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Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis

World Journal of Gastroenterology 2010年第43期16卷 5510-5517页

作者： Jia-Li Liu, Zhen-Ning Wang, Department of Surgical Oncology and General Surgery, the First affiliated hospital of China Medical University, Shenyang 110001, Liaoning Province, China Yuan Liang, Department of Oncology, the Shengjing affiliated hospital of China Medical University, Shenyang 110001, Liaoning Province, China Xin Zhou, Department of Obstetrics and Gynecology, the Shengjing affiliated hospital of China Medical University, Shenyang 110001, Liaoning Province, China Li-Li Xing, Department of Oncology, the Fourth affiliated hospital of China Medical University, Shenyang 110032, Liaoning Province, China Department of Surgical Oncology and General Surgery the First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China.

AIM: To investigate the association of the cyclooxygenases-2 (COX-2) polymorphisms and susceptibility to gastric cancer (GC) by means of meta-analysis. METHODS: Publications addressing the association between polymorphisms of COX-2 and susceptibility to GC were selected from the MEDLINE, EMBASE and CBMdisc databases. Data was extracted from the studies by 2 independent reviewers. The meta-analyses were performed by RevMan 5.0.23. From these data, odds ratio (OR) with 95% confidence interval (CI) was ***: Ten studies were retrieved reporting a total of 11 COX-2 polymorphisms. Carriers of -765C, -1195A, -1290G, *2430T alleles and *429TT genotype revealed increased risk for GC (OR = 1.71, 95% CI: 1.01-2.90, P = 0.05; OR = 1.58, 95% CI: 1.05-2.38, P = 0.03; OR = 1.55, 95% CI: 1.01-2.39, P = 0.05; OR = 2.62, 95% CI: 1.20-5.73, P = 0.02 and OR = 0.74, 95% CI: 0.59-0.95, P = 0.02, respectively). CONCLUSION: The -765C, -1195A, -1290G, *2430T alleles and *429TT genotype of COX-2 polymorphisms were determined a significant association with susceptibility to GC.

关键词： Cyclooxygenases-2 Gastric cancer Polymorphisms Susceptibility Meta-analysis

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microRNA-181b targets MLK2 in HL-60 cells

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Science China(Life Sciences) 2010年第1期53卷 101-106页

作者： CHEN Hong1,CHEN Qun2,FANG Ming3 & MI Yan1 1 The First affiliated hospital of Harbin Medical University,Harbin 150101,China 2 Harbin Acheng District People’s hospital,Harbin 150300,China 3 Graduate Department of Harbin Medical University,Harbin 150001,China The First affiliated hospital of Harbin Medical University Harbin China Harbin Acheng District People’s hospital Harbin China Graduate department of Harbin Medical University Harbin China

microRNAs(miRNAs) play critical roles in many different cellular processes,including metabolism,apoptosis,differentiation and *** showed miR-181b to be highly expressed in acute myeloid leukemia(AML).Furthermore,miR-181b contributed to proliferation of AML cells by targeting *** results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs.

关键词： microRNA-181b MLK2 AML HL-60 proliferation apoptosis

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TRAF3 Interacts with Smac/DIABLO and Enhances the Proapoptotic Effect of Smac/DIABLO in Cytoplasm

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Acta Biochimica et Biophysica Sinica 2007年第2期39卷 108-116页

作者： Cuili ZHANG~(1,2) Lei XIE~4 Hai'en CHENG~3 and Yingxiong WANG~2 ~1Clinical Laboratory,Sichuan Corps hospital of The people's Armed Police Forces,Leshan 614000,China ~2Department of Procreation Medicine,Chongqing Medical Universtity,Chongqing 400016,China ~3Clinical Laboratory,Second affiliated hospital Zhejiang University College of Medicine,Hangzhou 310009,China ~4Sitchuan Corps hospital The People's Armed Police Forces,Leshan 614000,China Clinical Laboratory Sichuan Corps Hospital of The People's Armed Police ForcesLeshan 614000 China Department of Procreation Medicine Chongqing Medical UniversityChongqing 400016 China Sichuan Corps hospital of The People's Armed Police ForcesLeshan 614000 China Clinical Laboratory Second Affiliated Hospital Zhejiang University College of MedicineHangzhou 310009 China

