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Mother-to-Child Transmission of Human Papillomavirus in Burkina Faso

American Journal of Molecular Biology 2024年第1期14卷 13-24页

作者： Koudpoko Madeleine Kabre djénéba Ouermi théodora mahoukèdè zohon.on.fatié porzé wil.ried traore Prosper Bado Abdoul Karim Ouattara Ouamini Pulchérie de Prisca Gnoumou Rogomenoma Alice Ouedraogo Albert théophane Yonli Punya Akouélé Kuassi-Kpede Charlemagne Marie Ragnag-Néwendé Ouedraogo Jacques Simpore Laboratoire de Biologie Moléculaire et de Génétique (LABIOGENE) Université Joseph KI-ZERBO Ouagadougou Burkina Faso Centre de Recherche Biomoléculaire Pietro Annigoni (CERBA) Ouagadougou Burkina Faso Faculté des Sciences de la Santé Université Saint Thomas d’Aquin Ouagadougou Burkina Faso Laboratoire de Biologie Moléculaire H&#244pital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso University Joseph Ki-Zerbo UFR/SDS Ouagadougou Burkina Faso

Introduction: Human papillomavirus (HPV) infection is the most widespread sexually transmitted infection in the world. Today, there is growing evidence that HPV can be transmitted early in life, and one potential route is mother-to-child transmission. data on this route of HPV transmission are scarce in Africa and particularly in Burkina Faso, where no data on the subject are yet available. the aim of our study was to estimate the rate of mother-to-child transmission of HPV infection and to identify circulating genotypes. Methodology: Cervico-uterine samples were collected from 100 full-term pregnant women and, buccal samples were obtained from their newborns at Hopital Saint Camille de Ouagadougou (HOSCO) by the specialist physician. HPV dNA amplification and genotyping were performed by PCR followed by hybridization using the HPV direct Flow Chips kit, detecting 36 genotypes including 18 high-risk and 18 low-risk. Results: the prevalence of HPV in newborns was 8% (8/100). Six (6) HPV-positive neonates had HPV-positive mothers, while 2 HPV-positive neonates had HPV-negative mothers. the vertical transmission rate was 26.09% (6/23). Mother-newborn genotypes were concordant. However, the genotype profile of the newborns was more restricted than that of the mothers. Conclusion: HPV dNA was found in 8% of newborns in our study. the genotype profile of the mother-newborn pair was concordant. Asymptomatic HPV infection in a pregnant woman could constitute a risk factor for vertical transmission.

关键词： Mother-to-Child Transmission Human Papillomavirus PCR Genotypes Burkina Faso

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