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Up-grading of natural ilmenite ore by combining oxidation and acid leaching

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International Journal of Minerals,Metallurgy and Materials 2018年第7期25卷 729-736页

作者： Takehito Hiraki Yuichi Maruyama Yuta Suzuki Satoshi Iloh tetsuya Nagasaka Department of Metallurgy Graduate School of EngineeringTohoku UniversitySendai 980-8579Japan Toho Titanium Co. Ltd.Kanagawa 253-8510Japan Fanuc Co. Ltd.Oshino-muraYamanashi 401-0511Japan Before retirement:Graduate School of Environmental Studies Tohoku UniversitySendai 980-8579Japan

Rutile （TiO2） is heavily used in pigments mid colormlts, mid the most abundmlt source of rutile is ilmeinte. Upon oxidation of ilmeinte, mtile cml be formed wiffl modest energy consumption; furfflermore, after leaching, only a few byproducts are formed. Unfortunate- ly, one drawback is file necessarily long oxidative process of typically used mefflods. In fflis study, we show fflat a fluidized bed reactor cml be used to oxidize ilmeinte ore to rapidly form ruffle mid pseudobrookite （Fe2TiOs） phases. Ilmeinte was oxidized wiffl 5vo1% 02 in Ar at temperatures of 1173 K or 1223 K mid subsequently leached using a diluted H2SO4 solution to dissolve file pseudobrookite phase. The effects of acid concentration, temperature, mid cooling rate after oxidation were investigated. We show fflat file ilmeinte was rapidly oxidized to form rutile mid pseudobrookite phases at 1173 mid 1223 K in a 5vo1% O2/95vo1% Ar environment wifflin 40 min. The fmal maximum mtile yield was 84.2mo1% after leaching in （1 ＋ 1） H2SO4 solution at 393 K for 12 h.

关键词： ilmenite oxidation fluidized bed reactor acid leaching rutile pseudobrookite

Molecular mechanisms of transcription and replication of the influenza A virus genome

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Frontiers in Biology 2011年第6期6卷 446-461页

作者： Shijian ZHANG tetsuya TOYODA Shanghai Medical College of Fudan University Shanghai 200032China Choju Medical Institute Fukushimura Hospital19-14 AzanakayamaNoyori-choToyohashiAichi 441-8124Japan Infectious Disease Regulation Project Tokyo Metropolitan Institute of Medical Sciences1-6Kamikitazawa 2-chomeSetagaya-kuTokyo156-8506Japan

Influenza Avirus is one of the major pathogens that pose a large threat to human health worldwide and has caused *** A virus is the Orthomyxoviridae prototype,and has 8 segmented negative-sense singlestranded RNA(vRNA)as its *** virus RNA polymerase(RdRp)consists of three subunits PB2,PB1 and PA,and catalyzes both transcription and ***,intensive biochemical and structural analysis of its RdRp has been *** this paper,we review the details from the biochemical analysis of the purified influenza virus RdRp and the classical ribonucleoprotein complex,as well as piece together their structures to form an overall picture.

关键词： influenza virus RNA polymerase ribonucleoprotein complex transcription replication

Surgery and chemotherapy for intrahepatic cholangiocarcinoma

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World Journal of Hepatology 2010年第2期2卷 58-64页

作者： Zenichi Morise Atsushi Sugioka Takamasa tokoro Yoshinao Tanahashi Yasuhiro Okabe Tadashi Kagawa Chinatsu Takeura Department of Surgery Fujita Health University School of Medicine 1-98 Dengakugakubo Kutsu- kake-cho Toyoake Aichi 470-1192 Japan

Cholangiocarcinoma, arising from bile duct epithelium, is categorized into intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC), including hilarcholangiocarcinoma. Recently, there has been a worldwide increase in the incidence and mortality from ICC. Complete surgical resection is the only approach to cure the patients with ICC. However, locoregional extension of these tumors is usually advanced with intrahepatic and lymph-node metastases at the time of diagnosis. Resectability rates are quite low and variable (18%-70%). The five-year survival rate after surgical resection was reported to be 20%-40%. Median survival time after ICC resection was 12-37.4 mo. Only a small number of ICC cases, accompanied with ECC, gall bladder carcinoma, and ampullary carcinoma, have been reported in the studies of chemotherapy due to the rarity of the disease. However, in some reports, significant anti-cancer effects were achieved with a response rate of up to 40% and a median survival ofone year. Although recurrence rate after hepatectomy is high for the patients with ICC, the residual liver and the lung are the main sites of recurrence after tentative curative surgical resection. Several patients in our study had a long-term survival with repeated surgery and chemotherapy. Repeated surgery, combined with new effective regimens of chemotherapy, could benef it the survival of ICC patients.

