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二膦酸盐类药（YM175）对大鼠股骨骨折的长程影响

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二膦酸盐类药（YM175）对大鼠股骨骨折的长程影响

Comparison of DWI and PET/CT in evaluation of lymph node metastasis in uterine cancer

第三届国际骨质疏松研讨会

作者： Chaoyang Li Satoshi Mori Jiliang Li Yoshio kaji Tomoyuki Akiyama Jun Kawanishi Hiromichi Norimatsu Department of Orthopedic Surgery Kagawa Medical UniversityKagawa 761-1793Japan

＜正＞在我们以前进行的16周的大鼠骨折的研究中,持续使用YM175治疗出现的骨痂没有发现在皮质骨外壁和新的骨髓腔。以我们原先研究的为基础,这个实验是为了更进一步研究YM175对治疗骨折的长期影响。实验用六周龄的雌性SD大鼠,注射YM175 ... 详细信息

＜正＞在我们以前进行的16周的大鼠骨折的研究中,持续使用YM175治疗出现的骨痂没有发现在皮质骨外壁和新的骨髓腔。以我们原先研究的为基础,这个实验是为了更进一步研究YM175对治疗骨折的长期影响。实验用六周龄的雌性SD大鼠,注射YM175 a)10ug/kg

关键词：二膦酸盐大鼠股骨骨折影响

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World Journal of Radiology 2012年第5期4卷 207-214页

作者： Kazuhiro Kitajima Erena Yamasaki Yasushi kaji Koji Murakami Kazuro Sugimura Department of Radiology Kobe University Graduate School of Medicine Kobe 650-0017 Japan Department of Radiology Dokkyo University School of Medicine Mibu 321-0293 Japan Division of Nuclear Medicine Department of Diagnostic Radiology Keio University School of Medicine Tokyo 160-8582 Japan

AIM: To investigate diffusion-weighted imaging (DWI) and positron emission tomography and computed tomography (PET/CT) with Ⅳ contrast for the preoperative evaluation of pelvic lymph node (LN) metastasis in uterine cancer. METHODS: Twenty-five patients with endometrial or cervical cancer who underwent both DWI and PET/CT before pelvic lymphadenectomy were included in this study. For area specific analysis, LNs were divided into eight regions: both common iliac, external iliac, internal iliac areas, and obturator areas. The classification for malignancy on DWI was a focally abnormal signal intensity in a location that corresponded to the LN chains on the T1WI and T2WI. The criterion for malignancy on PET/CT images was increased tracer uptake by the ***: A total of 36 pathologically positive LN areas were found in 9 patients. With DWI, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy for detecting metastatic LNs on an LN area-by-area analysis were 83.3%, 51.2%, 27.3%, 93.3% and 57.0%, respectively, while the corresponding values for PET/CT were 38.9%, 96.3%, 70.0%, 87.8% and 86.0%. Differences in sensitivity, specificity and accuracy were significant (P < 0.0005). CONCLUSION: DWI showed higher sensitivity and lower specificity than PET/CT. Neither DWI nor PET/CT were sufficiently accurate to replace lymphadenectomy.

关键词： Uterine cancer Lymph node metastasis Magnetic resonance imaging Diffusion-weighed imaging Positron emission tomography and computed tomography

Plasma copeptin concentration is a predictor of tolvaptan efficacy in patients with hepatic ascites

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Portal Hypertension & Cirrhosis 2023年第3期2卷 109-114页

作者： Fumimasa Tomooka Kei Moriya Takahiro Kubo Akihiko Shibamoto Jyunya Suzuki Satoshi Iwai Soichi Takeda Yuki Fujimoto Masahide Enomoto Koji Murata Yuki Tsuji Yukihisa Fujinaga Koh Kitagawa Norihisa Nishimura Hiroaki Takaya Kosuke kaji Hideto Kawaratani Tadashi Namisaki Takemi Akahane Akira Mitoro Hitoshi Yoshiji Department of Gastroenterology and Hepatology Nara Medical UniversityKashiharaJapan Department of Gastroenterology Nara Prefectural General Medical CenterShichijo-NishimachiJapan

