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Ziwan-Taoren herb pair can exert an therapeutical effect in primary Sjogren’s syndrome through inhibiting the TLR/NF-κB pathway

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Traditional Medicine Research 2024年第8期9卷 11-22页

作者： Kuok-Tong Lei Yun-Xia Wu Yun Lu Zi-Shan Wang thi-Huong nguyen Qiu-Ying Cai Wen Zhu Yue Wang First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210000China Faculty of Traditional Medicine Phenikaa UniversityHa Noi 100803Vietnam Department of Rheumatology and Immunology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210000China

Background:Ziwan and Taoren(ZT)is a classic medicine pair in the formula of Mai Dong Di Shao Decoction,has been used to treat primary Sjogren’s syndrome(pSS)for more than 20 *** its action mechanism is still *** study is aimed to reveal the potential mechanism of ZT treated pSS and discover its active compounds of ZT and therapeutic target for ***:Firstly,the potential pathways of ZT for pSS treatment were predicted through network pharmacology and GO and KEGG enrichment ***,the inter-structural relationships between active compounds of ZT and target proteins were visualized using molecular docking ***,efficacy and mechanism were conducted through in vivo experiments,such as water intake,spleen index,hematoxylin-eosin staining pathological changes,ELISA,Western Blot analysis,and immunofluorescence ***:Nine active compounds were extracted from network pharmacology,including quercitrin,luteolin,kaempferol,β-sitosterol,isorhamnetin,galangin,hederagenin,diosmetin and gibberellin *** disease targets were identified:RELA,TP53,AKT1,interleukin(IL)6,MAPK1,ESR1,IL10;with RELA being the most core *** and GO enrichment analysis indicated that ZT may act through the TLR/NF-κB/RELA inflammatory mechanism *** results of molecular docking showed that ZT’s active compounds bind well to the RELA(p65)*** vivo results demonstrated that a high dose of ZT significantly improved water intake and reduced lymphocytes infiltration in submandibular gland pathology in NOD *** expression content of AQP5 and vasoactive intestinal peptide in the submaxillary gland was significantly increased,while levels of inflammatory factors such as tumor necrosis factor-α,IL-6,and IL-1βalong with protein expressions including toll-like receptor4,p-p65 and p-IKKα/βin NF-κB pathway were ***:The ZT treatment exhibits a promising efficacy in mitigating dryness symptoms of pSS,potentially attr

关键词： traditional Chinese medicine primary Sjogren’s syndrome NF-κB RELA

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Breast cancer awareness in reproductive women in the low-and middle-income countries:a scoping review

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Frontiers of Nursing 2024年第2期11卷 139-151页

作者： Made Satya Nugraha Gautama Saranya Pimolkatekul nguyen Ngoc Nhat thanh Department of Nursing Faculty of MedicineUniversitas Pendidikan GaneshaBali 81116Indonesia School of Nursing College of NursingTaipei Medical UniversityTaipeiTaiwan 110China Global Health and Development Program College of Public HealthTaipei Medical UniversityTaipeiTaiwan 110China

Objective:this study aimed to assess breast cancer(BC)awareness among reproductive women in low-and middle-income countries(LMICs),identify influencing factors,and propose feasible interventions or ***:We followed a 5-step process using a modified version of Arksey and O’Malley framework methodology.A comprehensive search was conducted on the Embase,PubMed,and CINAHL electronic databases for literature published within 10 years(from 2012 to 2022).Results:thirty-three papers published between 2012 and 2020,spanning 18 countries,were *** these,45.6%described a good level of knowledge,while 24.2%reported that women at reproductive ages had good *** influencing factors were identified in 3 categories:socio-demographic(family history,personal history,marital status,age,religion,income status,living place,and occupation),personal(self-efficacy,education,and perceived level),and external(advertisements promoting awareness).Educational programs were recommended in most(>72%)of the included ***:While most studies reported high levels of knowledge and awareness,some found low prevalence among certain *** affecting knowledge and awareness were classified into socio-demographic,personal,and external categories,with socio-demographic factors such as age,education,income,and marital status being the most frequently *** studies recommended implementing educational programs,health prevention strategies,and social interventions to increase BC knowledge and awareness.

