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大重科技 1993年第1期 47-55页

作者： honma,M 王东辉

GC/FT-IR Analysis of Novel 4,6,9-Triene and 2,4,6,9-Tetraene Occurring in a Female Pheromone Gland of <i>Arctia plantaginis</i>(Erebidae: Arctiinae)

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American Journal of Analytical Chemistry 2017年第10期8卷 645-656页

作者： Yuta Muraki Rei Yamakawa Masanobu Yamamoto Hideshi Naka Atsushi honma Johanna Mappes Kaisa Suisto Tetsu Ando Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology Tokyo Japan Laboratory of Applied Entomology Faculty of Agriculture Tottori University Tottori Japan Department of Ecosystem Studies School of Environmental Science The University of Shiga Prefecture Hikone City Japan Centre of Excellence in Biological Interactions Department of Biological and Environmental Science University of Jyv&auml skylä Jyv&auml skylä Finland

Fifteen subspecies of the wood tiger moth, Arctia plantaginis (Lepidoptera: Erebidae: Arctiinae), have been recorded in the Northern Hemisphere. An analysis of crude pheromone extracts by GC equipped with an electroantennographic (EAG) detector showed four EAG-active components (Comps. I–IV) that were commonly involved in the pheromone glands of two subspecies inhabiting Japan and Finland. Comp. I is a major component (>75%) and the others are minor components (3% - 15%). Their mass spectra, measured by GC/MS, revealed the chemical structures of C21 unsaturated hydrocarbons as follows: 3,6,9-triene for Comp. I, 4,6,9-triene for Comp. II, 1,3,6,9-tetraene for Comp. III, and 2,4,6,9-tetraene for Comp. IV. Comps. I and III are known Type II pheromone compounds, and their retention times coincide with those of the authentic standards with all Z configurations. As a next step, the extract was analyzed by GC/FT-IR to determine the configuration of Comps. II and IV. Their IR spectra showed two characteristic C-H bending absorptions around 990 and 945 cm-1 due to the conjugated dienyl moieties;thus, Z and E configurations were assigned to the double bonds at the 2- and 4-positions, respectively. Their Z double bonds at the 6- and 9-positions are indicated by no absorptions around 970 cm-1, due to the isolated double bonds with E configurations. Finally, the structures of Comps. II and IV were confirmed by synthesis using a double Wittig reaction. The synthetic (4E,6Z,9Z)-4,6,9-triene and (2Z,4E,6Z,9Z)-2,4,6,9-tetraene showed strong EAG activity, and their chemical data coincided well with those of the natural Comps. II and IV, indicating the correctness of the structure determination by GC/FT-IR analysis and its usefulness for Type II pheromone compounds.

关键词： Natural Products Insect Sex Pheromone GC/FT-IR Wood Tiger Moth (4E 6Z 9Z)-4 6 9-Henicosatriene (2Z 4E 9Z)-2 4 9-Henicosatetraene

Impact of Oxaliplatin-Induced Neuropathy on Subsequent Paclitaxel for Advanced Gastric Cancer

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International Journal of Clinical Medicine 2020年第9期11卷 526-537页

作者： Jun Sato Satoru Iwasa Yoshitaka honma Atsuo Takashima Natsuko Okita Ken Kato Tetsuya Hamaguchi Yasuhide Yamada Narikazu Boku Gastrointestinal Medical Oncology Division National Cancer Center Hospital Tokyo Japan

Purpose: Several studies have shown that fluoropyrimidine plus oxaliplatin (SOX) is non-inferior to fluoropyrimidine plus cisplatin as first-line chemotherapy for advanced gastric cancer. We investigated retrospectively the choice of second-line regimen, along with the proportion and feasibility of paclitaxel-containing regimen, in the subsequent treatment of patients with advanced gastric cancer treated with SOX as first-line chemotherapy. Materials and Methods: We retrospectively analyzed the impact of oxaliplatin-induced neuropathy on both the choice of subsequent regimens and feasibility of subsequent chemotherapy with paclitaxel, focusing on patients with advanced gastric cancer who received S-1 plus oxaliplatin as first-line chemotherapy. Results: Twenty-seven from a total of 31 patients enrolled into the phase 2 and phase 3 study assessing S-1 plus oxaliplatin were analyzed (4 patients were deemed ineligible). Among 24 patients that had received second-line treatment, paclitaxel was not selected in 2 patients due to oxaliplatin-induced neuropathy. Paclitaxel was selected as second-line chemotherapy in 16 patients, as third-line chemotherapy in 6 patients and fourth-line chemotherapy in one patient. Severity of sensory neuropathy was grade 0/1/2/3 in 11/10/2/0 patients, respectively, immediately before treatment with paclitaxel, while the worst toxicity profile during paclitaxel treatment was grade 0/1/2/3 in 7/13/1/2 patients, respectively. Although there were no patients requiring dose reductions of paclitaxel due to neuropathy, 2 patients discontinued paclitaxel use due to grade 3 sensory neuropathy after 4 or 8 administrations of paclitaxel. Conclusion: Oxaliplatin-induced neuropathy during first-line chemotherapy may affect the choice and feasibility of subsequent chemotherapy with paclitaxel in advanced gastric cancer patients.

