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Harnessing bacteria for tumor therapy:Current advances and challenges

Chinese Chemical Letters 2024年第2期35卷 97-106页

作者： lina Guo Jinsong Ding Wenhu Zhou Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Changsha Medical university Academician WorkstationChangsha 410219China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410008China

After a century of standstill,bacteria-based tumor therapy has resurged recently benefiting from the revolution of tumor immunotherapy,which provides unique solutions to tackle the obstacles of traditional tumor *** and facultative anaerobes with active tropism can selectively colonize at tumor sites and suppress tumor growth via different mechanisms,serving as attractive tools for tumor treatment either as a monotherapy or combining with other therapies for synergistic anti-tumor *** this critical review,we introduce the recent advances of bacteria-based tumor therapy from the following ***,the general properties of bacteria are reviewed emphasizing on their structural components related to tumor immunotherapy,and the main bacteria that have been used in tumor therapy are ***,the benefits of bacteria for tumor therapy are illustrated,such as tumor targetability,deep penetration,and facile genetic engineering for attenuation,enhanced efficacy,as well as ***,anti-tumor mechanisms of bacteria are summarized,which refer to intrinsic tumoricidal activities,immune activation,bacteria metabolism,and their capability to regulate gut microbiota ***,bacteria could act as carriers to deliver various types of therapeutics to achieve combination therapy with improved *** addition,several challenges for anti-tumor applications of bacteria are discussed regarding the delivery,efficacy and safety issues,and potential solutions are also ***,the possible improvements and perspectives are discussed in the end,which provide a guideline for the design of advanced bacteria-based tumor therapeutics in the future.

关键词： Bacteria Tumor targeting Immunotherapy Combination therapy Genetic engineering Surface decoration

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Structural Engineering of Anode Materials for Low-Temperature Lithium-Ion Batteries:Mechanisms,Strategies,and Prospects

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Nano-Micro Letters 2024年第8期16卷 169-195页

作者： Guan Wang Guixin Wang Linfeng Fei lina Zhao Haitao Zhang Beijing Key Laboratory of Ionic Liquids Clean Process Institute of Process EngineeringChinese Academy of SciencesBeijing 100190People’s Republic of China School of Chemical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Energy Materials and Chemical Engineering Hefei UniversityHefei 230601People’s Republic of China School of Materials Science and Engineering Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Polymer and Catalyst Synthesis Technology of Liaoning Province School of Environmental and Chemical EngineeringShenyang University of TechnologyShenyang 110870People’s Republic of China

the severe degradation of electrochemical performance for lithium-ion batteries(LIBs)at low temperatures poses a significant challenge to their practical ***,extensive efforts have been contributed to explore novel anode materials with high electronic conductivity and rapid Li^(+)diffusion kinetics for achieving favorable low-temperature performance of ***,we try to review the recent reports on the synthesis and characterizations of low-temperature anode ***,we summarize the underlying mechanisms responsible for the performance degradation of anode materials at subzero ***,detailed discussions concerning the key pathways(boosting electronic conductivity,enhancing Li^(+)diffusion kinetics,and inhibiting lithium dendrite)for improving the low-temperature performance of anode materials are ***,several commonly used low-temperature anode materials are briefly ***,recent progress in the engineering of these low-temperature anode materials is summarized in terms of structural design,morphology control,surface&interface modifications,and multiphase ***,the challenges that remain to be solved in the field of low-temperature anode materials are *** review was organized to offer valuable insights and guidance for next-generation LIBs with excellent low-temperature electrochemical performance.

关键词： Low-temperature performance Anode materials Microstructural regulations Surface modifications

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Study of the ability of SWOT to detect sea surface height changes caused by internal solitary waves

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Acta Oceanologica Sinica 2024年第5期43卷 54-64页

作者： Hao Zhang Chenqing Fan lina Sun Junmin Meng First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Technology Innovation Center for Ocean Telemetry Ministry of Natural ResourcesQingdao 266061China College of Oceanography and Space Informatics China University of Petroleum(Huadong)Qingdao 266580China

