检索结果-南通市图书馆

Artemisia vulgaris Induces Tumor-selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) signaling

Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos santos Zamarioli Michele Rosana Maia santos Adolfo Garcia Erustes Vanessa Marques Meccatti tha.s cristine pereira.sora.a.s sma.li Maria Cristina Marcucci Carlos Rocha Oliveira Gustavo Js pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and sKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,sKBR-3 and K562 cells(Plity of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(Ps with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(Pse of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(Pse mainly from lysosomes in K562 cells(Psed the number of non-viable cells treated with HEAV(Psions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antimicrobial and synergistic effects of lemongrass and geranium essential oils against streptococcus mutans,staphylococcus aureus,and Candida spp.

引用

World Journal of Critical Care Medicine 2024年第3期13卷 63-74页

作者： Patrícia Michelle Nagai de lima tha.s cristine pereira Lara steffany de Carvalho Letícia Ferreira dos santos Carlos Eduardo Rocha Oliveira Lucas de Paula Ramos Maria Cristina Marcucci Amjad Abu Hasna Luciane Dias de Oliveira Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000SPBrazil Anhembi Morumbi University School of MedicineSão Josédos Campos 12230-002SPBrazil Department of Restorative Dentistry Endodontics DivisionInstitute of Science and TechnologySão Paulo State UniversitySão Josédos Campos 12245000São PauloBrazil

BACKGROUND The oral cavity harbors more than 700 species of bacteria,which play crucial roles in the development of various oral diseases including caries,endodontic infection,periodontal infection,and diverse oral *** To investigate the antimicrobial action of Cymbopogon schoenanthus and Pelargonium graveolens essential oils against streptococcus mutans,staphylococcus aureus,Candida albicans,***,and *** Minimum microbicidal concentration was determined following Clinical and Laboratory standards Institute *** synergistic antimicrobial activity was evaluated using the Broth microdilution checkerboard method,and the antibiofilm activity was evaluated with the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide *** were analyzed by one-way analysis of variance followed by the Tukey post-hoc test(P≤0.05).REsULTs *** and *** essential oils were as effective as 0.12%chlorhexidine against *** and *** monotypic biofilms after 24 *** 24 h *** essential oil at 0.25%was more effective than the nystatin group,and *** essential oil at 0.25%was as effective as the nystatin *** *** and *** essential oils are effective against ***,***,***,***,and *** at different concentrations after 5 min and 24 h.

关键词： Antifungal effect Lemongrass Geranium Candida albicans Candida dubliniensis Candida krusei staphylococcus aureus streptococcus mutans

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

香椿的树木年轮宽度与超年生殖行为的相互关系:对树轮学研究的警示

引用

Journal of Plant Ecology 2024年第1期17卷 165-171页

作者： Monique silva Costa tha.s Jorge de Vasconcellos Claudio sergio lisi Arno Fritz Neves Brandes Mario Tomazello-Filho Cátia Henriques Callado Instituto de Aplicação Fernando Rodrigues da silveira Universidade do Estado do Rio de JaneiroRua Barão de Itapagipe96.Rio Comprido 20261-005Rio de JaneiroBrazil Laboratório de Anatomia Vegetal Universidade do Estado do Rio de JaneiroRua São Francisco Xavier524Maracanã20550-013Rio de JaneiroBrazil Departamento de Biologia Universidade Federal de SergipeAv.Marechal Rondon s/n-Rosa Elze.São Cristóvão 49100-000SergipeBrazil Departamento de Biologia Geral Universidade Federal FluminenseRua Prof.Marcos Waldemar de Freitas ReisS/N.Gragoatá24210-201Rio de JaneiroBrazil Escola superior de Agricultura Luiz de Queiroz Universidade de São PauloAv.Pádua Dias11.Piracicaba 13418-900São PauloBrazil

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的... 详细信息

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的树木年轮宽度与超年生殖行为相关联。总体而言,生殖结构的发育发生在湿润的年份,在生长季初期没有出现水分亏缺。然而,在这些年份,树木年轮宽度较小。这些结果可能与树木年轮宽度与当地气候之间缺乏相关性有关。因此,我们强调在径向生长研究中纳入生殖数据的重要性,以扩大对热带森林生长变异性的理解。

关键词：植物生长策略树木年轮学树木生态学生殖权衡

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The versatility of mesenchymal stem cells:From regenerative medicine to COVID,what is next?

