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Small serotonin-positive pancreatic endocrine tumors caused obstruction of the main pancreatic duct

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World Journal of Gastroenterology 2012年第45期18卷 6669-6673页

作者： Masami Ogawa Yoshiaki Kawaguchi Atsuko Maruno Hiroyuki Ito Toshio Nakagohri Kenichi Hirabayashi Hiroshi Yamamuro Tomohiro Yamashita tetsuya Mine Department of Gastroenterology Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan Department of Gastroenterological Surgery Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan Department of Pathology Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan Department of Radiology Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan

We report 2 cases of pancreatic endocrine tumors that caused obstruction of the main pancreatic duct(MPD).A 49-year-old asymptomatic man was referred to our institution because dilation of the MPD was revealed by abdominal ultrasonography(US).No tumor was detected by endoscopic ultrasonography,computed tomography(CT),and magnetic resonance imaging(MRI).The diameter of the MPD was > 20 mm at the body,and no dilation was noted at the *** malignancy was not confirmed through cytology or imaging,pancreatic cancer was strongly ***-denectomy was *** and immunohistochemical examination revealed a 5 mm × 3 mm serotonin-positive endocrine *** was present around the MPD and seemed to cause stricture.A 32-year-old asymptomatic man had elevated serum amylase,and US demonstrated dilation of the *** tumor was detected by CT and *** cancer was suspected due to stricture and dilation of the *** of middle part of pancreas was *** and immunohistochemical examination revealed a serotonin-positive endocrine tumor sized 5 mm × 4 *** report 2 cases of serotonin-positive pancreatic endocrine tumors that caused stricture of the MPD in spite of the small size of the tumor.

关键词： Serotonin Pancreatic endocrine tumor Main pancreatic duct Obstruction Dilatation

740 Gbit/s (37 x 20 Gbit/s) DWDM Transmission Experiment Using Er^(3+)-Doped Tellurite Fiber Amplifiers and Distributed Raman Amplification

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光学学报 2003年第S1期23卷 569-570页

作者： Hiroyuki Toda Maoki Suzuki Ryo Takami tetsuya Miyazaki Takeshi Makino Fumito Kubota Graduate School of Engineering Osaka University 2-1 Yamada-Oka Suita Osaka 565-0871 Japan Communications Research Laboratory 4-2-1 Nukui-Kitamachi Koganei Tokyo 184-8795 Japan

We demonstrate 740 Gbit/s (37 x 20 Gbit/s) DWDM recirculating transmission experiment with 59 nm continuous bandwidth over 300 km by employing Er3+-doped tellurite fiber amplifiers. The use of Raman amplification is e... 详细信息

关键词： Raman Amplification transmission bandwidth Raman amplification fiber amplifiers

Novel Radio on Fiber Access Eliminating External Electric Power Supply at Base Station

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光学学报 2003年第S1期23卷 611-612页

作者： tetsuya Miki Katsuyasu Kawano Nobuo Nakajima Naoto Kishi Masaru Miyamoto Tetsu Aoki The University of Electro-Communications Tokyo JapanThe University of Electro-Communications Tokyo JapanThe University of Electro-Communications Tokyo JapanThe University of Electro-Communications Tokyo JapanIwatsu Co. LTD. Tokyo Japan 1-5-1 Chohugaoka Chohu-shi Tokyo 182-8585 JapanIwatsu Co. LTD. Tokyo Japan 1-5-1 Chohugaoka Chohu-shi Tokyo 182-8585 Japan

A novel Radio On Fiber(ROF) access is proposed and demonstrated which enables the pico-cell Base Station (BS) for high-speed wireless communications to eliminate external electric power supply facilities. We demonstrated 2.4-GHz band radio signal transmission through the BS without external electric power supply. The electrical power used for BS circuit is feeded by optical power over optical fiber from central station.

关键词： Radio be ROF BS LNA link Novel Radio on Fiber Access Eliminating External Electric Power Supply at Base Station EAM

Large stereoscopic LED display by use of parallax barrier of aperture grille type(Invited Paper)

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Chinese Optics Letters 2014年第6期12卷 21-25页

作者： Hirotsugu Yamamoto Hayato Nishimura tetsuya Abe Yoshio Hayasaki Department of Optical Science and Technology University of Tokushima2-1 Minamijosanjima Tokushima CityTokushima 7708506 Japan Center for Optical Research and Education Utsunomiya University7-1-2 Yoto Utsunomiya City Tochigi 3218585 Japan

We propose a large parallax barrier by use of aperture grille. Main advantages of using aperture grille include no reflection and no absorption in apertures, as well as wide viewing angle. These advantages are investigated with theoretical calculations and experiments by use of several kinds of LED panels, such as a fine-pitch LED panel and a 140-inch large LED panel. Limitations of viewing angle by parallax barrier are analyzed in conventional black stripes on a transparent substrate type and in aperture grille type. Experimental results straw use of aperture grille increases contrast and reduce reflection on the aperture surface.

