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Myocardial metastasis from ZEB1-and TWIST-positive spindle cell carcinoma of the esophagus:A case report

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World Journal of Gastroenterology 2024年第11期30卷 1636-1643页

作者： Yoshihiro Shibata Hirofumi ohmura Kazuki Komatsu Kosuke Sagara Atsuji Matsuyama Ryuji Nakano Eishi Baba Department of Medical Oncology Fukuoka Wajiro HospitalFukuoka 811-0213Japan Department of Oncology and Social Medicine Kyushu University Graduate School of Medical SciencesFukuoka 812-8582Japan Department of Pathology and Oncology University of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Diagnostic Pathology Fukuoka Wajiro HospitalFukuoka 811-0213Japan

BACKGROUND Metastatic cardiac tumors are known to occur more frequently than primary cardiac tumors,however,they often remain asymptomatic and are commonly dis-covered on *** tumors with a relatively high frequency of cardiac metastasis include mesothelioma,melanoma,lung cancer,and breast cancer,whereas reports of esophageal cancer with cardiac metastasis are *** SUMMARY The case of a 60-year-old man who complained of dysphagia is *** gastrointestinal endoscopy showed a submucosal tumor-like elevated lesion in the esophagus causing ***-enhanced computed tomography showed left atrial compression due to the esophageal tumor,multiple liver and lung metastases,and a left pleural *** examination of a biopsy speci-men from the esophageal tumor showed spindle-shaped cells,raising suspicion of esophageal *** disease progressed rapidly,and systemic chemotherapy was deemed necessary,however,due to his poor general condition,adminis-tration of cytotoxic agents was considered *** his high Combined Positive Score,nivolumab was administered,however,the patient soon died from the *** autopsy confirmed spindle cell carcinoma(SCC)of the esophagus and cardiac metastasis with similar histological *** stem cell markers,ZEB1 and TWIST,were positive in both the primary tumor and the cardiac *** To the best of our knowledge,there have been no prior reports of cardiac metastasis of esophageal *** case highlights our experience with a patient with esophageal SCC who progressed rapidly and died from the disease,with the autopsy examination showing cardiac metastasis.

关键词： Spindle cell carcinoma Esophagus Myocardial metastasis Epithelial-mesenchymal transition Case report

Microstructure effect on nanohardness distribution for medium-carbon martensitic steel

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Science China(Technological Sciences) 2006年第1期49卷 10-19页

作者： ohmura Takahito TSUZAKI Kaneaki Steel Research Center National Institute for Materials Science Tsukuba 305-0047 Japan

Nanoindentation measurement was performed to evaluate the local hardness distribution for quenched and tempered martensitic steel with ferrite-cementite constituent. The ratio of standard deviation to the average nanohardness was 15.4% when nanoin-dentation tests were carried out at the peak load of 1000 μN, while that of the Vickers hardness was only 1.5% at 9.8 N. Electron backscatter diffraction analysis and SEM ob-servation all showed that the large scattering of nanohardness did not depend on the crystallographic orientation of each grain but from the inhomogeneous microstructure in the sub-micron scale such as cementite distribution. Compared with the results on tung-sten single crystals with different surface orientations as well as another martensite proc-essed by modified-ausforming with the same chemical composition but more homogene-ous cementite distribution, the nanohardness showed smaller scattering, supporting the conclusion.

关键词： martensitic steel, cementite, hardness distribution, nanoindentation.

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Foreword

Journal of Earth Science 2011年第4期22卷 421-422页

作者： Atsumu ohmura Institute for Atmospheric and Climate Science Swiss Federal Institute of Technology (ETH) Zurich Universittstrasse 168092 Switzerland

China has 46 377 glaciers with a total area of 59 425 km2, which accounts for 11%-14.5% of the total area of mountain glaciers in the world. As one of the largest mountain ranges in Central Asia and Northwest China, the Tianshan contains 15 935 glaciers with a total area of 15 416 km2. These glaciers are a vital source of water for more than 100 million people and for wildlife ecosystems in this vast arid and semi-arid land. Urumqi Glacier No. 1, the best monitored glacier in China, is located at the headwaters of the Urumqi River in eastern Tianshan and is within the core area of Central Asia.

关键词： Asia Foreword

Small-scale analysis of brittle-to-ductile transition behavior in pure tungsten

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Journal of Materials Science & Technology 2022年第10期105卷 242-258页

作者： Yeonju Oh Won-Seok Ko Nojun Kwak Jae-il Jang Takahito ohmura Heung Nam Han Department of Materials Science and Engineering&Research Institute of Advanced Materials Seoul National UniversitySeoul 08826South Korea School of Materials Science and Engineering University of UlsanUlsan 44610South Korea Division of Materials Science and Engineering Hanyang UniversitySeoul04763South Korea National Institute for Materials Science 1-2-1 SengenTsukubaIbaraki 305-0047Japan

Tungsten as a material exhibits broad and increasingly important applications;however,the characterization of its ductile-to-brittle transition(BDT)is currently limited to large-scale scenarios and destructive *** this study,we overcome this challenge by implementing small-scale techniques to provide a comprehensive understanding of the BDT behavior of pure *** order to predict the failure mode at various temperature ranges,the practical fracture analysis diagram has been proposed to describe the resistance to shear flow and cracking behavior with *** temperature nano-indentation tests have provided the inherent mechanical responses corresponding to the maximum shear stress at various temperatures,which is required for dislocation activities in an atomic scaled activation *** one hand,atomistic simulations have provided the temperature dependence of brittle fracture stress,where the atomic bonds break due to intergranular or intragranular *** considered four tungsten specimens having various microstructures prepared using different processing conditions of cold-rolling and post-annealing,and their BDT ranges were inferred using the obtained fracture analysis diagram with the statistical data *** fracture analysis diagram of each specimen obtained were compared with the direct observation of fracture responses in macroscopic mechanical tests,which conclusively indicated that the small-scale inherent mechanical properties are greatly relevant to the macroscopic BDT behavior in pure *** on the BDT estimations by small-scale characterization,we provided further insights into the factors affecting the BDT behavior of tungsten,focusing on the contributions of different types of dislocations.