Smac/DIABLO (second mitochondria-derived activator of caspase/direct IAP-binding proteinwith low PI) is a 29 kDa mitochondrial precursor protein,which is proteolytically processed in mitochondriainto a 23 kDa mature *** is released from the mitochondrial intermembrane space to cytosol after anapoptotic ***/DIABLO acts as a dimer and it contributes to caspase activation by sequestering theinhibitor of apoptosis proteins (IAPs).In order to further investigate the mechanism of Smac/DIABLOaction,we used the mature form of Smac/DIABLO as a bait and screened proteins that interact with matureSmac/DIABLO in human liver cDNA library using the yeast two-hybrid ***-two colonies wereobtained after 5.8x 10～6 colonies were screened by nutrition limitation and X-galactosidase *** DNAsequence analysis and homology retrieval,one of the candidate proteins was identified as TRAF domain ofthe TNF receptor associated factor 3 (TRAF3).The interaction site between TRAF3 and Smac/DIABLOwas identified by β-galactosidase test. The interaction between TRAF3 and Smac/DIABLO via TRAF domainwas identified in vivo by co-immunoprecipitation in HepG2 cells,and the direct interaction between TRAF3and Smac/DIABLO in vitro was identified by GST-pull down ***-expression of TRAF3 and matureSmac/DIABLO in 293 cells could enhance the Smac/DIABLO-mediated *** results suggestedthat TRAF3 interacted with Smac/DIABLO via TRAF domain,leading to an increased proapoptotic effectof Smac/DIABLO in cytoplasm.

关键词： Smac/DIABLO TRAF3 apoptosis yeast two-hybrid system GST-pull down assay

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Effects of simvastatin on cardiac performance and expression of sarcoplasmic reticular calcium regulatory proteins in rat heart

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Acta Pharmacologica Sinica 2005年第6期26卷 696-704页

作者： Xia ZHENG, Shen-jiang HU~2 The First affiliated hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China The First affiliated hospital College of Medicine Zhejiang University Hangzhou China

Aim: To investigate the effect of simvastatin on the cardiac contractile function and the alteration of gene and protein expression of the sarcoplasmic calcium regulatory proteins, including sarcoplasmic reticulum Ca2+-ATPase (SERCA), phospholamban (PLB), and ryanodine receptor 2 (RyR2) in rat hearts. Methods: Langendorff-perfused rat hearts were subjected to 60-min perfusion with different concentrations of simvastatin (1,3,10, 30, or 100 μmol/L), and the parameters of cardiac function such as left ventricular developed pressure (LVDP), +dP/dtmax, and -dp/dtmaxwere determined. The cultured neonatal rat ventricular cardiomyocytes were incubated with simvastatin (1,3,10,30, and 100 μmol/L) for 1 h or 24 h. The levels of SERCA, PLB, and RyR2 expression were measured by reverse tran-scription-polymerase chain reaction and Western blot. Cytotoxic effect of simvastatin on ventricular cardiomyocytes was assessed by the MTT colorimetric assay. Results: LVDP, +dp/dtmaxand -dp/dtmaxof hearts were increased significantly after treatment with simvastatin 3, 10, and 30 μmol/L. In simvastatin-treated isolated hearts, the levels of mRNA expression of SERCA and RyR2 were elevated compared with the control (Prdiomyocytes were incubated with 3,10,30, and 100 μmol/L simvastatin for 1 h, SERCA and RyR2 mRNA expressions of cardiomyocytes rose, but there was no alteration in protein expressions. However, with the elongation of simvastatin treatment to 24 h, the protein expression of SERCA and RyR2 were also elevated. Additionally, simvastatin (1-30 μmol/L) had no influence on cell viability of cultured cardiac myocytes, but simvastatin 100 μmol/L inhibited the cell viability. Conclusion: Simvastatin improved cardiac performance accompanied by the elevation of SERCA and RyR2 gene and protein expression.