关键词： Gastric Cancer Neuropathy Oxaliplatin Paclitaxel

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DNA指纹法父系检测中的父系慨率

国外医学（遗传学分册） 1990年第4期13卷 198-200页

作者： Masamitsu honma 熊正刚

用小卫星核心探针进行DNA杂交所得到的基因组Southern印迹图象由一系列复杂的、大而高度变异的DNA片段组成。由于它具有很好的识别能力,Jeffreys等称之为“DNA指纹”。它不仅对个体识别很有用处,对于父系鉴定也很有用处,这是因为每一片... 详细信息

用小卫星核心探针进行DNA杂交所得到的基因组Southern印迹图象由一系列复杂的、大而高度变异的DNA片段组成。由于它具有很好的识别能力,Jeffreys等称之为“DNA指纹”。它不仅对个体识别很有用处,对于父系鉴定也很有用处,这是因为每一片段都按孟德尔定律分离。在一组由孩子、母亲和假定父亲这三人组成的病例,孩子的多态片段接近半数源于父亲,这些来自父亲的片段可以通过比较母亲和孩子的DNA指纹而得到证实。所有这些来自父亲的片段必定在父亲的DNA指纹中出现。由于DNA指纹法进行了多重排除,故可高度排除假阳性。

关键词： DNA指纹父系鉴定 DNA

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Characteristics of High-Speed Copper Plating Films Using a Jet Flow Device

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材料科学与工程（中英文A版） 2019年第3期9卷 91-97页

作者： Yohei Suzuki Yushi Miyashita Yasushi Umeda Christpher E.J.Cordonier Hideo honma Osamu Takai Joo-Hyong Noh Department of Materials and Surface Engineering Graduate School of EngineeringKanto Gakuin University Odawara 250-0042Japan Kanto Gakuin University Materials&Surface Engineering Research InstituteOdawara 250-0042Japan Yamamoto-MS Co. Ltd.Tokyo 151-0051Japan

Since copper has excellent properties such as malleability and conductivity,it is widely used in the electronics *** sulfate plating is expanding further in fields requiring thick deposits such as for heat dissipation boards and bumps for stress relaxation during semiconductor *** this study,high-speed copper plating at 50 A/dm2 or more was achieved using a jet flow *** addition,as a result of comparison with the low current density film,the current density had little effect on electrical conductivity and film surface *** the other hand,it was confirmed that the etching rate of the high current density film was greatly increased as the crystallites on the film surface became smaller than low current density *** in productivity is expected due to shorter plating time enabled by film deposition at high current ***,the increase of etching rate is expected to contribute to the suppression of undercuts that occur when removing the seed layer during wiring and bump fabrication.

关键词： Electro copper plating high current density film characteristics jet flow device

Cotylenin A加IFN-α的抗肿瘤效果:卵巢肿瘤的可能治疗手段

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世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 38-39页

作者： honma Y Kasukabe T Yamori T 朱亮 Department of Life Science Shimane University Faculty of Medicine 89- 1 Enya Izumo-city Shimane 693- 8501 Japan

Recently,we found that cotylenin A and IFN- α synergistically inhibited growth both in vitro and in vivo, and induced apoptosis in human cancer cells. For the clinical application of this combined treatment, suitable cancer targets should be selected. Methods. We examined the combined effects of these compounds on various types of cancer cells by a human cancer cell line panel assay, and on cancer cells that had been freshly isolated from patients in three-dimensional cultures embedded in collagen gel. Results. In the analysis of 39 cancer cell lines, ovarian cancer cells were highly sensitive to combined treatment with cotylenin A and IFN- α in inhibiting cell growth. This treatment was also effective toward ovarian cancer cells that were refractory to CDDP, and significantly inhibited the growth of ovarian cancer cells as xenografts without apparent adverse effects. Ovarian cancer cells from the patients were also sensitive to the combined treatment in primary cultures. Conclusion. Combined treatment with cotylenin A and IFN- α may have therapeutic value in treating ovarian cancer.

