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MONOTONICITY CORRECTIONS FOR NINE-POINT SCHEME OF DIFFUSION EQUATIONS

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Journal of Computational Mathematics 2024年第5期42卷 1305-1327页

作者： Wang kong Zhenying hong Guangwei Yuan Zhiqiang Sheng School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China Key Laboratory of mathematical Modelling and High Performance Computing of Air Vehicles(NUAA) MIITNanjing 211106China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China HEDPS Center for Applied Physics and TechnologyPeking UniversityBeijing 100871China

In this paper,we present a nonlinear correction technique to modify the nine-point scheme proposed in[SIAM ***.,30:3(2008),1341-1361]such that the resulted scheme preserves the *** first express the flux by the cell-centered unknowns and edge unknowns based on the stencil of the nine-point ***,we use a nonlinear combination technique to get a monotone *** order to obtain a cell-centered finite volume scheme,we need to use the cell-centered unknowns to locally approximate the auxiliary *** present a new method to approximate the auxiliary unknowns by using the idea of an improved multi-points flux *** numerical results show that the new proposed scheme is robust,can handle some distorted grids that some existing finite volume schemes could not handle,and has higher numerical accuracy than some existing positivity-preserving finite volume schemes.

关键词： Monotonicity corrections Diffusion equation Improved MPFA Distorted meshes

Biochar-based composites for removing chlorinated organic pollutants: Applications, mechanisms, and perspectives

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Environmental Science and Ecotechnology 2024年第5期21卷 47-61页

作者： Qingqing Song Fanying kong Bing-Feng Liu Xueting Song hong-Yu Ren State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China School of Water Conservancy and Civil Engineering Northeast Agricultural UniversityHarbin150030China

Chlorinated organic pollutants constitute a significant category of persistent organic pollutants due to their widespread presence in the environment,which is primarily attributed to the expansion of agricultural and industrial *** pollutants are characterized by their persistence,potent toxicity,and capability for long-range dispersion,emphasizing the importance of their eradication to mitigate environmental *** conventional methods for removing chlorinated organic pollutants encompass advanced oxidation,catalytic oxidation,and bioremediation,the utilization of biochar has emerged as a prominent green and efficacious method in recent *** we review biochar's role in remediating typical chlorinated organics,including polychlorinated biphenyls(PCBs),triclosan(TCS),trichloroethene(TCE),tetrachloroethylene(PCE),organochlorine pesticides(OCPs),and chlorobenzenes(CBs).We focus on the impact of biochar material properties on the adsorption mechanisms of chlorinated *** review highlights the use of biochar as a sustainable and eco-friendly method for removing chlorinated organic pollutants,especially when combined with biological or chemical *** facilitates electron transfer efficiency between microorganisms,promoting the growth of dechlorinating bacteria and mitigating the toxicity of chlorinated organics through ***,biochar can activate processes such as advanced oxidation or nano zero-valent iron,generating free radicals to decompose chlorinated organic *** observe a broader application of biochar and bioprocesses for treating chlorinated organic pollutants in soil,reducing environmental ***,for water-based pollutants,integrating biochar with chemical methods proved more effective,leading to superior purification *** review contributes to the theoretical and practical application of biochar for removing environmental chlorinated organic pollutants.

关键词： Biochar Chlorinated organic pollutants Polychlorinated biphenyls Triclosan Trichloroethene

Prominent removal of trace lead(Ⅱ)ions from polluted water by terephthalic acid reformed Al/Zn metal organic nanoflakes

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Particuology 2024年第1期84卷 81-88页

作者： Junhua Li Lingshu Gao Junmao hong Xiaofeng Shi Sifang kong Jingyu Wang Hassan Algadi Benbin Xu Zhanhu Guo School of Chemistry and Chemical Engineering North University of ChinaTaiyuan030051China School of Traffic&Environment Shenzhen Institute of Information TechnologyShenzhen518172China Department of Electrical Engineering Faculty of EngineeringNajran UniversityNajran11001Saudi Arabia Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon TyneNE18STUK

Terephthalic acid reformed Al/Zn metal organic nanoflake was prepared and functionalized with trie-thylamine(T-AlZn).Without adding terephthalic acid,there was no product of metal organic nanoflake.T-AlZn has a remarkable performance in removing trace lead(Ⅱ)ions(Pb^(2+)).The adsorption equipoise with the removal rate≥97%was reached within 35 *** removal rates of T-AlZn for Pb^(2+)declined by only 16.73%after four *** adsorption of T-AlZn for Pb^(2+)follows the Langmuir isotherms model and pseudo-second-order dynamics *** utmost adsorption competence was calculated as 215.27 mg g^(-1).The T-AlZn adsorbent exhibits a bright prospect in the adsorption for Pb^(2+)and is a considerable candidate in the disposal of industrial sewage.

关键词： Metal organic complex Nanoflake Trace level Pb^(2+) Adsorption

“Treat-all”Strategy for Patients with Chronic Hepatitis B Virus Infection in china:Are We There Yet?

