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Chinese Medicines and Bioactive Compounds for the Treatment of Stroke

Chinese Journal of Integrative Medicine 2015年第2期21卷 90-101页

作者： thanasekaran jayakumar Antoinet Ramola Elizebeth 颜廷霖许准榕 Graduate Institute of Medical Sciences Taipei Medical University Department of Biotechnology Periyar Maniammai University Department of Pharmacology Taipei Medical University

Stroke is an important cause of mortality and morbidity worldwide but effective therapeutic strategy for the prevention of brain injury in patients with cerebral ischemia is lacking. Although tissue plasminogen activator has been used to treat stroke patients, this therapeutic strategy is confronted with ill side effects and is limited to patients within 3 h of a stroke. Due to the complexity of the events and the disappointing results from single agent trials, the combination of thrombolytic therapy and effective neural protection therapy may be an alternative strategy for patients with cerebral ischemia. Chinese medicine （CM） is the most widely practiced form of herbalism worldwide, as it is a sophisticated system of medical theory and practice that is specifically different from Western medicine. Most traditional therapeutic formulations consist of a combination of several drugs. The combination of multiple drugs is thought to maximize therapeutic efficacy by facilitating synergistic actionsand preventing possible adverse effects while at the same time marking at multiple targets. CM has been labeled in ancient medicine systems as a treatment for various diseases associated with stroke. This review summarizes various CMs, bioactive compounds and their effects on cerebral ischemia.

关键词： Taohong Siwu Decoction Xuefu Zhuyu Decoction xanthohumol andrographolide stroke,Chinese medicine

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Anti-embolic effect of Taorenchengqi Tang in rats with embolic stroke induced by occluding middle cerebral artery

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Journal of Traditional Chinese Medicine 2017年第3期37卷 326-332页

作者： Li Jiun-Yi Chang Ting-Chen Chang Nen-Chung thanasekaran jayakumar Chang Chao-Chien Department of Cardiovascular Surgery MackayMemorial Hospitaland Mackay Medical CollegeTaipei10449Taiwan China Department of Lymphatic Vascular Surgery Wan Fang HospitalTaipei 116Taiwan China Department of Cardiology School ofMedicineTaipei Medical UniversityTaipei 110Taiwan China Department of Pharmacology and Graduate Institute of Medical Sciences College of MedicineTaipei Medical UniversityTaipei 110Taiwan China Department of Pharmacology and Graduate Institute of Medical Sciences College of MedicineTaipei Medical UniversityTaipei 110Taiwan China Depart-ment of Cardiology Cathay General HospitalTaipei 106Tai-wan China

OBJECTIVE: To investigate the anti-embolic effect of Taorenchengqi Tang(TRCQT), a formulas from Traditional Chinese Medicine, plus aspirin in rats with embolic stroke induced by selective occlusion of the middle cerebral artery(MCA). Possible side effects of hemorrhagic incident and other bleeding events and anti-platelet effect were also ***: Ninety rats were randomly separatedinto 9 groups(n = 10): group 1 a sham-operated group(n = 10); groups 2 and 3 orally treated with an isovolumetric solvent(distilled water) for 1 and3 months, followed by thromboembolic occlusion(n = 10); groups 4 and 5 orally treated with aspirin(5 mg/kg) alone for 1 and 3 months, followed by thromboembolic occlusion(n = 10); groups 6 and 7orally treated with TRCQT(0.5 g/kg) alone for 1 and3 months, followed by thromboembolic occlusion(n = 10); groups 8 and 9 orally treated with TRCQT plus aspirin for 1 and 3 months, respectively followed by thromboembolic occlusion(n = 10). The ischemic stroke in rats was induced by selective MCA occlusion. One was orally administered. After the treatments, rats' brains were removed, sectioned and stained with triphenyltetrazolium chloride(TTC) for infarct volume measurement. The incidence of subarachnoid hemorrhage(SAH) and intracerebral hemorrhage(ICH) were observed. A potential gastric bleeding side effect was assessed by measuring hemoglobin(Hb), and prothrombin time(PT). Collagen-induced platelet activation and tail vein bleeding time were ***: Treatment with TRCQT alone or in combination with aspirin reduced infarct volume for 1(P < 0.05), and 3(P < 0.01) months without SAH and ICH incidences, and gastric bleeding. TRCQT treatment for 1 month was also not altered PT. Moreover, a concentration dependent inhibition of collagen-induced platelet activation, followed by increasing of tail vein bleeding time was observed after TRCQT ***: Either TRCQT alone or TRCQT plus aspirin exhibits potent neuroprotective effect

关键词：抗血栓大脑大鼠栓塞闭塞动脉凝血酶原时间阿司匹林

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蚝菇提取物对老年大鼠肝肾组织内过氧化物酶表达及蛋白质氧化的影响(英文)

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中西医结合学报 2010年第8期8卷 774-780页

作者： thanasekaran jayakumar Philip Aloysius Thomas Mathivanan Isai Pitchairaj Geraldine Department of Animal Science School of Life SciencesBharathidasan UniversityTiruchirappalli 620 024 Institute of Ophthalmology Joseph Eye HospitalTiruchirappalli 620 001

目的:探讨蚝菇提取物对老年大鼠(24月龄)肝肾组织内过氧化物酶基因表达及蛋白质羰基含量的影响。方法:18只大鼠被分为3组,每组6只。组1为健康年轻大鼠(4月龄)对照组;组2为健康老年大鼠(24月龄)对照组;组3为健康老年大鼠(24月龄)蚝菇提... 详细信息

目的:探讨蚝菇提取物对老年大鼠(24月龄)肝肾组织内过氧化物酶基因表达及蛋白质羰基含量的影响。方法:18只大鼠被分为3组,每组6只。组1为健康年轻大鼠(4月龄)对照组;组2为健康老年大鼠(24月龄)对照组;组3为健康老年大鼠(24月龄)蚝菇提取物干预组,干预措施为每天腹腔注射蚝菇提取物200 mg/kg体质量,连续注射30 d。第31天处死全部大鼠并取出肝肾组织。使用逆转录聚合酶链反应及分光光度测定法分别测定大鼠肝肾组织内过氧化物酶基因表达情况及蛋白质羰基的含量。结果:组3老年大鼠注射蚝菇提取物后,其肝肾组织内过氧化物酶基因表达显著高于组2老年大鼠,且组3老年大鼠肝肾组织内蛋白羰基含量显著低于组2老年大鼠。结论:蚝菇提取物能够增加老年大鼠肝肾组织内抗氧化酶基因的表达并减少自由基引起的蛋白质氧化,对于自由基引起的年龄相关性疾病可能有保护作用。

关键词：蚝菇过氧化氢酶活性氧逆转录聚合酶链反应蛋白质羰基大鼠

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