检索结果-南通市图书馆

Relationship between clinicopathological features and mucin phenotypes of advanced gastric adenocarcinoma

World Journal of Gastroenterology 2010年第22期16卷 2764-2770页

作者： Fumiaki Toki Atsushi Takahashi Ryusuke Aihara Kyoichi Ogata Hiroyuki Ando tetsuro ohno Erito Mochiki Hiroyuki Kuwano Department of General Surgical Science (Surgery I) Gunma University Graduate School of Medicine

AIM: To investigate a relationship between the clinicopathological features and mucin phenotypes in advanced gastric adenocarcinoma (AGA). METHODS: Immunohistochemical staining was performed to determine the mucin phenotypes in 38 patients with differentiated adenocarcinomas (DACs), 9 with signet-ring cell carcinomas (SIGs), and 48 with other diffuse-type adenocarcinomas (non-SIGs) of AGA. The mucin phenotypes were classified into 4 types: gastric (G), gastrointestinal (GI), intestinal, and unclassified. RESULTS: The G-related mucin phenotypes were highly expressed in all the histological subtypes of AGA. The expression of the GI phenotype in SIG patients was lower than that in DAC patients (P = 0.02), and this phenotype was observed in 56% of the non-SIG patients in the intramucosal layer. Among non-SIG cases, the expression of the GI phenotype was significantly higherin patients with extended adenocarcinomas and those with positive rates of lymph node metastasis. There was no difference between the expressions of the G and other GI phenotypes factors. Among DAC and non-SIG patients, there were no differences between the survival rates of the corresponding patient groups. CONCLUSION: The GI phenotype might possess more invasive characteristics than the G phenotype in nonSIG. Neither of the phenotypes indicated a poor prognosis of DAC and non-SIG.

关键词： Mucins Phenotype Diffuse type Undifferentiated type Gastric neoplasms Adenocarcinoma Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanism of gastrointestinal abnormal motor activity induced by cisplatin in conscious dogs

引用

World Journal of Gastroenterology 2014年第42期20卷 15691-15702页

作者： Hiroyuki Ando Erito Mochiki tetsuro ohno Mitsuhiro Yanai Yoshitaka Toyomasu Kyoichi Ogata Yuichi Tabe Ryuusuke Aihara Toshihiro Nakabayashi Takayuki Asao Hiroyuki Kuwano Department of General Surgical Science Gunma University Graduate School of Medicine

AIM: To investigate whether 5-hydroxytryptamine(serotonin; 5-HT) is involved in mediating abnormal motor activity in dogs after cisplatin ***: After the dogs had been given a 2-wk recovery period, all of them were administered cisplatin, and the motor activity was recorded using strain gauge force transducers. Blood and intestinal fluid samples were collected to measure 5-HT for 24 h. To determine whether 5-HT in plasma or that in intestinal fluids is more closely related to abnormal motor activity we injected 5-HT into the bloodstream and the intestinal tract of the ***: Cisplatin given intravenously produced abnormal motor activity that lasted up to 5 h. From 3 to 4 h after cisplatin administration, normal intact dogs exhibited retropropagation of motor activity accompanied by emesis. The concentration of 5-HT in plasma reached the peak at 4 h, and that in intestinal fluids reached the peak at 3 h. In normal intact dogs with resection of the vagus nerve that were administered kytril, cisplatin given intravenously did not produce abnormal motor activity. Intestinal serotonin administration did not produce abnormal motor activity, but intravenous serotonin administration ***: After the intravenous administration of cisplatin, abnormal motor activity was produced in the involved vagus nerve and in the involved serotonergic neurons via another pathway. This study was the first to determine the relationship between 5-HT and emesis-induced motor activity.

关键词： Cisplatin Emesis 5-hydroxytryptamine Abnormal moto

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of 5-HT2B, 5-HT3 and 5-HT4 receptor antagonists on gastrointestinal motor activity in dogs

引用

World Journal of Gastroenterology 2013年第39期19卷 6604-6612页

作者： Hiroki Morita Erito Mochiki Nobuyuki Takahashi Kiyoshi Kawamura Akira Watanabe Toshinaga Sutou Atsushi Ogawa Mitsuhiro Yanai Kyoichi Ogata Takaaki Fujii tetsuro ohno Souichi Tsutsumi Takayuki Asao Hiroyuki Kuwano Department of General Surgical Science (Surgery 1) Gunma UniversityGraduate School of MedicineGunma 371-8511Japan RaQualia Pharma Inc. Research and Development5-2 TaketoyoAichi 470-2341Japan

AIM:To study the effects of 5-hydroxytryptamine(5-HT)receptor antagonists on normal colonic motor activity in conscious ***:Colonic motor activity was recorded using a strain gauge force transducer in 5 dogs before and after 5-HT2B,5-HT3 and 5-HT4 receptor antagonist *** force transducers were implanted on the serosal surfaces of the gastric antrum,terminal ileum,ileocecal sphincter and *** materials or vehicle alone was administered as an intravenous bolus injection during a quiescent period of the whole colon in the interdigestive *** effects of these receptor antagonists on normal gastrointestinal motor activity were ***:5-HT2B,5-HT3 and 5-HT4 receptor antagonists had no contractile effect on the fasting canine terminal *** 5-HT3 and 5-HT4 receptor antagonists inhibited phaseⅢof the interdigestive motor complex of the antrum and significantly inhibited colonic motor *** the proximal colon,the inhibitory effect was dose *** dependency,however,was not observed in the distal *** 5-HT2B receptor antagonist had no contractile effect on normal colonic motor ***:The 5-HT3 and 5-HT4 receptor antagonists inhibited normal colonic motor ***5-HT2B receptor antagonist had no contractile effect on normal colonic motor activity.

关键词： 5-hydroxytryptamine receptor antagonist Colonic motility Irritable bowel syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：