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Journal of Mountain Science 2019年第2期16卷 383-401页

作者： Andang Suryana SOMA tetsuya kubota Hideaki MIZUNO Faculty of Forestry Hasanuddin University Faculty of Agriculture Kyushu University

Landslide susceptibility maps(LSMs) play a vital role in assisting land use planning and risk mitigation. This study aims to optimize causative factors using logistic regression(LR) and an artificial neural network(ANN) to produce a LSM. The LSM is produced with 11 causative factors and then optimized using forward-stepwise LR(FSLR), ANN, and their combination(FSLR-ANN) until eight causative factors were found for each method. The ANN method produced superior validation results compared with LR. The ROC values for the training data set ranges between 0.8 and 0.9. On the other hand, validation with the percentage of landslide fall into LSM class high and very high, ANN method was higher(92.59%) than LR(82.12%). FSLR-ANN with nine causative factors gave the best validation results with respect to area under curve(AUC) values, and validation with the percentage of landslide fall into LSM class high and very high. In conclusion, ANN was found to be better than LR when producing LSMs. The best Optimization was combination of FSLR-ANN with nine causative factors and AUC success rate 0.847, predictive rate 0.844 and validation with landslide fall into high and very high class with 91.30%. It is an encouraging preliminary model towards a systematic introduction of FSLR-ANN model for optimization causative factors in landslide susceptibility assessment in the mountainous area of Ujung Loe Watershed.

关键词： Optimized causative factor Landslide, Logistic Regression Artificial neural network Indonesia

Eco-morphological characteristics of fern species for slope conservation

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Journal of Mountain Science 2019年第3期16卷 504-515页

作者： Laura SANCHEZ-CASTILLO Ken’ichirou KOSUGI Naoya MASAOKA tetsuya kubota Faculty of Forestry Sciences Autonomous University of Nuevo Leon Forest and Biomaterials Science Division Graduate School of AgricultureKyoto University Forest Environment Science Division Faculty of AgricultureKyushu University

Degradation of slopes due to shallow landslide and the subsequent erosional processes are a big challenge on the application of soil bioengineering techniques; that is the use of plants as main structural components of a slope protection and conservation system. An optimal application of soil bioengineering techniques should include not only the technical factor of plants as structural components but also the ecology of species and the plant adaptations to disturbances, which is crucial if a longterm successful slope restoration system is intended. Ferns are a dominant understory vegetation species in the forest of Japan, but its characteristics and influences on the recovery of shallow landslide scars have not been fully studied yet. This study aims to find out the ecological characteristics of fern species through the calculation of ecological indicators and the quantification of the morphological features of specimens growing on disturbed and non-disturbed forest slopes in Japan. Gleichenia japonica was found as the vegetation species with biggest ecological indicators on both slopes. The analysis of morphological characteristics of the specimens growing on both sites showed that the development of the specimens is focused in below-ground characteristics. The pull-out force of Gleichenia japonica root system as an indicator of ecological adaptation to a constraint environment and morphological characteristics quality is influenced by height and root length according to the principal component analysis. The eco-morphological characteristics of species can be used as an indicator of an optimal element in soil bioengineering establishment for slope conservation proposes. The long and fibrous root system could be placed on forest roads, steep or small slopes where space limitation is an issue for the establishment of bigger species and if the slope conditions allow it, it can control soil losses due to rainfall and provide stability.

关键词： Slope conservation Soil bioengineering Root system Shallow landslide Natural regeneration

Role of innate lymphoid cells(ILCs) in the induction of diet induced obesity

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Role of innate lymphoid cells(ILCs) in the induction of diet...

A Phase II Study of Erlotinib in Patients with Previously Treated Non-Small Cell Lung Cancer

第九届全国免疫学学术大会

作者： Takaharu Sasaki Kazuyo Moro tetsuya kubota Naoto kubota Takashi Kadowaki Shigeo Koyasu Laboratory for Immune Cell System RIKEN Center for Integrative Medical Sciences(IMS) Graduate School of Pharmaceutical Sciences The University of Tokyo Division of Immunobiology Department of Medical Life Science Graduate School of Medical Life ScienceYokohama City University precursory Research for Embryonic Science and Technology(PRESTO) Japan Science and Technology Agency Laboratory for Metabolic Homeostasis RIKEN Center for Integrative Medical Sciences(IMS) Department of Diabetes and Metabolic Diseases Graduate School of MedicineUniversity of Tokyo Department of Microbiology and Immunology Keio University School of Medicine

Obesity is now recognized as a global *** this pathological condition,low grade inflammation takes place but how the immune system is involved in the initiation of obesity is *** this study,we aimed to elucidate the r...