Surface Water and Ocean Topography(SWOT)is a next-generation radar altimeter that offers high resolution,wide swath,imaging *** has provided free public data worldwide since December *** paper aims to preliminarily analyze the detection capabilities of the Ka-band radar interferometer(KaRIn)and Nadir altimeter(NALT),which are carried out by SWOT for internal solitary waves(ISWs),and to gather other remote sensing images to validate SWOT *** effectively detects ISW surface features and generates surface height variation maps reflecting the modulations induced by ***,its swath width does not completely cover the entire wave packet,and the resolution of L2/L3 level products(about 2 km)cannot be used to identify ISWs with smaller ***,significant wave height(SWH)images exhibit blocky structures that are not suitable for ISW studies;sea surface height anomaly(SSHA)images display systematic leftright *** optimize this imbalance using detrending methods;however,more precise treatment should commence with L1-level *** analysis based on L3-level SSHA data indicates that the average SSHA variation induced by ISWs ranges from 10 cm to 20 *** disturbed by ISWs record unusually elevated SWH and SSHA values,rendering the data unsuitable for analysis and necessitating targeted corrections in future retracking *** the normalized radar cross section,Ku-band and four-parameter maximum likelihood estimation retracking demonstrated greater sensitivity to minor changes in the sea surface,making them more suitable for ISW *** conclusion,SWOT demonstrates outstanding capabilities in ISW detection,significantly advancing research on the modulation of the sea surface by ISWs and remote sensing imaging mechanisms.

关键词： internal solitary waves Surface Water and Ocean Topography(SWOT) Ka-band radar interferometer(KaRIn) Nadir altimeter(NALT) sea surface height anomaly(SSHA) normalized radar cross section(NRCS)

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A creep model for ultra-deep salt rock considering thermal-mechanical damage under triaxial stress conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 588-596页

作者： Chao Liang Jianfeng Liu Jianxiong Yang Huining Xu Zhaowei Chen lina Ran College of Water Resource and Hydropower Sichuan UniversityChengdu610065China CNPC Key Laboratory of Oil and Gas underground Storage Engineering Langfang065007China CNPC Engineering Technology R&D Company Limited Beijing102206China

To investigate the specific creep behavior of ultra-deep buried salt during oil and gas exploitation,a set of triaxial creep experiments was conducted at elevated temperatures with constant axial pressure and unloading confining pressure *** results show that the salt sample deforms more significantly with the increase of applied temperature and deviatoric *** accelerated creep phase is not occurring until the applied temperature reaches 130℃,and higher temperature is beneficial to the occurrence of accelerated *** describe the specific creep behavior,a novel three-dimensional(3D)creep constitutive model is developed that incorporates the thermal and mechanical variables into mechanical ***,the standard particle swarm optimization(SPSO)method is adopted to fit the experimental data,and the sensibility of key model parameters is analyzed to further illustrate the model *** a result,the model can accurately predict the creep behavior of salt under the coupled thermo-mechanical effect in deep-buried *** on the research results,the creep mechanical behavior of wellbore shrinkage is predicted in deep drilling projects crossing salt layer,which has practical implications for deep rock mechanics problems.

关键词： Creep experiments Creep model thermal and mechanical damage Fractional derivative

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Exploring centimeter-sized crystals of bismuth-iodide perovskite toward highly sensitive X-ray detection

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Chinese Chemical Letters 2024年第6期35卷 185-188页

作者： Xin Dong Jing Liang Zhijin Xu Huajie Wu Lei Wang Shihai You Junhua Luo lina Li College of Chemistry Fuzhou UniversityFuzhou 350116China State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China university of Chinese Academy of Sciences Beijing 100049China

Lead-halide perovskites exhibit outstanding performance in X-ray detection due to their intrinsic features such as high charge carrier mobility,large atomic number,and long carrier lifetime,but the toxicity of lead is regarded as the major factor hindering their ***,we introduce organic molecule(R)-(-)-2-methylpiperazine(R-MPz)into the bismuth-based structure to synthesize lead-free(R)-(H_(2)MPz)BiI_(5)(R-MBI).the high-quality centimeter-sized single crystals have been obtained,which show a low dark current and superior environmental ***,the single-crystal device of R-MBI exhibits a highμτproduct up to 1.88×10^(-4)cm^(2)/V and a low trap density of 1.21×10^(10)cm^(-3).Further,the detector displays excellent detection sensitivity of 263.58μC Gy_(air)^(-1)cm^(-2)and a favorable low detection limit of 4.35μGyair/s,both of which meet the requirement for medical *** findings shed light on the exploration of innovative bismuth-based hybrid perovskites for high-performance X-ray detection.

