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Journal of Modern power Systems and Clean Energy 2021年第1期9卷 190-198页

作者： thais p.teixeira Carmen L.T.Borges the Federal University of Rio de Janeiro Rio de JaneiroBrazil

The variability of wind power generation requires the allocation of a flexible energy reserve which is capable of compensating for possible imbalances between the load and generation. To reduce the variability of wind power generation and loss of load in generation deficit, we propose operation strategies for coordinating battery energy storage with wind power generation. The effects of the operation strategies on system reliability are evaluated by the developed computation model that represents the main aspects and operation limitations of the batteries. The performance evaluation of the power system is based on the composite reliability indices of loss of load probability(LOLp) and expected energy not supplied(EENS), which is calculated through sequential Monte Carlo simulation. Tests are performed by the developed model with a tutorial system consisting of five busbars and the IEEE RTS system. The results show that the use of large-scale batteries is an alternative to physically guarantee the wind power plants and to act as an operation reserve to reduce the risk of loss of load.

关键词： Energy storage wind power generation power system reliability Monte Carlo simulation

A WW Domain-Containing protein Forms Immune Nuclear Bodies against Begomoviruses

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Molecular plant 2018年第12期11卷 1449-1465页

作者： lara p. Calil lana p.S. Quadros thais C. Araujo Christiane E.M. Duarte Bianca C. Gouveia-Mageste Jose Cleydson F. Silva Otavio J.B. Brustolini Ruan M. teixeira Caue N. Oliveira Rafael W.M.M. Milagres Gilberto S. Martins Joanne Chory pedro A.B. Reis Joao paulo B. Machado Elizabeth p.B. Fontes Departament of Biochemistry and Molecular Biology Universidade Federal de Vigosa Vigosa Minas Gerais 36570-000 Brazil Nati onal In stitute of Science and Tech no logy in plant-pest Interactions Bioagro Universidade Federal de Vicosa Vinosa Minas Gerais 36570-000 Brazil Departament of Genetics Universidade Federal do Rio de Janeiro Rio de Janeiro Rio de Janeiro Brazil Howard Hughes Medical Institute and plant Biology Laboratory The Salk Institute of Biological Studies La Jolla CA 92037 USA Agronomy Institute Universidade Federal de Vigosa Campus Florestal Florestal Minas Gerais 35690-000 Brazil These authors contributed equally to this article

The bipartite begomoviruses (Geminiviridae family), which are DNA viruses that replicate in the nucleus of infected cells, encode the nuclear shuttle protein (NSp) to facilitate the translocation of viral DNA from the nucleus to the cytoplasm via nuclear pores. This intracellular trafficking of NSp-DNA complexes is accessorized by the NSp-interacting guanosine triphosphatase (NIG) at the cytosolic side. Here, we report the nuclear redistribution of NIG by AtWWpI, a WW domain-containing protein that forms immune nuclear bodies (NBs) against begomoviruses. We demonstrated that AtWWpI relocates NIG from the cytoplasm to the nucleus where it is confined to AtWWp1-NBs, suggesting that the NIG-AtWWp1 interaction may interfere with the NIG pro-viral function associated with its cytosolic localization. Consistent with this assumpti on joss AtWWpI functi on cuased plants more susceptible to begomovirus infection, whereas overexpression of AWWp1 enhaneed plant resistance to begomovirus. Furthermore, we found that a mutant versi on of AtWWpI defective for NB formatio n was noIonger capable of interacti ng with and relocating NIG to the nucleus and lost its immune function against begomovirus. The antiviral function of AtWWp1-NBs, however, could be antagonized by viral infection that induced either the disruption or a decrease in the number of AtWWp1-NBs. Collectively, these results led us to propose that AtWWpI organizes nuclear structures into nuclear foci, which provide intrinsic immunity against begomovirus infection.

关键词： nuclear bodies antiviral immunity begomovirus NIG AtWWp1

Antipsychotics preserve telomere length in peripheral blood mononuclear cells after acute oxidative stress injury

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Neural Regeneration Research 2022年第5期17卷 1156-1160页

作者： Gabriel B.polho Giancarlo M.Cardillo Daniel S.Kerr thais Chile Wagner F.Gattaz Orestes V.Forlenza Helena p.Brentani Vanessa J.De-paula Laboratório de Neurociências(LIM-27) Departamento e Instituto de PsiquiatriaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSPBrasil Laboratório de psicobiologia(LIM-23) Departamento e Instituto de PsiquiatriaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSPBrasil

Antipsychotics may prolong or retain telomere length,affect mitochondrial function,and then affect the metabolism of nerve *** validate the hypothesis that antipsychotics can prolong telomere length after oxidative stress injury,leukocytes from healthy volunteers were extracted using Ficoll-Histopaque density *** mononuclear cells layer was resuspended in cell culture *** stress was induced with hydrogen peroxide in cultured *** days later,leukocytes were treated with aripiprazole,haloperidol or clozapine for 7 ***-time pCR revealed that treatments with aripiprazole and haloperidol increased the telomere length by 23%and 20%in peripheral blood mononuclear cells after acute oxidative stress *** results suggest that haloperidol and aripiprazole can reduce the damage to telomeres induced by oxidative *** experiment procedure was approved by the Ethics Committee of Faculty of Medicine of the University of Sao paulo(FMUSp/CAAE approval No.52622616.8.0000.0065).

