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Microglia lactylation in relation to central nervous system diseases

Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan mo le Tong Jianhong dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

the development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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法治是中国式现代化的重要保障

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 7-16,F0002页

作者：莫纪宏中国社会科学院法学研究所北京100720

党的二十届三中全会审议通过的《中共中央关于进一步全面深化改革、推进中国式现代化的决定》明确提出“法治是中国式现代化的重要保障”,对法治与现代化之间的辩证关系从理论与实践相结合的角度作出系统阐述,对不断完善和健全法治在保... 详细信息

党的二十届三中全会审议通过的《中共中央关于进一步全面深化改革、推进中国式现代化的决定》明确提出“法治是中国式现代化的重要保障”,对法治与现代化之间的辩证关系从理论与实践相结合的角度作出系统阐述,对不断完善和健全法治在保障中国式现代化中的能力,推动法治与现代化同频共振、并肩前行发挥了政策引领作用。从法理层面准确认识法治对中国式现代化的保障机制和制度功能,要从历史维度、政治维度、理论维度、比较维度和实践维度“五个维度”有机统一的角度认识中国式现代化的具体特征和制度形态,针对不同层面的中国式现代化目标采取不同性质的法治应对和保障措施。法治在中国式现代化进程中,通过保障制度现代化推进中国式现代化。其中,法治自身也需要现代化。没有法治现代化就没有社会主义现代化。法治在推进中国式现代化过程中,通过不断提升自身效能和保障能力,逐步实现自身的现代化,成为中国式现代化事业的重要组成部分。

关键词：法治中国式现代化历史维度政治维度理论维度比较维度实践维度

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Periodical Oscillations of Supercurrent Fluctuation in Mesoscopic Josephson Junctions in Quantized Electromagnetic Fields

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Chinese Physics letters 1996年第5期13卷 359-361页

作者： KUANG le-man WANG Yi-wen GE mo-lin theoretical Physics division Nankai Instilute of MathematicsTianjin 300071 department of Physics Hu'nan Normal UriiversityChangsha 410081

Supercurrent fluctuation of a mesoscopic Josephson jutiction(MJJ)in the presence of a de static voltage and a time-varying quantized electromagnetic field(QEMF)is *** is shown thm the fluctuation of supercurrent in the MJJ exhibits periodical oscillations with a periodicity shich depends upon the rate of the classical static external voltage and the frequency of the QEMF.

关键词： Josephson Electromagnetic Periodical

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng le Wang Wenwu Zhang Gang Li Xing Cheng Peiqiang Su Yong Wan Xiang Li department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further d.monstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and.motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Approximation Algorithms for 3d Orthogonal Knapsack

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Journal of Computer Science & Technology 2008年第5期23卷 749-762页

作者： Florian diedrich Rolf Harren Klaus Jansen Ralf thle Henning thomas Institute of Computer Science University of Kiel Max-Planck-Institut für Informatik Campus E1466123 Saarbrücken Germany department of Computer Science ETH ZurichZurich Switzerland

We study non-overlapping axis-parallel packings of 3d boxes with profits into a dedicated bigger box where rotation is either forbidden or permitted, and we wish to maximize the total profit. Since this optimization problem is NP-hard, we focus on approximation algorithms. We obtain fast and simple algorithms for the non-rotational scenario with approximation ratios 9 ＋ ε and 8 ＋ ε, as well as an algorithm with approximation ratio 7 ＋ ε that uses more sophisticated techniques; these are the smallest approximation ratios known for this problem. Furthermore, we show how the used techniques can be adapted to the case where rotation by 90° either around the z-axis or around all axes is permitted, where we obtain algorithms with approximation ratios 6 ＋ ε and 5 ＋ ε, respectively. Finally our methods yield a 3d generalization of a packability criterion and a strip packing algorithm with absolute approximation ratio 29/4, improving the previously best known result of 45/4.

