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Development of simple HPLC/UV with a column-switching method for the determination of nicotine and cotinine in hair samples

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Health 2013年第4期5卷 687-694页

作者： Masayoshi Tsuji Yayoi Mori Hideyuki Kanda Teruna Ito Tomoo Hidaka Takeyasu Kakamu Tomohiro Kumagai Takehito Hayakawa Yoneatsu Osaki tetsuhito fukushima Department of Epidemiology and Public Health School of Medicine Yokohama City University Yokohama Japan Department of Hygiene and Preventive Medicine School of Medicine Fukushima Medical University Fukushima Japan Division of Environmental and Preventive Medicine Department of Social Medicine Faculty of Medicine Tottori University Yonago Japan

Nicotine and cotinine in hair are good biomarkers for assessing long-term exposure to smoking. However, analytical devices such as GC/MS are associated with high cost and are not widely used. HPLC/UV is used widely in laboratories, but is unsuitable for measurement of minor constituents, except when using the column-switching method. Thus, we aimed to establish a simple, inexpensive and sensitive method based on HPLC/UV with column switching for measuring nicotine and cotinine in hair. First, we compared the presence and absence of a column selection unit. We then measured amounts of nicotine and cotinine in hair samples collected from the general population, and compared both the corresponding levels and the detection limits with those in previous studies. Finally, initial and running costs of HPLC/UV were compared with other analytical methods. As one of the results, the areas of nicotine and cotinine measured by HPLC/UV with column-switching method were 12.9 and 16.9 times greater, respectively, than those without the column-switching method. The amount of nicotine and cotinine in hair was significantly correlated to number of cigarettes smoked per day (r = 0.228, p = 0.040). In addition, the HPLC/UV method showed similar sensitivity and detection limit (nicotine, 0.10 ng/mg;cotinine, 0.08 ng/mg) as reported in previous studies. The cost of the HPLC/UV method is lower than that of other analytical methods. We were able to establish a low-cost method with good sensitivity for measuring nicotine and cotinine in hair. The HPLC/UV with a column-switching method will be useful as a first step in screening surveys in order to better understand the effects of smoking exposure.

关键词： HPLC/UV Column-Switching Method Nicotine Hair Cotinine

基于神经网络ODE和非线性MPC的DEA建模与控制

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自动化学报 2025年第1期51卷 186-196页

作者：黄鹏王亚午吴俊东苏春翌福岛 E.文彦中国地质大学(武汉)自动化学院武汉430074 复杂系统先进控制与智能自动化湖北省重点实验室武汉430074 地球探测智能化技术教育部工程研究中心武汉430074 东京工科大学工学部日本东京192-0982 康考迪亚大学Gina Cody工程与计算机科学学院加拿大蒙特利尔QC H3G 1M8

针对介电弹性体驱动器(Dielectric elastomer actuator,DEA)建模与控制的挑战性问题,提出基于神经网络常微分方程(Ordinary differential equation,ODE)和非线性模型预测控制(Model predictive control,MPC)的DEA动力学建模与跟踪控制方法.首先,基于神经网络ODE建立DEA的动力学模型以描述其复杂的动态行为.然后,基于所建立的DEA动力学模型,设计非线性模型预测控制器实现其跟踪控制目标.最后,在所搭建的实验平台上进行一系列跟踪控制实验.在所有实验结果中,DEA的运动均能很好地跟踪目标轨迹,且相对均方根误差均不超过3.30%,说明了所提动力学建模与跟踪控制方法的有效性.

关键词：介电弹性体驱动器神经网络常微分方程动力学建模非线性模型预测控制

Numerical Investigations on Fluid Flow and Heat Transfer Characteristics of an Ultra-Thin Heat Pipe with Separated Wick Structures

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Frontiers in Heat and Mass Transfer 2024年第3期22卷 869-887页

作者： Yasushi Koito Akira fukushima Division of Industrial Fundamentals Faculty of Advanced Science and TechnologyKumamoto UniversityKumamoto860-8555Japan Department of Mechanical and Mathematical Engineering Graduate School of Science and TechnologyKumamoto UniversityKumamoto860-8555Japan

Thermal and fluid-flow characteristics were numerically analyzed for ultra-thin heat *** studies have been conducted for ultra-thin heat pipes with a centered wick structure,but this study focused on separated wick structures to increase the evaporation/condensation surface areas within the heat pipe and to reduce the concentration of heat flux within the wick structure.A mathematical heat-pipe model was made in the threedimensional coordinate system,and the model consisted of three regions:a vapor channel,liquid-wick,and container wall *** conservation equations for mass,momentum,and energy were solved numerically with boundary conditions by using a code developed by one of the *** numerical results with the separated wick structures were compared with those with the centered,which confirmed the effectiveness of the separation of the wick ***,the effectiveness of the separation was affected by the position of the separated wick structure.A simple equation was presented to determine the optimum position of the separated wick *** analyses were also conducted when the width of the heat pipe was increased with the cooled section,which clarified that the increase in the cooled-section width with the addition of wick structures wasmore effective than the increase in the cooled-section length.A 44%reduction in the total temperature difference of the heat pipe was obtained under the present numerical ***,a comparison wasmade between experimental results and numerical results.

