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Retrorectal tumors in adults:Magnetic resonance imaging findings

World Journal of Gastroenterology 2010年第46期16卷 5822-5829页

作者： Bo-Lin Yang,Yun-Fei Gu,Wan-Jin Shao,Hong-Jin Chen,Gui-Dong Sun,Department of Coloproctology,The affiliated hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China Hei-Ying Jin,Department of Coloproctology,the 3rd affiliated hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China Xin Zhu,Department of Radiology,The affiliated hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China Department of Radiology The Affiliated Hospital of Nanjing University of Chinese Medicine No.155 Hanzhong Road Nanjing 210029 China.

AIM:To retrospectively evaluate the magnetic resonance imaging (MRI) features of adult retrorectal tumors and compare with histopathologic ***:MRI features of 21 patients with preoperative suspicion of retrorectal tumors were analyzed based on the histopathological and clinical ***:Fourteen benign cystic lesions appeared hypointense on T1-weighted images,and hyperintense on T2-weighted images with regular peripheral *** or dermoid cysts were unilocular,and tailgut cysts were *** of intracystic intermediate signal intensity was observed in one case of tailgut cyst with a component of *** solid tumors were malignant lesions and showed heterogeneous intensity on *** adenocarcinomas showed high signal intensity on T2-weighted and mesh-like enhancing areas on fat-suppressed T2-weighted *** was a fistula between the mass and anus with an internal opening in mucinous adenocarcinomas arising from anal *** stromal tumors displayed low signal intensity on T1-weighted images,and intermediate to high signal intensity on T2-weighted *** necrosis could be seen as a high signal on T2-weighted ***:MRI is a helpful technique to define the extent of the retrorectal tumor and its relationship to the surrounding structures,and also to demonstrate possible complications so as to choose the best surgical approach.

关键词： Retrorectal tumor Presacral lesions Magnetic resonance imaging Congenital cyst Malignant tumor Diagnosis

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The Effects of Retinal Ischemia on Retinal Nerve Fiber Layers of Patients with Retinal Vein Occlusion

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眼科学报 1997年第1期13卷 21-24页

作者： Hai Lu, Qi ZangDepartment of Ophthalmologu , the 3rd affiliated hospital, Beijing Medical UniversityBeijing 100083, ChinaDepartment of Ophthalmology, The 2nd affiliated Hsopital, Xian Medical University, Xian 710004 , China Department of Ophthalmologu 3rd Affiliated Hospital Beijing Medical University Beijing 100083 China.

Purpose: To demonstrate the effects of retinal ischemia on retinal nerve fiber layer (RNFL) and the associated visual *** :52 subjects with retinal vein occlusin (RVO) were studied both in RVO eyes and in the contra-lateral eyes via red-free light fundus photography. The semi-quantitative analysis of RNFL defects was done,and the severity of RNFL defects of the ischemic and the non-ischemic groups were ***: The RNFL defects occurred in 75.5% of the total 53 eyes with RVO. The incidences of RNFL defects were significantly higher in eyes with cotton-wool spots and capillary non-perfusion than in other RVO eyes and controls. The RNFL defects were significantly severer in ischemic eyes than in non-ischemic ones. Conclusion : Retinal ischemia can result in RNFL defects, and the severity of RNFL defects was closely related to that of ischemia. Eye Science 1997; 13 :21 - 24 .

关键词：神经元荧光素血管造影术视网膜病

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A 3-year clinical trial of lamivudine in treatment of patients with chronic hepatitis B

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Hepatobiliary & Pancreatic Diseases International 2004年第2期3卷 188-193页

作者： Guang-Bi Yao, Zhen-Yu Cui, Bao-En Wang, Ji-Lu Yao and Min-De Zeng Shanghai, China Shanghai Jing-An Qu Central hospital, Shanghai 200040, China Beijing Ditan hospital, Beijing 100011 , China Beijing Friendship hospital, Beijing 100050, China 3rd affiliated hospital, Sun Yat-Sen University, Guangzhou 510630, Chinaand Shanghai Renji hospital, Shanghai Second Medical University, Shanghai 200001 , China Shanghai Jing-An Qu Central hospital Shanghai 200040 China. yaogb@***