Aims:No solid evidence-based opinion was raised regarding predictors of the degree of ascites reduction with *** retrospective cohort study aimed to examine whether serum copeptin concentration is a useful predictor of ***:The study population consisted of 80 patients with liver cirrhosis treated with tolvaptan for hepatic ascites effusions at Nara Medical University Hospital from May 2014 to December ***-three patients who lost>1.5 kg of body weight in the first week after starting tolvaptan were classified as good responders and the remaining 37 as poor *** laboratory parameters were measured immediately before the start of tolvaptan therapy to examine factors associated with predicting its ***:In the univariate analysis,no significant differences with respect to age(67.6 vs.69.8 years,p>0.05),sex,body mass index(24.8 vs.23.7 kg/m^(2),p>0.05),Child-Pugh score(9.4 vs.9.7,p>0.05),and Model for End-stage Liver Disease score(11 vs.12,p>0.05)were found between the two ***,aspartate transferase and alanine transaminase(ALT)levels were significantly lower in the good response group(52.9±56.3 vs.68.8±50.7 U/L,p<0.05;26.2±30.6 vs.40.5±33.5 U/L,p<0.01),whereas serum copeptin and serum sodium concentrations were significantly higher(57.1±15.0 vs.45.8±16.0 pg/mL,p<0.01;136.3±3.4 vs.133.8±5.8 mEq/L,p<0.05).In the multivariate analysis,serum copeptin concentration and ALT were statistically significant factors(p<0.01,p<0.05).Regression analysis of the association between the tolvaptan efficacy for refractory ascites and pretreatment serum copeptin concentration showed that a copeptin concentration cutoff of 45.9 pg/mL could predict treatment efficacy with a sensitivity,specificity,and area under the curve of 76.7%,59.5%,and 0.71%,***:Serum copeptin concentration may be a predictor of tolvaptan efficacy for refractory ascites effusion in Japanese patients with liver cirrhosis.

关键词： ascites copeptin decompensated liver cirrhosis diuretics tolvaptan

Publication and integration of Glycodatabase

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Publication and integration of Glycodatabase

A case of severe acalculous cholecystitis associated with sorafenib treatment for advanced hepatocellular carcinoma

2008年全国糖生物学学术会议

作者： Shikanai T. Shimma Y. Suzuki Y. Fujita N. Kameyama A. Hirabayashi J. kaji H. Togayachi A. Sato T. Ito H. Tateno H. Narimatsu H. Research Center for Medical Glycoscience(RCMG) National Institute of Advanced Industrial Science and Technology (AIST).JAPAN

Construction of a human glycogene library and the development of two kinds of systems for analyzing oligosaccharide sturctures in AIST through NEDO ***,186 human glycogenes were expressed and produced human type *** h...

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World Journal of Gastrointestinal Oncology 2012年第5期4卷 115-118页

作者： Yosuke Aihara Hitoshi Yoshiji Masaharu Yamazaki Yasuhide Ikenaka Ryuichi Noguchi Chie Morioka Kosuke kaji Haruki Tastumi Keisuke Nakanishi Maiko Nakamura Junichi Yamao Masahisa Toyohara Akira Mitoro Masayoshi Sawai Motoyuki Yoshida Masao Fujimoto Masahito Uemura Hiroshi Fukui Third Department of Internal Medicine Nara Medical UniversityNara 634-8522Japan

Sorafenib,a multikinase inhibitor,is the first and only drug,which improves significantly the overall survival in patients with advanced hepatocellular carcinoma(HCC).However,many patients experience diverse side effects,some of them severe and *** date,acute acalculous cholecystitis has not been documented in association with a HCC patient treated with ***,we report the case of a 43-yearold woman with hepatitis C virus-related advanced *** received sorafenib,and later complained ofa sudden onset of severe right hypocondrial pain with rebound tenderness and muscle *** examination showed mild elevation of transaminases,biliary enzymes,bilirubin,inflammation markers,and a marked peripheral *** computed tomography(CT) revealed a swollen gallbladder with exudate associated with severe inflammation without stones or ***,sorafenib treatment was stopped immediately,and steroid-pulse therapy was *** therapy drastically improved all clinical manifestations along with normalization of CT findings,eosinophilia,and liver *** summary,we herein report a rare case of acute severe acalculous cholecystitis associated with sorafenib in the patient with advanced HCC.

关键词： Hepatocelluar carcinoma Sorafenib Acalculous cholecystitis

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劳力士学习中心

建筑技艺 2010年第5期16卷 92-99页

作者： Yumiko Yamada Rikiya Yamamoto Osamu Kato Naoto Noguchi Mizuko kaji Takayuki Hasegawa Louis-Antoine Grego Tetsuo Kondo Matthias Haertel Catarina Canas 朱晓琳 SAPS/Sasaki and Partners B+G Ingenieure Bollinger und Grohmann GmbH Walther Mory Maier Bauingenieure AG BG Ingénieurs Conseils SA Losinger Construction SA