关键词： simvastatin Ca2+-transporting ATPase endoplasmic reticulum calcium regulatory protein myocardial contraction ryanodine receptor calcium release channel reverse transcriptase polymerase chain reaction

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Mycophenolic acid inhibits SLE-associated cytokine expression and promotes apoptosis of peripheral blood mononuclear cells from patients with systemic lupus erythematosus

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Acta Pharmacologica Sinica 2006年第8期27卷 1051-1057页

作者： Ding-lei SU~(2,3) Hui-juan WANG~2 Xiao-hui JI~(2,5) Yuan-yuan LI~4 Heng-bao XUAN~4 Chun HENG~4 Yu-feng LI~4 ~2Department of Immunology,Nanjing Medical University,Nanjing 210029,China:~3Department of Hematology,Nanjing First hospital affiliated to Nanjing Medical University,Nanjing 210029,China ~4Department of Hematology,affiliated Huai'an First hospital of Nanjing Medical University,Huai'an 223300.China Department of Immunology Nanjing Medical University Nanjing China Department of Hematology Nanjing First Hospital Affiliated to Nanjing Medical University Nanjing China Department of Hematology Affiliated Huai'an First Hospital of Nanjing Medical University Huai'an China

Aim:To investigate the effect of the novel immunosuppressant mycophenolicacid（MPA）on cytokine production and apoptosis of the peripheral blood mono-nuclear cells（PBMC）of patients with systemic lupus erythematosus（SLE）.Methods:The levels of IL-10,IL-12,IFN-γ,sFas and sFasL in the supernatants ofcultured PBMC from 41 SLE patients was determined by the ABC-ELISA *** percentage of IFN-γIL- 10-,IFN-γ-IL-10+,and IFN-γ+IL-10+subsets in CD4+ceils were detected by three-color flow *** percentage of apoptoticTh cells was detected by AV-FITC/PI flow *** from 22 sex-andage-comparable healthy people were used as normal ***:The lev-els of IL-10,IL-12,and IFN-γwere all significantly elevated in the supernatants ofcultured PBMC from SLE samples,compared with normal *** enhancedproductions of IL-10,IL-12,and IFN-γ by PBMC from SLE both spontaneouslyand stimulated by phytohaemagglutinin（PHA）were significantly reduced by *** percentages of CD4+IFN-γIL-10+and CD4+IFN-γ+IL-10+cell subsets in cul-tured PBMC from SLE were significantly increased,but decreased when MPA wasadded into the *** being cultured in vitro for 48h,the PBMC of SLEpatients showed a higher secretion of sFasL as well as a higher percentage *** significantly increased the apoptotic percentage of SLE PBMC,but reduced the secretion of sFasL and ***:MPA reduces theabnormal production of SLE-associated cytokines,such as IL-10,IL-12,and IFN-γ,inhibits the increase of CD4+IFN-γ+IL-10,CD4+IFN-γIL-10+and CD4+IFN-γ+IL-10+subset;and promotes the apoptosis of PBMC in SLE patients,which may beassociated with the therapeutic mechanism of MPA for SLE.

关键词： systemic lupus erythematosus mycophenolic acid cytokine apoptosis therapeutic mechanism

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^(103)Pd-induced apoptosis of proliferative smooth muscle cells in bile ducts of dogs:significance and effects on related genes

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Hepatobiliary & Pancreatic Diseases International 2007年第5期6卷 521-526页

作者： Gui-Jin He,Fa-Qiang Yu,Rong Wu,Qin-Yi Gao,Shu-He Xu,Hong Gao, Wei-Guo Jiang,Tao Jiang and Xian-Wei Dai Department of General Surgery,Second affiliated hospital(Shengjing hospital),China Medical University,Shenyang 110004,China,Radiotherapy Center,Second affiliated hospital(Shengjing hospital),China Medical University,Shenyang 110004,China,Pediatrics Surgery Laboratory,Second affiliated hospital(Shengjing hospital),China Medical University,Shenyang 110004,China,Department of Pathology,Second affiliated hospital(Shengjing hospital),China Medical University,Shenyang 110004,China Isotope Unit,First affiliated hospital,China Medical University,Shenyang 110001,China and Isotope Research Institute,China Institute of Atomic Energy,Beijing 100050,China Department of General Surgery Second Affiliated Hospital (Shengjing Hospital) China Medical University Shenyang 110004 China. 23318199@***

