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Branched-chain amino acid treatment before transcatheter arterial chemoembolization for hepatocellular carcinoma

World Journal of Gastroenterology 2012年第12期18卷 1379-1384页

作者： Hiroki Nishikawa Yukio Osaki Tadashi Inuzuka Haruhiko Takeda Jun Nakajima Fumihiro Matsuda Shinichiro Henmi Azusa Sakamoto tetsuro ishikawa Sumio Saito Ryuichi Kita Toru Kimura Department of Gastroenterology and Hepatology Osaka Red Cross Hospital

AIM:To examine the significance of branched-chain amino acid (BCAA) treatment before transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC).METHODS:This study included 99 patients who underwent TACE therapy for HCC at our hospital and were followed up without treatment for at least 6 mo between January 2004 and January 2010.They were divided into 2 groups:those receiving BCAA granules (n=40) or regular diet (n=59,control).Data obtained were retrospectively analyzed (prior to TACE,and 1 wk,1,3,and 6 mo after TACE) in terms of nutritional condition and clinical laboratory parameters (serum albumin level and Child-Pugh score),both of which are determinants of hepatic functional reserve.RESULTS:The BCAA group comprised 27 males and 13 females with a mean age of 69.9 ± 8.8 years.The patients of the BCAA group were classified as follows:Child-Pugh A/B/C in 22/15/3 patients,and Stage Ⅱ/Ⅲ /ⅣA HCC in 12/23/5 patients,respectively.The controlgroup comprised 32 males and 27 females with a mean age of 73.2 ± 10.1 years.In the control group,9 patients had chronic hepatitis,Child-Pugh A/B/C in 39/10/1 patients,and StageⅠ/Ⅱ/Ⅲ/ⅣA HCC in 1/11/35/12 patients,respectively.Overall,both serum albumin level and Child-Pugh score improved significantly in the BCAA group as compared with the control 3 and 6 mo after TACE (P 3.5 g/dL;and (3) epirubicin dose.A similar trend indicating a significant improvement of all variables in the BCAA group was noted (P < 0.05).CONCLUSION:Treatment with BCAA granules in patients who have undergone TACE for HCC is considered useful to maintain their hepatic functional reserve.

关键词：支链氨基酸肝细胞癌治疗栓塞化疗导管动脉 NOMA

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Breast Conserving Surgery and Sentinel Lymph Node Biopsy under Local Anesthesia for Breast Cancer

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Journal of Cancer Therapy 2012年第5期3卷 810-813页

作者： Shinichiro Kashiwagi Naoyoshi Onoda Tsutomu Takashima Yuka Asano Naoki Aomatsu Masanori Nakamura Hidemi Kawajiri tetsuro ishikawa Kosei Hirakawa Department of Surgical Oncology Osaka City University Graduate School of Medicine Osaka Japan

Background: Breast conserving surgery and sentinel lymph node biopsy has become the standard operation for early breast cancer. This operation has been performed under local anesthesia for patients that would like short-term admission or for those not indicated for general anesthesia due to complications. This report presents the outcomes of breast conserving surgery and sentinel lymph node biopsy under local anesthesia. Patients and Methods: The study included 61 patients with breast cancer that were all definitely diagnosed before surgery. The indications were preoperatively diagnosed localized DCIS, invasive carcinoma measuring less than 3 cm in tumor diameter on ultrasound, and tumors with negative axillary lymph nodes. The surgical procedures included breast conserving surgery associated with sentinel lymph node navigation biopsy. Results: The surgery could be performed under local anesthesia in all 61 patients, and no patient was converted to general anesthesia. Four patients had sentinel lymph node metastasis. Surgical stumps were positive in 18 patients (29.5%). Ten Gy of boost irradiation of the tumor bed was added to the conventional breast irradiation for these patients. There were no serious complications associated with surgery. Conclusion: Breast conserving surgery and sentinel lymph node biopsy for early breast cancer can be performed safely under local anesthesia. This procedure contributes to shortening the length of hospitalization and thereby saving medical resources without deceasing the quality of treatment.

关键词： Breast Cancer Local Anesthesia Breast Conserving Surgery

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Mucosal necrosis of the small intestine in myopathy,encephalopathy,lactic acidosis,and stroke-like episodes syndrome

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World Journal of Gastroenterology 2012年第41期18卷 5986-5989页

作者： Keita Fukuyama Yasuhide ishikawa tetsuro Ogino Hidenobu Inoue Ryoya Yamaoka tetsuro Hirose Tomohiko Nishihira Department of Gastroenterological Surgery Takamatsu Red Cross HospitalTakamatsu 760-0017Japan Department of Pathology Takamatsu Red Cross HospitalTakamatsu 760-0017Japan

This report presents a case of massive mucosal necrosis of the small intestine in a patient with mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes(MELAS),which particularly affects the brain,nervous system and muscles.A 45-year-old Japanese female,with an established diagnosis of MELAS,presented with vomiting.Computed tomography showed portomesenteric venous gas and pneumatosis intestinalis.She underwent a resection of the small intestine.A microscopic study showed necrosis of the mucosa and vacuolar degeneration of smooth muscle cells in the arterial wall.Immunohistochemistry showed anti-mitochondrial antibody to be highly expressed in the crypts adjacent the necrotic mucosa.The microscopic and immunohistochemical findings suggested the presence of a large number of abnormal mitochondria in MELAS to be closely linked to mucosal necrosis of the small intestine.

