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American Journal of Plant Sciences 2011年第1期2卷 15-26页

作者： Hiroshi Hayakawa tetsuya Kobayashi Yukio Minaniya Katsura ito Akira Miyazaki Tatsuya Fukuda Yoshinori Yamamoto 不详

Dried and fresh rhizomes of the spice turmeric (Curcuma longa L.) are well known in traditional medicine, and curcu- min is widely used in various geographic regions. Although there are differences in the amount of curcumin within this species, identification of the candidate line by rhizome is difficult because of the relative simplicity of its morphological characteristics. To accurately identify lines of C. longa with a high content of curcumin, we analysed several sequences of chloroplast DNA. First, to determine the appropriate outgroup taxa in which to conduct infras-pecific analyses of C. longa, we reconstructed the molecular phylogenetic tree of C. longa and its allied species. The results showed that C. aromatica and C. zedoaria are closely related to C. longa. Next, to develop a molecular marker for identifying lines of C. longa with a high content of curcumin, a network analysis using chloroplast microsatellite regions was performed. Results showed that a unique haplotype within C. longa corresponds to the high curcumin content line. Therefore, the chloroplast microsatellite regions used for the analysis allowed us to determine the lines of this species with high cur- cumin content.

关键词： Chloroplast DNA Curcuma Curcuma Longa Curcumin Molecular Analysis

Diffusion-weighted MRI in abdominal oncology:Clinical applications

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World Journal of Gastroenterology 2010年第7期16卷 832-836页

作者： Reiji Sugita Kei ito Naotaka Fujita Shoki Takahashi Department of Radiology Sendai City Medical CenterSendai 983-0824Japan Department of Gastroenterology Sendai City Medical CenterSendai 983-0824Japan Department of Diagnostic Radiology Graduate School of MedicineTohoku UniversitySendai 980-8574Japan

Diffusion-weighted magnetic resonance imaging(DWI) provides image contrast that is different from that obtained by conventional magnetic resonance *** previously,DWI has been used to evaluate various diseases of the central nervous system,several technical advances have expanded the clinical applications of DWI beyond the central nervous *** a result,many reports have been published on the use of DWI in abdominal ***,abdominal DWI has now being focused on evaluation of patients with abdominal *** can be used for pretreatment tumor detection,characterization including predicting tumor response to therapy,monitoring tumor response during therapy,and follow-up study after treatment to detect possible tumor recurrence.

关键词： Diffusion weighted magnetic resonance imaging Abdominal neoplasms

Design and Development of Oblique-Incident Interferometer for Form Measurement of Hand-Scraped Surfaces

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Nanomanufacturing and Metrology 2021年第2期4卷 69-76页

作者： So ito Daiki Kameoka Kimihisa Matsumoto Kazuhide Kamiya Department of Intelligent Robotics Faculty of EngineeringToyama Prefectural University5180KurokawaImizuToyama939-0398Japan

Precision flat surfaces finished by hand-scraping are extensively used in the sliding parts of precision positioning systems or the surface plates of precision measuring *** hand-scraped surfaces are employed to improve the flatness of the machined surfaces and the motion accuracy of the *** numerous depressions of micrometer-scale depth on a scraped surface are thought to prevent wringing and improve the lubrication properties by forming oil *** measurement of the micrometer-scale features of a hand-scraped surface is one of the reasonable methods for investigating its effect on the motion accuracy of the positioning systems or the lubrication properties of the sliding *** a hand-scraped surface is a rough surface composed of micrometric complex features,it is difficult to conduct precision measurement of the three-dimensional surface form using conventional measurement instruments,such as vertical-incident interferometers or stylus-type *** this study,an oblique-incident interferometer based on Abramson interferometry is introduced to measure the form of a rough surface produced by *** this technique can detect high-intensity reflected light on a rough surface,it allows the measurement of the form of the hand-scraped surface in noncontact *** order to shorten the measurement time,the form calculation based on a five-step phase shifting method was introduced.