关键词： LED Large stereoscopic LED display by use of parallax barrier of aperture grille type

Remarkably different results between two studies from North America on genomic mutations and sensitivity to DNA demethylating agents for myelodysplastic syndromes

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Chinese Journal of Cancer Research 2017年第6期29卷 587-588页

作者： Guiping Wang Shanshan Guo Huashi Xiao Liang Zong tetsuya Asakawa Masanobu Abe Wenqing Hu Jiafu Ji Medical Research Center Clinical Medical College of Yangzhou University(Northern Jiangsu People's Hospital)Yangzhou 225001China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Center of Gastrointestinal SurgeryPeking University Cancer Hospital&InstituteBeijing 100142China Departrnent of Gastrointestinal Surgery Clinical Medical College of Yangzhou University(Northern Jiangsu People's Hospital)Yangzhou 225001China Department of Neurosurgery Hamamatsu University School of MedicineHandayamaHamamatsu-cityShiznoka 431-3192Japan Division for Health Service Promotion University of Tokyo HospitalTokyo 113-003Japan Division for Health Service Promotion Heji Hospital of Changzhi Medical CollegeChangzhi 046011China

Sekeres et al. （1） conducted a multicenter randomized, controlled trial to compare whether azacitidine-based combinations with lenalidomide or vorinostat produce superior overall response rates to azacitidine in the treatment of myelodysplastic syndromes （MDS）. In that trial, 224 patients with higher-risk MDS and 53 with chronic myelomonocytic leukemia （CMML） were enrolled and randomly assigned to the ＂azacitidine＂ group, ＂azacitidine plus lenalidomide＂ group or ＂azacitidine plus vorinostat＂ group. The researchers found that patients with MDS treated with azacitidine-based combinations had similar response rate to azacitidine monotherapy. Using genomic mutation analysis, they found that the overall response rate to azacitidine-based treatment was higher for patients with mutations in DNMT3A and lower for those with mutations in SRSF2. Whereas in another study, Welch et al. enrolled 26 patients with MDS and 90 with acute myeloid leukemia （AML） who were treated with decitabine, and they found that patients with TP53 mutations had a higher response rate, but not those with DNMT3A mutations （2）. We propose that this big discrepancy in the conclusions between the two studies might have been caused by the presence of many co-interacting factors, e.g. study aims, DNA demethylating agents, treatment protocols, and patient sources.

关键词： MDS DNA Remarkably different results between two studies from North America on genomic mutations and sensitivity to DNA demethylating agents for myelodysplastic syndromes

Optical Properties of Chiral Azo-Schiff Base Mn(II) and Zn(II) Complexes with Silver Nanoparticles

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Journal of Materials Science and Chemical Engineering 2021年第4期9卷 1-10页

作者： Kazuya Saiga Tomoyuki Haraguchi Yasutaka Kitahama Takuya Hosokai Hiroyuki Matsuzaki Dohyun Moon Mutsumi Sugiyama Michikazu Hara Takashiro akitsu Department of Chemistry Faculty of Science Tokyo University of Science Tokyo Japan National Institute of Advanced Industrial Science and Technology Tsukuba Japan Pohang Accelerator Laboratory Pohang Korea Department of Electrical Engineering Faculty of Science and Technology Tokyo University of Science Noda Japan Materials and Structures Laboratory Tokyo Institute of Technology Yokohama Japan

Herein we have originally designed chiral azo-salen Mn(II) and Zn(II) complexes for interacting silver nanoparticles (AgNPs) exhibiting localized surface plasmon resonance (LSPR). Understanding excited state and reaction intermediate during light irradiation to return to ground state may be important for such composite systems. Therefore, we investigated such optical properties for systems using time-resolved luminescence and transient absorption measurements. DMSO solutions of the four newly prepared and characterized complexes (MMn, MZn, CMn, and CZn) and ethanol solutions of the composite materials of each complex with AgNPs were served for optical measurements. The time-correlated single photon counting (TCSPC), the streak camera which is much shorter period of time than TCSPC and transient absorption measurement, was performed for the eight samples. The fluorescence lifetime of the sole complexes and the composite materials with AgNPs was derived from curve-fitting analysis of luminescence decay curves of TCSPC. Lifetime of the composite systems with AgNPs was longer than that of the corresponding sole metal complexes for three cases. It was revealed that composite systems may go through three reaction intermediates during relaxation from excited state to ground state.

