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Spatial Cell Signaling Mediated by Microtubule Regulations in Neurons

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Spatial Cell Signaling Mediated by Microtubule Regulations i...

Numerical Simulation of Wake Deflection Control around NACA0012 Airfoil Using Active Morphing Flaps

The 1st International Symposium on Brain Function and Disorders（SBFD）

作者： YOSHIYUKI konishi Molecular Imaging Frontier Research Center Hamamatsu University School of Medicine

＜正＞To shape organs,it is crucial to regulate number and position of cells as well as cellular *** processes are especially important in the nervous system,in which neurons make connection with specific target,thereby enable to process *** cellular processes such as differentiation,migration,survival,morphogenesis and

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Journal of Flow Control, Measurement & Visualization 2020年第3期8卷 121-133页

作者： Yoshiaki Abe Takayuki konishi Tomonaga Okabe Tohoku University Institute of Fluid Science Katahira Sendai Japan

This study demonstrates an active flow control for deflecting a direction of wake vortex structures behind a NACA0012 airfoil using an active morphing flap. Two-dimensional direct numerical simulations are performed for flows at the chord Reynolds number of 10,000, and the vortex pattern in the controlled and noncontrolled wakes as well as the effect of an actuation frequency on the control ability are rigorously investigated. It is found that there is an optimum actuation-frequency regime at around F + = 2.00 which is normalized by the chord length and freestream velocity. The wake vortex pattern of the well-controlled case is classified as the 2P wake pattern according to the Williamson’s categorization [1] [2], where the forced oscillation frequency corresponds to the natural vortex shedding frequency without control. The present classification of wake vortex patterns and finding of the optimum frequency regime in the wake deflection control can lead to a more robust design suitable for vortex-induced-vibration (VIV) related engineering systems.

关键词： Flow Control Wake Deflection Control Vortex Morphing Flap Direct Numerical Simulation Unsteady Flow Simulation

Investigation of Inspiratory Circuit Condensation due to Room Temperature in a Heated Humidifier during Mechanical Ventilation

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Open Journal of Emergency Medicine 2022年第4期10卷 176-182页

Heating and humidification control during mechanical ventilation is important. Water condensation can occur due to insufficient humidification. Condensation in the breathing circuit can cause various adverse events. In this study, we investigated whether the occurrence of tubing condensation in the breathing circuit could be affected by room temperature using a simulated respiratory circuit with a humidifier. The room temperature was set at 23°C, 25°C, and 27°C, and mechanical ventilation was performed for 8 h. The inspired gas was appropriately heated and humidified according to the manufacturer’s instructions. The weight of the circuit was measured every 2 h at room temperature to estimate the amount of condensation. During the mechanical ventilation, condensation continued to increase at a room temperature of 23°C, but only for the first 2 h at 25°C, and did not occur at 27°C. The room temperature of the indoor environment was one of the factors generating water condensation in the breathing circuit with a humidifier even when a heater wire in the breathing circuit was appropriately operated.

关键词： Room Temperature Heated Humidifier Mechanical Ventilation

A Case of Multiple Idiopathic Root Resorption

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Open Journal of Stomatology 2023年第4期13卷 156-165页

作者： Ryosuke konishi Arisa Mori Takeshi Yoshida Department of Oral and Maxillofacial Surgery Graduate School of Medicine Kyoto University Kyoto Japan

Tooth root resorption is multifactorial, and its etiology and pathogenesis are poorly understood. Tooth root resorption is often incidentally revealed on radiographic examination. Here, we report a case of root resorption in multiple teeth of unknown etiology. Radiographic examination revealed root resorption in the cervical region of the left lateral incisor, canine, first and second premolars, and first and second molars of the mandible. Panoramic radiographs revealed no mandibular lesions that could cause tooth resorption. The patient did not wish to undergo any treatment and is currently under observation. Tooth root resorption with unknown etiology is rare, and further case collection is needed to determine the cause and treatment.