BACKGROUND: Lamivudine was approved for the treat- ment of chronic hepatitis B in China in 1999; however the long-term result has not yet been reported in detail. This clinical trial was to evaluate the long-term efficacy and safe- ty of 3-year lamivudine treatment for chronic hepatitis B and the impact of emergence of YMDD mutation of hepa- titis B virus (HBV). METHODS: This multi-center, randomized, double-blind, placebo controlled trial began from 1996 to 1999. A total of 429 patients with serum HBsAg, HBeAg and HBV DNA positive were randomized to receive either lamivudine 100 mg daily (322 patients) or placebo (107) for the first 12 weeks. All patients were given subsequently open labelled lamivudine 100 mg/d for a total of 156 weeks. RESULTS: After 12-week lamivudine therapy, the levels of serum HBV DNA decreased rapidly. The negativity of HBV DNA (3 years, serum HBV DNA continued to be substantially suppressed with a me- dian level below a detectable level in patients with non-YM- DD variant HBV, which was increased to 86 mEq/ml (bD- NA method, equivalent hybridization method 10 pg/ml) in patients with YMDD mutation. At the end of 1, 2 and 3 years, the rates of HBeAg loss were 9.5%, 16.8% and 20.0% respectively and the rates of HBeAg/anti-HBe sero- conversion were 8.3%, 11.5% and 17.3%. The rates of HBeAg loss and seroconversion were correlated with the baseline level of ALT. In patients with a baseline level of alanine transaminase (ALT)>2 × upper limit of normal (ULN) and ALT >5×ULN, the rates of HBeAg loss were 42.2% and 66.7%, and the rates of seroconversion were34.4% and 61.1% respectively (P3. The levels of ALT at year 3 remained normal in 58.8% of patients whose baseline level of ALT was elevated

关键词： clinical trial hepatitis B virus chronic hepatitis B lamivudine

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妊娠高血压综合征孕妇肝肾功能生化指标的变化

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实用妇产科杂志 2003年第2期19卷 103-104页

作者：安慧芳白桂岭天津市第三中心医院天津300170

目的 :通过对妊娠高血压综合征 (妊高征 )孕妇及正常妊娠孕妇肝肾功能生化指标的对比分析 ,寻找妊高征孕妇肝肾功能受损指标。方法 :对 74例妊高征孕妇及 78例正常妊娠孕妇住院后第 1天或次日清晨抽取空腹血测定肝肾功能。结果 :肝功能... 详细信息

目的 :通过对妊娠高血压综合征 (妊高征 )孕妇及正常妊娠孕妇肝肾功能生化指标的对比分析 ,寻找妊高征孕妇肝肾功能受损指标。方法 :对 74例妊高征孕妇及 78例正常妊娠孕妇住院后第 1天或次日清晨抽取空腹血测定肝肾功能。结果 :肝功能显示妊高征组ALT、AST、ALP、T Bi均高于正常妊娠组 ;Alb轻度降低 ,GT相似。肾功能显示BUN、UA、Cr妊高征组明显增高。结论 :肾功能的变化要比肝功能敏感。

关键词：妊娠高血压综合征肝功能肾功能

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转染p53抑癌基因体外抑制K562细胞克隆的形成

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中山大学学报(医学科学版) 1999年第1期 61-63页

作者： Huang Renwei Xia Zhongjun Lin Guizheng Lin Dongjun Tang Jiaming Li Mingquan (Department of Hematology of the 3rd affiliated hospital, Sun Yat sen University of Medical Sciences, Guangzhou, 510630)

目的：构建ｐ５３表达质粒，研究ｐ５３基因对白血病细胞Ｋ５６２细胞生长的抑制作用。方法：以Ｔ４连接酶把２１６０ｂｐ的ｐ５３ｃＤＮＡ片段插入ｐＲｃ／ＣＭＶ质粒，重组构建ｐＲｃ／ｐ５３表达质粒，以Ｌｉｐｏｆｅｃｔｉｎ介导ｐ... 详细信息

