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Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy

World Journal of Clinical Cases 2024年第2期12卷 276-284页

作者： Taiichiro Miyake Hiroaki Yanagimoto Daisuke Tsugawa Masayuki Akita Riki Asakura Keisuke Arai Toshihiko Yoshida Shinichi So Jun Ishida Takeshi Urade Yoshihide Nanno Kenji Fukushima Hidetoshi Gon Shohei Komatsu Sadaki Asari Hirochika Toyama Masahiro Kido tetsuo ajiki Takumi Fukumoto Division of Hepato-Biliary-Pancreatic Surgery Department of SurgeryKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Venous thromboembolism(VTE)is a potentially fatal complication of *** use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative ***,we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after *** To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after *** The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively *** were divided into two groups according to whether or not they developed VTE after hepatectomy,as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower *** factors,including demographic data and perioperative D-dimer values,were compared between the two *** operating characteristic curve analysis was performed to determine the D-dimer cutoff *** and multivariate analyses were performed using logistic regression analysis to identify significant *** In total,234 patients who underwent hepatectomy were,of whom(5.6%)were diagnosed with VTE following hepatectomy.A comparison between the two groups showed significant differences in operative time(529 vs 403 min,P=0.0274)and blood loss(530 vs 138 mL,P=0.0067).The D-dimer levels on postoperative days(POD)1,3,5,7 were significantly higher in the VTE group than in the non-VTE *** the multivariate analysis,intraoperative blood loss of>275 mL[odds ratio(OR)=5.32,95%confidence interval(CI):1.05-27.0,P=0.044]and plasma D-dimer levels on POD 5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were independent risk factors for VTE after *** Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the

关键词： Hepatectomy Malignant tumor Postoperative complication D-dimer Early diagnosis Venous thromboembolism

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Benefits and limitations of middle bile duct segmental resection for extrahepatic cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 147-152页

作者： Masayuki Akita tetsuo ajiki Kimihiko Ueno Daisuke Tsugawa Motofumi Tanaka Masahiro Kido Hirochika Toyama Takumi Fukumoto Department of Hepato-Biliary-Pancreatic Surgery Kobe University Graduate School of MedicineKobe650-0017Japan

Background:Pancreaticoduodenectomy(PD)is a standardized strategy for patients with middle and distal bile duct *** aim of this study was to compare clinicopathological features of bile duct segmen-tal resection(BDR)with PD in patients with extrahepatic ***:Consecutive cases with extrahepatic cholangiocarcinoma who underwent BDR(n=21)or PD(n=84)with achievement of R0 or R1 resection in Kobe University Hospital between January 2000 and December 2016 were enrolled in the present ***:Patients who underwent PD were significantly younger than those receiving *** frequency of preoperative jaundice,biliary drainage and cholangitis was not significantly different between the two *** duration of surgery was longer and there was more intraoperative bleeding in the PD than in the BDR group(553 vs.421 min,and 770 vs.402 mL;both PClavien-DindoⅢa)were observed in the PD group(46%vs.10%,P<0.01).Postoperative hospital stay was also longer in that group(30 vs.19 days,P=0.02).Pathological assessment revealed that tumors were less advanced in the BDR group but the rate of lymph node metastasis was similar in both groups(33%in BDR and 48%in PD,P=0.24).The rate of R0 resection was significantly higher in the PD group(80%vs.38%,P<0.01).Adjuvant chemotherapy was more frequently administered to patients in the BDR group(62%vs.38%,P=0.04).Although 5-year overall survival rates were similar in both groups(44%for BDR and 51%for PD,P=0.72),in patients with T1 and T2,the BDR group tended to have poorer prognosis(44%vs.68%at 5-year,P=0.09).Conclusions:BDR was comparable in prognosis to PD in middle bile duct *** invasiveness and lower morbidity of BDR justified this technique for selected patients in a poor general condition.

关键词： Cholangiocarcinoma Middle bile duct resection Pancreaticoduodenectomy

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Risk factors for occult metastasis detected by inflammation-based prognostic scores and tumor markers in biliary tract cancer

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World Journal of Clinical Cases 2021年第32期9卷 9770-9782页

作者： Yu Hashimoto tetsuo ajiki Hiroaki Yanagimoto Daisuke Tsugawa Kenta Shinozaki Hirochika Toyama Masahiro Kido Takumi Fukumoto Department of Surgery Division of Hepato-Biliary-Pancreatic SurgeryKobe University Graduate School of MedicineKobeHyogo 650-0017Japan

