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Murine model to study brain,behavior and immunity during hepatic encephalopathy

World Journal of Hepatology 2014年第4期6卷 243-250页

作者： Lindisley Ferreira Gomides Pedro Elias marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes Laboratório de Imunobiofotonica Department of MorphologyICBUFMGBelo Horizonte 31270-901Brazil School of Medicine UFMGBelo Horizonte 31270-901Brazil Department of Physiology ICBUFMGBelo Horizonte 31270-901Brazil Department of Morphology UFMGBelo Horizonte 31270-901Brazil Department of Biochemistry and Immunology UFMGBelo Horizonte 31270-901Brazil

AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the ***:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital *** was evaluated using prolonged prothrombin and partial thromboplastin *** parameters were measured through tail *** levels were quantified in serum and brain ***(EEG) and psychomotor activity score were performed to show brain *** edema was evaluated using magnetic resonance ***:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver *** intense hepatic neutrophil accumulation occurred in response to TAA-induced liver *** led to mice mortality and weight loss,which was associated with severe ***,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance *** agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in *** this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction ***:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment.

关键词： Hepatic encephalopathy Liver injury Thioacetamide Neurological dysfunction Neuropsychomotor abnormalities Intracranial hypertension Cerebral herniation

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Red Onion (Allium cepa L.) Methanolic Extract Increases Extracellular Nucleotide Hydrolysis in Rat Serum

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Open Journal of Applied Sciences（应用科学） 2020年第12期

作者： Janayne Luihan silva Bruno Quintanilha Faria Vinícius marques Arruda

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The Biology of Szelenyiopria talitae (Hymenoptera: Diapriidae): Larval Parasitoid of the Leaf-Cutting Ant Acromyrmex subterraneus (Hymenoptera: Formicidae)

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Advances in Entomology（昆虫学） 2021年第3期

作者： Thalles Cardoso Mattoso Denise Delores Oliveira Moreira thais Berçot Pontes Teodoro Claudio Luiz Moreira de Souza Rita de Kássia Guarnier da silva Veronica de Morais Carlos Peres silva Milton Erthal Jr. Richard Ian Samuels

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Physiological plasticity in eucalyptus clones in the vegetative stage contributes to drought tolerance

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林业研究（英文版） 2023年第5期

作者： Vilma marques Ferreira Jailma Ribeiro de Andrade Claudiana Moura dos Santos Sebasti?o de Oliveira Maia Júnior Jo?o Correia de Araújo Neto Andrea Francisca da silva Santos Vicente Mota da silva Lucas Teles Bezerra Laurício Endres

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Duodenal subepithelial hyperechoic lesions of the third layer: Not always a lipoma

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World Journal of Gastrointestinal Endoscopy 2013年第10期5卷 514-518页

作者： Pedro C Figueiredo Pedro Pinto-marques Evelina Mendona Pedro Oliveira Maria Brito david Serra Gastroenterology Department Hospital Garcia de OrtaAvenida Torrado da Silva Pathology Department Hospital da Luz Avenida Lusíada no100 Pathology Department Hospital Garcia de OrtaAvenida Torrado da Silva Gastroenterology Department Hospital da LuzAvenida Lusíada no100

Endoscopic ultrasonography is the most accurate procedure for the evaluation of subepithelial lesions. The finding of a homogeneous, hyperechoic, well-delimited lesion, originating from the third layer of the gastrointestinal tract(submucosa) suggests a benign tumor,generally lipoma. As other differential diagnoses have not been reported, echoendoscopists might not pursue a definitive pathological diagnosis or follow-up the patient. This case series aims to broaden the spectrum of differential diagnosis for duodenal hyperechoic third layer subepithelial lesions by providing four different and relevant pathologies with this echoendoscopic pattern.

关键词： Endoscopic ultrasonography Endoscopic ultrasound-guided fine needle aspiration Duodenum Subepithelial tumor Lipoma

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Ancient DNA of the pygmy marmoset type specimen Cebuella pygmaea (Spix, 1823) resolves a taxonomic conundrum

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动物学研究 2021年第6期

作者： Jean P.Boubli Mareike C.Janiak Leila M.Porter Stella de la Torre Liliana Cortés-Ortiz Maria N.F.da silva Anthony B.Rylands Stephen Nash Fabrício Bertuol Hazel Byrne Felipe E.silva Fabio Rohe Dorien de Vries Robin M.D.Beck Irune Ruiz-Gartzia Lukas F.K.Kuderna Tomas marques-Bonet Tomas Hrbek Anneke H.van Heteren Christian Roos Izeni P.Farias

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Factors Associated with Umbilical Cord Stump Healing Practices: Literature Review

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Open Journal of Obstetrics and Gynecology（妇产科期刊） 2020年第8期

作者： Marilya Rodrigues Reis Marília Cordeiro de Sousa Lays de Souza silva Lívia Roberta Rodrigues Conceição Marcela de Andrade Silvestre Camila de Pina Soares Sudário Renata Calciolari Rossi Janaína Valadares Guimarães Thaíla Corrêa Castral Karina Machado Siqueira Pedro Teixeira Meireles Bruno Belmonte Martineli Gomes George Kemil Abdalla Douglas Reis Abdalla Ana Karina marques Salge

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