关键词：小肠黏膜坏死性酸中毒肌病脑病酸性综合征乳

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Effectiveness and safety of chemotherapy for patients with malignant gastrointestinal obstruction:A Japanese populationbased cohort study

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World Journal of Clinical Cases 2022年第16期10卷 5253-5265页

作者： Gota Fujisawa Ryota Niikura Takuya Kawahara tetsuro Honda Kenkei Hasatani Naohiro Yoshida Tsutomu Nishida Tetsuya Sumiyoshi Shu Kiyotoki Takashi Ikeya Masahiro Arai Yoku Hayakawa Takashi Kawai Mitsuhiro Fujishiro Department of Gastroenterology Graduate school of MedicineThe University of TokyoTokyo 1138655Japan Gastroenterological Endoscopy Tokyo Medical UniversityTokyo 1600023Japan Clinical Research Support Center The University of Tokyo HospitalTokyo 1138655Japan Department of Gastroenterology Nagasaki Harbor Medical CenterNagasaki 8508555Japan Department of Gastroenterology Fukui Prefectural HospitalFukui 9108526Japan Department of Gastroenterology Ishikawa Prefectural Central HospitalIshikawa 9208530Japan Department of Gastroenterology Toyonaka Municipal HospitalOsaka 5608565Japan Department of Gastroenterology Tonan HospitalHokkaido 0600004Japan Department of Gastroenterology Shuto General HospitalYamaguchi 7420032Japan Department of Gastroenterology St.Luke's International HospitalTokyo 1048560Japan Department of Gastroenterology Nerima Hikarigaoka HospitalTokyo 1790072Japan

BACKGROUND The impacts of chemotherapy on patients with malignant gastrointestinal obstructions remain unclear,and multicenter evidence is lacking.AIM To evaluate the effectiveness and safety of chemotherapy in patients with unresectable malignant gastrointestinal obstructions.METHODS We conducted a multicenter retrospective cohort study that compared the chemotherapy group who received any chemotherapeutics after interventions,including palliative surgery or selfexpandable metal stent placement,for unresectable malignant gastrointestinal obstruction vs the best supportive care(BSC)group between 2014 and 2019 in nine hospitals.The primary outcome was overall survival,and the secondary outcomes were patency duration and adverse events,including gastrointestinal perforation and gastrointestinal bleeding.RESULTS In total,470 patients in the chemotherapy group and 652 patients in the BSC group were analyzed.During the follow-up period of 54.1 mo,the median overall survival durations were 19.3 mo in the chemotherapy group and 5.4 mo in the BSC group(log-rank test,P<0.01).The median patency durations were 9.7 mo[95% confidence interval(CI):7.7-11.5 mo]in the chemotherapy group and 2.5 mo(95%CI:2.0-2.9 mo)in the BSC group(log-rank test,P<0.01).The perforation rate was 1.3%(6/470)in the chemotherapy group and 0.9%(6/652)in the BSC group(P=0.567).The gastrointestinal bleeding rate was 1.5%(7/470)in the chemotherapy group and 0.5%(3/652)in the BSC group(P=0.105).CONCLUSION Chemotherapy after interventions for unresectable malignant gastrointestinal obstruction was associated with increased overall survival and patency duration.

关键词： Gastrointestinal cancer Chemotherapy Malignant gastrointestinal obstruction Self-expandable metal stent Palliative surgery

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Classification of archaic rice grains excavated at the Mojiaoshan site within the Liangzhu site complex reveals an Indica and Japonica chloroplast complex

食物生产加工与营养(英文)

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食物生产加工与营养(英文) 2020年第1期2卷 148-159页

作者： Katsunori Tanaka Chunfang Zhao Ningyuan Wang Shinji Kubota Masaaki Kanehara Nobuhiko Kamijo Ryuji ishikawa Hiroyuki Tasaki Minako Kanehara Bin Liu Minghui Chen Shin-ichi Nakamura tetsuro Udatsu Cailin Wang Faculty of Agriculture and Life Science Hirosaki University3 BunkyoHirosakiAomori 036-8561Japan Institute of Food Crops Jiangsu Academy of Agricultural SciencesXiaolingweiNanjing 210014Jiangsu ProvinceChina Zhejiang Provincial Institute of Cultural Relics and Archaeology Gongshuqu Jiashanxincun26Hangzhou 310014Zhejiang ProvinceChina Center for Cultural Resource Studies Kanazawa University Kanazawa UniversityKakumaKanazawaIshikawa 920-1192Japan Department of Teacher Training and School Education Nara University of EducationTakahataNaraNara 630-8528Japan Archaeological Research Center Ehime University10-13 Dogo-hi-mataMatsuyamaEhime 790-8577Japan Agricultural Museum Faculty of AgricultureMiyazaki University1-1 Gakuen-Kibana-dai-NishiMiyazakiMiyazaki 889-2192Japan