关键词： approximation algorithm computational and structural complexity geometric configurations

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A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells

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Cellular & molecular Immunology 2023年第10期20卷 1114-1126页

作者： morgane thomas Charlotte Bruzeau ophélie Alyssa Martin Justine Pollet Sébastien Bender Claire Carrion Sandrine le Noir Eric Pinaud Laboratoire Contrôle de la Réponse Immune B et des Lymphoproliférations(CRIBL) Universitéde LimogesCNRS UnitéMixte de Recherche 7276Inserm Unité1262LimogesFrance Centre Hospitalier Universitaire dupuytren Service d’ImmunopathologieLimogesFrance Centre Hospitalier Universitaire de Limoges Centre National de l’Amylose AL et Autres Maladies par Dépôt d’Immunoglobulines MonoclonalesLimogesFrance Laboratoire Suivi des therapies Innovantes Institut de Genetique HumaineUMR 9002 CNRS-UMMontpellierFrance

SATB1(Special A-T rich Binding protein 1)is a cell type-specific factor that regulates the genetic network in developing T cells and *** T cells,SATB1 is required for lineage commitment,VdJ recombination,development and *** that its expression varies during B-cell differentiation,the involvement of SATB1 needs to be clarified in this *** a KO mouse model in which SATB1 was deleted from the pro-B-cell stage,we examined the consequences of SATB1 deletion in naive and activated B-cell *** model indicates first,unlike its essential function in T cells,that SATB1 is dispensable for B-cell development and the establishment of a broad IgH ***,we show that SATB1 exhibits an ambivalent function in mature B cells,acting sequentially as a positive and negative regulator of Ig gene transcription in naive and activated cells,***,our study indicates that the negative regulatory function of SATB1 in B cells extends to the germinal center response,in which this factor limits somatic hypermutation of Ig genes.

关键词： B cells Nuclear factor Ambivalent Somatic hypermutation

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CdTe/CdSe-sensitized photocathode coupling with Ni-substituted polyoxometalate catalyst for photoelectrochemical generation of hydrogen

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Nano Research 2022年第2期15卷 1347-1354页

作者： Junhao Zhang mo Zhang Yuanyuan dong Congcong Bai Yeqin Feng le Jiao Hongjin Lv moE Key Laboratory of Cluster Science School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 102488China

In terms of photoelectrochemical(PEC)hydrogen evolution,substantial challenge still remains regarding the controllable fabrication of quantum dots(Qds)-sensitized photocathodes with enhanced visible-light absorption,efficient charge carrier separation,and directional migration at the electrode *** this work,the CdTe/CdSe Qds-sensitized photocathodes were delicately constructed on p-type NiO-coated indium tin oxide(ITO)electrodes by spin-coating *** resulting co-sensitized photocathode exhibits a favorable pseudo-Type Ⅱ energetic band alignment that combines the advantages of strong light absorption of constituent Qds as well as the effective and oriented charge separation and *** green led light illumination,the photogenerated electrons could be effectively transferred to a tetra-nickel-substituted polyoxometalate catalyst for hydrogen production while photogenerated holes will be scavenged at the NiO/ITO *** minimally optimized conditions,the pseudo-Type Ⅱ CdTe/CdSe-sensrtized photocathode yields a photcx:urrent density of over 100 pA/cm^(2) and a Faradaic efficiency of〜100%,which is among one of the most efficient Qds-based photocathode systems coupling with Ni-substituted polyoxometalate catalyst for photoelectrochemical hydrogen generation.

关键词： polyoxometalates quantum dots-sensitized photocathode favorable energetic gradient photoelectrochemical water splitting hydrogen generation

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Fabrication of macroporous polystyrene/graphene oxide composite monolith and its adsorption property for tetracycline

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Chinese Chemical letters 2016年第4期27卷 511-517页

作者： le-Chen Chen Shan lei mo-Zhen Wang Jun Yang Xue-Wu Ge the USTC-Anhui Tobacco Joint Laboratory of Tobacco Chemistry CAS Key Laboratory of Soft Matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China the USTC-Anhui Tobacco Joint Laboratory of Tobacco Chemistry Research Center of Tobacco and Health University of Science and Technology of China