关键词： Intrahepatic cholangiocarcinoma Surgery Chemotherapy

Durability of Bridge Expansion Joints with Perforated Dowels Under Traffic Impact Loading

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Transactions of Tianjin University 2006年第B09期12卷 42-45页

作者： YODA Teruhiko YOSHIDA tetsuya SETA Makoto Department of Civil and Environmental Engineering Waseda UniversityTokyo 169-8555Japan Kyouryou Maintenance Co.Ltd Tokyo 115-0055Japan

In design phases, expansion joints are required to have movement capacity, bearing capacity for static and dynamic loading, watertight, low noise emission and traffic safety. On the basis of the fact that failure due to dynamic loading is the main reason for the observed damages, attention is focused on the bearing capacity for dynamic loading governed by impact, because it differs from the static loading. In this study, from the viewpoint of durability, experimental studies for dynamic behavior were conducted for aluminium alloy expansion joints with perforated dowels. The validity of the perforated dowels against traffic impact loading was confirmed by both experimental and numerical studies.

关键词： bridge expansion joints traffic impact loading durability aluminium alloy

The Pre-rRNA Processing Complex in Arabidopsis Includes Two WD40-Domain-Containing Proteins Encoded by Glucose-Inducible Genes and Plant-Specific Proteins

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Molecular Plant 2016年第2期9卷 312-315页

作者： tetsuya Ishida Shugo Maekawa Shuichi Yanagisawa Laboratory of Plant Functional Biotechnology Biotechnology Research Center The University of Tokyo Yayoi 1-1-1 Bunkyo-ku Tokyo 113-8657 Japan

Dear Editor,In plants, sugars not only serve as energy and metabolic resources but they also exhibit hormone-like activity. Sugars modulate several fundamental processes throughout a plant＇s life cycle, including embryogenesis, germination, vegetative growth, development, reproduction, and senescence （Eveland and Jackson, 2012; Lastdrager et al., 2014; Ruan, 2014）. Previous studies have revealed that various pathways and molecular mechanisms are involved in plant sugar responses,

关键词： glucose component embryo

New pyrometallurgical process of EAF dust treatment with CaO addition

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International Journal of Minerals,Metallurgy and Materials 2015年第8期22卷 788-797页

作者： Romchat Chairaksa-Fujimoto Yosuke Inoue Naoyoshi Umeda Satoshi Itoh tetsuya Nagasaka Department of Metallurgy Graduate School of Engineering Tohoku University Toho Titanium Co. Ltd. Honda Motor Co. Ltd.

The non-carbothermic zinc pyrometallurgical processing of electric arc furnace(EAF) dust was investigated on a laboratory scale. The main objective of this process was to convert highly stable zinc ferrite(Zn Fe2O4), which accounts for more than half of total zinc in the EAF dust, into Zn O and Ca2Fe2O5 by Ca O addition. The EAF dust was mixed with Ca O powder in various ratios, pressed into pellets, and heated in a muffle furnace in air at temperatures ranging from 700 to 1100°C for a predetermined holding time. All Zn Fe2O4 was transformed into Zn O and Ca2Fe2O5 at a minimum temperature of 900°C within 1 h when sufficient Ca O to achieve a Ca/Fe molar ratio of 1.1 was added. However, at higher temperatures, excess Ca O beyond the stoichiometric ratio was required because it was consumed by reactions leading to the formation of compounds other than Zn Fe2O4. The evaporation of halides and heavy metals in the EAF dust was also studied. These components could be preferentially volatilized into the gas phase at 1100°C when Ca O was added.