引用

BIOCELL 2022年第4期46卷 913-922页

作者： tha.s CAsAGRANDE PAIM MÁRCIA ROsÂNGELA WINK Laboratório de Biologia Celular Universidade Federal de Ciências da Saúde de Porto Alegre(UFCSPA)Porto Alegre90050-170Brazil

Mesenchymal stem cells(MsCs)play key roles in regenerative medicine by promoting tissue *** can be isolated from different adult tissues and they are able to differentiate into several *** to their antiinflammatory,angiogenic and immune-modulatory properties,MsCs are suitable for tissue engineering applications and,when associated with biomaterials,their benefits can be ***,recently,MsCs have been studied for new clinical applications,such as in the treatment of patients with *** regenerative potential has been attributed to their secretome,which comprises extracellular matrix,soluble proteins and several elements,including the release of extracellular *** though,in order to explore all their therapeutic potential,it is still necessary to advance in the investigation of their basic cell biology characteristics.

关键词： Mesenchymal stem cells Regenerative medicine secretome Biomaterials Extracellular vesicles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intraoperative application of three-dimensional printed guides in total hip arthroplasty: A systematic review

引用

World Journal of Orthopedics 2024年第7期15卷 660-667页

作者： Tim P Crone Bart M W Cornelissen Jakob Van Oldenrijk Pieter Koen Bos Ewout s Veltman Department of Orthopedic surgery and sports Medicine Erasmus Medical CenterRotterdam 3015 GDNetherlands Department of Oral and Maxillofacial surgery Erasmus Medical CenterRotterdam 3015 GDNetherlands

BACKGROUND Acetabular component positioning in total hip arthroplasty(tha)is of key importance to ensure satisfactory post-operative outcomes and to minimize the risk of *** majority of acetabular components are aligned freehand,without the use of navigation *** specific instruments(PsI)and three-dimensional(3D)printing of tha placement guides are increasingly used in primary tha to ensure optimal *** To summarize the literature on 3D printing in tha and how they improve acetabular component *** PubMed was used to identify and access scientific studies reporting on different 3D printing methods used in *** studies with 236 hips in 228 patients were *** studies could be divided into two main categories;3D printed models and 3D printed *** 3D printing in tha helped improve preoperative cup size planning and post-operative Harris hip scores between intervention and control groups(P=0.019,P=0.009).Otherwise,outcome measures were heterogeneous and thus difficult to *** overarching consensus between the studies is that the use of 3D guidance tools can assist in improving tha cup positioning and reduce the need for revision tha and the associated *** The implementation of 3D printing and PsI for primary tha can significantly improve the positioning accuracy of the acetabular cup component and reduce the number of complications caused by malpositioning.

关键词： Total hip arthroplasty Three-dimensional printing Hip replacement surgery Three-dimensional planning surgical guides

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of ulinastatin combined with dexmedetomidine on cognitive dysfunction and emergence agitation in elderly patients who underwent total hip arthroplasty

引用

World Journal of Psychiatry 2024年第1期14卷 26-35页

作者： Qi-Fan Huo li-Juan Zhu Jian-Wei Guo Yan-An Jiang Jing Zhao Department of Anesthesiology Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina

BACKGROUND With the continuous growth of the modern elderly population,the risk of fracture *** fracture is a common type of fracture in older *** hip arthroplasty(tha)has significant advantages in relieving chronic pain and promoting the recovery of hip joint *** To investigate the effect of ulinastatin combined with dexmedetomidine(Dex)on the incidences of postoperative cognitive dysfunction(POCD)and emergence agitation in elderly patients who underwent *** A total of 397 patients who underwent tha from February 2019 to August *** conducted a three-year retrospective cohort study in shaanxi Provincial People’s *** demographic data were obtained from the electronic medical record *** collected preoperative,intraoperative,and postoperative *** hundred twenty-nine patients who were administered Dex during the operation were included in the Dex *** hundred fifty patients who were intravenously injected with ulinastatin 15 min before anesthesia induction were included in the ulinastatin *** hundred eighteen patients who were administered ulinastatin combined with Dex during the operation were included in the Dex+ulinastatin *** patients’perioperative conditions,hemodynamic indexes,postoperative Mini-Mental state Examination(MMsE)scores,Ramsay score,incidence of POCD,and serum inflammatory cytokines were *** There was a significant difference in the 24 h visual analogue scale score among the three groups,and the score in the Dex+ulinastatin group was the lowest(Plinastatin group,the MMsE scores of the Dex+ulinastatin group were significantly increased at 1 and 7 d after the operation(all Pse in the Dex and ulinastatin groups,incidence of POCD,levels of serum inflammatory cytokines in the Dex+ulinastatin group were significantly decreased at 1 and 7 d after the operation(all Pserver’s assessment of th

关键词： Ulinastatin Dexmedetomidine Postoperative cognitive dysfunction Inflammatory cytokines Total hip arthroplasty