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Advances in Lung Cancer 2014年第1期3卷 10-20页

作者： tetsuya kubota Yoshio Okano Mizu Sakai Takashi Yamane Naoki Shiota Hiroshi Ohnishi Hisanori Machida Nobuo Hatakeyama Eiji Takeuchi Tomoyuki Urata Fumitaka Ogushi Akihito Yokoyama Department of Hematology and Respiratory Medicine School of Medicine Kochi University Kochi Japan Division of Pulmonary Medicine Kochi Medical Center Kochi Japan Division of Pulmonary Medicine Kochi Red Cross Hospital Kochi Japan Division of Pulmonary Medicine NHO Kochi Hospital Kochi Japan

Background: Erlotinib has been reported to be effective for the treatment of non-small cell lung cancer (NSCLC). To evaluate the efficacy and safety of erlotinib under conditions similar to daily clinical practice, a phase II trial was conducted in Japanese patients with previously treated NSCLC. Methods: The eligibility criteria were stage IIIB/IV NSCLC, a performance status (PS) of 0 - 2, and previous treatment with 1 - 2 non-EGFR-TKI regimens. Patients received erlotinib (150 mg/day) orally until disease progression or intolerable toxicity occurred. The primary endpoint was the objective response rate (ORR). In addition, the disease control rate (DCR), progression-free survival (PFS), overall survival (OS), safety, and EGFR gene mutation status were evaluated. Results: Thirty-eight patients were enrolled, and 37 patients were evaluated. The median age was 69 years (range, 50 - 80 years). Patient characteristics were as follows: 26 were male and 11 were female;12 had a PS of 0, 20 had a PS of 1, and 5 had a PS of 2;and 26 had adenocarcinoma, and 11 had non-adenocarcinoma histology. The ORR and DCR were 21.6% (95% confidence interval [CI], 11.4% - 37.2%) and 54.1% (95% CI, 35.9% - 66.6%), respectively. Twenty-seven patients could be evaluated for EGFR gene status (12, mutated;15, wild-type). The ORR for EGFR-mutated patients was 41.7%, while that for patients with wild-type EGFR was 13.3%. The median PFS was evaluated as 4.4 months (95% CI, 2.2 - 10.7 months). The median OS was 14.9 months (95% CI, 9.2 months - not reached). Common adverse events were tolerable skin toxicities, diarrhea, and stomatitis. In addition, interstitial lung disease occurred in 8.1% of patients. Conclusion: As efficacy and safety were similar to previous studies, erlotinib was found to be effective for Japanese patients with previously treated NSCLC in clinical practice.

关键词： Non-Small Cell Lung Cancer Phase II Study Erlotinib Previously Treated

Tone Modulation in a Passive OTDM Multiplexer for Clock Recovery from a 160 Gbit/s OTDM Signal

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光学学报 2003年第S1期23卷 591-592页

作者： tetsuya. Miyazaki Fumito kubota Communications Research Laboratory 4-2-1 Nukui-kita Koganei Tokyo 184-8795 JapanCommunications Research Laboratory 4-2-1 Nukui-kita Koganei Tokyo 184-8795 Japan

Tone modulation in a passive OTDM multiplexer for clock recovery from a 160-Gbit/s OTDM signal by using a base-rate receiver is demonstrated. We performed synchronous demultiplexing in back-to-back arrangement and opt... 详细信息

关键词： OTDM Tone Modulation in a Passive OTDM Multiplexer for Clock Recovery from a 160 Gbit/s OTDM Signal in for from

NUMERICAL PREDICTION OF DYNAMIC PERFORMANCE OF PELTON TURBINE

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Journal of Hydrodynamics 2007年第3期19卷 356-364页

作者： kubota Takashi College of Electric Power South China University of Technology Guangzhou 510640 China

Different from the reaction turbines, the hydraulic performance of Pelton turbine is dynamic due to the unsteady flow in the rotating buckets in time and space. The dynamic energy efficiency of bucket ηεB and power efficiency of bucket ηPB within a short period can be predicted from the dynamic flow pattern of the free-surface sheet flow in the rotating bucket, whereas the dynamic discharge efficiency of bucket ηQB is defined as the resident discharge in the bucket at the respective moment. Under the operation of higher unit speed non than the optimum one, the power efficiency of bucket is deteriorated by the jet interference with the rear surface of bucket △Prear at the first stage of the dynamic performance, as well as the loss power due to the spilt flow from the cutout of bucket at the later stage of performance. Based on the dynamic performance prediction presented, the future possibility of the quantitative investigation for the negative scale effect of Pelton turbines was discussed.