关键词：卵巢肿瘤 Cotylenin A IFN-α 抗肿瘤效果卵巢癌细胞人肿瘤细胞 CDDP 协同抑制

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数字移动无线通信中的恒定包络调制方法

通信技术 1981年第5期 57-63页

作者： Kouichi honma Eiichirou Murata Yasuhiro Rikou 谷守仁

本文介绍用于数字移动无线通信系统中调制——解调(Modem)设备的分析与设计。设计方法是基于在调制器和解调器中使用PLL电路的,通过使用PLL来满足Modem的如下要求,即已调信号包络的振幅恒定;抑制调制器的带外寄生频谱和具有优良的比特... 详细信息

本文介绍用于数字移动无线通信系统中调制——解调(Modem)设备的分析与设计。设计方法是基于在调制器和解调器中使用PLL电路的,通过使用PLL来满足Modem的如下要求,即已调信号包络的振幅恒定;抑制调制器的带外寄生频谱和具有优良的比特错误率特性。另外,总传输特性应符合奈奎斯特第一准则,从而实现不受样本影响的数据传输。首先给出系统的轮廓,其次提供某些设计方法的考虑意见,最后叙述用25KHz信道间隔传16Kbps数据的设计与试验结果。

关键词：移动无线通信错误率解调器 PLL 传输函数相位均衡器调制方法特性分析调制器包络

白细胞提取法可有效诱导但不能维持溃疡性结肠炎的缓解

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 48-49页

作者： honma T Sugimura K Asakura H. 张欣 Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University 757 Ichibanchou Asahimachidori Niigata JapanDr.

Goals and Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by dense infiltration of lymphocytes, plasma cells, neutrophils, and monocyte-macrophages into the colonic mucosa. Leukocytapheresis is a procedure for selectively removing white blood cells from withdrawn blood. It i s used for the treatment of several autoimmune diseases. This study was performe d to evaluate the effectiveness of leukocytapheresis for inducing and maintainin g remission in corticosteroid-resistant UC, as compared with corticosteroid res ponsive UC. Study: Forty-five patients with active UC who were treated with a d ose of 1 mg/kg per day or more of prednisolone given systemically for at least 2 weeks were evaluated. Twenty patients (6 males, 14 females) in whom improvement was induced only by high doses of prednisolone were allocated as the corticoste roid-responsive group. The other 25 patients (11 males, 14 females) who did not respond to the above-mentioned dose of prednisolone therapy were allocated as the corticosteroid-resistant group and received leukocytapheresis therapy once a week for 5 weeks. Of patients who had a remission, the corticosteroid-respons ive group continued to have the conventional therapy and the corticosteroid-res istant group were given leukocytapheresis once every 4 weeks for at least 2 year s as maintenance therapy. Results: Remission was induced by 5 weeks of leukocyta pheresis in 23 of the 25 (92%) patients with corticosteroid-resistant active U C. The number of days required to achieve remission of UC was fewer in patients who received leukocytapheresis than in those who did not. Follow-up study of th e patients who had remission showed similar relapse rates at 2 years in the pati ents who received leukocytapheresis and those given high doses of prednisolone a lone. Conclusions: Leukocytapheresis is an effective treatment of acute corticos teroid-resistant UC but does not prevent the recurrence of UC.

关键词：白细胞提取法溃疡性结肠炎激素抵抗型炎症性肠病自身免疫性疾病皮质激素氢化泼尼松肠黏膜敏

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运营信息控制系统和车辆段管理系统的现状与展望

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铁道勘测与设计 2006年第6期 41-44页

作者： Hidetoshi honma Toshishige Nagao 叶芹禄（译）杨铭（译）不详铁道第四勘察设计院设备处武汉430063

通过对远程监控系统、列车维护管理系统、车辆段管理系统和维护工作现代化系统的介绍，阐述了改善车辆段运营维护的方法与途径。

关键词：车辆段远程监控系统(RMS) 列车维护管理系统(MMS) 车辆段管理系统(DMS) 维护工作现代化系统

下丘脑室旁核和室旁下核钙信号的次昼夜生物节律

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下丘脑室旁核和室旁下核钙信号的次昼夜生物节律