroves' highly specialized traits（vivipary and red bark） thought to be adaptive in the intertidal habitats. Despite the many adaptive features, m.ngroves are among the least genetically diverse plants, likely the result of continual habitat turnovers caused by repeated rises and falls of sea level in the geologically recent past. m.ngrove genomes thus inform about their past evolutionary success as well as portend a possibly difficult future.

关键词： m.ngrove whole-genome sequencing adaptive evolution protein evolution genetic diversity sea-level changes

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Effect of solidification rate on dendrite segregation and mechanical properties of Cu-15Ni-8Sn alloy prepared by directional solidification

引用

Journal of Iron and Steel Research international 2023年第8期30卷 1586-1597页

作者： Yu-fan shi Cheng-jun Guo ming-quan Yuan Zhen-bin Jia Gui-huan An Xiang-peng Xiao Bin Yang Faculty of materials metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000JiangxiChina Jiangxi Advanced Copper Industry Research Institute Yingtan 335000JiangxiChina

The microstructures and mechanical properties of the directionally solidified Cu-15Ni-8Sn alloy were investigated at solidification rates ranging from 100 to 3000μm/*** results showed that the solidification rate significantly affects the phase distribution of the as-cast Cu-15Ni-8Sn *** primary and secondary dendritic spacing reduces and eventually becomes stable as the solidification rate ***,the size of the primary phase decreases,and its distribution becomes more *** most severe segregation problem of this alloy has been greatly *** solidification at 100μm/s,the as-cast Cu-15Ni-8Sn alloy consists of the α-Cu matrix,γ-CuNi_(2)Sn phase,discontinuous precipitation structure,modulated structure,and DO_(22) ordered ***,as the solidification rate increases,the discontinuous precipitation structure,modulated structures,and DO_(22) ordered phases decrease and even disappear,reducing *** the solidification rate increases,after homogenization treatment,the composition and microhardness distributions of Cu-15Ni-8Sn alloy become more *** time for homogenization is also *** reduces production energy usage and facilitates further mechanical processing.

关键词： Cu-15Ni-8Sn alloy Dendrite segregation Directional solidification Discontinuous precipitation structure DO_(22)ordered phase

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

引用

Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu michael H Perlin David Danko Jun Lu manuela Oliveira Johannes Werner maria m Zambrano maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-Chong Soojin Jang Haruo Suzuki marina Nieto-Caballero Bharath Prithiviraj Patrick K H Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E mason Tieliu shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA Department of Pulmonary medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied Environmental metagenomics and Infectious Diseases Research(AEmIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of Environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of Energy and Environment City University of Hong KongHong Kong 999077China Department of microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AmR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the meta SUB international consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一种新型肾透明细胞癌焦亡相关基因预后风险模型的建立和验证

引用

解剖学报 2022年第5期53卷 620-627页

作者：王万里任伟南赵千石贞玉厉永强河南大学口腔医学院河南开封475004 河南大学基础医学院医学生物信息学研究所河南开封475004

目的建立一种新型肾透明细胞癌焦亡相关基因风险模型。方法从癌症基因组图谱(TCGA)数据库、基因型组织表达(GTEx)数据库分别下载了522例肾透明细胞癌(KIRC)患者和72例正常组织样本。对TCGA和GTEx的数据进行差异分析,采用单因素和多因素... 详细信息

目的建立一种新型肾透明细胞癌焦亡相关基因风险模型。方法从癌症基因组图谱(TCGA)数据库、基因型组织表达(GTEx)数据库分别下载了522例肾透明细胞癌(KIRC)患者和72例正常组织样本。对TCGA和GTEx的数据进行差异分析,采用单因素和多因素COX回归分析以及LASSO Cox回归分析构建基因风险模型。使用国际癌症基因组联盟(ICGC)数据作为外部验证数据集。对TCGA_KIRC队列的高、低风险组进行基因本体论(GO)富集分析与京都基因与基因组百科全书(KEGG)通路富集分析,探讨高、低风险组之间基因功能和通路的差异。利用CIBERSORT数据库探讨高、低风险组的免疫浸润情况。结果通过差异分析,得到13个差异表达的焦亡相关基因。采用单因素、多因素和LASSO Cox回归分析构建1个6基因风险模型。Kaplan-meier分析结果显示,两个队列中高风险组生存时间均短于低风险组。在TCGA_KIRC队列中,1、2、3年曲线下面积(AUC)分别为0.710、0.683和0.727。在ICGC_RECA队列中,1、2、3年曲线下面积为0.592、0.531和0.545。独立预后分析显示,风险分数是1个独立预后因素。GO功能富集分析和KEGG通路富集分析结果表明,其主要与免疫和炎症反应相关。肿瘤的免疫浸润结果表明,高风险组中CD4^(+)T细胞调节性T细胞、自然杀伤细胞、单核细胞、m2巨噬细胞和嗜酸性粒细胞浸润水平低,B细胞、CD8^(+)T细胞、滤泡辅助性T细胞浸润水平高。结论细胞焦亡相关基因可能在KIRC肿瘤免疫中发挥重要作用,联合与细胞焦亡相关的6基因风险模型可以为KIRC患者的个性化治疗方案提供预测依据。

关键词：肾透明细胞癌免疫浸润预后 LASSO Cox回归分析人

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

影响中国汉族≥75岁老年口服华法林病人IWPC预测模型准确性的相关因素

引用

实用老年医学 2021年第2期35卷 126-131页

作者：杨海燕李曼潘丰慧崔雯霞施晓婷高蕾王春南京大学医学院附属鼓楼医院干部保健中心江苏省南京市210008

目的探讨影响≥75岁老年病人国际华法林药物基因组协会(IWPC)预测模型准确性的相关因素,为≥75岁病人更合理地应用华法林提供参考。方法收集≥75岁口服华法林抗凝治疗的老年病人的临床资料,根据预测剂量与实际剂量间的差异率分为差异轻... 详细信息

目的探讨影响≥75岁老年病人国际华法林药物基因组协会(IWPC)预测模型准确性的相关因素,为≥75岁病人更合理地应用华法林提供参考。方法收集≥75岁口服华法林抗凝治疗的老年病人的临床资料,根据预测剂量与实际剂量间的差异率分为差异轻微组、差异一般组和差异显著组,比较各组性别、年龄、BmI、血压、心率、合并疾病及合并用药等临床指标差异,并分析各指标与剂量差异率的相关性。结果73例病人分为差异轻微组42例,差异一般组21例,差异显著组10例。3组病人性别、年龄、肝功能等指标及各基因型分布差异无统计学意义(P>0.05)。差异轻微组心力衰竭(心衰)病史及应用利尿剂比例明显低于差异显著组,血清肌酐明显低于差异一般组及差异显著组,估算的肾小球率过滤(eGFR)明显高于差异一般组及差异显著组,差异有统计学意义(均P0.05)。将eGFR按四分位数分为低水平[mL/(min·1.73m^2)]、中低水平[59.5~76.3 mL/(min·1.73m^2)]、中高水平[76.4~96.5 mL/(min·1.73m^2)]、高水平[>96.5 mL/(min·1.73m^2)]4个等级,eGFR低水平病人引起华法林实际与预测剂量间明显差异的OR值是eGFR高水平病人的4.455倍;eGFR中低水平病人引起华法林实际与预测剂量间明显差异的OR值是eGFR高水平病人的5.135倍。结论中国汉族≥75岁病人华法林平均实际稳定剂量mg/d;实际剂量越低,与IWPC模型公式预测剂量差异越大;eGFR与剂量差异大小有显著相关性。

关键词：老年人华法林 IWPC预测模型稳定剂量

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：