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

sarcopenia in chronic viral hepatitis:From concept to clinical relevance

引用

World Journal of Hepatology 2023年第5期15卷 649-665页

作者： Marta Paula pereira Coelho Pedro Alves soares Vaz de Castro tha.s Pontello de Vries Enrico Antônio Colosimo Juliana Maria Trindade Bezerra Gifone Aguiar Rocha Luciana Diniz silva sciences Applied to Adult Health Care Post-Graduate Programme Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Medical Undergraduate student Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of statistics Instituto de Ciências ExatasUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of Biological sciences Universidade Estadual do MaranhãoAçailândia 65715-000MaranhãoBrazil Post-Graduate Programme of Animal science Universidade Estadual do MaranhãoSão Luiz do Maranhão 65.055-310MaranhãoBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil Department of Internal Medicine Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130-100Minas GeraisBrazil

Although the frequency of metabolic risk factors for cirrhosis and hepatocellular carcinoma(HCC)is increasing,chronic hepatitis B(CHB)and chronic hepatitis C(CHC)remain the most relevant risk factors for advanced liver disease *** addition to liver damage,hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are associated with a myriad of extrahepatic manifestations including mixed cryoglobulinaemia,lymphoproliferative disorders,renal disease,insulin resistance,type 2 diabetes,sicca syndrome,rheumatoid arthritislike polyarthritis,and autoantibody ***,the list has grown to include *** of muscle mass or muscle function is a critical feature of malnutrition in cirrhotic patients and has been found in approximately 23.0%-60.0%of patients with advanced liver ***,among published studies,there is significant heterogeneity in the aetiologies of hepatic diseases and measurement methods used to determine *** particular,the interaction between sarcopenia,CHB and CHC has not been completely clarified in a real-world *** can result from a complex and multifaceted virus-host-environment interplay in individuals chronically infected with HBV or ***,in the present review,we provide an overview of the concept,prevalence,clinical relevance,and potential mechanisms of sarcopenia in patients with chronic viral hepatitis,with an emphasis on clinical outcomes,which have been associated with skeletal muscle loss in these patients.A comprehensive overview of sarcopenia in individuals chronically infected with HBV or HCV,independent of the stage of the liver disease,will reinforce the necessity of an integrated medical/nutritional/physical education approach in the daily clinical care of patients with CHB and CHC.

关键词： clinical hepatitis sarcopenia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Primary Total Hip Arthroplasty on Complex Hips Conditions in a Low-Resource setting

引用

Open Journal of Orthopedics 2024年第7期14卷 325-333页

作者： souleymane Ouédraogo Malick Diallo sékou sidibé Massadiami soulama Adama sidibé Ousmane Ouermi Patrick W. H. Dakouré Orthopedics and Traumatology Department University Hospital Sour SANOU Bobo-Dioulasso Burkina Faso superior Institute of Medical sciences University Nazi BONI Bobo-Dioulasso Burkina Faso

Introduction: Total hip arthroplasty of complex morphology is a challenge for the orthopaedic surgeon. Careful analysis of the hip’s anatomy helps to unravel the difficulties and anticipate the procedures to be performed and the implants to be planned. The aim was to identify the types of hip that make first-line THR difficult, specify the technical procedures to be used on these sites, and assess the functional results of the series. Material and Methods: This was a retrospective study that concerned patients operated on for total hip arthroplasty between January 2015 and December 2022 at the medical center “La Grâce” in Bobo-Dioulasso, Burkina Faso. Patients with coxarthrosis (on hip dysplasia, acetabular protrusio, acetabular malunion or neurological hip) and those with ankylosis of the hip, osteonecrosis secondary to neglected dislocation of the hip or hemoglobinopathy were included. Results: A total of 31 total hip replacements were performed in 30 patients. The mean age of patients at the surgery time was 36.2 years with extremes of 17 and 61 years. The male-to-female sex ratio was 1. The main indications for tha were the dysplasic hip osteoarthritis (11 cases) and the neglected hip dislocations (7 cases). In situ femoral neck osteotomy before hip dislocation was performed in seven cases. The acetabulum reconstruction techniques varied from the structural iliac bone graft (n = 3) and cancellous bone graft (n = 4) to the Kerboull plate (n = 1). After 45 months of mean follow-up, all hips were evaluated. The mean PMA score increased from 7.1 [4 - 8] before the surgery to 13.2 [13 - 17]. Conclusion: The large spectrum of challenges in complex hip management requires effective preoperative planning. Preoperative planning minimizes complications and ensures a better outcome.

