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Enhancing Erectile Function and Alleviating Andropause Symptoms: Clinical Efficacy of a Human Stem Cell Conditioned Medium Cream

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Health 2024年第7期16卷 626-634页

作者： Hoichi amano eHealth Clinic Shinjuku Tokyo Japan Graduate School of Public Health Teikyo University Tokyo Japan

Erectile dysfunction (ED) is increasingly prevalent in Japan, exceeding 30%, and increasing with age. Unhealthy lifestyle habits, obesity, insufficient exercise, and smoking have been implicated in its pathogenesis, along with endothelial dysfunction of the corpora cavernosa and impaired blood flow to the penis considered underlying factors. However, the current treatments are limited to Phosphodiesterase-5 (PDE5) inhibitors. ED is the primary symptom of andropathy. This study reports the clinical efficacy of human stem cell-conditioned medium cream for ED treatment. Ten men without underlying diseases suspected of andropause with ED (mean age 43.2 ± 4.4 y, Hb 15.2 ± 0.6 gm/dL, AST/ALT 30.2/37.9 ± 12.4/14.0, eGFR 82.7 ± 12.4 mL/min/1.73 m2) were targeted. The cream was applied twice daily to the genital and scrotal areas. The erectile hardness score (EHS), International Index of Erectile Function-5 (IIEF-5), and Aging Male Symptoms (AMS) scale were used to evaluate the participants before and 30 days after use, and the results were compared using paired t-tests. The post-use qualitative opinions were collected through interviews. Significant improvements were observed compared to baseline in the IIEF-5 (11.8 ± 4.6→17.2 ± 5.1, P < 0.001), and AMS (46.3 ± 6.7→37.6 ± 5.3, P < 0.001) scores post cream use. EHS did not show a statistically significant difference, but a trend towards improvement was observed. Qualitative feedback included increased morning erection, improved maintenance of erection during intercourse, and reduced post work fatigue. Human stem cell-conditioned medium contains endothelial growth factors that potentially contribute to the improvement of ED and andropause by enhancing corporal endothelial function. Future studies should include control groups to further investigate the efficacy of these treatments.

关键词： Erectile Dysfunction Andropause Human Stem Cell Conditioned Medium Cream Stem Cell

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Evaluation of mitral chordae tendineae length using four-dimensional computed

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World Journal of Cardiology 2024年第5期16卷 274-281页

作者： Takuya Mori Satoshi Matsushita Terumasa Morita Abulaiti Abudurezake Junji Mochizuki Atsushi amano Department of Cardiovascular Surgery Juntendo University Faculty of MedicineTokyo 113-8421Japan Department of Cardiovascular Surgery JACCT Japan Animal Cardiovascular Care TeamOsaka 533-0033Japan Department of Radiology Minamino Cardiovascular HospitalTokyo 192-0918Japan

BACKGROUND Mitral valvuloplasty using artificial chordae tendineae represents an effective surgical approach for treating mitral *** precise measurements of artificial chordae tendineae length(CL)is an important factor in the procedure;however,no objective index currently exists to facilitate this ***,preoperative assessment of CL is critical for surgical planning and ***-dimensional x-ray micro-computed tomography(4D-CT)may be useful for accurate CL measurement considering that it allows for dynamic three-dimensional(3D)evaluation compared to that with transthoracic echocardiography,a conventional inspection *** To investigate the behavior and length of mitral chordae tendineae during systole using *** Eleven adults aged>70 years without mitral valve disease were evaluated.A 64-slice CT scanner was used to capture 20 phases in the cardiac cycle in electrocardiographic *** length of the primary chordae tendineae was measured from early systole to early diastole using the 3D *** primary chordae tendineae originating from the anterior papillary muscle and attached to the A1-2 region and those from the posterior papillary muscle and attached to the A2-3 region were designated as cA and cP,*** behavior and maximum lengths[cA(ma),cP(max)]were compared,and the correlation with body surface area(BSA)was *** In all cases,the mitral anterior leaflet chordae tendineae could be *** most cases,the cA and cP chordae tendineae could be measured *** mean cA(max)and cP(max)were 20.2 mm±1.95 mm and 23.5 mm±4.06 mm,***(max)was significantly *** correlation coefficients(r)with BSA were 0.60 and 0.78 for cA(max)and cP(max),*** cA and cP exhibited constant variation in CL during systole,with a maximum 1.16-fold increase in cA and a 1.23-fold increase in cP from early to *** cP,CL reached a plateau at 15%and remaine

关键词： Mitral valve Chordae tendineae Computed tomography Four-dimensional Cardiac cycle

