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Anticancer activity of Δ^(9)-tetrahydrocannabinol and cannabinol in vitro and in human lung cancer xenograft

Asian Pacific Journal of Tropical Biomedicine 2022年第8期12卷 323-332页

作者： surang Leelawat Kawin Leelawat thaniya Wannakup Worawan saingam Nanthaphong Khamthong Fameera Madaka Athip Maha Patamaporn Pathompak Lukman sueree Thanapat songsak Medicinal Cannabis Research Institute College of PharmacyRangsit UniversityPathum Thani 12000Thailand Department of surgery Bumrungrad International HospitalBangkok 10110Thailand Drug and Herbal Product Research and Development Center College of PharmacyRangsit UniversityPathum Thani 12000Thailand College of Oriental Medicine Rangsit UniversityPathum Thani 12000Thailand Department of Pharmacognosy College of PharmacyRangsit UniversityPathum Thani 12000Thailand

Objective:To investigate the effects of Δ^(9)-tetrahydrocannabinol,the principal psychoactive compound of Cannabis sativa,and cannabinol,a Δ^(9)-tetrahydrocannabinol degradative product,on human non-small cell lung cancer ***:Δ^(9)-Tetrahydrocannabinol and cannabinol were tested for anticancer activity in human non-small cell lung cancer(A549)*** effects on cell proliferation,apoptosis,and phosphorylation profiles were *** effects of Δ^(9)-tetrahydrocannabinol and cannabinol on tumor growth were also investigated using a xenograft nude mouse *** and targeted phosphorylation were verified by ***:Δ^(9)-Tetrahydrocannabinol and cannabinol significantly inhibited cell proliferation and increased the number of apoptotic cells in a concentration-dependent *** Δ^(9)-tetrahydrocannabinol-and cannabinol-treated cells had lower levels of phosphorylated protein kinase B[AKT(s473)],glycogen synthase kinase 3 alpha/beta,and endothelial nitric oxide synthase compared to the *** study of xenograft mice revealed that tumors treated with 15 mg/kg Δ^(9)-tetrahydrocannabinol or 40 mg/kg cannabinol were significantly smaller than those of the control *** tumor progression rates in mice treated with 15 mg/kg Δ^(9)-tetrahydrocannabinol or 40 mg/kg cannabinol were significantly slower than in the control ***:These findings indicate that Δ^(9)-tetrahydrocannabinol and cannabinol inhibit lung cancer cell growth by inhibiting AKT and its signaling pathways,which include glycogen synthase kinase 3 alpha/beta and endothelial nitric oxide synthase.

关键词： Cannabis Δ9-Tetrahydrocannabinol Cannabinol Non-small cell lung cancer AKT Cannabis sativa Glycogen synthase kinase 3 alpha/beta Endothelial nitric oxide synthase

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Common molecular subtypes among Asian hepatocellular carcinoma and cholangiocarcinoma

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Cancer Biology & Medicine 2018年第S1期15卷 10-11页

作者： Jittiporn Chaisaingmongkol Anuradha Budhu Hien Dang siritida Rabibhadana Benjarath Pupacdi so Mee Kwon Marshonna Forgues Yotsawat Pomyen Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Anon Chotirosniramit Chawalit Pairojkul Chirayu UAuewarakul thaniya s.icharunrat Kannika Phornphutkul suleeporn sangrajrang Maggie Cam Ping He stephen M.Hewitt Kris Ylaya Xiaolin Wu Jesper B.Andersen snorri s.Thorgeirsson Joshua J.Waterfall Yuelin J.Zhu Jennifer Walling Holly s.stevenson Daniel Edelman Paul s.Meltzer Christopher A.Loffredo Natsuko Hama Tatsuhiro shibata Robert H.Wiltrout Curtis C.Harris Chulabhorn Mahidol Mathuros Ruchirawat Xinwei Wang Laboratory of Human Carcinogenesis Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Laboratory of Chemical Carcinogenesis Chulabhorn Research InstituteBangkokThailand Center of Excellence on Environmental Health and Toxicology Office of Higher Education CommissionMinistry of EducationBangkokThailand Faculty of Medicine Khon Kaen UniversityKhon KaenThailand Faculty of Medicine Chiang Mai UniversityChiang MaiThailand HRH Princess Chulabhorn College of Medical science BangkokThailand Chulabhorn Hospital BangkokThailand Rajavej Hospital Chiang MaiThailand National Cancer Institute BangkokThailand Center for Cancer Research National Cancer InstituteBethesdaMarylandUSA FDA Silver SpringMarylandUSA Laboratory of Pathology Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Frederick National Laboratory for Cancer Research FrederickMarylandUSA Biotech Research and Innovation Center(BRIC) Department of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Genetics Branch Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Georgetown University Medical Center WashingtonDCUSA Division of Cancer Genomics National Cancer Center Research InstituteThe University of TokyoTokyoJapan Laboratory of Molecular Medicine Human Genome CenterThe Institute of Medical ScienceThe University of TokyoTokyoJapan Cancer Inflammation Program Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA

Objective:Intrahepatic cholangiocarcinoma(ICC)and hepatocellular carcinoma(HCC)are clinically disparate primary liver cancers with etiological and biological *** Thailand,both cancer types represent the primary cause ... 详细信息

关键词： Common molecular subtypes

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