Macroporous polystyrene microsphere/graphene oxide（PS/GO） composite monolith was first prepared using Pickering emulsion droplets as the soft template. the Pickering emulsion was stabilized by PS/GO composite particles in-situ formed in an acidic water phase. With the evaporation of water and the oil phase（octane）, the Pickering emulsion droplets agglomerated and combined with each other, forming a three-dimensional macroporous PS/GO composite matrix with excellent mechanical strength. the size of the macrospores ranged from 4 mm to 20 mm. the macroporous PS/GO composite monolith exhibited high adsorption capacity for tetracycline（TC） in an aqueous solution at p H 4–6. the maximum adsorption capacity reached 197.9 mg g 1at p H 6. the adsorption behaviour of TC fitted well with the Langmuir model and pseudo-second-order kinetic model. this work offers a simple and efficient approach to fabricate macroporous GO-based.monolith with high strength and adsorption ability for organic pollutants.

关键词： Graphene oxide Polystyrene microsphere Macroporousm Adsorption Tetracycline

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Alloying-engineered high-performance broadband polarized Bi_(1.3)In_(0.7)Se_(3)photodetector with ultrafast response

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Nano Research 2022年第9期15卷 8451-8457页

作者： Fen Zhang Yali Yu Zhangxun mo le Huang Qinglin Xia Bo Li Mianzeng Zhong Jun He Hunan Key Laboratory of Nanophotonics and devices School of Physics and ElectronicsCentral South UniversityChangsha 410083China State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of Sciences&Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100083China School of Material and Energy Guangdong University of TechnologyGuangzhou 510006China department of Applied Physics School of Physics and ElectronicsHunan UniversityChangsha 410082China

Topological insulators have important potential for applications in the field of nano/micro-optoelectronic ***,the large dark current seriously hinders the improvement of device *** is an important means to control the physical properties of topological *** this work,we have designed and prepared Bi_(1.3)In_(0.7)Se_(3)*** optoelectronic properties of the individual Bi_(1.3)In_(0.7)Se_(3)nanowire-based photodetector are systematically *** photodetector is very sensitive to broadband wavelength from solar-blind ultraviolet C(254 nm)to near-infrared(1,064 nm),showing superior optoelectrical properties with photoresponsivity of 241.3 A·W^(–1)and detectivity of 1.18×10^(12)Jones at 638 ***,the photodetector d.monstrates ultrafast photoresponse characteristics with a photoresponse time of about 770 ns,which is 3 to 6 orders of magnitude lower than other compound semiconductors based on Bi or In reported so *** addition,it also exhibits good polarization sensitivity in a broadband range from ultraviolet C(266 nm)to near-infrared(1,064 nm)and obtained the maximum dichroic ratio is 1.73 at 1,064 *** results suggest that this platform creates new opportunities for the development of low-cost,high-sensitivity,high-speed,and broadband angle-sensitive photodetectors.

关键词： photodetectors alloying of Bi_(1.3)In_(0.7)Se_(3) broadband ultrafast response polarization

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Hydrodynamic Characteristics of three-Bucket Jacket Foundation for Offshore Wind Turbines during the Lowering Process

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China Ocean Engineering 2023年第1期37卷 73-84页

作者： ZHANG Pu-yang QI Xin WEI Yu-mo ZHANG Sheng-wei le Cong-huan dING Hong-yan State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China

the three-bucket jacket foundation is a new type of foundation for offshore wind turbine that has the advantages of fast construction speed and suitability for deep water. the study of the hoisting and launching process is of great significance to ensure construction safety in actual projects. In this paper, a new launching technology is proposed that is based on the foundation of the three-bucket jacket for offshore wind turbine. A complete time domain simulation of the launching process of three-bucket jacket foundation is carried out by a theoretical analysis combined with hydrodynamic software moses. At the same time, the effects of different initial air storage and sea conditions on the motion response of the structure and the hoisting cable tension are studied. the results show that the motion response of the structure is the highest when it is lowered to 1.5 times the bucket height. the natural period of each degree of freedom of the structure increases with the increase of the lowering depth. the structural motion response and the hoisting cable tension vary greatly in the early phases of Stages Ⅰ and Ⅲ, smaller in Stage Ⅱ, and gradually stabilize in the middle and late phases of Stage Ⅲ.

关键词： three-bucket jacket foundation time domain simulation hoisting construction motion response offshore wind turbine

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