目的：构建ｐ５３表达质粒，研究ｐ５３基因对白血病细胞Ｋ５６２细胞生长的抑制作用。方法：以Ｔ４连接酶把２１６０ｂｐ的ｐ５３ｃＤＮＡ片段插入ｐＲｃ／ＣＭＶ质粒，重组构建ｐＲｃ／ｐ５３表达质粒，以Ｌｉｐｏｆｅｃｔｉｎ介导ｐＲｃ／ｐ５３质粒转染Ｋ５６２细胞，以甲基纤维素半固体培养方法作Ｋ５６２细胞体外克隆培养，观察转染ｐ５３基因后Ｋ５６２细胞克隆形成改变。结果：ｐ５３ｃＤＮＡ质粒转染的Ｋ５６２细胞，体外培养克隆形成能力明显减低。在接种１×１０４细胞时，未转染的空白对照组及空质粒对照组白血病细胞集落数分别是２７９７±２６４和２７２５±２６１；而ｐ５３质粒转染组细胞集落数是１０６１±１６０；与空质粒转染组及未转染的Ｋ５６２细胞组比较有非常显著性差异（Ｐ＜０００１，ｎ＝１０）。结论：转染ｐ５３基因能抑制Ｋ５６２细胞的生长。

关键词： K562细胞基因.p53 基因转染白血病

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Low prevalence of HBV infection in SLE patients-a good side of type Ⅰ interferon

Low prevalence of HBV infection in SLE patients-a good side ...

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The 8th International Congress on SLE

作者： Caisheng Lu Taohua Wong Xiaodong Zhang jijun Zhao Qiujin Wei Yinjuan Jiang Division of Rheumatology Department of Internal Medicine the 3rd affiliated hospital of Sun Yat-sen University Guangzhou People’s Republic of China

＜正＞Purpose:Type I interferon（IFN）represents the first line of defense in response to viral infection,meanwhile it mediates multiple immune system alterations,including dendritic cell maturation,immunoglobulin class switching and induction of IL-10,IFN-γ and other immunoregulatory *** has been widely accepted that type I IFN,mainly IFN-alpha, plays an important role in the pathogenesis of ***

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The regulatory effects of SREBP-1c on IRS-1 in L6 myotubes

The regulatory effects of SREBP-1c on IRS-1 in L6 myotubes

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中华医学会第十一次全国内分泌学学术会议

作者： Sunyinyan Tang~1,yan Bi~1,jing Sun~1,yingying Chen~1,hua Liang~1, dalong Zhu~1,jianping Weng~1 1.Drum Tower hospital affiliated to Nanjing University medical school 2.the 3rd affiliated hospital,Sun Yat-sen University

Objective To study the regulatory effects of sterol regulatory element-binding proteinlc(SREBP-lc) on insulin receptor substΤte I(IRS-1) in L-6 myotubes. Methods L-6 cell line was induced to differentiation until myotubes could be observed.L-6 myotubes were incubated with palmitic acid(PA) and insulin for the four groups:control, control+insulin,PA,PA+*** differentiation-induced L-6 myotubes were added with adenovirus vectors which expressed

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针刺复合麻醉下胃大部切除术的临床观察

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针刺研究 1981年第4期 248-250页

作者：王友良李钊北京医学院第三附属医院

大量的临床及实验室研究已充分证明,针刺麻醉虽然具有一定的镇痛效应,但仍镇痛不全,为提高针麻的镇痛效果,克服镇痛不全的缺点,我们除术前用综合予测的方法选择适宜针麻的个体外,还应用一些药物麻醉方法来配合针刺麻醉.针麻的镇痛不全... 详细信息

大量的临床及实验室研究已充分证明,针刺麻醉虽然具有一定的镇痛效应,但仍镇痛不全,为提高针麻的镇痛效果,克服镇痛不全的缺点,我们除术前用综合予测的方法选择适宜针麻的个体外,还应用一些药物麻醉方法来配合针刺麻醉.针麻的镇痛不全可由少量的麻醉药物补足,同时针麻本身的镇痛效应又可减少麻醉药物的用量,因而相应地减少了麻醉药物所引起的生理机能紊乱.我们自1978年起选择针麻效果尚不稳够定的胃大部初除应用针刺复合麻醉方法(下称针麻复合方法)进行临床观察,初步报告如下.