关键词： dynamic energy efficiency dynamic discharge efficiency dynamic power efficiency rotating bucket Pelton turbine

S-1 induced secondary acute erythroid leukemia with a chromosome inv(12)(p13;q13)

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World Journal of Gastroenterology 2011年第41期17卷 4632-4634页

作者： Kensuke Matsumoto Akira Kitanaka Makiko Uemura Fusako Waki tetsuya Fukumoto Hiroaki Ohnishi Yoshitsugu kubota Toshihiko Ishida First Department of Internal Medicine Faculty of MedicineKagawa Univesity Hematology Faculty of MedicineKagawa Univesity Department of Transfusion Medicine Kagawa University

Adjuvant chemotherapy by S-1 following gastrectomy is considered standard treatment in *** of follow-up data have proved the effi cacy of S-1 admin-istration,and that hematological adverse events were relatively *** anti-metabolites,including S-1,have shown relatively lower risks for secondary hematological malignancies in comparison to alkylat-ing agents and topoisomerase-Ⅱ *** here report a case of therapy-related leukemia after S-1 administration.A patient who had received S-1as the sole adjuvant chemotherapy was diagnosed with acute erythroid *** the best of our knowledge,our patient represents the fi rst report of S-1 induced acute leukemia.

关键词： S-1 Secondary leukemia Acute erythroidLeukemia Gastric cancer

740 Gbit/s (37 x 20 Gbit/s) DWDM Transmission Experiment Using Er^(3+)-Doped Tellurite Fiber Amplifiers and Distributed Raman Amplification

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光学学报 2003年第S1期23卷 569-570页

作者： Hiroyuki Toda Maoki Suzuki Ryo Takami tetsuya Miyazaki Takeshi Makino Fumito kubota Graduate School of Engineering Osaka University 2-1 Yamada-Oka Suita Osaka 565-0871 Japan Communications Research Laboratory 4-2-1 Nukui-Kitamachi Koganei Tokyo 184-8795 Japan

We demonstrate 740 Gbit/s (37 x 20 Gbit/s) DWDM recirculating transmission experiment with 59 nm continuous bandwidth over 300 km by employing Er3+-doped tellurite fiber amplifiers. The use of Raman amplification is e... 详细信息

关键词： Raman Amplification transmission bandwidth Raman amplification fiber amplifiers

Unsteady separation of jet branch by cutout of rotating Pelton bucket

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Science China(Technological Sciences) 2011年第2期54卷 302-310页

作者： kubota Takashi College of Electric Power South China University of Technology

As a part of boundaries for a free curved surface of a Pelton bucket,the cutout is indispensable to secure the smooth entrance of the unsteady inflow of water jet into the rotating *** cutout of the rotating bucket unsteadily separates a free jet into two branches in both space and time:the impinging branch landing on the relevant bucket surface,and the flow-off branch separated by the cutout toward the preceding *** order to investigate the unsteady jet separation by the cutout three-dimensionally,a semicircular free jet was discretized into 641 nodes of boundary-fitted *** position P of impinging jet branch landing on the bucket surface was acquired with the relative velocity W and the water depth D at each *** trailing edge surface of the flow-off jet branch was simultaneously computed *** complicate unsteady interaction of the bucket cutout with the branched free jets was clarified visually with the 3D view of illustrations in order to research the unsteady hydraulic performance of Pelton turbines in space and time.

关键词： cutout rotating bucket jet branch trailing edge surface of jet unsteady in space and time

Nerve conduction models in myelinated and unmyelinated nerves based on three-dimensional electrostatic interaction

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Neural Regeneration Research 2018年第5期13卷 779-785页

作者： tetsuya Akaishi Department of Neurology Tohoku University Graduate School of Medicine Department of Neurology Yonezawa National Hospital

Until now, nerve conduction has been described on the basis of equivalent circuit model and cable theory, both of which supposed closed electric circuits spreading inside and outside the axoplasm. With these conventional models, we can simulate the propagating pattern of action potential along the axonal membrane based on Ohm＇s law and Kirchhoff＇s law. However, we could not fully explain the different conductive patterns in unmyelinated and myelinated nerves with these theories. Also, whether we can really suppose closed electrical circuits in the actual site of the nerves or not has not been fully discussed yet. In this report, a recently introduced new theoretical model of nerve conduction based on electrostatic molecular interactions within the axoplasm will be reviewed. With this new approach, we can explain the different conductive patterns in unmyelinated and myelinated nerves. This new mathematical conductive model based on electrostatic compressional wave in the intracellular fluid may also be able to explain the signal integration in the neuronal cell body and the back-propagation mechanism from the axons to the dendrites. With this new mathematical nerve conduction model based on electrostatic molecular interactions within the intracellular fluid, we may be able to achieve an integrated explanation for the physiological phenomena taking place in the nervous system.

关键词： nerve conduction ion channels electrostatic interactions electrostatic compressional wave saltatory conduction myelinated nerves unmyelinated nerves saltatory equations