BACKGROUND:With the objective of developing a locally- produced radioactive stent,the present study used in vivo animal experiments to explore apoptosis of proliferative smooth muscle cells resulting from facilitation of the expression of genes caused byγ-radiation in order to prevent bile duct *** therefore explored the effects and significance ofγ-radiation on the activity of caspase-3,Fas and Bcl-2 genes in apoptosis of proliferative smooth muscle cells in the bile duct walls of dogs. METHODS:Twelve dogs were randomly divided into 2 groups(6 in each group).A postinjury bile duct stenosis model was established and radioactive 103 Pd( 103 palladium) or ordinary bile duct stents were implanted into the bile *** staining,RT-PCR and immunohistochemistry were used to detect the proliferation and apoptosis of bile duct smooth muscle cells in proliferative endomembrane and the expression of related caspase-3,Bcl-2 and Fas genes. RESULTS:The expression of caspase-3 and Fas genes in the bile duct tissues of dogs with radioactive stents was higher than that of dogs with ordinary *** was significant apoptosis of proliferative smooth muscle cells in the bile *** expression of the Bcl-2 gene in the bile duct tissues of dogs with radioactive stents was lower than that in those with ordinary *** was significant apoptosis of proliferative smooth muscle cells in the dogs with low Bcl-2 gene expression. CONCLUSIONS:Radiation increases the activity of caspase-3 and Fas genes and is associated with apoptosis. The radioactive 103 Pd stent may facilitate apoptosis of proliferative smooth muscle cells in the bile ducts of dogs by activating these *** Bcl-2 gene expression level is correlated with the occurrence of apoptosis and the radiosusceptibility of cells.

关键词： radioactive 103 Pd stent γ-radiation caspase-3 gene Fas gene Bcl-2 gene apoptosis

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Cloning,Structural Organization and Chromosomal Mapping of Rat Costimulatory Molecule 4-1BBL

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Acta Biochimica et Biophysica Sinica 2005年第10期37卷 694-701页

作者： Qiu-Ming DONG~1 Li-Jie MA~2 Guang-Bo ZHANG~1 Ya-Fang WU~3 Jia-Yao SHEN~1 Ying CHEN~1 Yong-Jing CHEN~1 Xiang-Ke PU~1 Sai-Yu HANG~1 Xue-Guang ZHANG~(1*) 1 Biotechnology Institute,Soochow University,Suzhou 215007,China 2 Genetics Institute,Fudan University,Shanghai 200433,China 3 First affiliated hospital of Soochow University,Suzhou 215006,China Biotechnology Institute Soochow UniversitySuzhou 215007 China Genetics Institute Fudan UniversityShanghai 200433 China First affiliated hospital of Soochow UniversitySuzhou 215006 China

4-1BBL (TNFSF9) is a member of the tumor necrosis factor (TNF) ligand superfamily,whichis expressed on some activated antigen presenting cells and B *** isolated a rat cDNA clone encodingthe rat homologue of the human 4-1BBL (GenBank accession ***259541).The deduced rat 4-IBBLprotein,consisting of 308 amino acids with a molecular weight of 33,469 Da,was a typical type Ⅱtransmembrane glycoprotein,the same as human and routine 4-IBBL.“SDAA” in the cytoplasmic domain ofrat 4-1BBL was deduced to act as the phosphorylation site for casein kinase Ⅰ(“SXXS” motif),which ispresent in the cytoplasmic domains of human and murine 4-1BBL,and all other TNF ligand family membersknown to utilize reverse *** two introns of 4-1BBL were also cloned (GenBank accession ***332409).Rat 4-IBBL is much more homologous with murine 4-1BBL than with human 4-1BBL,in bothnucleotide and amino acid *** 4-1BBL was expressed in all tested tissues:brain,lung,colon,liver,thymus,testicle,kidney,adrenal,stomach,spleen and *** chromosomal location of rat 4-1BBL wasfirst identified by bioinformatics,then by fluorescence in situ hybridization at 9q11(GenBank accessionUni Gene ***.46783).Rat,murine and human 4-1BBL genes are evolved from a common *** and characterization of the rat counterpart of human 4-1BBL will facilitate studies of the biologicalfunction of this molecule.