日本SANAA事务所设计的劳力士学习中心于2010年的2月22日开放。SANAA （Sejima And Nishizawa And Associates）是由建筑师妹岛和世和西泽立卫两人共同成立的建筑事务所，该事务所设计的劳力士学习中心建筑新颖大胆而且具有高度的实验... 详细信息

日本SANAA事务所设计的劳力士学习中心于2010年的2月22日开放。SANAA （Sejima And Nishizawa And Associates）是由建筑师妹岛和世和西泽立卫两人共同成立的建筑事务所，该事务所设计的劳力士学习中心建筑新颖大胆而且具有高度的实验性质，向人们展示了21世纪人类新的学习方式和交互性影响的意义。作为瑞士洛桑联邦理工学院（EPFL）的一部分，

关键词：学习方式劳力士建筑事务所建筑师设计

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射精后前列腺周围带和精囊T2值的显著改变

国际医学放射学杂志 2018年第3期 362-362页

作者： T.Shin Y.kaji T.Shukuya M.Nozaki S.Soh H.Okada 刘磊 Department of Radiology Dokkyo Medical University

摘要目的应用MRI分析射精后前列腺和精囊(SV)的定量改变。方法招募10名健康的年轻男性受试者,并在2次连续的射精前后进行T2WI和Tmapping MRI检查。分别

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Experiments on synthesis of the heaviest elements at RIKEN

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Experiments on synthesis of the heaviest elements at RIKEN

6th China-Japan Joint Nuclear Physics Symposium

作者： K.Morimoto K.Morita D.kaji A.Yoneda H.Haba T.Akiyama N.Sato S.Goto E.Ideguchi K.Katori H.Kikunaga H.Koura H.Kudo T.Ohnishi A.Ozawa T.Suda K.Sueki F.Tokanai T.Yamaguchi A.Yoshida RIKEN (The Institute of Physical and Chemical research) Wako Saitama 351-0198Japan RIKEN (The Institute of Physical and Chemical research) Wako Saitama 351-0198Japan Department of PhysicsSaitama UniversitySakuraSaitama 338-8570Japan RIKEN (The Institute of Physical and Chemical research) Wako Saitama 351-0198Japan Departent of PhysicsTohoku UniversitySendalMiyagi 980-8578Japan Department of Chemistry Niigata University IkarashiNiigata 950-2181Japan Center for Nuclear Science University of Tokyo Wako-shiSaitama 351-0198Japan RIKEN (The lnstitute of Physical and Chemical research) Wako Saitama 351-0198Japan Japan Atomic Energy Agency (JAEA) Naka-gun Ibaraki 319-1184Japan Department ofChemistry Niigata University IkarashiNiigata 950-2181Japan University of Tsukuba Tsukuba lbaraki 305-8577Japan Department of Physics Yamagata University ShirakawaYamagata 990-8560Japan Department of Physics Saitama University SakuraSaitama 338-8570Japan

In the Institute of Physical and Chemical Research(RIKEN),using high intensity heavy ion beams from the R/KEN Linear Accelerator,productions and decays of isotopes of the heaviest elements have been investigated by using the gas-filled recoil separator,*** isotopes studied were Hs,Ds,Rg,112,and 113,*** on the observed decay chains consisting of consecutive alpha decays connected to the previously known alpha decays or spontaneous fissions,assignments of the initially produced isotopes were *** data with the atomic number from 108 to 112,agree well with the data previously *** production cross section of the isotope 113 of the 113th element have reached around 32 tl0 which shows the simple decrease of the cross section with the increase of the atomic number. The isotopes were produced,for the first time in the In evaporation channel from heavy-ion induced fusion reaction.

关键词： 277112 278113 production and decay gas-filled recoil separator

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水听式传感技术在塑料管线测漏中的应用

城市勘测 2018年第A1期 200-203页

作者：王雨夕森山健一铃木贤一加治克宏北京富急探仪器设备有限公司北京100029 日本富士(地探)株式会社

本论文所阐述的水听式传感器基于一种新概念而开发,以影响塑料管道漏水探测效果的核心因素为设计框架,通过判定和分析来自塑料管道漏水声的频率,从而提高相关仪的非金属管漏水检测能力。本文中所论述的新型水听器具有独特的结构,并在塑... 详细信息

本论文所阐述的水听式传感器基于一种新概念而开发,以影响塑料管道漏水探测效果的核心因素为设计框架,通过判定和分析来自塑料管道漏水声的频率,从而提高相关仪的非金属管漏水检测能力。本文中所论述的新型水听器具有独特的结构,并在塑料管道漏水探测方面得到了现场印证。

关键词：供水管道管网维护漏损管理漏水检测塑料管道水听式传感器相关仪

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