关键词： Brittle-to-ductile transition Nano-indentation Molecular dynamics Dislocation Tungsten

Accumulation over the Greenland Ice Sheet as Represented in Reanalysis Data

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Advances in Atmospheric Sciences 2011年第5期28卷 1030-1038页

作者：陈琳玲 Ola M.JOHANNESSEN 王会军 Atsumu ohmura Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of Sciences Beijing 100029 Mohn-Sverdrup Center Nansen Environmental and Remote Sensing Center Bergen 5006 Norway Nansen Scientific Society Bergen 5006 Norway Mohn-Sverdrup Center Nansen Environmental and Remote Sensing CenterBergen 5006Norway Nansen Scientific Society Bergen 5006Norway Institute for Atmospheric and Climate Science Swiss Federal Institute of Technology(ETH)Zrich 8092Switzerland

Annual precipitation,evaporation,and calculated accumulation from reanalysis model outputs have been investigated for the Greenland Ice Sheet （GrIS）,based on the common period of *** ERA-40 and ERA-interim reanalysis data showed better agreement with observations than do NCEP-1 and NCEP-2 ***,ERA-interim showed the closest spatial distribution of accumulation to the *** temporal variations,ERA-interim showed the best correlation with precipitation observations at five synoptic stations,and the best correlation with in situ measurements of accumulation at nine ice core *** mean annual precipitation averaged over the whole GrIS from ERA-interim （363 mm yr 1） and mean annual accumulation （319 mm yr 1） are very close to the *** validation of accumulation calculated from reanalysis data against ice-core measurements suggests that further improvements to reanalysis models are needed.

关键词： Greenland Ice Sheet reanalysis data precipitation accumulation

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天山冰川消融参数化能量平衡模型

地理学报 1994年第5期49卷 467-476页

作者：康尔泗 ohmura,A 中国科学院兰州冰川冻土研究所

本文运用在天山乌鲁木齐河源的冰川能量平衡观测和常规气象站观测要素，建立了冰川消融参数化能量平衡模型。以日照、日平均气温、低云量、水汽压和风速为模型基本输入因子，模拟计算和讨论了消融期冰川表面辐射平衡和能量平衡。

关键词：冰川消融参数化能量平衡模型

Relations between Dysmorphic Tendency and Body Satisfaction in Female Japanese Youth

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Journal of Health Science 2015年第2期3卷 57-61页

作者： Minako ohmura Department of Psychology University of Social Welfare Tokyo 170-0013 Japan

This study examined the relationship of dysmorphic tendency and satisfaction with each body part （body shape, eyes, nose and mouth, skin, and hair） among female Japanese youth. Participants were 186 female university students. The study found that satisfaction with body parts and dysmorphic tendency were related. However, differences were found in dysmorphic tendency based on feelings about each body part.

关键词： Dysmorphic tendency body satisfaction female youth.

天山冰川作用流域能量、水量和物质平衡及径流模型

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中国科学（B辑） 1994年第9期24卷 983-991页

作者：康尔泗 A.ohmura 中国科学院兰州冰川冻土研究所兰州730000 Swiss Federal Institute of Technology CH-8057 Zürich

基于天山乌鲁木齐河源冰川作用流域能量、水量和物质平衡的观测试验研究,建立了一个冰川消融和径流模型。将常规气象站的观测要素作为模型的初始输入,模拟计算出冰雪面能量平衡、流域积雪量、产流量和水文流量过程线。

关键词：冰川作用流域能量水量物质平衡

天山冰川作用流域能-水-质平衡和水文流量模型研究

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科学通报 1993年第10期38卷 925-929页

作者：康尔泗 Atsumu ohmura 中国科学院兰州冰川冻土研究所兰州730000 瑞士联邦理工学院

本项研究基于1986—1989年在天山乌鲁木齐河源开展的高山冰川作用流域气候、水文和冰川综合过程观测试验,探讨高山冰川区能-水-质平衡过程及其和水文流量形成的关系,建立了一个天山冰川消融和水文流量模型.该模型把气候变量和冰川作用... 详细信息

本项研究基于1986—1989年在天山乌鲁木齐河源开展的高山冰川作用流域气候、水文和冰川综合过程观测试验,探讨高山冰川区能-水-质平衡过程及其和水文流量形成的关系,建立了一个天山冰川消融和水文流量模型.该模型把气候变量和冰川作用流域的物理过程联系起来,而又把该过程和径流的形成联系起来。将常规气象要素输入模型,经过流域响应模拟,再模拟计算出流域出口处的逐日流量过程。

关键词：冰川作用流域能-水-质平衡水文