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Antihypercholesterolemic effect of Bacopa monniera linn,on high cholesterol diet induced hypercholesterolemia in rats

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Asian Pacific Journal of Tropical Medicine 2012年第12期5卷 949-955页

作者： Venkatakrishnan Kamesh thangarajan sumathi Department of Medical Biochemistry Dr.A.LM.Post Graduate Institute of Basic Medical SciencesUniversity of MadrasTaramani CampusChennai-600113Tamil NaduIndia

Objective:To explore the effect of alcoholic extract of Bacopa monniera(AEBM) on high cholesterol diet-induced ***:The shade-dried and coarsely powdered whole plant material(Bacopa monniera) was extracted with 90%ethanol,finally filtered and dried in vacuum *** experimental rats were divided into 4 groups:control(group-Ⅰ),Rats fed with hvpercholesterolemic diet(HCD) for 45 days[4%cholesterol(w/w) and 1%cholic acid].Rats fed with HCD for 45 days+AEBM(40mg/kg,body weight/day orally) for last 30 days(group-Ⅲ) and AEBM alone(group-IV).Blood and tissues(Aorta) were removed to ice cold containers for various biochemical and histological ***:AEBM treatment significantly decreased the levels of TC,TG,PL,LDL,VLDL,atherogenic index,LDL/HDL ratio,and TC/HDL ratio but significantly increased the level of HDL when compared to HCD induced *** on liver antioxidant status(SOD,CAT,CPx,CR,GST) were significantly raised with concomitant reduction in the level of LPO were obtained in AEBM treated rats when compared to HCD *** with AEBM significantly lowered the activity of SCOT,LDH and *** of aorta of cholesterol fed rat showed intimal thickening and foam cell deposition were ***: These results suggests that AEBM extended protection against various biochemical changes and aortic pathology in hypercholesterolemic *** the plant may therefore be useful for therapeutic treatment of clinical conditions associated hypercholesterolemia.

关键词： Bacopa monniera Hypercholesterolemia Lipid profile Antioxidant status Cardiac markers enzymes Histopathology

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