关键词： antipsychotic aripiprazole cell culture clozapine haloperidol oxidative stress peripheral blood mononuclear cell telomere length

Exercise training as an intervention for frailty in cirrhotic patients on the liver transplant waiting list:A systematic review

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World Journal of Hepatology 2023年第10期15卷 1153-1163页

作者： thais Mellato Loschi Melline D T A Baccan Bianca Della Guardia paulo N Martins Amanda p C S Boteon Yuri L Boteon Transplant Centre Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israelita de Ensino e pesquisa Albert Einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil Department of Surgery Transplant DivisionUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States

BACKGROUND The existing literature suggests that exercise for cirrhotic patients is safe and favours significant improvement to their physical ***,exercise training for this population and how to deliver activities,especially in severe stages of the disease and while waiting for a liver transplant(LT),remain *** To review the existing exercise prescriptions for cirrhotic patients on the waiting list for LT,their results for frailty evolution and their effect on clinical *** A systematic review was performed following the preferred Reporting Review and Meta-Analysis guidelines and searching the pubMed,MEDLINE,and Scopus *** keyword“liver transplant”was used in combination with the free terms“frailty”and“exercise”for the literature *** studies that evaluated the effect of a regular training program,independent of supervision or the duration or intensity of physical exercise,in cirrhotic patients on the waiting list for LT were *** data on safe physical activity prescriptions following Frequency,Intensity,Time,and Type recommendations were extracted and *** Nine articles met the inclusion criteria for this *** instruments for frailty assessment were used,frequently in *** studies prescribed physical activity for patients,one in-person and four to be performed remotely and *** remaining four studies only used a self-report instrument to assess the level of physical *** reported adverse events related to exercise *** exercise frequency mainly varied from daily to a minimum of twice per *** intensity depended on frailty and included increasing levels of *** type of exercise was predominantly a combination of aerobic and resistance *** duration of exercise varied from 4 to 12 *** articles evaluated the effect of the exercise program on clinical outcomes,reporting a reduction in 90-d readmission rates post-tran

关键词： End-stage liver disease Liver transplant Frailty Exercise Rehabilitation Sarcopenia

Murine model to study brain,behavior and immunity during hepatic encephalopathy

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World Journal of Hepatology 2014年第4期6卷 243-250页

作者： Lindisley Ferreira Gomides pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz pereira Sylvia Stella Amaral thais Reis Lage Gustavo Henrique Souza Resende patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana paiva Martins Marco Antonio peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins teixeira Márcio Flávio Moraes Antonio Lúcio teixeira Gustavo Batista Menezes Laboratório de Imunobiofotonica Department of MorphologyICBUFMGBelo Horizonte 31270-901Brazil School of Medicine UFMGBelo Horizonte 31270-901Brazil Department of physiology ICBUFMGBelo Horizonte 31270-901Brazil Department of Morphology UFMGBelo Horizonte 31270-901Brazil Department of Biochemistry and Immunology UFMGBelo Horizonte 31270-901Brazil

AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the ***:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital *** was evaluated using prolonged prothrombin and partial thromboplastin *** parameters were measured through tail *** levels were quantified in serum and brain ***(EEG) and psychomotor activity score were performed to show brain *** edema was evaluated using magnetic resonance ***:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver *** intense hepatic neutrophil accumulation occurred in response to TAA-induced liver *** led to mice mortality and weight loss,which was associated with severe ***,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance *** agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in *** this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction ***:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment.