关键词： Multiple Teeth Cement Enamel Junction External Cervical Resorption

Histological mixed-type as an independent prognostic factor in stageⅠgastric carcinoma

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World Journal of Gastroenterology 2015年第2期21卷 549-555页

作者： Shuhei Komatsu Daisuke Ichikawa Mahito Miyamae Hiroki Shimizu Hirotaka konishi Atsushi Shiozaki Hitoshi Fujiwara Kazuma Okamoto Mitsuo Kishimoto Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Surgical Pathology Kyoto Prefectural University of MedicineKyoto 602-8566Japan

AIM: To evaluate the clinicopathological features of mixed-type gastric cancer and their influence on prognosis of mixed-type stageⅠgastric ***: We analyzed 446 patients who underwent curative gastrectomy for stageⅠgastric cancer between 1999 and 2009. The patients were divided into two groups: those with differentiated or undifferentiated cancer(non-mixed-type, n = 333) and those with a mixture of differentiated and undifferentiated cancers(mixed-type, n = 113).RESULTS: The overall prevalence of mixed-type gastric cancer was 25.3%(113/446). Compared with patients with non-mixed-type gastric cancer, those with mixedtype gastric cancer tended to be older at onset(P = 0.1252) and have a higher incidence of lymph node metastasis(P = 0.1476). They also had significantly larger tumors(P < 0.0001), more aggressive lymphatic invasion(P = 0.0011), and deeper tumor invasion(P < 0.0001). In addition, they exhibited significantly worse overall survival rates than did patients with non-mixedtype gastric cancer(P = 0.0026). Furthermore, mixedtype gastric cancer was independently associated with a worse outcome in multivariate analysis [P = 0.0300, hazard ratio = 11.4(1.265-102.7)].CONCLUSION: Histological mixed-type of gastric cancer contributes to malignant outcomes and highlight its usefulness as a prognostic indicator in stageⅠgastric cancer.

关键词： Mixed-type gastric cancer Histological type Progno

Liver metastasis is the only independent prognostic factor in AFP-producing gastric cancer

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World Journal of Gastroenterology 2013年第36期19卷 6055-6061页

作者： Shoji Hirajima Shuhei Komatsu Daisuke Ichikawa Takeshi Kubota Kazuma Okamoto Atsushi Shiozaki Hitoshi Fujiwara Hirotaka konishi Hisashi Ikoma Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of Medicine

AIM:To investigate differences between common gastric cancer andα-fetoprotein(AFP)-producing gastric cancer according to the presence or absence of liver ***:Between 1997 and 2011,1299 patients underwent gastrectomy for gastric cancer(GC)at our institute and their hospital records were reviewed *** were immunohistochemically divided into two groups:23 patients(1.8%)with AFPproducing GC and 1276 patients(98.2%)without ***:AFP-producing GC patients had a significantly higher incidence of deeper tumors,venous invasion,lymphatic invasion,lymph node metastasis,and liver metastasis and a poorer prognosis(P<0.005)than those without AFP-producing ***,multi-variate analysis revealed that AFP-positivity was not an independent prognostic *** prognosis of AFPproducing GC was similar to that of AFP-non producing GC according to the presence or absence of liver *** recurrence,47.8%of patients(11/23)with AFP-producing GC and 20.0%of patients(256/1276)without AFP-producing GC exhibited *** metastasis[90.9%(10/11)]was the most prevalent in AFP-producing GC *** analysis revealed that liver metastasis was the only independent prognostic factor in AFP-producing GC(HR=17.6,95%CI:2.1-147.1;P=0.0081).CONCLUSION:AFP-producing GC is similar to common GC without liver metastasis,which should be specifically targeted in an effort to improve the prognosis of AFP-producing GC patients.

关键词： α-fetoprotein Gastric cancer Liver metastasis Poor prognosis Immunostaining

Application of Tunable Diode Laser Absorption Spectroscopy with Optical Hollow Fiber to Engine Exhaust Gas Measurement

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Journal of Mechanics Engineering and Automation 2012年第11期2卷 656-662页

作者： Akira Adachi Yoshihiro Deguchi Shinichirou konishi Graduate School of Advanced Technology and Science The University of Tokushima Tokushima 770-8506 Japan