关键词： electric arc furnace dust pyrometallurgy zinc oxid

Space-charge effect on photogenerated-current and-voltage inⅢ-nitride optoelectronic semiconductors

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Photonics Research 2021年第9期9卷 1820-1828页

作者： DONG-PYO HAN MOTOAKI IWAYA tetsuya TAKEUCHI SATOSHI KAMIYAMA ISAMU AKASAKI Faculty of Science and Technology Meijo UniversityNagoya 468-8502Japan Akasaki Research Center Nagoya UniversityNagoya 464-8603Japan

In this study,we attempted to elucidate the carrier dynamics behind the abnormal characteristics of photogenerated current and voltage(IPhand VPh)at cryogenic temperature inⅢ-nitride optoelectronic semiconductors by employing space-charge *** this end,we carefully investigated and analyzed excitation-powerdependentⅠ-Ⅴ(PDIV)curves operated by quasiresonant excitation of an Al Ga In N-based p-i-n junction semiconductor at 300 K and 15 *** 300 K,the curves exhibited typical characteristics and were well described by the conventional ***,the PDIV curves at 15 K could no longer be described by the conventional *** elucidate the mechanism behind this phenomenon,we proposed a model in which the space-charge effect(SCE)plays a key *** on this model,we proposed the modified Shockley diode equation,which can explain the PDIV characteristic at 15 K,including the *** also discussed the SCE on the efficiency of devices.

关键词： optoelectronic Shockley charge

Quantitative determination of erlotinib in human serum using competitive enzyme-linked immunosorbent assay

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Journal of Pharmaceutical Analysis 2018年第2期8卷 119-123页

作者： Yuta Yamamoto tetsuya Saita Yutaro Yamamoto Masashi Shin Applied Life Science Department Faculty of Biotechnology and Life Science Sojo University

A selective and sensitive competitive enzyme-linked immunosorbent assay(ELISA) method was developed and validated for the quantification of erlotinib in 50 mL of samples of human serum. Anti-erlotinib serum was obtained by immunizing mice with an antigen conjugated with bovine serum albumin and 3,4-bis(2-methoxyethoxy)benzoic acid using the N-succinimidyl ester method. Enzyme labeling of erlotinib with horseradish peroxidase was similarly performed using 3,4-bis(2-methoxyethoxy)benzoic acid. A simple competitive ELISA for erlotinib was developed using the principle of direct competition between erlotinib and the enzyme marker for anti-erlotinib antibody, which had been immobilized on the plastic surface of a microtiter plate. Serum erlotinib concentrations lower than 40 ng/mL were reproducibly measurable using the ELISA. This ELISA was specific to erlotinib and showed very slight cross-reactivity(6.7%) with a major metabolite, O-desmethyl erlotinib. Using this assay, drug levels were easily measured in the blood of mice after oral administration of erlotinib at a single dose of 30 mg/kg. ELISA should be used as a valuable tool for therapeutic drug monitoring and in pharmacokinetic studies of erlotinib.

关键词： Erlotinib Enzyme-linked immunosorbent assay O-desmethyl erlotinib Tyrosine-kinase inhibitor

Population structures and spatial patterns of two unpalatable Arisaema species(Araceae) with and without clonal reproduction in a riparian forest intensively grazed by Sika deer

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Journal of Forestry Research 2020年第1期31卷 155-162页

作者： tetsuya K.Matsumoto Muneto Hirob Yasuaki Akaji Yuko Miyazaki Graduate School of Environmental and Life Science Okayama UniversityTsushima-Naka 1-1-1Kita-kuOkayama 700-8530Japan Present Address:Center for Environmental Biology and Ecosystem Studies National Institute for Environmental StudiesOnogawa 16-2Tsukuba 305-8506Japan

General decline of understory cover can result from increased abundance of and foraging pressure by *** population size and degree of aggregation can increase for unpalatable understory plants that escape foraging *** reproduction can enable unpalatable plant species to increase their population sizes while trending toward spatially aggregated ***,the details of the relationship between clonal reproduction in unpalatable plants and their dynamics under intensive deer herbivory are not *** compared the population structures and spatial patterns of two coexisting unpalatable plant species,Arisaema ovale(with clonal reproduction)and ***(without clonal reproduction)in a riparian forest intensively grazed by Sika deer,and examined the null hypothesis that the extent of spatial aggregation and local population size would not differ between the clonal and non-clonal Arisaema *** a 0.36-ha plot,*** had a larger population size(1087 individuals)with a higher abundance ratio of small plants(p<0.01)than ***(84 individuals).Analyses of spatial point processes showed that both populations were spatially aggregated(p<0.05).The spatial aggregation of ***,however,became weaker than that of ***,when we excluded one dense patch originating from irregular seed *** results,excluding the aggregated distribution observed in ***,suggested a substantial contribution of clonal reproduction to the expansion of the local *** population following intensive grazing by Sika deer.

关键词： Arisaema ovale Arisaema peninsulae Deer herbivory Spatial pattern Unpalatable plant