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世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 21-21页

作者： mylonas I Makovitzky J Shabani N 郭慧方

Leukaemia inhibitory factor (LIF) is a pleiotrophic cytokine, which might play an important role in human reproduction and endocrine-responsive tumours. ther efore, the aim of this study was to determine the frequency and tissue distribut ion of LIF in normal, hyperplastic and malignant endometrium. Paraffin-fixed en dometrial tissue was obtained from normal premenopausal women (n = 15), endometr ial hyperplasia (n = 20), endometroid adenocarcinoma (n = 32) and endometrial po lyps (n = 9). the LIF expression was demonstrated by immunohistochemical means a nd evaluated with a semiquantitative immunoreactive score. the Mann-Whitney U- test was used for statistical evaluation. the lowest expression of LIF was obser ved in endometrial adenocarcinomas compared to all groups, while endometrial pol yps expressed the highest LIF immunostaining. the expression in normal human gla ndular cells was significantly higher during the late secretory phase than in th e proliferative phase. the highest expression of LIF was observed in endometrial polyps. Simple hyperplasia showed a significantly higher LIF expression than pr oliferative endometrium and adenocarcinoma. Adenomatous hyperplasia (AH) grade I -III had a significantly higher LIF expression than adenocarcinoma. the lowest expression of LIF was observed in adenocarcinoma, being statistically significan t compared to all groups. LIF was immunohistochemically demonstrated in normal, hyperplastic and malignant endometrial tissue, suggesting a widespread but compl ex role for LIF in hyperplastic and malignant endometrial growth regulation. AH I-III also expressed LIF with statistically higher immunostaining than adenocar cinoma. Since AH III can be considered as a precursor of endometrial cancer, LIF could be a marker of cell transformation.

关键词：白血病抑制因子子宫内膜单纯增生癌前病变绝经前女性细胞转化免疫染色多效性细胞因子内分泌反应人类生殖

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