关键词： Oblique-incident interferometer Abramson interferometry Hand-scraped surface Rough surface Surface form measurement

Surface Emitting THz Wave Parametrical Oscillator Using MgO：LiNbO3

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Chinese Physics Letters 2007年第11期24卷 3153-3156页

作者：张显斌施卫 T. Ikari H. ito Department of Physics Xi'an University of Technology Xi'an 710048 Photo Dynamics Research Center RIKEN 519-1399 Aramaki-Aoba Sendai 980-8577 Japan

Room-temperature operation terahertz （THz） wave source is demonstrated using three MgO：LiNbO3 crystals which have a noncollinear arrangement. The experimental results show that the THz wave can be tunable from 0.8 THz to 3.0 THz, and the peak energy output is 103 pJ/pulse at 1.5 THz. The noncoilinear cavity configuration makes the THz beam have Gaussian-like spatial distribution, small divergence angle, perpendicularly eradiated from the crystal surface. The beam quality factor M2 is measured to be Mx^2 = 1.15, Mx^2 = 1.25 for characterizing the THz wave beam. Experiments also show that the THz beam can be focused by using a polyethylene lens, and the focal spot size is close to the diffraction limit.

关键词： coated conductor buffer layer self-epitaxy CeO2

Influence of normal to high stroke volume on congestive heart failure development after transcatheter aortic valve implantation:case series

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Journal of Geriatric Cardiology 2021年第1期18卷 83-88页

作者： Tomoko Tomioka Tomohiro ito Ryokichi Takahasi Shuhei Tanaka Department of Cardiology South Miyagi Medical CenterShibataJapan

Aortic stenosis(AS)is the most common valvular disease in the older adults'population,and its prevalence will likely continue to increase with the aging society.[1]Surgical aortic valve replacement(SAVR)for elderly patients is known as a high-risk procedure.[2-4]Transcatheter aortic valve implantation(TAVI)is a reasonable alternative to SAVR for older and inoperable patients with AS,and TAVI significantly improves outcomes in elderly patients with severe AS and serious comorbidities,[5,6]TAVI achieves a 20%relative reduction in mortality compared with SAVR.

关键词： aortic mortality implantation

Added value of indocyanine green fluorescence imaging in liver surgery

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 310-317页

作者： Nobuyuki Takemura Kyoji ito Fuyuki Inagaki Fuminori Mihara Norihiro Kokudo Department of Surgery Hepato-Biliary Pancreatic Surgery DivisionNational Center for Global Health and Medicine1-21-1 ToyamaShinjyuku-kuTokyo162-8655Japan

Recently,indocyanine green(ICG)fluorescence imaging has been widely used as a substitute for cholangiography in hepatobiliary surgery,to detect hepatic tumors,for accurate anatomical hepatectomy,and to increase the safety and accuracy of minimally invasive(laparoscopic and robotic)*** clinical relevance of this method has been increasing gradually,as new procedures develop in this *** important roles and the latest added value of ICG fluorescence imaging in liver surgery are discussed in this report.

关键词： Florescence imaging Indocyanine green Hepatocellular carcinoma Colorectal metastasis Hepatectomy Minimally invasive surgery

Recent advances of high-pressure generation in a multianvil apparatus using sintered diamond anvils

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Geoscience Frontiers 2011年第1期2卷 101-106页

作者： Shuangmeng Zhai Eiji ito Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of Education School of Earth and Space Sciences Peking University Beijing 100871 China Institute for Study of the Earth＇s Interior Okayama University Misasa Tottori-ken 682-0193 Japan

The tried and tested multianvil apparatus has been widely used for high-pressure and hightemperature experimental studies in Earth science. As a result, many important results have been obtained for a better understanding of the components, structure and evolution of the Earth. Due to the strength limi- tation of materials, the attainable multianvil pressure is generally limited to about 30 GPa （corresponding to about 900 km of the depth in the Earth） when tungsten carbide cubes are adopted as second-stage anvils. Compared with tungsten carbide, the sintered diamond is a much harder material. The sintered diamond cubes were introduced as second-stage anvils in a 6--8 type multianvil apparatus in the 1980s, which largely enhanced the capacity of pressure generation in a large volume press. With the development of material synthesis and processing techniques, a large sintered diamond cube （14 ram） is now available. Recently, maximum attainable pressures reaching higher than 90 GPa （corresponding to about 2700 km of the depth in the Earth） have been generated at room temperature by adopting 14-mm sintered diamond anvils. Using this technique, a few researches have been carried out by the quenched method or combined with synchrotron radiation in situ observation. In this paper we review the properties of sintered diamond and the evolu- tion of pressure generation using sintered diamond anvils. As-yet unsolved problems and perspectives for uses in Earth Science are also discussed.