关键词： Perovskite Lead-free Bismuth-based X-ray detection Sensitivity

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Exciting lattice oxygen of nickel–iron bi-metal alkoxide for efficient electrochemical oxygen evolution reaction

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Journal of Energy Chemistry 2024年第1期88卷 194-201,I0005页

作者： Saihang Zhang Senchuan Huang Fengzhan Sun Yinghui Li Li Ren Hao Xu Zhao Li Yifei Liu Wei Li lina Chong Jianxin Zou National Engineering Research Center of Light Alloy Net Forming&State Key Laboratory of Metal Matrix Composites Center of Hydrogen ScienceSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Laboratory of Advanced MaterialsShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsiChEM and State Key Laboratory of Molecular Engineering of PolymersCollege of Chemistry and MaterialsFudan UniversityShanghai 200433China

High efficiency,cost-effective and durable electrocatalysts are of pivotal importance in energy conversion and storage *** electro-oxidation of water to oxygen plays a crucial role in such energy conversion ***,we report a robust method for the synthesis of a bimetallic alkoxide for efficient oxygen evolution reaction(OER)for alkaline electrolysis,which yields current density of 10 mA cm^(-2)at an overpotential of 215 mV in 0.1 M KOH *** catalyst demonstrates an excellent durability for more than 540 h operation with negligible degradation in *** spectra revealed that the catalyst underwent structure reconstruction during OER,evolving into oxyhydroxide,which was the active site proceeding OER in alkaline ***-situ synchrotron X-ray absorption experiment combined with density functional theory calculation suggests a lattice oxygen involved electrocatalytic reaction mechanism for the in-situ generated nickel–iron bimetal-oxyhydroxide *** mechanism together with the synergy between nickel and iron are responsible for the enhanced catalytic activity and *** findings provide promising strategies for the rational design of nonnoble metal OER catalysts.

关键词： Oxygen evolution reaction Nickel-iron bi-metal alkoxide Lattice oxygen-mediated reaction mechanism Alkaline electrolysis Electrocatalysts

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Lead-free hybrid two-dimensional double perovskite with switchable dielectric phase transition

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Chinese Chemical Letters 2024年第6期35卷 176-179页

作者： Tian Yang Yi Liu lina Hua Yaoyao Chen Wuqian Guo Haojie Xu Xi Zeng Changhao Gao Wenjing Li Junhua Luo Zhihua Sun College of Chemistry Fuzhou UniversityFuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Molecular dielectric switches constitute a type of intelligent materials that are highly coveted for their distinctive advantages of switchable dielectric responses,lightweight,and mechanical ***(2D)hybrid perovskites have demonstrated excellent promise for assembling dielectric switches,in which the dynamic motions of organic moieties afford driving force to trigger switchable dielectric phase ***,we successfully assembled a new lead-free hybrid double perovskite,(CHA)4Cu Bi Br8(1,CHA=cyclohexylammonium),adopting a typical 2D structural motif,which shows dielectric anisotropy and bistable behaviors during the reversible phase transition near T_(c)=378 K(the Curie temperature).that is,its dielectric constants could be switched and tuned between high-dielectric and low-dielectric *** analyses reveal that the ordered-disordered transformation of the organic CHA+moiety and distortion of inorganic framework account for its phase *** result will stimulate further exploration of molecular dielectric switches in this 2D environmentally friendly family.

关键词： Dielectric switch Lead-free Double perovskite Phase transition Symmetry breaking

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地方智慧旅游公共服务平台持续使用意愿研究

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旅游学刊 2024年第1期39卷 105-116页

作者：钟栎娜董英超北京第二外国语学院旅游科学学院北京100024

地方智慧旅游公共服务平台的建设和运营已经成为各地全域旅游建设与发展的重要组成部分,但是平台的持续使用一直是学术和行业界讨论的重点。文章以“游云南”平台为案例,基于刺激-机体-反应理论框架,运用混合研究方法对地方智慧旅游公... 详细信息

地方智慧旅游公共服务平台的建设和运营已经成为各地全域旅游建设与发展的重要组成部分,但是平台的持续使用一直是学术和行业界讨论的重点。文章以“游云南”平台为案例,基于刺激-机体-反应理论框架,运用混合研究方法对地方智慧旅游公共服务平台的持续使用意愿进行研究,并提出“因素-感知-使用”地方智慧旅游公共服务平台持续使用意愿综合分析模型,得到如下研究结果。1)在地感知、地方依恋均能够显著提高游客对地方智慧旅游公共服务平台的感知信任和情感依恋,进而提高满意度。其中,平台情感依恋在提高平台持续使用意愿方面具有显著正向作用。具体而言,在地感知会通过信息拓展、形象匹配之机制,地方依恋会通过情感外溢、期待满足之机制促进平台情感依恋和信任的产生,并最终提高持续使用意愿。2)功能集群、享乐体验均能够显著提高游客对地方智慧旅游公共服务平台的感知有用性、感知易用性和感知信任,进而提高游客使用满意度,最终提高持续使用意愿。功能集群通过“信息全面、减少成本”之机制,享乐体验通过“逃离惯常、精美设计”之机制影响游客对平台的积极感知。