关键词： Hepatic encephalopathy Liver injury Thioacetamide Neurological dysfunction Neuropsychomotor abnormalities Intracranial hypertension Cerebral herniation

Novel fibrin-fibronectin matrix accelerates mice skin wound healing

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Bioactive Materials 2020年第4期5卷 949-962页

作者： Carlos poblete Jara Ou Wang thais paulino do prado Ayman Ismail Frank Marco Fabian Han Li Licio A.Velloso Mark A.Carlson William Burgess Yuguo Lei William H.Velander Eliana p.Araújo Nursing School University of CampinasCampinasSPBrazil Laboratory of Cell Signaling University of CampinasCampinasSPBrazil Department of Chemical and Biomolecular Engineering University of NebraskaLincolnNEUSA Biomedical Engineering program University of NebraskaLincolnNEUSA School of Biological Science University of NebraskaLincolnNEUSA Department of Surgery University of Nebraska Medical Center and the VA Nebraska-Western Iowa Health Care SystemUSA Mary and Dick Holland Regenerative Medicine program University of Nebraska Medical CenterOmahaNEUSA Fred&pamela Buffett Cancer Center University of Nebraska Medical CenterOmahaNEUSA

plasma fibrinogen(F1)and fibronectin(pFN)polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound *** 90%of plasma F1 has a homodimeric pair ofγchains(γγF1),and 10%has a heterodimeric pair ofγand more acidicγ′chains(γγ′F1).We have synthesized a novel fibrin matrix exclusively from a 1:1(molar ratio)complex ofγγ′F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII(rFXIIIa).In this matrix,the fibrin nanofibers were decorated with pFN nanoclusters(termedγγ′F1:pFN fibrin).In contrast,fibrin made from 1:1 mixture ofγγF1 and pFN formed a sporadic distribution of“pFN droplets”(termedγγF1+pFN fibrin).Theγγ′F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells(HUVECs)relative to theγγF1+FN *** dimensional(3D)culturing showed that theγγ′F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human *** in the 3Dγγ′F1:pFN fibrin exhibited a starkly enhanced vascular morphogenesis while an apoptotic growth profile was observed in theγγF1+pFN *** toγγF1+pFN fibrin,mouse dermal wounds that were sealed byγγ′F1:pFN fibrin exhibited accelerated and enhanced *** study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing.

关键词： Fibrin Fibronectin Nanoclusters Wound healing

Metabolic-associated fatty liver disease is associated with low muscle mass and strength in patients with chronic hepatitis B

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World Journal of Hepatology 2022年第8期14卷 1652-1666页

作者： Cecy Maria de Lima Santos Matheus Duarte Brito pedro Alves Soares Vaz de Castro thais pontello de Vries Nataly Lopes Viana Marta paula pereira Coelho Olívio Brito Malheiro Tatiana Bering Maria Cristina Gonzalez Rosangela teixeira Rodrigo Dias Cambraia Gifone Aguiar Rocha Luciana Diniz Silva Sciences Applied to Adult Health Care post-Graduate programme Faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Outpatient Clinic of Viral Hepatitis Instituto Alfa de GastroenterologiaFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of Locomotor System Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of Food and Nutrition Universidade Federal de Mato GrossoCuiabá78060-900Mato GrossoBrazil postgraduate program in Health and Behaviour Catholic University of PelotasPelotas 96015-560Rio Grande do SulBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of Internal Medicine Universidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Although the prognostic relevance of sarcopenia has been increasingly recognised in the context of liver disease,there is a paucity of data evaluating body composition in patients with chronic hepatitis B(CHB).Beyond virus-related factors,nutritional and metabolic aspects can be associated with skeletal muscle abnormalities in these patients and should not be *** To evaluate the association between components of sarcopenia and demographic,clinical,lifestyle,nutritional,and biochemical variables in CHB *** Dual-energy X-ray absorptiometry(DXA)was used to assess muscle mass by quantifying appendicular lean mass(ALM)adjusted for body mass index(ALMBMI).Muscle function was evaluated by hand grip strength(HGS)and the timed up and go ***-associated fatty liver disease(MAFLD)was defined according to the criteria proposed by an international expert panel.A body shape index and the International physical Activity Questionnaire were used to assess central obesity and physical activity level,*** This cross-sectional study included 105 CHB outpatients followed at the tertiary care ambulatory centre(mean age,48.5±12.0 years;58.1%males;76.2%without cirrhosis;23.8%with compensated cirrhosis).The DXA-derived fat mass percentage was inversely correlated with the ALMBMI(r=-0.87)and HGS(r=-0.63).In the multivariable analysis,MAFLD,sedentarism and central obesity were positively and independently associated with low *** and central obesity were independently associated with low *** MAFLD and central obesity were associated with low muscle mass and strength in patients with chronic hepatitis B,independent of the liver disease stage.