关键词：胃大部切除术内脏连续硬膜外麻醉镇痛不全针刺复合麻醉麻醉剂量牵拉痛平均血压麻醉药物针刺麻醉针麻用药量剂量临床观察

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Multi-center clinical study of the prevalence rate of senile osteoporotic fracture in China

Multi-center clinical study of the prevalence rate of senile...

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International Conference on Osteoporosis and Bone Research 2008

作者： Zhenming Hu~1 Xianzheng Luo~2 Kerong Dai~3 Xiaolin Li~4 Tianzun Tao~5 Lihua Zhu~6 Hanchang Lao~7 Yanling Zhao~8 Shou Zhang~9 Fachou Zhang~(10) Gang Zhao~(11) Jie Hao~1 Xuesong Li~8 ~1 Department of Orthopaedic Surgery The First affiliated hospital Chongqing Medical University Chongqing China ~2 Department of Orthopaedic Surgery The affiliated Beijing Friendship hospital Capital Medical University Beijing China ~3 Department of Orthopaedic Surgery The affiliated Shanghai 9th hospital Shanghai Jiao Tong University Shanghai China ~4 Department of Orthopaedic Surgery The affiliated Shanghai 6th hospital Shanghai Jiao Tong University Shanghai China ~5 Department of Orthopaedic Surgery The 2nd affiliated hospital Harbin Medical University Heilongjiang China ~6 Department of Orthopaedic Surgery Nanjing Gulou hospital Nanjing Medical University Jiangsu China ~7 Department of Orthopaedic Surgery The 2nd affiliated hospital Kunming Medical College Yunnan China ~8 Chinese Osteoporosis Foundation of CHPF Beijing China ~9 Department of Orthopaedic Surgery Haikou Peoples hospital Hainan China ~10 Department of Orthopaedic Surgery Beijing hospital Beijing China ~11 Department of Orthopaedic Surgery the 3rd affiliated hospital Kunming Medical College Yunnan China

＜正＞Objective:To study the prevalence of senile osteoporotic fracture in ten clinical center patients in China,in order to afford many epidemiology evidences for prevention of the different kinds of osteoporotic fra...

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丙泊酚对正常成人中性粒细胞功能的影响

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中国新药与临床杂志 2009年第8期28卷 595-598页

作者：庞红宇程楠池信锦黑子清葛缅中山大学附属第三医院麻醉科广东广州510630

目的探讨丙泊酚对正常成人静脉血中性粒细胞(PMN)的呼吸爆发功能、凋亡、PMN上黏附分子CD18表达、白细胞介素8(IL-8)及肿瘤坏死因子α(TNF-α)释放的影响。方法采集6例健康成人志愿者静脉血分别制备PMN,用RPMI1640培养液制成悬液。每例... 详细信息

目的探讨丙泊酚对正常成人静脉血中性粒细胞(PMN)的呼吸爆发功能、凋亡、PMN上黏附分子CD18表达、白细胞介素8(IL-8)及肿瘤坏死因子α(TNF-α)释放的影响。方法采集6例健康成人志愿者静脉血分别制备PMN,用RPMI1640培养液制成悬液。每例样本均分入3组:空白对照组(PMN+培养液),溶剂对照组(PMN+脂肪乳注射液),丙泊酚组[PMN+丙泊酚(终浓度5mg·L-1)]。PMN加药培养12h后,流式细胞仪检测PMN发生呼吸爆发的平均荧光强度、CD18的表达量及发生早期凋亡的百分比,ELISA法检测培养上清液TNF-α、IL-8的浓度。结果3组PMN呼吸爆发功能、凋亡率、CD18的表达量均无显著差异(P>0.05)。培养上清液中IL-8和TNF-α的浓度3组间比较差异也无显著意义(P>0.05)。结论丙泊酚及其脂肪乳溶剂对正常成人PMN的呼吸爆发功能、凋亡及黏附分子CD18的表达无明显影响,也不会改变PMN炎症介质TNF-α、IL-8的释放。

关键词：丙泊酚呼吸爆发细胞凋亡抗原,CD18 肿瘤坏死因子α 中性粒细胞

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