关键词：地方智慧旅游服务平台持续使用意愿功能集群在地感知地方依恋

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LncRNA CCRR maintains Ca^(2+)homeostasis against myocardial infarction through the FTO-SERCA2a pathway

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Science China(Life Sciences) 2024年第8期67卷 1601-1619页

作者： Hua Yang lina Xuan Shengjie Wang Huishan Luo Xiaomeng Duan Jianjun Guo Shijia Cui Jieru Xin Junwei Hao Xiufang Li Jun Chen Feihan Sun Xiaolin Hu Siyun Li Ying Zhang Lei Jiao Baofeng Yang Lihua Sun Department of Pharmacology Harbin Medical University(State Key Laboratory of Frigid Zone Cardiovascular Diseasethe State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of EducationJoint International Research Laboratory of Cardiovascular Medicine ResearchMinistry of EducationChina)College of PharmacyHarbin Medical UniversityHarbin 150081China

Cardiac conduction regulatory RNA(CCRR)has been documented as an antiarrhythmic lncRNA in our earlier *** study aimed to evaluate the effects of CCRR on SERCA2a and the associated Ca^(2+)homeostasis in myocardial infarction(MI).Overexpression of CCRR via AAV9-mediated delivery not only partially reversed ischemia-induced contractile dysfunction but also alleviated abnormal Ca^(2+)homeostasis and reduced the heightened methylation level of SERCA2a following *** effects were also observed in CCRR overexpressing transgenic mice.A conserved sequence domain of CCRR mimicked the protective function observed with the full ***,silencing CCRR in healthy mice led to intracellular Ca^(2+)overloading of *** increased SERCA2a protein stability by upregulating FTO *** direct interaction between CCRR and FTO protein was characterized by RNA-binding protein immunoprecipitation(RIP)analysis and RNA pulldown *** of NFATc3 was identified as an upstream mechanism responsible for CCRR downregulation in *** study demonstrates that CCRR is a protective lncRNA that acts by maintaining the function of FTO,thereby reducing the m^(6)A RNA methylation level of SERCA2a,ultimately preserving calcium homeostasis for myocardial contractile function in ***,CCRR may be considered a promising therapeutic strategy with a beneficial role in cardiac pathology.

关键词： CCRR calcium homeostasis FTO myocardial infarction SERCA2a

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Endoscopic ultrasound-guided tissue acquisition for the diagnosis of focal liver lesion

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World Journal of Radiology 2024年第4期16卷 72-81页

作者： Alina Tantău Cosmina Sutac Anamaria Pop Marcel Tantău Department of Internal Medicine and Gastroenterology “Iuliu Hatieganu”University of Medicine and PharmacyThe 4th Medical Clinic CF HospitalCluj-Napoca 400012ClujRomania Department of Gastroenterology “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400162ClujRomania Department of Gastroenterology and Hepatology Gastroenterology and Hepatology Medical CenterDigenio HospitalCluj-Napoca 400058ClujRomania Department of Internal Medicine and Gastroenterology “Iuliu Hatieganu”University of Medicine and Pharmacy“Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and HepatologyCluj-Napoca 400162ClujRomania

In patients with liver tumors,the histopathology examination can assist in diagnosis,staging,prognosis,and therapeutic management *** ultrasound(EuS)-guided tissue acquisition using fine needle aspiration(FNA)or more newly fine needle biopsy(FNB)is a well-developed technique in order to evaluate and differentiate the liver *** goal of the EuS-FNA or EuS-FNB is to provide an accurate sample for a histopathology ***,malignant tumors such as hepatocarcinoma,cholangiocarcinoma and liver metastasis or benign tumors such as liver adenoma,focal hyperplastic nodular tumors and cystic lesions can be accurately diagnosed using EuS-guided tissue ***-FNB using 19 or 22 Ga needle provide longer samples and a higher diagnostic accuracy in patients with liver masses when compared with *** data are available on the diagnostic accuracy of EuS-FNB when compared with percutaneously,ultrasound,computer tomography or transjugulary-guided liver *** review will discuss the EuS-guided tissue acquisition options in patients with liver tumors and its efficacy and safety in providing accurate *** results of the last studies comparing EuS-guided liver biopsy with other conventional techniques are *** EuS-guided tissue acquisition using FNB can be a suitable technique in suspected liver lesions in order to provide an accurate histopathology diagnosis,especially for those who require endoscopy.

关键词： Endoscopic ultrasound-guided liver biopsy Liver tissue acquisition Fine-needle aspiration Fine-needle biopsy Liver tumors Focal liver lesions

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