关键词： Chronic hepatitis B Appendicular lean mass Muscle strength Metabolic associated fatty liver disease Central obesity physical performance

The Use of Insulin Negatively Impacts the Mortality of Severe COVID-19 in patients with Type 2 Diabetes—A Systematic Review

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Journal of Diabetes Mellitus 2024年第3期14卷 166-176页

作者： Caio F. Biolcatti Marcela R. Simoes thais p. prado Milena Monfort-pires Licio A. Velloso Obesity and Comorbidities Research Center Campinas Brazil Turku pET Centre University of Turku Turku Finland National Institute of Science and Technology on Neuroimmunomodulation Campinas Brazil

Obesity and type 2 diabetes are among the most important risk factors for severe coronavirus disease-19. Some studies have suggested that the use of insulin as a therapeutic agent to treat hyperglycemia and the metabolic abnormalities associated with type 2 diabetes during the acute phase of severe coronavirus disease-19 could have a negative impact on the disease’s progression;however, there is no consensus on this issue. Here, we performed a systematic review in an attempt to answer this important question. We included 29 articles published from December 2019 to August 2023, which reported the outcomes of 3,070,657 patients with severe coronavirus disease-19 that had the diagnosis of diabetes and were treated with either insulin or other glucose-reducing agents. The results show that using insulin as a pharmacological intervention to treat type 2 diabetes in patients with severe coronavirus disease-19 increases the likelihood of mortality by 193%.

关键词： SARS-CoV2 Obesity Inflammation Metabolism Glucose

Evaluating Nitrogen Behavior in Sugarcane after Fertilization Using Leaf and Sap Extract Analyzes

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American Journal of plant Sciences 2014年第18期5卷 2655-2664页

作者： Helio A.W.Joris thais R.Souza Zaqueu F.Montezano Vitor p.Vargas Heitor Cantarella Soils and Environmental Resources Center Instituto Agronomico(IAC)CampinasBrazil

Nitrogen (N) fertilization is important for sugarcane crops, for both agronomic and environmental reasons. Better use of N from fertilizer is required for crop management, and in order to achieve it, adequate N nutrition monitoring is necessary. Sap extract analysis is a sensitive technique that has been adopted in other crops to tackle this objective, and can be used for sugarcane. The aim of this study was to evaluate the behavior of N and the response of sugarcane after N fertilization, using sap and leaf tissue analysis. The study was undertaken in two experimental areas in 2012/2013 season, using ratoon cane, following application of 0, 50, 100, and 150 kg·ha-1 of N. The youngest visible leaves were sampled from sugarcane at five time points between 0 and 150 days after fertilization, to evaluate the nitrate, ammonium, and total N content of sap extract, and total N content of leaf tissue. At the first sampling point (30 days after N fertilizer application), mineral N in sap increased as a result of N fertilization in medium-textured soil, and remained high until 120 days after fertilization in clayey soil. The total N content of sap followed a similar behavior. Stalk yield was only observed to increase in sugarcane grown in the clayey soil. Sap analysis proved to be an efficient method for monitoring N status in sugarcane grown in different soil types.

关键词： Saccharum spp. Mineral Nitrogen Nitrogen Absorption Ratoon Cane Nutritional Status

Use of Agaricus bisporus mushroom in beef burgers:antioxidant,flavor enhancer and fat replacing potential

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Food production, processing and Nutrition 2019年第1期1卷 64-78页

作者： Iliani patinho Erick Saldaña Miriam Mabel Selani Adriano Costa de Camargo thais Cardoso Merlo Beatriz Schmidt Menegali Anna paula de Souza Silva Carmen J.Contreras-Castillo Departamento de Agroindústria Alimentos e Nutrição(LAN)Escola Superior de Agricultura“Luiz de Queiroz”(ESALQ)Universidade de São Paulo(USP)Avenida Pádua Dias11PiracicabaSP 13418-900Brazil Centro de Ciências da Natureza Campus Lagoa do SinoUniversidade Federal de São CarlosRod.Lauri Simões de BarrosKm 12BuriSPBrazil Departamento de Ciencias Vegetales Facultad de Agronomía e Ingeniería ForestalPontificia Universidad Católica de ChileCasilla306-22 SantiagoChile Facultad de Ingeniería Agroindustrial Universidad Nacional de Moquegua(UNAM)MoqueguaPeru

This study aimed to evaluate the potential use of Agaricus bisporus mushroom as a natural antioxidant,fat/salt substitute and flavor enhancer in beef *** treatments were considered using a fractional factorial design(salt[0.5,1.25 and 2.0%],fat[10,15 and 20%]and mushroom content[0,15 and 30%]).Treatments were characterized by instrumental and sensory *** statistical design indicated that fat content had little influence on the *** principal component analysis showed that the incorporation of mushrooms and salt modified the texture,moisture and water *** stability decreased as the salt content increased,at a low-fat ***,the sensory profile was affected by the mushroom and salt contents,with the fat content exerting the least ***,mushroom incorporation in beef burger may be a feasible strategy to reduce the fat content of beef burgers.

关键词： Beef burger Agaricus bisporus Lipid oxidation Texture profile analysis Descriptive analysis