关键词： Schiff Base Metal Complexes Azobenzene Silver Nanoparticles Fluorescence Lifetime

A patient presenting painful chest wall swelling: Tietze syndrome

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World Journal of Emergency Medicine 2019年第2期10卷 122-124页

作者： Kohei Sawada Hiromi Ihoriya Taihei Yamada tetsuya Yumoto Kohei Tsukahara Takaaki Osako Hiromichi Naito Atsunori Nakao Department of Emergency Critical Care and Disaster Medicine Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Dear editor,Patients frequently visit the emergency room with acute chest *** some potentially life-threatening disorders may cause the pain,in approximately 80%of cases,the chest pain source is benign,and musculoskeletal chest pain accounts for nearly 20%– 50%of those cases.^[1–6]Thus,pain caused by benign and pathological conditions of the chest wall encountered in the emergency department is sometimes incorrectly attributed to angina pectoris or pleuritic and other serious cardiopulmonary diseases.

关键词： Patients frequently emergency room life-threatening

Effect of transforming growth factor-β1 on human intrahepatic cholangiocarcinoma cell growth

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World Journal of Gastroenterology 2006年第39期12卷 6316-6324页

作者： tetsuya Shimizu Shigeki Yokomuro Yoshiaki Mizuguchi Yutaka Kawahigashi Yasuo Arima Nobuhiko Taniai Yasuhiro Mamada Hiroshi Yoshida Koho Akimaru Takashi Tajiri Surgery for Organ Function and Biological Regulation Graduate School of Medicine Nippon Medical School Tokyo 113-8603 Japan

AIM： To elucidate the biological effects of transforming growth factor-β1 （TGF-β1） on intrahepatic cholangiocarcinoma （ICC）.METHODS： We investigated the effects of TGF-β1 on human ICC cell lines （HuCCT1, MEC, and HUH-28） by monitoring the influence of TGF-β1 on tumor growth and interleukin-6 （IL-6） expression in ICC cells.RESULTS： All three human ICC cell lines produced TGF-β1 and demonstrated accelerated growth in the presence of TGF-β1 with no apoptotic effect. Studies on HuCCT1 revealed a TGF-β1-induced stimulation of the expression of TGF-β1, as well as a decrease in TGF-β1 mRNA expression induced by neutralizing anti-TGF-β1 antibody. These results indicate that TGF-β1 stimulates the production and function of TGF-β1 in an autocrine fashion. Further, IL-6 secretion was observed in all three cell lines and exhibited an inhibitory response to neutralizing anti-TGF-β1 antibody. Experiments using HuCCT1 revealed a TGF-β1-induced acceleration of IL-6 protein expression and mRNA levels. These findings demonstrate a functional interaction between TGF-β1 and IL-6. All three cell lines proliferated in the presence of IL-6. In contrast, TGF-β1 induced no growth effect in HuCCT1 in the presence of small interfering RNA against a specific cell surface receptor of IL-6 and signal transducer and activator of transcription-3.CONCLUSION： ICC cells produce TGF-β1 and confer a TGF-β1-induced growth effect in an autocrine ***-β1 activates ILo6 production, and the functional interaction between TGF-β1 and IL-6 contributes to ICC cell growth by TGF-β1.

关键词： Transforming growth factor-β1 Interleukin-6 Intrahepatic cholangiocarcinoma

Tsunami Force Reduction due to Obstacle in Front of Coastal Dike and Evaluation of Collision Force by Driftage

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Journal of Energy and Power Engineering 2017年第5期11卷 300-310页

作者： Shuhei Ono tetsuya Hiraishi Disaster Prevention Research Institute Kyoto University Kyoto 612-8235 Japan

Tsunami caused by the Tohoku earthquake on March 11, 2011 washed away a lot of buildings and deprived many lives on unexpected scale. Seawall is one of the measures to reduce tsunami damage, but itself is also given great damages by tsunami. Study on mechanism of tsunami force acting on seawalls is also quite important and improvement of countermeasures is very important. Hydraulic experiments were conducted to estimate wave force and collision force by driftage due to tsunami on various conditions. The tsunami force reduction due to obstacles installed shoreline is examined and assessed by previous formula. Collision force by driftage due to tsunami is also investigated and assessed by previous formula.

关键词： Seawall tsunami wave force obstacle driftage collision force.