关键词： Primary Total Hip Arthroplasty Hip Dysplasia Complex Hip

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Detection and determination of undeclared synthetic caffeine in weight loss formulations using HPLC-DAD and UHPLC-Ms/Ms

引用

Journal of Pharmaceutical Analysis 2018年第6期8卷 366-372页

作者： Carine Viana Gabriela M.Zemolin tha.s R.Dal Molin Luciana Gobo sandra Maria Ribeiro Gabriela C.Leal Gabriela Z.Marcon Leandro M.de Carvalho Graduate Program in Pharmaceutical sciences Federal University of Santa Maria (UFSM) Center of Health sciences Federal University of Santa Maria (UFSM) Department of Chemistry Federal University of Santa Maria (UFSM)

Caffeine is present in products marketed for weight loss, with the purpose of increasing thermogenesis and lipid metabolism. The dosage declared by the product manufacturer, or even its presence, is not always correctly described on the label. This work aimed to investigate the undeclared synthetic caffeine in weight loss formulations by a high-performance liquid chromatography with diode array detection(HPLC-DAD) method. From one hundred products purchased through Brazilian e-commerce, seventeen contained caffeine, either naturally or synthetically added to formulation. The caffeine-containing samples were confirmed by an ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-Ms/Ms) method, and adulteration was clearly proven in five products. The content highest caffeine contained 448.8 mg per dose. Other irregularities were also found; nevertheless, the most serious was the addition of synthetic drugs without asking the consumers. Additional drugs expose the consumer to more possible side-effects as well as deleterious drug interactions. Intentional adulteration with any unlabeled substance is typically motivated by a desire to increase or alter the claimed effect of the marketed product to gain a commercial advantage.

关键词： Undeclared synthetic caffeine Weight loss formulations HPLC-DAD UHPLC-Ms/Ms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuropsychological features of progranulin-associated frontotemporal dementia: a nested case-control study

引用

Neural Regeneration Research 2021年第5期16卷 910-915页

作者： Marisa lima Miguel Tábuas-pereira Diana Duro João Durães Daniela Vieira Inês Baldeiras Maria Rosário Almeida Isabel santana Neurology Department Centro Hospitalar e Universitário de CoimbraCoimbraPortugal University of Coimbra Faculty of MedicineCoimbraPortugal University of Coimbra Center for Neuroscience and Cell BiologyCoimbraPortugal University of Coimbra Center for Research in Neuropsychology and Cognitive Behavioral Intervention(CINEICC)Faculty of Psychology and Educational SciencesCoimbraPortugal

The distinction between sporadic and genetic behavioural-variant frontotemporal dementia(bvFTD)regarding some neuropsychological(NP)features remains ***,progranulin(GRN)-associated bvFTD frequently presents with early episodic memory impairment and some degree of parietal dysfunction which are supporters of Alzheimer’s disease(AD)*** this context,we aimed to characterize the NP profile of GRN-bvFTD as compared to sporadic-bvFTD and AD in patients with mild dementia(Mini-Mental state Examination score≥17 and Clinical Dementia Rating scale score≤*** identified 21 patients at Centro Hospitalar e Universitário de Coimbra,Portugal with GRN mutations belonging to fifteen different *** our focus was bvFTD variants,FTD-related aphasic forms(3 patients)were *** remaining 18 GRN-bvFTD were further matched with 18 sporadic-bvFTD and 18 AD patients according to disease staging,age and *** patients completed the Mini-Mental state Examination,Montreal Cognitive Assessment(MoCA)and a comprehensive NP assessment *** were converted into *** between groups in individual NP measures and NP domains were assessed through non-parametric tests(Kruskal-Wallis test analysis)and eta squared(ŋ2)was calculated as a measure of effect *** comparisons show that GRN patients have worse performances on verbal retrieval processes(P=0.039,ŋ2=0.110)and visuoconstructive abilities(P=0.039,ŋ2=0.190)than sporadic bvFTD *** compared to AD,GRN patients present a higher impairment in frontal(P=0.001,ŋ2=0.211)and parietal(P=0.041,ŋ2=0.129)measures and a better performance in memory tasks(P=0.020,ŋ2=0.120).sporadic-bvFTD forms are worse than AD in frontal measures(P=0.032,ŋ2=0.200),being better in both memory(P=0.010,ŋ2=0.131)and visuospatial skills(P=0.023,ŋ2=0.231).Considering these results,we conclude that GRN-bvFTD patients present a NP profile that associates the typical patterns of FTD and AD ***

关键词： Alzheimer’s disease behavioral variant frontotemporal dementia cognitive profile frontotemporal dementia genetics memory neuropsychology progranulin visuoconstructive ability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：