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中华微生物学和免疫学杂志 2010年第1期30卷 17-20页

作者：曹立宇 Tetsuya Tsukamoto Yoshiharu Takenaka Hisayo Ban 安徽医科大学病理教研室合肥230032 日本爱知癌症中心研究所肿瘤病理学部

目的探讨幽门螺杆菌（Hp）感染在蒙古沙鼠胃类癌发生中的作用及坳去除后对胃类癌发生的影响。方法100只蒙古沙鼠分成7组，A、B为空白对照组，C、D、E、F、G为Hp感染组，其中F、G组Hp感染后再去除。结果空白对照组（A、B组）未见ECL细胞... 详细信息

目的探讨幽门螺杆菌（Hp）感染在蒙古沙鼠胃类癌发生中的作用及坳去除后对胃类癌发生的影响。方法100只蒙古沙鼠分成7组，A、B为空白对照组，C、D、E、F、G为Hp感染组，其中F、G组Hp感染后再去除。结果空白对照组（A、B组）未见ECL细胞增生／异型增生及类癌形成，却感染后（C、D、E组），血清抗Hp IgG抗体、胃泌素水平均明显增高（P〈0．01），ECL细胞增生／异型增生及类癌发生率分别为27．8％（5／18）、31．2％（5／16）、58．3％（14／24）和16．7％（3／18）、31．2％（5／16）、62．5％（15／24），均明显高于对照组（P〈0．01），随着坳感染时间的延长，ECL病变面积明显增加（P〈0．01）；Hp去除后，血清抗Hp IgG抗体、胃泌素水平明显降低，EEL细胞增生／异型增生及类癌的发生率降低，分别为25．0％（4／16）、15．4％（2／13）和37．5％（6／16）、23．1％（3／13）。早期阶段去除Hp（G组），ECL病变发生率及类癌的面积明显低于非去除组（E组）（P〈0．001）。血清抗Hp IgG抗体与胃泌素水平及胃泌素水平与胃类癌的发生呈正相关（P〈0．001）。结论坳感染在蒙古沙鼠胃类癌发生中起重要作用，去除印可有效预防蒙古沙鼠胃类癌的发生。

关键词：胃类癌幽门螺杆菌蒙古沙鼠

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Expression of Osteopontin and caudal-related homeobox gene 2:indications of phenotypes and prognosis in advanced gastric cancer

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福州总医院学报 2010年第4期17卷 212-217页

作者： Xia Zhang Tetsuya Tsukamoto Tsutomu Mizoshita Ban Hisayo Toyoda Takeshi Masae Tatematsu Division of Oncological Pathology Aichi Cancer Center Research Institute 1 - 1Kanokoden Chikusa-ku Nagoya Aichi 464-8681 Japan. Oncology department of Nanjing Command Fuzhou general hospital xi＇ er huan - lu156 Fuzhou 86-350025 China

Objective:To investigate the expression of osteopontin(OPN)and caudal-related homeobox gene 2(CDX2)in advanced gastric cancer,and to correlate them with clinicopathological features.Method:One-hundred and nine patients suffered from gastric cancer recruited.Expression of OPN and CDX2 and other molecular markers were determined using immunohistochemistry method.Results:Total positive rate of OPN expression was 46.79%,and related with depth of cancer invasion and different phenotype(P<0.001),no association with the patient's age,gender,tumor histological type and lymph node metastasis.In different phenotypes of gastric cancers,OPN frequently expressed in CDX2-negative-expressed G and N type(16/109 and 21/109,respectively),and in CDX2-positive-expressed GI and I types expression level were lower.OPN expression reversely correlated with cdx-2 expression(P<0.001).Patients with OPN positive expression had worse 5-year survival,and patients with OPN negative,5-year survival time better(P<0.001).Further analysis revealed patients with OPN-/CDX2+ had better 5-year survival than other three groups including OPN+/CDX2-,OPN-/CDX2-and OPN+/CDX2+.With multivariate analysis for 5-year survival,it suggested that OPN was the most significant predictor of poor prognosis in gastric cancer(P =0.0043),with lymph node metastasis and tumor depth of invasion were also independent indicators(P =0.0359 and P =0.0315,respectively).Conclusion:Osteopontin is a useful prognostic marker in gastric cancer,and combined with CDX2,it may be much more useful for predicting the survival time in advanced gastric cancer patients.Furthermore it also gave us a clue that in gastric cancer,CDX2 may be a transcription factor modulating the expression of osteopontin.

关键词：胃癌肿瘤症状临床分析

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Gastric-and-Intestinal Mixed Intestinal Metaplasia Is Irreversible Point with Eradication of Helicobacter pylori

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Open Journal of Pathology 2016年第2期6卷 93-104页

作者： Yuka Kiriyama Tomomitsu Tahara Tomoyuki Shibata Masaaki Okubo Mitsuru Nakagawa Asako Okabe Naoki Ohmiya Makoto Kuroda Atsushi Sugioka Masao Ichinose Masae Tatematsu Tetsuya Tsukamoto Department of Diagnostic Pathology School of Medicine Fujita Health University Toyoake Aichi Japan Department of Gastroenterology School of Medicine Fujita Health University Toyoake Aichi Japan Department of Hepatobiliary and Liver Transplant Surgery School of Medicine Fujita Health University Toyoake Japan Second Department of Internal Medicine Wakayama Medical University Wakayama Japan Japan Bioassay Research Center Hadano Japan

Helicobacter pylori (H. pylori) represents an important factor in the development of atrophic gastritis, intestinal metaplasia (IM), and gastric cancer. Eradication of H. pylori has been reported to prevent gastric cancer only in cases without atrophy or IM. However, histological changes with eradication have yet to be fully clarified. We evaluated 38 H. pylori-positive cases before and after eradication at the gland level;pyloric glands were classified as showing gastric proper (G) and IM gland types, with the latter including gastric-and-intestinal mixed IM (GI-IM) and solely intestinal IM (I-IM), depending on the remaining gastric phenotypes. On eradication, acute and chronic inflammation attenuated rapidly and gradually, respectively, whereas levels of MUC5AC and MUC6 expression were not markedly altered. Gland width, size of nuclei and cytoplasm and their ratio in surface foveolar epithelium, the number of Ki-67-positive cells and the length of the proliferating zone in each gland were significantly decreased in G glands after eradication compared with those in GI-IM and I-IM. The number of mitotic phase cells, positive for phosphorylated histone H3 at serine 28, was increased in both types of IM compared to that in G glands in the H. pylori-infected state, but unexpectedly remained unchanged with eradication. These results suggest that GI-IM, as the beginning of IM, could represent a histological irreversible point with eradication and be considered as a “histological point of no return”.

关键词： Helicobacter pylori Chronic Atrophic Gastritis Intestinal Metaplasia Eradication Stomach

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