关键词： awareness breast cancer low-and middle-income countries reproductive women scoping review

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越南学生“常常”“往往”习得偏误及教学对策研究

越南学生“常常”“往往”习得偏误及教学对策研究

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作者： nguyen thi LUU LY（阮氏琉璃）河北大学

学位级别：硕士

“常常”“往往”是汉语中典型的频率副词,在语义、句法和语用特征方面较为复杂且不易区分。笔者作为越南留学生,在学习汉语过程中发现,越南学生受母语的影响在理解和应用“常常”“往往”时遇到了显著的障碍。为了探究越南学生在习得... 详细信息

“常常”“往往”是汉语中典型的频率副词,在语义、句法和语用特征方面较为复杂且不易区分。笔者作为越南留学生,在学习汉语过程中发现,越南学生受母语的影响在理解和应用“常常”“往往”时遇到了显著的障碍。为了探究越南学生在习得“常常”“往往”时出现的偏误情况,并据此提出适用于越南学生的教学与学习策略,文章从本体角度对“常常”“往往”进行了对比分析,从语义、句法及语用三个角度综合比较了“常常”与“往往”的共性与差异。研究显示,尽管这两个词在词性和功能方面有很大相似性,但在语义和使用上各有特点。在此基础上,文章将汉语的“常常”“往往”与越南语中相应的词语进行了对照分析,发现越南语中有“th(?)(?)ng”“th(?)(?)ng th(?)(?)ng”“th(?)(?)ng xuyên”“th(?)(?)ng hay”“lu(?)n lu(?)n”几个词语与汉语的“常常”“往往”在语义上非常相似,但在句法特征和语用情景方面,越南语中的相应表达表现出较强的灵活性和自由度。为更确切地了解越南学生习得“常常”“往往”的情况,本文以问卷调查的形式考察了越南学生在习得“常常”“往往”时的感受和可能存在的偏误。通过对问卷情况的分析,总结出越南学习者的偏误可分为语义偏误、句法偏误和语用偏误三种类型。文章从语义及句法复杂性、学习者母语及教学媒介语因素、教材因素等三个角度进行了原因分析,研究结果表明,母语影响是导致越南学生在汉语学习中出现偏误的重要因素之一,同时也指出了教材在处理这些频率副词时存在的不足。基于以上研究,本文有针对性地提出了面向越南学生习得“常常”“往往”的教学对策。在教材编写方面,建议提高翻译的精确度、注释的准确性,并增强练习的针对性。对于教师,本文倡导采用情境教学法、对比教学法以及强化实践练习。此外,给越南学生的语言习得提出了若干建议,包括通过汉语思维减少母语负迁移、善于对比以及敢于交际的学习策略。

关键词：越南学生常常往往问卷调查教学对策

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Comparison of Treatment Efficacy of Different Number of Botulinum Toxin Type A Injection Sites for Crow’s Feet Lines: A Single-Center Retrospective Clinical Study in Vietnam

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International Journal of Dermatology And Venereology 2024年第03期

作者： Quang Minh nguyen Le thi Mai Phuc Hieu Duong Vu thai Ha Le Huu Doanh Department of Stem Cell Research and Application National Hospital of Dermatology and Venereology Hanoi Vietnam Department of Healthcare Activity Direction National Hospital of Dermatology and Venereology Hanoi Vietnam Department of Dermatology Hanoi Medical University Hanoi Vietnam

Objective: Botulinum toxin type A is frequently used to treat crow’s feet lines. However, the optimal dose and injection sites are still controversial. The objective of this study was to compare the efficacy of different botulinum toxin type A injection patterns for the treatment of crow’s ***: this single-center, retrospective, clinical study was conducted at the National Hospital of Dermatology and Venereology from July 2020 to December 2020. Data on 60 patients with crow’s feet were collected and divided into 2 groups (3-or 4-point intramuscular injection) according to the intramuscular injection technique the patients received. The treatment efficacy was assessed based on the changes in the Crow’s Feet Grading Scale score at 1, 4, and 16 weeks after treatment. Repeated measures analysis of variance was used for the assessment of changes in scores over time between the two ***: After treatment, the average Crow’s Feet Grading Scale score was significantly decreased compared with the pretreatment score at all timepoints (1, 4, and 16 weeks) in both states (dynamic: For 3-point intramuscular injection technique, 1 week: 1.90 ± 0.71vs. 2.97 ± 0.56; 4 weeks: 1.87 ± 0.68vs. 2.97 ± 0.56; 16 weeks: 2.60 ± 0.67vs. 2.97 ± 0.56. For 4-point intramuscular injection technique, 1 week: 1.73 ± 0.83vs. 3.03 ± 0.49; 4 weeks: 1.73 ± 0.74vs. 3.03 ± 0.49; 16 weeks: 2.57 ± 0.68vs. 3.03 ± 0.49, allP < 0.001. and static: For 3-point intramuscular injection technique, 1 week: 1.20 ± 0.89vs. 2.20 ± 0.85; 4 weeks:1.20 ± 0.89vs. 2.20 ± 0.85; 16 weeks: 1.87 ± 0.97vs. 2.20 ± 0.85; For 4-point intramuscular injection technique, 1 week: 1.50 ± 0.86vs. 2.30 ± 0.84; 4 weeks: 1.33 ± 0.84vs. 2.30 ± 0.84; 16 weeks: 1.87 ± 0.97vs. 2.30 ± 0.84. AllP < 0.001). The average subjective patient-rated satisfaction scores after treatment were significantly higher in the 4-point injection group than in the 3-point injection group (P = 0.028). The adverse events were post-injection bruisi

