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Annual meeting of the Japan Traditional Chinese Medicine Association: Quantifying and objectifying traditional Chinese medicine

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Journal of Traditional Chinese Medical Sciences 2017年第1期4卷 10-13页

作者： Koh Iwasaki Takao Namiki Mitsuyuki Takamura tetsuhiro yoshino Shin Takayama Kaoru Sakatani Long Term Care Facility Aoinosono-East Sendai SendaiJapan Department of Japanese-Oriental(Kampo)Medicine Chiba University HospitalSchool of MedicineChiba UniversityChibaJapan Kampo Medicine Outpatient Clinic Mie University HospitalMieJapan Center for Kampo Medicine Keio University School of MedicineTokyoJapan Department of Education and Support for Regional Medicine Department of Kampo MedicineTohoku University HospitalSendaiJapan College of Engineering NEWCAT Research InstituteSchool of MedicineNihon UniversityTokyoJapan

Five researchers reported on their studies to quantify and objectify traditional medicine at the symposium 'Verification of Traditional Chinese Medicine' during the 2016 annual meeting of the Japan Traditional Chinese Medicine *** Namiki reported on a methodology to quantify tongue *** yoshino presented work on predictive prescribing two Kampo formulas for dysmenorrhea,Tangkuei and Peony Powder (Danggui Shaoyao San) and Cinnamon Twig and Poria Pill (Guizhi Fuling Wan).Koh Iwasaki presented work on validation of a questionnaire for assessing qi stagnation and Mitsuyuki Takamura reported on application of the questionnaire to evaluate the efficacy of Pinellia and Magnolia Bark Decoction (Banxia Houpo Tang).Kaoru Sakatani presented research on near-infrared spectroscopy as a diagnostic tool for wei bing,a concept of pre-symptomatic state in traditional Chinese medicine.

关键词： Validation of traditional Chinese medicine Tongue diagnosis qi stagnation Traditional Japanese medicine Near infrared spectroscopy

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A Report of 2 Cases of Disseminated Invasive Aspergillosis with Myocarditis in Immunocompromised Patients

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Open Journal of Pathology 2013年第4期3卷 166-169页

作者： tetsuhiro yoshino Hiroko Nishida Takashi Takita Masanori Nemoto Michihiro Sakauchi Mami Hatano Kazuyuki Koyama Masao Hori Katsuyuki Obara Department of Internal Medicine Keio University School of Medicine Tokyo Japan

Invasive aspergillosis is a life-threatening opportunistic infection that occurs most often in immunocompromised patients, especially those with either hematological malignancies treated with chemotherapy or in organ transplant recipients. Here, we report 2 cases of disseminated invasive aspergillosis with myocarditis proven pathologically by autopsy. These 2 cases occurred in immunocompromised patients: the first patient received chemotherapy for acute myeloid leukemia with myelodysplasia-related changes (AML-MRC);the second patient received methotrexate therapy for rheumatoid arthritis (RA). Invasive aspergillosis with myocarditis has high morbidity and mortality rates, therefore it is necessary to make prompt diagnosis and to start intensive treatments quickly.

关键词： Invasive Aspergillosis Myocarditis Acute Myeloid Leukemia Rheumatoid Arthritis

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The Efficacy and Safety of Yokukansankachimpihange for Treating Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: An Open-Label Pilot Study

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Advances in Alzheimer's Disease 2018年第4期7卷 141-152页

作者： Ryutaro Arita tetsuhiro yoshino Miwako Ohgishi Takuya Hamaguchi Yuko Horiba Kaori Sawai Kei Funaki Hajime Tabuchi Mizuki Oka Takahito Yoshizaki Kenji Watanabe Masaru Mimura Center for Kampo Medicine School of Medicine Keio University Tokyo Japan Department of Neuropsychiatry School of Medicine Keio University Tokyo Japan Department of Neurology School of Medicine Keio University Tokyo Japan Faculty of Environmental and Information Study Keio University Fujisawa Japan

Previous clinical trials have demonstrated the efficacy of yokukansan, a traditional Japanese medicine, for the treatment of behavioral and psychological symptoms of dementia (BPSD). However, less evidence is available for the treatment of BPSD with yokukansankachimpihange (YKSCH), which consists of yokukansan and two additional herbal ingredients. The present study was conducted to investigate the efficacy and safety of YKSCH for treating BPSD in patients with Alzheimer’s disease (AD). We enrolled outpatients with mild-to-moderate AD who exhibited BPSD and obtained a Neuropsychiatric Inventory (NPI) score of >3 including subscale scores for “agitation”, “anxiety”, “irritability”, and “sleep and night-time behavior change”. A daily YKSCH dose of 7.5 g was administered for 12 weeks with concomitant administration of anti-dementia medication. BPSD was evaluated using the NPI at baseline and every 4 weeks during the intervention. We also examined apathy using the Japanese translation of the Apathy Scale, the short version of the Japanese version of the Zarit Caregiver Burden Interview, and the Modified Crichton Rating Scale for Predicting Activities of Daily Living. Cognitive dysfunction was evaluated using the Mini Mental State Examination and the AD Assessment Scale-Cognitive (Japanese version). Five participants were enrolled. The NPI total score tended to decrease between the baseline and 8-week evaluations during the YKSCH intervention (Wilcoxon signed rank test, P = 0.063). In terms of the NPI subscale scores, “apathy”, “agitation”, “delusions”, and “sleep and night-time behavior change” decreased after the intervention in those who exhibited each symptom at baseline. There were no significant differences in the other scores examined. No serious adverse events were observed. YKSCH could ameliorate BPSD in patients with mild-to-moderate AD with agitation, anxiety, irritability, and sleep and night-time behavior change, and it was well-tolerated.

关键词： Alzheimer’s Disease Behavioral and Psychological Symptoms of Dementia Yokukansankachimpihange Kampo Medicine Apathy Neuropsychiatric Inventory

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