关键词： TNF superfamily rat 4-1BBL cloning mapping

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CT examination, clinical situation and experimental characteristics of infants with intracranial hemorrhage induced by delayed vitamin K deficiency

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Neural Regeneration Research 2006年第9期1卷 801-805页

作者： Zhiqing Lin1, Feng Fang1, Min Chen2, Guoxiang Cai3 1Department of Pediatrics, Tongji hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China 2Department of Pediatrics, 3Department of Radiation Medicine, Zhongshan hospital affiliated to Xiamen University, Xiamen 361004, Fujian Province, China Department of Pediatrics Tongji Hospital Huazhong University of Science and Technology Wuhan 430030 Hubei Province China Department of pediatrics Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China Department of Radiation Medicine Zhongshan Hospital Xiamen University Xiamen 361004 Fujian Province China

BACKGROUND: Delayed vitamin K deficiency is characterized by acute onset, severe illness and high fatality rate. 33%-50% survivors accompany with other various nervous system sequelas. Therefore, diagnosis and treatment of intracranial hemorrhage in time become a key factor for improving healing rate and reducing fatality rate and incidence of sequela. OBJECTIVE: To investigate the clinical situation, experimental characteristics, CT examination and terminative characteristics of infants with intracranial hemorrhage induced by delayed vitamin K deficiency. DESIGN: Case analysis. SETTING: Department of Pediatrics, Zhongshan hospital affiliated to Xiamen University. PARTICIPANTS: A total of 17 infants with intracranial hemorrhage induced by delayed vitamin K deficiency aged 1-3 months including 11 boys and 6 girls were selected from Department of Pediatrics, Zhongshan hospital affiliated to Xiamen University from January 1994 to December 2005. All infants had drowsiness, rejective milk, spiting milk, gaze of both eyes, tic, coma, full anterior fontanelle, high muscular tension and cerebral hernia, etc. Experimental examination demonstrated that infants had anemia at various degrees; prothrombin time and partial thromboplastin time were prolonged; platelet count was normal. CT examination indicated that screenages of subarachnoid hemorrhage, subdural hematoma, cerebral parenchyma hemorrhage and intraventricular hemorrage were changed. Hemorrhage was stopped by the application of vitamin K. All patients provided informed consent. METHODS: ① Clinical situation and physical sign of infants were observed after hospitalization and scanned with rapid spiral CT scanning system. The thickness and average space of layers were 8-10 mm and the scanning time was 5 s with window width of 30-80 Hu and window position of 28-35 Hu. ② After hospitalization, four items of blood coagulation was measured with Futura meter and biochemical indexes of blood, such as serum calcium, serum alka

关键词： clinical situation and experimental characteristics of infants with intracranial hemorrhage induced by delayed vitamin K deficiency CT examination

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Clinical significance of mrp gene in primary hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2003年第3期2卷 397-403页

作者： Bai-Lin Wang Xiao-Ping Chen Shu-Ping Zhai De-Feng Chen the 3rd Department of Surgery, First affiliated hospital of Guangzhou University of Traditional Medicine and Pharmacy, Guangzhou 510405, China the Hepatic Surgery Center, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China The 3rd Department of Surgery First Affiliated Hospital of Guangzhou University of Traditional Medicine and Pharmacy Guangzhou 510405 China. wbl672000@***

