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Re-analysis of hepatitis B virus integration sites reveals potential new loci associated with oncogenesis in hepatocellular carcinoma

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World Journal of Virology 2023年第3期12卷 209-220页

作者： Ryuta Kojima Shingo Nakamoto Tadayoshi Kogure Yaojia Ma Keita Ogawa terunao iwanaga Na Qiang Junjie Ao Ryo Nakagawa Ryosuke Muroyama Masato Nakamura Tetsuhiro Chiba Jun Kato Naoya Kato Department of Gastroenterology Graduate School of MedicineChiba UniversityChiba 260-8670Japan

BACKGROUND Hepatitis B virus(HBV)is a major cause of hepatocellular carcinoma(HCC).HBV DNA can get integrated into the hepatocyte genome to promote ***,the precise mechanism by which the integrated HBV genome promotes HCC has not been *** To analyze the features of HBV integration in HCC using a new reference database and integration detection *** Published data,consisting of 426 Liver tumor samples and 426 paired adjacent non-tumor samples,were re-analyzed to identify the integration *** Reference Consortium Human Build 38(GRCh38)and Telomere-to-Telomere Consortium CHM13(T2T-CHM13(v2.0))were used as the human reference *** contrast,human genome 19(hg19)was used in the original *** addition,GRIDSS VIRUSBreakend was used to detect HBV integration sites,whereas high-throughput viral integration detection(HIVID)was applied in the original study(HIVID-hg19).RESULTS A total of 5361 integration sites were detected using *** the tumor samples,integration hotspots in the cancer driver genes,such as TERT and KMT2B,were consistent with those in the original *** VIRUSBreakend detected integrations in more samples than by *** of integration was observed at chromosome 11q13.3,including the CCND1 pro-moter,in tumor *** integration sites were observed in mitochondrial *** GRIDSS VIRUSBreakend using T2T-CHM13 is accurate and sensitive in detecting HBV ***-analysis provides new insights into the regions of HBV integration and their potential roles in HCC development.

关键词： Carcinoma Hepatocellular Hepatitis B virus Virus integration

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