BACKGROUND Radiological detection of small liver metastasis or peritoneal metastasis is still difficult,and some patients with biliary tract cancer(BTC)are unresectable after *** laparoscopy may help avoid unnecessary ***,which category of BTC is amenable with staging laparoscopy remains *** To clarify the risk factors for occult metastasis in patients with *** Medical records of patients with BTC who underwent surgery at our institution between January 2008 and June 2014 were retrospectively *** patients were divided into two groups,according to resection or exploratory laparotomy(EL).Preoperative laboratory data,including inflammation-based prognostic scores and tumor markers,were compared between the two *** importance of detected risk factors was also *** A total of 236 patients were enrolled in this ***-six(11%)patients underwent *** the EL patients,there were 16 cases of occult metastasis(7 liver metastases and 9 abdominal disseminations).Serum carcinoembryonic antigen level,carbohydrate antigen 19-9 level,neutrophil-lymphocyte ratio and modified Glasgow prognostic score were significantly higher in the EL group than in the resected group,and these factors were *** these factors,carcinoembryonic antigen>7 ng/mL was the most useful to predict occult metastasis in *** patients have more than three of these positive factors,the rate of occult metastasis *** Inflammation-based prognostic scores and tumor markers are useful in detecting occult metastasis in BTC;based on these factors,staging laparoscopy may reduce the rate of EL.

关键词： Biliary tract cancer Staging laparoscopy Neutrophil-lymphocyte ratio Modified Glasgow prognostic score Carbohydrate antigen 19-9 Carcinoembryonic antigen

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Computational Modeling of Optical Response from Excitons in a Nano OpticalMedium

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Communications in Computational Physics 2008年第10期4卷 1051-1068页

作者： Yuanchang Sun Hiroshi ajiki Gang Bao Department of Mathematics Michigan State UniversityEast LansingMI 48824USA Graduate School of Engineering Science Osaka University1-3 MachikaneyamaToyonaka 560-8531Japan

Consider a time-harmonic electromagnetic plane wave incident on a microscopic *** the medium,at any given frequencyω,more than one polariton mode can arise with the same frequency but different wavenumbers due to the presence of *** Maxwell’s boundary conditions,additional boundary conditions are required to handle the multi-mode *** order to model the confinement effect of excitons in the microscopic semiconductor,Maxwell’s equations and the Schr¨odinger equation are coupled to characterize the polarization in terms of the quantum *** the weak confinement regime,we derive a perturbed dispersive dielectric constant by taking the exciton effect into *** also analyze and compute the optical linear response of the exciton in both one-dimensional and two-dimensional *** the one-dimensional case,the existence and uniqueness of the analytical solution are established in the resonance region.A finite difference method is developed to compute the two dimensional confinement.

关键词： Nano optics exciton modeling

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Corn Leaf Water Retention as Affected by OrganicFertilizations and Effective Microbes Applications

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Pedosphere 1998年第1期8卷 1-8页

作者： XU HUILIAN N. ajiki WANG XIAOJU C. SAKAKIBARA and H. UMEMURA (International Nature Farming Research Center, Hata-machi, Nagano 390-14 (Japan)) International Nature Farming Research Center Hata-machi Nagano 390-14 Japan

Effects of organic fertilizers and effective microbes on leaf water retention of sweet corn (Zea mays L. ***-Bantam) were studied. Sweet corns were grown with organic or chemical fertilizers with or without effective microbes (EM). A water retention curve was obtained by drying the excised leaves under a light of 500 μmol (m2·s)-1. The curve shows two distinct phases. The initial steep slope indicates the water loss speed by stomatal transpiration (Est) and the gentle slope of the second phase indicates water loss speed by cuticular transpiration (Ecu). Both Est and Ecu were lower for leaves of plants grown with organic materials than for those with chemical fertilizers. Addition of EM to both organic and chemical fertilizers decreased Est but showed no effect on Ecu. The water retention ability of the excised leaves was proportional to photosynthetic maintenance ability under soil water deficit conditions as well as the solute concentration in leaves. The results suggested that organic fertilization and EM application increased water stress resistance both under in situ conditions and in excised leaves of sweet corn plants.

关键词： cuticular transpiration effective microorganism organic fertilizer water stress Zea mays

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Microcrystalline Silicon-germanium Thin Films Prepared by the Multi-target RF Sputtering System

Microcrystalline Silicon-germanium Thin Films Prepared by th...

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第十五届国际光伏科学与工程大会

作者： Toru ajiki Isao Nakamura Masao Isomura Department of Electrical and Electronic Engineering Tokai University 1117 kitakaname Hiratsuka Kanagawa 259-1292 Japan

Microcrystalline silicon-germanium (μc-SiGe) films were prepared by the multi-target RF sputtering system using Ar and Ar-H mixture gases. The crystallization temperature of SiGe films could be reduced from 600℃to 300℃by the introduction of H into the sputtering gases. Higher H/Ar flow ratios are effective for the reduction in crystallization temperature. The low dark conductivity of 1.7×10/cm and one order of magnitude of photosensitivity were achieved at 400℃with the H/Ar flow ratio of 2. The results suggest that the H introduction has important roles both to reduce the dangling bond defects and to decrease the crystallization temperature of the μc-SiGe films.

关键词： μc-SiGe RF sputtering Raman Spectra XRD Pattern Absorption Coefficient Electrical Conductivity

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