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单次静脉注射尼可地尔对ST段抬高的急性心肌梗死再灌注前的影响

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首都食品与医药 2015年第14期22卷 111-112页

作者： Hideki Ishii Satoshi Ichimiya Masaaki Kanashiro tetsuya amano Kenji Imai Toyoaki Murohara Tatsuaki Matsubara 田玉敬不详北京四环科宝制药有限公司 100079

主要临床结果见附表3。终点定义为心血管死亡或者因CHF入院,12（6.5%）例病人接受尼可地尔治疗,30（16.4%）人给予安慰剂（危害比,0.39;95%CI,0.20~0.76;P=0.0058）（见附图）。尼可地尔组有6（3.2%）例病人,安慰剂组有20（10.9%）例病... 详细信息

主要临床结果见附表3。终点定义为心血管死亡或者因CHF入院,12（6.5%）例病人接受尼可地尔治疗,30（16.4%）人给予安慰剂（危害比,0.39;95%CI,0.20~0.76;P=0.0058）（见附图）。尼可地尔组有6（3.2%）例病人,安慰剂组有20（10.9%）例病人因CHF恶化而意外入院治疗（危害比,0.29;95%CI,0.11~0.71;P=0.0072）。

关键词：尼可地尔 ST段抬高单次静脉注射安慰剂再灌注心律失常冠心病死亡血栓溶解疗法连续输注再灌注损伤下壁

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单次静脉注射尼可地尔对ST段抬高的急性心肌梗死再灌注前的影响

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首都食品与医药 2015年第12期22卷 103-104页

作者： Hideki Ishii Satoshi Ichimiya Masaaki Kanashiro tetsuya amano Kenji Imai Toyoaki Murohara Tatsuaki Matsubara 田玉敬不详北京四环科宝制药有限公司 100079

血栓溶解冠状再灌注和/或经皮冠状介入（PCI）被广泛用于治疗急性心肌梗塞（AMI）。完全闭塞冠状动脉的早期再灌注减少了梗塞面积、心脏死亡率和病人住院率。药理学治疗与再灌注治疗结合也可以减轻AMI伴随的心肌功能障碍。近期临床实验... 详细信息

血栓溶解冠状再灌注和/或经皮冠状介入（PCI）被广泛用于治疗急性心肌梗塞（AMI）。完全闭塞冠状动脉的早期再灌注减少了梗塞面积、心脏死亡率和病人住院率。药理学治疗与再灌注治疗结合也可以减轻AMI伴随的心肌功能障碍。近期临床实验显示,尼可地尔是一个三磷酸腺苷–敏感的钾离子通道开启器和硝酸盐的混合体,能够作为缺血性心脏病的辅助治疗手段发挥有益的作用。实验证明,这些效应由于缺血预适应促成了心脏保护。静脉注射尼可地尔能够改善AMI病人的早期机能和临床问题,然而,其对后续状态的作用尚不明确,并且AMI患者在进行再灌注前单独注射尼可地尔是否有效还没有有力的数据支撑。

关键词：尼可地尔 ST段抬高再灌注治疗单次静脉注射梗塞面积急性心肌梗塞缺血性心脏病缺血预适应钾离子通道心肌功能障碍

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静脉注射尼可地尔对短期和长期患有心绞痛的急性ST段抬高型心肌梗塞患者的影响

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首都食品与医药 2015年第18期22卷 87-88页

作者： Hideki Ishii Satoshi Ichimiya Masaaki Kanashiro tetsuya amano Yasuhiro Ogawa Hirotsugu Mitsuhashi Shinichi Sakai Tadayuki Uetani Ryuichiro Murakami Keiko Naruse Toyoaki Murohara Tatsuaki Matsubara 王青不详北京四环科宝制药有限公司 100079

（接8月下）在这篇文章的研究中,每组又被分为2个子组：给予52名前驱心绞痛患者安慰剂,给予129名非前驱心绞痛患者尼克地尔治疗,给予56名前驱心绞痛患者尼克地尔治疗,给予131名非前驱心绞痛患者安慰剂。前驱心绞痛被定义为急性心肌梗死... 详细信息

（接8月下）在这篇文章的研究中,每组又被分为2个子组：给予52名前驱心绞痛患者安慰剂,给予129名非前驱心绞痛患者尼克地尔治疗,给予56名前驱心绞痛患者尼克地尔治疗,给予131名非前驱心绞痛患者安慰剂。前驱心绞痛被定义为急性心肌梗死前的休息时持续时间少于30分钟的短暂性胸痛。

关键词：尼可地尔 ST段抬高前驱心绞痛急性心肌梗死心肌梗塞患者胸痛再灌注损伤心电图描记疼痛持续时间再灌注心律失常

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Rare earth application for heat-resisting alloys