In recent years, tighter regulation has been already enforced on harmful substances such as NOx, CO, and particles. Considering the above situation, it is important to monitor controlling factors of engine systems in order to improve efficiencies of their operations. As to car engines, an increasing concern in environmental issues such as air pollution, global warming and petroleum depletion has helped drive researches into various ways. Laser diagnostics has been applied to measure species concentration in the actual industrial fields. However there are several challenges to proceed in applying laser diagnostics to practical application. Especially stability of the measurement system is one of the most difficult issues. The purpose of this research is the development of a prompt measurement technique which can be applicable to various engine conditions. The Tunable Diode Laser Absorption Spectroscopy （TDLAS） using the hollow fiber has been developed to satisfy above requirements. By using a hollow fiber, misalignment of an optical axis and vulnerability of measurement environment such as vibration can be greatly reduced with sensitive and fast response features. It was demonstrated that this method can be applicable to measure gas compositions in engine exhaust with a range of millisecond response time. A sensitive method using tunable UV diode laser absorption spectroscopy was also discussed to detect NOx in exhausts.

关键词： Tunable diode laser absorption spectroscopy optical hollow fiber exhaust gas concentration measurement.

PRECISION POLYMERIZATION OF DESIGNED PHENOL: A NEW ASPECTS OF PHENOLIC RESIN

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PRECISION POLYMERIZATION OF DESIGNED PHENOL: A NEW ASPECTS O...

Assessment the Optimal Effect of Time of Repetition: Extrinsic Pulse Parameter on Gd-DTPA Enhanced, Spin-Echo T1-Weighted MR Images under Low Magnetic Field Strength

第四届国际高分子化学学术讨论会

作者： Gen-ichi konishi Department of Organic ＆ Polymeric Materials Tokyo Institute of Technology

＜正＞Phenolic resins and related polymers are a very important class of common organic polymers,and they have numerous applications in the development of materials such as thermosetting resins,adhesives,photoresists,and polymer *** main characteristics of phenolic resins,such as heat stability and mechanical properties,are attributed to their rigid rod-like polymer backbone of

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2016年第3期5卷 196-203页

作者： Bimali Sanjeevani Weerakoon Toshiaki Osuga Takehisa konishi Graduate School of Advanced Integration Science Chiba University Chiba Japan Department of Radiography/Radiotherapy Faculty of Allied Health Sciences University of Peradeniya Peradeniya Sri Lanka Center for Frontier Medical Engineering Chiba University Chiba Japan

The contrast agent concentration, the time of repetition (TR) and magnetic field strength are significant parameters that influence for the accurate signal intensity (SI) in quantitative Magnetic Resonance Imaging (MRI). Therefore, this study was conducted to investigate and refine the dependence and the optimal effect of Time of Repetition (TR) on the relationship between signal intensity and Gd-DTPA (Gadolinium-diethylene-triaminepenta-acetic acid) concentration, after applying two-dimensional (2D) Spin Echo (SE) pulse sequence under low-field MRI. In addition to that, the optimal concentration of Gd-DTPA at given sequence parameters at low-field MRI was also evaluated. A water-filled phantom was constructed for a range of Gd-DTPA concentrations (0 - 6 mmol/L) and the mean signal intensities (SIs) were assessed in the defined region of interest on T1-weighted images with different TR values (40 - 2000 ms). The generated signal-concentration curves for Gd-DTPA revealed that increasing TR was associated with the increase of the overall SIs and the maximum relationship between SI to concentration. Moreover, the required Gd-DTPA concentration to produce the maximum SI was associated to decrease with the increase of TR. In addition to this, the application of beyond 100 ms TR values in this study with relatively higher concentrations (beyond 1 - 2 mmol/L) has resulted predominantly non-linear patterns in the signal-concentration curves and it appears the saturation or decay of the SIs due to T2 effect. From these results, it can be suggested that the selection of relatively lower Gd-DTPA concentration ( mmol/L) with less than 800 ms (<800 ms) TR values can produce a better linear relationship between the concertation and SIs in T1-weighted SE low field contrast-enhanced MRI. Furthermore, this study also outlined the significance and necessity of the optimization of TR in SE sequence in low field MRI prior to a particular examination.

关键词： Gd-DTPA Concentration Spin Echo Pulse Sequence Signal Intensity Time of Repetition T1-Weighted Images Low Field MRI