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Journal of Clinical and Translational Hepatology 2024年第6期12卷 589-593页

作者： Mengyang Zhang Yuanyuan kong Xiaoqian Xu Yameng Sun Jidong Jia hong You Liver Research Center Beijing Friendship HospitalCapital Medical UniversityBeijing Key Laboratory of Translational Medicine on Liver CirrhosisNational Clinical Research Center of Digestive DiseasesState Key Lab of Digestive HealthBeijingChina Clinical Epidemiology and EBM Unit Beijing Friendship HospitalCapital Medical UniversityBeijing Clinical Research InstituteBeijingChina

Chronic hepatitis B remains the primary cause of liver-related events in *** World Health Organization set a goal to eliminate viral hepatitis as a public health threat by ***,achieving this goal appears challenging due to the current low rates of diagnosis and ***“Treat-all”strategy,which proposes treating all patients with detectable hepatitis B virus(HBV)DNA or even all patients with positive HBsAg,has been suggested to simplify anti-HBV *** 2022,the chinese Society of Hepatology and the chinese Society of Infectious Diseases updated the guidelines for the prevention and treatment of chronic hepatitis B in china,expanding antiviral indications and simplifying the treatment *** to this latest guideline,nearly 95%of patients with detectable HBV DNA are eligible for antiviral *** review aimed to provide a detailed interpretation of the treatment indications outlined in the chinese Guidelines for the Prevention and Treatment of Chronic Hepatitis B(version 2022)and to identify gaps in achieving the“Treat-all”strategy in china.

关键词： Chronic hepatitis B Antiviral therapy Treatment indication Expanding treatment Treatment rate “Treat-all”strategy

Competition of Composition Fluctuation Modes in Weakly Segregated Salt-doped Symmetric Diblock Copolymers

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chinese Journal of Polymer Science 2024年第9期42卷 1375-1385,I0008页

作者： Yuan-Xin Zhou Xian kong South china Advanced institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

Salt-doped block copolymers have widespread applications in batteries,fuel cells,semiconductors,and various industries,where their properties crucially depend on phase separation ***,investigations into salt-doped diblock copolymers have predominantly focused on microphase separation,overlooking the segregation between ionic and polymeric *** study employs weak segregation theory to explore the interplay between phase separation dominated by the polymer-modulated mode and the salt-out-modulated mode,corresponding to microscopic and macroscopic phase separations,*** comparing diblock copolymers doped with salts to those doped with neutral solvents,we elucidate the significant role of charged species in modulating phase *** phase separation mode exhibits a transition between the polymer-modulated and salt-out-modulated modes at different *** systems doped with neutral solvents,this transition is stepwise,while in salt-ion-doped systems,it is *** a sufficiently large Flory-Huggins parameter between ions and polymers,the salt-out-modulated mode becomes dominant,promoting macrophase *** to the solvation effect of salt ions,salt-doped systems are more inclined to undergo microphase ***,we explore factors influencing the critical wavenumber of phase separation,including doping level and the Flory-Huggins parameters between two blocks and between ions and polymeric *** findings reveal that in a neutral solvent environment,these factors alter only the boundary between micro-and macro-phase separations,leaving the critical wavenumber unchanged in microphase separation ***,in a salt-doped environment,the critical wavenumber of microphase separation varies with these *** provides valuable insights into the pivotal role of electrostatics in the phase separation of salt-doped block copolymers.

关键词： Block copolymer Phase separation Field theory Salt-doped

Evaluation of dry eye disease symptomatology and mental health status among patients with different COVID-19 statuses

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 822-830页

作者： Fang Ruan Wen-Jun kong Qian Fan hong-Wei Dong Wei Zhang Wen-Bin Wei Ying Jie Department of Ophthalmology Beijing You’an HospitalCapital Medical UniversityBeijing Infectious Eye Disease Diagnosis and Treatment CenterBeijing 100069China Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Institute of OphthalmologyBeijing Ophthalmology and Visual Sciences Key LabBeijing 100730China Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteNankai University Affiliated Eye HospitalNankai University Eye InstituteNankai UniversityClinical College of OphthalmologyTianjin Medical UniversityTianjin 300020China