To understand rice types that were utilized during postdomestication and in the modern age and the potential of genetic research in aged rice materials,archaeogenetic analysis was conducted for two populations of archaic rice grains from the Mojiaoshan site during the Liangzhu Period in China(2940 to 2840 BC).Sequencing after the PCR amplification of three regions of the chloroplast genome and one region of the nuclear genome showed recovery rates that were comparable to those in previous studies except for one chloroplast genome region,suggesting that the materials used in this work were appropriate for recovering genetic information related to domestication traits by using advanced technology.Classification after sequencing in these regions proved the existence of Japonica and Indica chloroplasts in archaic grains from the west trench,which were subsequently classified into eight plastid groups(type I–VIII),and indicated that these rice grains derived from different maternal lineages were stored together in storage houses at the Mojiaohsan site.Among these plastid groups,type V exhibited the same sequences as two modern Indica accessions that are utilized in basic studies and rice breeding.It was inferred that part of the chloroplast genome of archaic rice has been preserved in modern genetic resources in these two modern Indica accessions,and the results indicated that rice related to their maternal ancestor was present at the Mojiaoshan site during the Liangzhu Period in China.The usefulness of archaeogenetic analysis can be demonstrated by our research data as well as previous studies,providing encouragement for the possibility that archaeogenetic analysis can be applied to older rice materials that were utilized in the rice-domesticated period.

关键词： Agriculture Archaeology Archaic DNA Diversity Mojiaoshan Rice

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心肌模型和分析软件的研发及其在心肌SPECT显像标准化中作用的多中心研究

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中华核医学与分子影像杂志 2017年第8期37卷 523-523页

作者：唐军 Takayuki Shibutani Masahisa Onoguchi tetsuro Katafuchi Seigo Kinuya 苏州大学附属第二医院核医学科 215004 Department of Quantum Medical Technology Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan

目的该课题组自主研发了一款心肌模型和分析软件，通过标准化的定量指标来客观评价显像质量。研究目的是明确该模型和软件是否适用于显像的标准化。方法为对心肌SPECT显像进行标准化，课题组研发了心肌显像的评价分析软件（EMIT）和模... 详细信息

目的该课题组自主研发了一款心肌模型和分析软件，通过标准化的定量指标来客观评价显像质量。研究目的是明确该模型和软件是否适用于显像的标准化。方法为对心肌SPECT显像进行标准化，课题组研发了心肌显像的评价分析软件（EMIT）和模型，利用该模型对胸部进行模拟，其内设置了肺和心脏。心肌模型包括5个放射性正常区域和8个放射性缺损区域。

关键词： EMIT模型心肌SPECT显像标准化显像质量评价

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丙肝病毒NS5A蛋白对NS5B的RdRP活性影响的研究

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生物医学工程学杂志 2004年第5期21卷 795-799页

作者：罗宏秦伟平马媛媛岛上哲朗村上清史何芳赵连三四川大学华西医院人类疾病生物治疗教育部重点实验室成都610041 日本金沢大学癌症研究所

丙型肝炎病毒 (Hepatitis C virus,HCV )非结构蛋白 (Nonstructural,NS) 5 A在 HCV基因组复制中的作用目前尚不清楚。本文研究 His- NS5 A对 NS5 B的 RNA依赖性 RNA酶 (Rd RP)活性的影响 ,以了解 NS5 A在HCV RNA复制中的作用。采用变性 ... 详细信息

丙型肝炎病毒 (Hepatitis C virus,HCV )非结构蛋白 (Nonstructural,NS) 5 A在 HCV基因组复制中的作用目前尚不清楚。本文研究 His- NS5 A对 NS5 B的 RNA依赖性 RNA酶 (Rd RP)活性的影响 ,以了解 NS5 A在HCV RNA复制中的作用。采用变性 -复性方法 ,纯化大肠杆菌表达的重组组氨酸 NS5 A融合蛋白。 GST结合洗脱实验 (GST pull- down assay)研究 NS5 A和 NS5 B是否结合。以不同的摩尔浓度比 ,将纯化的 NS5 B和 NS5 A蛋白混合 ,检测 NS5 A对 NS5 B的 Rd RP活性的影响。获得高得率的纯化 His- NS5 A蛋白。重组 NS5 A蛋白可在体外与NS5 B结合并抑制后者的 Rd RP活性。本研究报道了纯化重组 His- NS5 A蛋白的变性 -复性方法 ,结果显示纯化的重组 NS5 A在体外可与 NS5 B相互结合 ,并明显抑制 NS5 B Rd RP活性。提示了 HCV NS5 A在病毒复制中的可能作用。

关键词： NS5A蛋白 RP HCV 活性体外丙肝病毒纯化复性变性基因组

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