关键词： Pressure generation Sintered diamond anvil Multianvil apparatus

Outpatient hybrid endoscopic submucosal dissection with SOUTEN for early gastric cancer,followed by endoscopic suturing of the mucosal defect:A case report

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世界胃肠外科杂志:英文版(电子版) 2023年第8期15卷 1831-1837页

作者： Renma ito Kazuhiro Miwa Yutaka Matano Internal Medicine Komatsu Municipal HospitalKomatsu 923-0961Japan

BACKGROUND Although endoscopic submucosal dissection(ESD)is becoming more common for early gastric cancer,it requires more advanced techniques and a longer treatment duration than endoscopic mucosal *** ESD using a multifunctional snare(SOUTEN)has been reported to be effective for colorectal lesions,as it can reduce treatment *** suturing of post-ESD mucosal defects has been reported to reduce the incidence of ESD-related *** SUMMARY This study reports outpatient hybrid ESD for early gastric cancer using SOUTEN,followed by endoscopic suturing of post-ESD mucosal defects in an 86-year-old *** referral for ESD,a 10-mm flat,depressed lesion was found on the posterior wall of the gastric antrum,the depth of which was expected to be *** his history of delirium,we performed outpatient endoscopic *** procedure used was hybrid ESD using SOUTEN to reduce the duration of treatment and endoscopic suturing of post-ESD mucosal ESD defects to reduce *** procedure time was 62 min and the lesion was completely resected based on histopathological examination,with no reported postoperative *** This safe and useful procedure may be especially important for outpatient endoscopic treatment.

关键词： Outpatient treatment Hybrid endoscopic submucosal dissection Multifunctional snare Early gastric cancer Endoscopic suturing Case report

Mitochondrial control of hematopoietic stem cell balance and hematopoiesis

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Frontiers in Biology 2015年第2期10卷 117-124页

作者： Massimo Bonora Paolo Pinton Keisuke ito Department of Morphology Surgery Experimental Medicine University of Ferrara Section of Pathology Oncologye Experimental~Bi~~~~gySa~b~rat~rY~f~r TechnologiesofAdvanced rherapies(LT.T.A) Ferrara Italy Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research Departments of Cell Biology and Medicine Albert Einstein Cancer Center and Einstein-Sinai Diabetes Research Center Albert Einstein College of Medicine Bronx NY 10461 USA

Hematopoietic stem cells （HSCs） are stem cells from mesodermal derivation that reside in bone marrow and provide blood cells for the whole life of an adult individual, through a process called hematopoiesis. The long lasting support of HSCs for hematopoiesis is permitted by the fine regulation of quiescence and division output. Exit from the quiescent state is to produce a committed and/or stem daughter cells, in an event defined asymmetric or symmetric division. A deregulation in the proportion between asymmetric and symmetric divisions is critical in the appearance of hematological disorders ranging from bone marrow failure to hematological malignancies. Over the past years, several studies have indicated how the metabolism of HSCs is determinant in the regulation of HSC quiescence and commitment process. A metabolism shifted to the glycolytic pathway promotes HSCs quiescence and sustainment of hematopoiesis. Boosting mitochondrial respiration promotes the stem cell commitment followed by stem pool exhaustion, and minimal mitochondrial activity is required to maintain the HSCs quiescence. In the present review are discussed the most recent advances in comprehension of the roles of mitochondria in the hematopoiesis and in the division balance.

关键词： mitochondria metabolism hematopoiesis hematopoietic stem cells division balance hypoxia inducible factor 1alpha (Hif- 1α)

State feedback stabilization of cascaded nonlinear systems with discontinuous connection

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控制理论与应用（英文版） 2008年第1期6卷 45-52页

作者： Maiko HIRANO Tielong SHEN Kazuhisa ito Katutoshi TAMURA Department of Mechanical Engineering Sophia University Tokyo 102-8554 Japan Department of Mechanical Engineering Tottori University Tottori 680-8552 Japan

In practical engineering, many phenomena are described as a discontinuous function of a state variable, and the discontinuity is usually the main reason for the degradation of the control performance. For example, in the set-point control problem of mechanical systems, the static friction （described by a sgn function of velocity of the contacting faces） causes undesired positioning error. In this paper, we will investigate the stabilization problem for a class of nonlinear systems that consist of two subsystems with cascaded connection. We will show the basic idea with a special case first, and then the result will be extended to more general cases. Some interesting numerical examples will be given to demonstrate the effectiveness of the proposed design approach.

关键词： Cascaded connection Discontinuous systems Filippov solution