关键词： Ultra-thin heat pipe vapor chamber heat transfer surface CFD thermal design

Annular Supersonic Swirling Flows with Heterogeneous Condensation

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Journal of Thermal Science 2016年第6期25卷 518-525页

作者： Yusuke fukushima Shigeru MATSUO Norimasa SHIOMI Toshiaki SETOGUCHI Graduate School of Science & Engineering Saga University Department of Advanced Technology Fusion Saga University Department of Mechanical Engineering Saga University Institute of Ocean Energy Saga University

In recent years,separating and extracting technologies of condensate gas have been developed by combining a swirl flow with non-equilibrium condensation phenomena of condensate gas generated in a supersonic *** technology can reduce the size of the device and does not use ***,there are many unresolved problems for performance of the separation,extraction and operating *** it is necessary to research further in order to improve the performance of the *** the present study,the numerical study was carried out to clarify the effect of the heterogeneous condensation on the characteristics of the swirling flow field in a supersonic annular nozzle,and the differences between homogeneous condensation and heterogeneous condensation in the flow *** the results,it is found that the condensation flow with a swirl affects the position of sonic line,the generating position of condensate and the radial distribution ratio of liquid phase.

关键词： condensation supersonic heterogeneous condensate viscosity chemicals generating annular nozzle regardless

A host lncRNA regulates the innate immune response to an RNA virus

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Cellular & Molecular Immunology 2019年第10期16卷 841-842页

作者： Kiyoharu fukushima Hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical CenterOsakaJapan

TO THE EDITOR Recent studies have shown that more than 70%of the mammalian genome is transcribed into RNAs;however,most of these RNAs do not encode proteins and are thus called noncoding RNAs(ncRNAs).

关键词： immune EDIT innate

Specific targeting of lung ILC2s via NRP1 in pulmonary fibrosis

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Cellular & Molecular Immunology 2022年第8期19卷 869-871页

作者： Takuro Nii Kiyoharu fukushima Hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical Center5-1-1 ToneyamaOsakaJapan Department of Respiratory Medicine and Clinical Immunology Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsakaJapan Laboratory of Host Defense World Premier Institute Immunology Frontier Research Center(WPI-IFReC)Osaka University3-1 YamadaokaSuitaOsakaJapan Department of Host Defense Research Institute for Microbial Diseases(RIMD)Osaka UniversityOsaka565-0871Japan Global Center for Medical Engineering and Informatics 2-2 YamadaokaSuitaOsakaJapan

Innate lymphoid cells are predominantly tissue-resident immune cells that have diverse functions similar to T-cell subsets and regulate tissue homeostasis and innate immunity without specific antigen recognition. Prev... 详细信息

关键词： ILC2s immunity homeostasis

Hepatoid carcinoma of the pancreas mimicking neuroendocrine tumor

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Hepatobiliary Surgery and Nutrition 2018年第6期7卷 501-502页

作者： Kentaro fukushima Akira Kobayashi First Department of Surgery Shinshu University School of MedicineMatsumotoJapan

A 44-year-old man was admitted to our hospital for further investigation of a tumor in the pancreatic *** had no symptoms or chronic liver *** hormones,CEA,and CA19-9 were *** alpha-fetoprotein and des-gamma-carboxy p... 详细信息

关键词： admitted pancreas assessed

Optimum sintering conditions for optical properties of translucent aluminum nitride ceramics

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Chinese Science Bulletin 2009年第5期54卷 842-845页

作者： KANECHIKA Yukihiro AZUMA Masanobu fukushima Hiroshi Tokuyama Corp. Graduate School of Engineering Hiroshima University

High translucency is one of the excellent properties of AlN ceramics because of its wide optical band gap energy of 6.2 eV. We have achieved success in producing AlN ceramic tube of 98% total visible light transmittance at 0.6 mm thick tube wall by applying an improved sintering technique. This AlN ceramic was produced by sintering at 1880℃ using Ca3Al2O6 as a sintering additive and in reduction atmosphere to remove the sintering additive from the final sintered material. After the sintering, the annealing with Al2O3 was carried out to improve the transmittance of AlN ceramics. The amount of metal impurities and carbon were 27ppm and 100ppm, respectively. It is noteworthy that the amount of oxygen in AlN ceramics after the annealing was 0.36wt% which was higher than the 0.07wt% of the as-sintered AlN ceramics. Therefore, total transmittance was improved by the oxygen doping. On the other hand, thermal conductivity of AlN after the annealing was lowered by 35% compared with that of as-sintered AlN. Positron Annihilation Lifetime (PAL) measurement was applied to investigation of a relationship between the total transmittance and lattice defects. The present PAL results confirms the presence of negatively charged atomic-size vacancies that is aluminum site vacancies and also sug-gests the increase in the concentration of the vacancies after the annealing compared with that of the as-sintered material. However, it can be concluded that there is no relation between aluminum site va-cancies and the light transmittance of AlN ceramics.

关键词：陶器阳电子湮没铝氮化物半透明性光学性能

Revealing the diversity of neutrophil functions and subsets

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Cellular & Molecular Immunology 2021年第4期18卷 781-783页

作者： Kiyoharu fukushima Hiroshi Nabeshima Hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical CenterOsakaJapan Department of Respiratory Medicine and Clinical immunology Osaka University Graduate School of MedicineOsakaJapan Laboratory of Host Defense World Premier Institute Im m unology Frontier Research Center(WPIIFReC)Osaka UniversityOsakaJapan Fujii Memorial Research Institute Otsuka Pharmaceutical CompanyLtdShigaJapan

Several recent studies have shown that diverse neutrophil subsets exhibit distinct phenotypic and functional properties in terms of disease onset and progression.1,2 In a study published in Nature Immunology,Sas et al.3 discovered a new neutrophil subset that promotes neuronal survival and axonal regeneration in the central nervous system(CNS).

关键词： neutrophil Immunology