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Journal of Rare Earths 2010年第S1期28卷 12-21页

作者： Tadaaki amano Department of Materials Science and Engineering Shonan Institute of Technology

High-temperature oxidation resistance of Al2O3-and Cr2O3-forming heat-resisting alloys with rare earths(yttrium-implanted FeCrAl,-added FeCrAl,-added FeCrAlPt alloys,Y2O3-or CeO2-coated NiCrSi,yttrium-or lutetium-added NiCr and NiCrSi) was studied in oxygen at high temperatures,by mass gain measurements,mass change measurements,amount of spalled oxide,observation of surface appearance,X-ray diffraction(XRD),scanning electron microscopy(SEM),electron probe X-ray microanalysis(EPMA) and transmission electron microscopy(TEM).After oxidation at 1573 K for 18 ks in oxygen,oxide scale on FeCrAl alloy spalled from the entire surface,however,yttrium-implanted FeCrAl alloys showed good oxide *** oxidation at 1473 K for 18 ks in oxygen,mass gain of FeCrAlY alloys decreased with increasing yttrium of up to 0.1 wt.% follwed by an increase with the yttrium content,and the mass gain of FeCrAl0.005Pt0.05Y alloy with appropriate additions of platinum and yttrium was lower than that of FeCrAl0.1Y ***-added FeCrAl alloys showed good oxide *** analysis revealed that the alumina/alloy interface of FeCrAl0.005Pt0.05Y alloy showed good *** scale surface of FeCrAl alloy was rough,however,those of FeCrAlY and FeCrAlPtY alloys were *** oxidation of NiCrSi,Y2O3-or CeO2-coated NiCrSi alloys was studied up to 10 cycles(1 cycle:300 s) at 1523 K in *** change of NiCrSi alloy increased up to 3 cycles and then decreased up to 10 cycles because of oxide spallation during *** the other hand,mass change of Y2O3-or CeO2-coated NiCrSi alloy increased up to 10 cycles,and these alloys showed good oxide *** Cr2O3 particles on Y2O3-coated NiCrSi alloy were in size smaller than these on CeO2-coated NiCrSi *** result suggested that oxidation rate of Y2O3-coated NiCrSi alloy was lower than that of CeO2-coated NiCrSi *** oxidation at 1473 and 1573 K for 18 ks in oxygen,mass gain of yttrium-or lutetium-added NiCr an

关键词： alumina chromia oxide adherence high-temperature oxidation rare earths

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An Adjustable Variant of Round Robin Algorithm Based on Clustering Technique

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Computers, Materials & Continua 2021年第3期66卷 3253-3270页

作者： Samih M.Mostafa Hirofumi amano Faculty of Computers and Information South Valley UniversityQena83523Egypt Research Institute for Information Technology Kyushu UniversityFukuoka819-0395Japan

CPU scheduling is the basic task within any time-shared operating *** of the main goals of the researchers interested in CPU scheduling is minimizing time *** between CPU scheduling algorithms is subject to some scheduling criteria(e.g.,turnaround time,waiting time and number of context switches(NCS)).Scheduling policy is divided into preemptive and *** Robin(RR)algorithm is the most common preemptive scheduling algorithm used in the time-shared operating *** this paper,the authors proposed a modified version of the RR algorithm,called dynamic time slice(DTS),to combine the advantageous of the low scheduling overhead of the RR and favor short process for the sake of minimizing time *** process has a weight proportional to the weights of all *** process’s weight determines its time slice within the current *** authors benefit from the clustering technique in grouping the processes that are similar in their attributes(e.g.,CPU service time,weight,allowed time slice(ATS),proportional burst time(PBT)and NCS).Each process in a cluster is assigned the average of the processes’time slices in this cluster.A comparative study of six popular scheduling algorithms and the proposed approach on nine groups of processes vary in their attributes was performed and the evaluation was measured in terms of waiting and turnaround times,and *** experiments showed that the proposed algorithm gives better results.