OBJECTIVE: To study the relations among the expression of the multidrug resistance associated-protein (mrp) gene and clinicopathologic features, the influence of α-fetoprotein (AFP), and prognosis of patients who received adjuvant chemotherapy after resection of primary hepatocellular carcinoma (HCC). METHODS: The expression of the mrp gene encoding MRP and mRNAmrp was determined in tissues from 54 untreated patients with HCC, adjacent tissues from 24 patients with HCC and archival paraffin-embedded tissues from 12 patients with posthepatitic cirrhosis. The relationship between the mrp gene expression and the change level of AFP was analyzed in the 24 postoperative HCC patients whose AFP level was measured after 2 weeks. All of the HCC patients were followed up. RESULTS: The percentage of positive expressions of MRP and mRNAmrp in the three kinds of tissues was 57.40%, 25.00%, 16.67%, and 72.22%, 37.50%, 33.33% respectively. Significant difference was noted in the untreated HCC tissue, compared to the other two tissues (P 0.05), but the expression was related to the degree of differentiation of HCC (P3-, 5-year survival rates of HCC patients (P>0.05), the mean survival time of postoperative HCC patients or the negative mrp gene expression group was longer than that of the positive group (P<0.05). CONCLUSIONS: Multidrug resistance (MDR) of HCC is related to mrp gene expression and initiates the intrinsic MDR. Detection of mrp gene expression is of great significance in accessing chemotherapeutic resistance of HCC, which provides evidence for reversing MDR in HCC. The mrp gene may be a useful marker in detecting prognosis of HCC p

关键词： hepatocellular carcinoma gene mrp MRP mrp RNV/messenger

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Molecular mechanisms of adenosine-induced apoptosis in human HepG2 cells

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Acta Pharmacologica Sinica 2006年第4期27卷 477-484页

作者： Ling-fei WU~(2,4) Guo-ping LI~2 Jia-lin FENG~3 Ze-jin PU~2 ~2Department of Gastroenterology:~3Department of Information,Second affiliated hospital,Shantou University Medical College,Shantou 515041.China Department of Gastroenterology Second Affiliated Hospital Shantou University Medical College Shantou China Department of Information Second Affiliated Hospital Shantou University Medical College Shantou China

Aim:To investigate effects of adenosine on cell proliferation and apoptosis inhuman HepG2 ***:HepG2 cells were incubated in the presence ofadenosine(0.1-5 mmol/L)for 12-48 h,and the effect of adenosine on cell prolifera-tion was evaluated by using 3-(4,5-dimethyl-2-yl)-2,5-diphenyl-2H-tetrazolium bro-mide(MTT)*** 33342 fluorescent staining,dUTP-fluoresceinisothiocyanate(FITC)fluorescence and flow cytometric analysis techniques wereused to observe cell *** effects of adenosine receptor(A1,A2a,A3and nonspecific receptor)antagonists(8-cpt,DMPX,MRS 1191,and theophylline)and an adenosine transporter protein inhibitor(dipyridamole)on adenosine-in-duced cell apoptosis were *** membrane potential was ana-lyzed using DePsipher fluorescent staining,and caspase activity was detectedusing a Fluorometric assay kit and a fluorescence microplate ***:Adenosine significantly reduced cell viability in a dose-and *** cytotoxicity of adenosine was related to the induction of cell *** adenosine receptor antagonists had no effect on cell ***,dipyridamole significantly reduced the percentage of adenosine-induced apoptoticcells from 27.3% to 7.1%(P3 mmol/L adenosineincreased caspase-3 activity 3.5-fold;dipyridamole markedly decreased caspase-3 activity 1.6-fold,and decreased apoptotic cell *** HepG2 cells weretreated with 3 mmol/L adenosine,mitochondrial membrane potential and theactivity of caspase-8 or-9 remained ***:Our results suggestthat adenosine-induced apoptosis in HepG2 cells is related to intracellular eventsrsther than cell surface receptors,and that a caspase-3 cascade activation isrequired,which is not mediated via a mitochondrial pathway.

关键词： adenosins adenosine receptor apoptosis caspase HepG2 mitochondria

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