AIM:To evaluate dry eye disease(DED)symptomatology and mental health status in different COVID-19 ***:A cross-sectional observational design was *** 123 eligible adults(46.34%of men,age range,18-59y)with COVID-19 included in the study from August to November,*** Surface Disease Index(OSDI),Five-item Dry Eye Questionnaire(DEQ-5),Hospital Anxiety and Depression Scale(HADS),and Pittsburgh Sleep Quality Index(PSQI)were used in this ***:OSDI scores were 6.82(1.25,15.91)in asymptomatic carriers,7.35(2.50,18.38)in mild cases,and 16.67(4.43,28.04)in recurrent cases,with 30.00%,35.56%,and 57.89%,respectively evaluated as having DED symptoms(χ2=7.049,P=0.029).DEQ-5 score varied from 2.00(0,6.00)in asymptomatic carriers,3.00(0,8.00)in mild cases,and 8.00(5.00,10.00)in recurrent cases,with 27.50%,33.33%,and 55.26%,respectively assessed as having DED symptoms(χ2=8.532,P=0.014).The prevalence of clinical anxiety(50.00%)and depression(47.37%)symptoms were also significantly higher in patients with recurrent infection(χ2=24.541,P<0.001;χ2=30.871,P<0.001).Recurrent infection was a risk factor for high OSDI scores[odds ratio,2.562;95%confidence interval(CI),1.631-7.979;P=0.033]and DEQ-5 scores(odds ratio,3.353;95%CI,1.038-8.834;P=0.043),whereas having a fixed occupation was a protective factor for OSDI scores(odds ratio,0.088;95%CI,0.022-0.360;P=0.001)and DEQ-5 scores(odds ratio,0.126;95%CI,0.039-0.405;P=0.001).CONCLUSION:Patients with recurrent COVID-19 have more severe symptoms of DED,anxiety,and depression.

关键词： COVID-19 dry eye disease recurrent infection mental health

Three-Dimensional Sound Source Location Algorithm for Subsea Leakage Using Hydrophone

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china Ocean Engineering 2024年第2期38卷 326-337页

作者： LI Hao-jie CAI Bao-ping YUAN Xiao-bing kong Xiang-di LIU Yong-hong Javed Akbar KHAN CHU Zheng-de YANG Chao TANG An-bang College of Mechanical and Electronic Engineering China University of PetroleumQingdao 266580China Shenzhen Urban Public Safety Technology institute Shenzhen 518000China institute of Hydrocarbon Recovery Universiti Teknologi PETRONASBandar Seri IskandarPerak Darul Ridzuan 32610Malaysia

Leakages from subsea oil and gas equipment cause substantial economic losses and damage to marine ecosystem,so it is essential to locate the source of the ***,due to the complexity and variability of the marine environment,the signals collected by hydrophone contain a variety of noises,which makes it challenging to extract useful signals for *** solve this problem,a hydrophone denoising algorithm is proposed based on variational modal decomposition(VMD)with grey wolf ***,the average envelope entropy is used as the fitness function of the grey wolf optimizer to find the optimal solution for the parameters K andα.Afterward,the VMD algorithm decomposes the original signal parameters to obtain the intrinsic mode functions(IMFs).Subsequently,the number of interrelationships between each IMF and the original signal was calculated,the threshold value was set,and the noise signal was removed to calculate the time difference using the valid signal obtained by ***,the arrival time difference is used to locate the origin of the *** localization accuracy of the method in finding leaks is investigated experimentally by constructing a simulated leak test rig,and the effectiveness and feasibility of the method are verified.

关键词： grey wolf optimizer variational modal decomposition mean envelope entropy correlation coefficient time difference of arrival

Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs

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chinese Chemical Letters 2024年第8期35卷 481-485页

作者： Jiaqi Huang Renjiang kong Yanmei Li Ni Yan Yeyang Wu Ziwen Qiu Zhenming Lu Xiaona Rao Shiying Li hong Cheng School of Biomedical Engineering&Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering Southern Medical UniversityGuangzhou 510515China School of Pharmaceutical sciences Guangzhou Medical UniversityGuangzhou 511436China

Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense ***,we develop an albumin-based nanomedicine to co-deliver chlorin e6(Ce6)and COH-SR4(CS),which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy(PDT).In which,CS acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione S-transferases(GSTs).Benefiting from it,the prepared HSA-Ce6@COH-SR4(HCCS)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of *** a result,HCCS obviously increases the ROS production to elevate intracellular oxidative ***,HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ***,the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality,which greatly declines the proliferation of breast cancer in *** study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.

关键词： Human serum albumin Drug delivery Reactive oxygen species Positive feedback uptake Oxidative damage

Asperochones A and B,two antimicrobial aromatic polyketides from the endophytic fungus Aspergillus ***-2

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chinese Chemical Letters 2024年第9期35卷 206-209页

作者： hong Zhang Cui-Ping Li Li-Li Wang Zhuo-Da Zhou Wen-Sen Li Ling-Yi kong Ming-Hua Yang Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

Two novel fungal metabolites,asperochones A and B,were obtained from an Aspergillus *** structures were determined by 1D/2D nuclear magnetic resonance(NMR)spectroscopy,high resolution electrospray ionization mass spectroscopy(HRESIMS),and single-crystal X-ray diffraction *** A possesses an intriguing skeleton bearing 5/6/6/6/7/5/5/5 octacyclic ring system,and asperochone B also exhibits an unusual carbon skeleton with five stereochiral *** structures were proposed as heterotrimeric and heterodimeric products of aromatic *** addition,asperochone A exhibited a potential anti-tuberculosis effect since it showed a moderate potency against Mycobacterium smegmatis.

关键词： Aspergillus sp. Asperochones A and B Aromatic polyketides Heterotrimeric compound Anti-tuberculosis effect Antifibrotic activity