关键词： botulinum toxin type A crow’s feet lines injection site dose

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自动化班级观察在师幼互动质量评估中的应用与展望

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北京师范大学学报（社会科学版） 2024年第3期 72-80页

作者：王楠张云运 nguyen thi Phuong 李莉赵晓婷北京师范大学中国基础教育质量监测协同创新中心北京100875 郑州师范学院初等教育学院郑州450044

师幼互动质量是学前教育质量最重要的过程性质量指标之一,也是科学、大规模评估需突破的难点。自动化班级观察是多模态数据驱动的教育研究新范式,为师幼互动质量评估提供了新方向。自动化班级观察已经覆盖了情感支持、课堂组织、教学支... 详细信息

师幼互动质量是学前教育质量最重要的过程性质量指标之一,也是科学、大规模评估需突破的难点。自动化班级观察是多模态数据驱动的教育研究新范式,为师幼互动质量评估提供了新方向。自动化班级观察已经覆盖了情感支持、课堂组织、教学支持等多个师幼互动领域,其中以情感支持领域的评估最为成熟;自动化评估也综合采用了面部表情、语音、眼动等多种数据模态,目前语音数据应用得最为广泛。自动化班级观察有助于推动实现教学评一体化和大规模评估,但仍面临数据可靠性、质量和伦理等挑战。未来我国可以从制定评估指标、重点突破关键技术、建设视频资源数据库、开展跨学科研究和完善规范标准等五个方面着力,借助自动化班级观察的应用驱动学前教育质量智能化评价的改革进程。

关键词：师幼互动质量自动化评估班级观察多模态数据

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Exact solution for thermal vibration of multi-directional functionally graded porous plates submerged in fluid medium

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Defence Technology（防务技术） 2024年第5期35卷 77-99页

作者： Quoc-Hoa Pham Van Ke Tran Phu-Cuong nguyen Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh CityViet Nam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoiViet Nam Advanced Structural Engineering Laboratory Department of Structural EngineeringFaculty of Civil EngineeringHo Chi Minh City Open UniversityHo Chi Minh CityViet Nam

An analytical method for analyzing the thermal vibration of multi-directional functionally graded porous rectangular plates in fluid media with novel porosity patterns is developed in this *** properties of MFG porous plates change according to the length,width,and thickness directions for various materials and the porosity distribution which can be widely applied in many fields of engineering and defence ***,new porous rules that depend on spatial coordinates and grading indexes are proposed in the present *** Hamilton's principle and the refined higher-order shear deformation plate theory,the governing equation of motion of an MFG porous rectangular plate in a fluid medium(the fluid-plate system)is *** fluid velocity potential is derived from the boundary conditions of the fluid-plate system and is used to compute the extra *** GalerkinVlasov solution is used to solve and give natural frequencies of MFG porous plates with various boundary conditions in a fluid *** validity and reliability of the suggested method are confirmed by comparing numerical results of the present work with those from available works in the *** effects of different parameters on the thermal vibration response of MFG porous rectangular plates are studied in *** findings demonstrate that the behavior of the structure within a liquid medium differs significantly from that within a vacuum ***,they offer appropriate operational approaches for the structure when employed in various mediums.

关键词： Plate-fluid contact Galerkin Vlasov's method Multi-directional functionally graded plate Novel porosity Thermal vibration Refined higher-order shear deformation theory

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An isogeometric approach to static and transient analysis of fluid-infiltrated porous metal foam piezoelectric nanoplates with flexoelectric effects and variable nonlocal parameters

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 461-489页

作者： Quoc-Hoa PHAM Van Ke Tran Phu-Cuong nguyen Faculty of Engineering and Technology Nguyen Tat Thanh UniversityHo Chi Minh City 700000Vietnam Faculty of Mechanical Engineering Le Quy Don Technical UniversityHanoi 100000Vietnam Advanced Structural Engineering Laboratory Department of Structural EngineeringFaculty of Civil EngineeringHo Chi Minh City Open UniversityHo Chi Minh City 700000Vietnam

In this work,a novel refined higher-order shear deformation plate theory is integrated with nonlocal elasticity theory for analyzing the free vibration,bending,and transient behaviors of fluid-infiltrated porous metal foam piezoelectric nanoplates resting on Pasternak elastic foundation with flexoelectric *** analysis(IGA)and the Navier solution are applied to the *** innovation in the present study is that the influence of the in-plane variation of the nonlocal parameter on the free and forced vibration of the piezoelectric nanoplates is investigated for the first *** nonlocal parameter and material characteristics are assumed to be material-dependent and vary gradually over the thickness of *** on Hamilton’s principle,equations of motion are built,then the IGA approach combined with the Navier solution is used to analyze the static and dynamic response of the ***,we investigate the effects of the porosity coefficients,flexoelectric parameters,elastic stiffness,thickness,and variation of the nonlocal parameters on the mechanical behaviors of the rectangular and elliptical piezoelectric nanoplates.