关键词： Clustering CPU scheduling round robin turnaround time waiting time

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The matrix metalloproteinase stromelysin-3 cleaves laminin receptor at two distinct sites between the transmembrane domain and laminin binding sequence within the extracellular domain

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Cell Research 2005年第3期15卷 150-159页

作者： Tosikazu amano,Olivia KWAK,Anastasia MARSHAK Laboratory of Gene Regulation and Development National Institute of Child Health and Human Development National Institutesof Health Bethesda MD 20892 USA Laboratory of Gene Regulation and Development National Institute of Child Health and Human Development National Institutesof Health Bethesda MD 20892 USA Laboratory of Gene Regulation and Development National Institute of Child Health and Human Development National Institutesof Health Bethesda MD 20892 USA

The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has long been implicated to play an important role in extracellular matrix (ECM) remodeling and cell fate determination during normal and pathological processes. However like other MMPs, the molecular basis of ST3 function in vivo remains unclear due to the lack of information on its physiological substrates. Furthermore, ST3 has only weak activities toward all tested ECM proteins. Using thyroid hormone-dependent Xenopus laevis metamorphosis as a model, we demonstrated previously that ST3 is important for apoptosis and tissue morphogenesis during intestinal remodeling. Here, we used yeast two-hybrid screen with mRNAs from metamorphosing tadpoles to identify potential substrate of ST3 during development. We thus isolated the 37 kd laminin receptor precursor (LR). We showed that LR binds to ST3 in vitro and can be cleaved by ST3 at two sites distinct from where other MMPs cleave. Through peptide sequencing, we determined that the two cleavage sites are in the extracellular domain between the transmembrane domain and laminin binding sequence. Furthermore, we demon strated that these cleavage sites are conserved in human LR. These results together with high levels of human LR and ST3 expression in carcinomas suggest that LR is a likely in vivo substrate of ST3 and that its cleavage by ST3 may alter cell-extracellular matrix interaction, thus, playing a role in mediating the effects of ST3 on cell fate and behavior ob- served during development and pathogenesis.

关键词： stromelysin-3 laminin receptor matrix metalloproteinase extracellular matrix Xenopus laevis cell surface substrate.

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静脉注射尼可地尔对短期和长期患有心绞痛的急性ST段抬高型心肌梗塞患者的影响

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首都食品与医药 2015年第16期22卷 128-128页

研究表明,急性心肌梗死（AMI）的前驱心绞痛有助于达到较好的治疗效果,尼可地尔对缺血性心脏具有保护作用。我们比较了静脉注射尼可地尔对前驱心绞痛预处理的急性心肌梗死患者和接受经皮冠状动脉介入治疗（PCI）的急性心肌梗死患者的心... 详细信息

研究表明,急性心肌梗死（AMI）的前驱心绞痛有助于达到较好的治疗效果,尼可地尔对缺血性心脏具有保护作用。我们比较了静脉注射尼可地尔对前驱心绞痛预处理的急性心肌梗死患者和接受经皮冠状动脉介入治疗（PCI）的急性心肌梗死患者的心脏保护作用。总体而言,将368名接受经皮冠状动脉介入治疗（PCI）的患有急性ST段抬高型心肌梗死的患者随机分组,于PCI治疗前,分别给予静脉注射12mg尼可地尔和安慰刷治疗。

关键词：急性ST段抬高型心肌梗死急性心肌梗死心肌梗死患者前驱心绞痛尼可地尔静脉注射经皮冠状动脉介入治疗心肌梗塞

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The process of life adjustment in patients at onset of glioma who are receiving continuous oral anticancer drug: A qualitative descriptive study

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International Journal of Nursing Sciences 2019年第2期6卷 134-140页

作者： Koji amano Kumi Suzuki Faculty of Nursing Doshisha Women's College of Liberal ArtsKyotoJapan Faculty of Nursing Osaka Medical CollegeOsakaJapan

Objective: Patients with malignant gliomas have to adjust their daily lives because of the threat of impending death and declining ***,clarifying the process of life adjustment in such patients would help them lead a normal *** clarify the process of life adjustment in patients at the onset of glioma,who continuously receive oral anticancer ***: The study institution consisted of two designated cancer ***-structured interviews were conducted with 10 patients,and the data were analyzed using the Modified Grounded Theory Approach of Kinoshita (M-GTA).Results: As a core category representing the process of life adjustment in patients at the onset of glioma,"trials and errors for self-fulfillment even in a limited lifespan" was *** began "seeking information about the unfamiliar life-threatening disease," and "imaging their uncertain lives after the disease and the resulting disability" while "conducting repeated trials and errors to establish coping methods according to their abilities." When facing difficulties in such trials and errors,they reported "losing self-confidence due to unexpected limitations." However,they regulated their feelings by "resigning themselves to their unchangeable reality." Contrarily,as "functional improvement enhanced their motivation to recover," they attempted to promote functional recovery and organized their daily lives in "fulfilling their desires in their limited lifespan." Conclusion: The process of life adjustment in patients with malignant gliomas involved identifying a way of living despite limited *** ensure appropriate nursing care for patients at the onset of glioma,it is important to help them establish coping methods in accordance with their abilities.

关键词： Adjustment Life Malignant glioma Patients Qualitative study

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