关键词： isogeometric analysis fluid-infiltrated porous piezoelectric nanoplates static and transient analysis flexoelectric effect variable nonlocal parameters

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Building the ARIMA Model for Forecasting the Production of Vietnam’s Coffee Export

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1237-1246页

作者： Duy Quang Phung Quoc Thang Trinh Quang Truong Do Ngan Giang nguyen Van Ha nguyen Gia Khiem Ngo thi Minh Ngoc Tran Faculty of Technology and Data Science Foreign Trade University Hanoi Vietnam School of Economics and International Business Foreign Trade University Hanoi Vietnam

Coffee is a significant industry, accounting for 3% of Vietnam’s GDP, with annual export turnover consistently exceeding USD 3 billion. Despite global economic challenges affecting purchasing power at various times, Vietnam’s coffee exports in December 2023 continued to surge, reaching the highest level in the past 9 months at 190,000 tons, a 59.3% increase compared to November 2023, but still a slight 3.5% decrease from the same period last year. The export turnover reached USD 538 million, a 51% increase from November 2023 and a 26.4% increase from the same period last year. Therefore, forecasting the coffee export volume holds significant importance for coffee producers nationwide. this research employs the Box-Jenkins method to construct an ARIMA model for forecasting Vietnam’s coffee export volume based on annual data published by the General Statistics Office. Results indicate that among the models considered, the ARIMA(1, 1, 2) model is the most suitable. The study also provides short-term forecasts for Vietnam’s coffee export volume. However, the current model is limited to forecasting and is not yet optimized, as the assumed linearity in the model is a simplification.

关键词： ARIMA Forecasting Coffee Export Volume Data Science

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Predicting 3D Radiotherapy Dose-Volume Based on Deep Learning

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Intelligent Automation & Soft Computing 2024年第2期39卷 319-335页

作者： Do Nang Toan Lam thanh Hien Ha Manh Toan nguyen Trong Vinh Pham Trung Hieu Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam

Cancer is one of the most dangerous diseaseswith *** of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and *** our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer *** image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction *** proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and *** strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the *** output of the network is added with a rectified linear unit(Re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation *** experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation *** results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the Dose-score and the Dose-volume histogram score(DVH-score).In the best training cases,the Dose-score is 3.08 and the DVH-score is *** addition,we also conducted a comparison with the results of another study in the same context of using the loss function.

关键词： CT image 3D dose prediction data preprocessing augmentation

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Tuberculosis Diagnosis and Visualization with a Large Vietnamese X-Ray Image Dataset

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Intelligent Automation & Soft Computing 2024年第2期39卷 281-299页

作者： nguyen Trong Vinh Lam thanh Hien Ha Manh Toan Ngo Duc Vinh Do Nang Toan Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Hanoi University of IndustryHanoi11915Vietnam

Tuberculosis is a dangerous disease to human life,and we need a lot of attempts to stop and reverse ***,in theCOVID-19 pandemic,access to medical services for tuberculosis has become very *** late detection of tuberculosis could lead to danger to patient health,even *** one of the countries heavily affected by the COVID-19 pandemic,andmany residential areas as well as hospitals have to be isolated for a long *** demands a fast and effective tuberculosis diagnosis solution to deal with the difficulty of accessingmedical services,such as an automatic tuberculosis diagnosis *** our study,aiming to build that system,we were interested in the tuberculosis diagnosis problem from the chest X-ray images of Vietnamese *** chest X-ray image is an important data type to diagnose tuberculosis,and it has also received a lot of attention from deep learning *** paper proposed a novel method for tuberculosis diagnosis and visualization using the deeplearning approach with a large Vietnamese X-ray image *** detail,we designed our custom convolutional neural network for the X-ray image classification task and then analyzed the predicted result to provide visualization as a *** prove the performance of our network model,we conducted several experiments to compare it to another study and also to evaluate it with the dataset of this *** support the implementation,we built a specific annotation system for tuberculosis under the requirements of radiologists in the Vietnam National Lung Hospital.A large experiment dataset was also from this hospital,and most of this data was for training the convolutional neural network *** experiment results were evaluated regarding sensitivity,specificity,and *** achieved high scores with a training accuracy score of 0.99,and the testing specificity and sensitivity scores were over *** on the X-ray image classification result,we visualize pr

关键词： Tuberculosis classification Vietnamese chest X-ray deep learning

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