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Diagnostic performance of abbreviated gadoxetic acid-enhanced magnetic resonance protocols with contrast-enhanced computed tomography for detection of colorectal liver metastases

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World Journal of Radiology 2022年第10期14卷 352-366页

作者： Kumi Ozaki Shota Ishida Shohei Higuchi Toyohiko Sakai Ayaki kitano Kenji Takata Kazuyuki Kinoshita Yuki Matta Takashi Ohtani Hirohiko Kimura Toshifumi Gabata Department of Radiology University of FukuiFukui 9101193Japan Department of Radiological Technology Faculty of Medical ScienceKyoto College of Medical ScienceKyoto 6220041Japan Department of Radiology Kanazawa University Graduate School of Medical ScienceKanazawa 9208641Japan

BACKGROUND Although contrast-enhanced magnetic resonance imaging(MRI)using gadoxetic acid has been shown to have higher accuracy,sensitivity,and specificity for the detection and characterization of hepatic metastases compared with other modalities,the long examination time would limit the broad *** abbreviated enhanced MRI(Ab-MRI)protocols without dynamic phases have been proposed to achieve equivalent diagnostic performance for the detection of colorectal liver ***,an optimal protocol has not been established,and no studies have assessed the diagnostic performance of Ab-MRI combined with contrast-enhanced computed tomography(CE-CT),which is the preoperative imaging of colorectal cancer staging in clinical settings,to determine the best therapeutic *** To compare the diagnostic performance of two kinds of Ab-MRI protocol with the standard MRI protocol and a combination of the Ab-MRI protocol and CE-CT for the detection of colorectal liver *** Study participants comprised 87 patients(51 males,36 females;mean age,67.2±10.8 years)who had undergone gadoxetic acid-enhanced MRI and CE-CT during the initial work-up for colorectal cancer from 2010 to *** exam was independently reviewed by two readers in three reading sessions:(1)Only single-shot fast spin echo(FSE)T2-weighted or fat-suppressed-FSE-T2-weighted,diffusion-weighted,and hepatobiliary-phase images(Ab-MRI protocol 1 or 2);(2)all acquired MRI sequences(standard protocol);and(3)a combination of an Ab-MRI protocol(1 or 2)and *** performance was then statistically *** A total of 380 Lesions were analyzed,including 195 metastases(51.4%).Results from the two Ab-MRI protocols were *** sensitivity,specificity,and positive and negative predictive values from Ab-MRI were non-inferior to those from standard MRI(P>0.05),while those from the combination of Ab-MRI protocol and CE-CT tended to be higher than those from Ab-MRI alone,alt

关键词： Colorectal liver metastases Gadoxetic acid Magnetic resonance imaging Hepatobiliary phase Contrast-enhanced computed tomography Diagnostic performance

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Are Umezupolyphenols in the Japanese plum (Prunus mume) protective against mild hypertension and oxidation? Evidence from a double-blind randomized placebo-controlled trial

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Open Journal of Preventive Medicine 2013年第9期3卷 561-569页

作者： Shigeki Takemura Kouichi Yoshimasu Kanae Mure Jin Fukumoto Nobuhiro Nishio Naomi kitano Kunihiro Kishida Fumiko Yano Takahiko Mitani Tatsuya Takeshita Kazuhisa Miyashita Department of Hygiene School of Medicine Wakayama Medical University Wakayama Japan Department of Public Health School of Medicine Wakayama Medical University Wakayama Japan Faculty of Biology-Oriented Science and Technology Kinki University Wakayama Japan Faculty of Biology-Oriented Science and Technology Kinki University Wakayama Japan Wakayama Industry Promotion Foundation Wakayama Japan

Medications or lifestyle changes to prevent or improve hypertension often press considerable efforts on patients suffering from mild hypertension. Beverages including Umezu polyphenols (UP), polyphenols in Japanese plums, may help them to control their blood pressure. Healthy medical students, workers, and community dwellers who had some concerns about their blood pressure were randomized in a doubleblind manner into UP ingesting and placebo groups. The first two samples (medical students and workers) were placed in a preliminary study, and based on the results from that study, and the dose of UP for the community dwellers was determined. All three groups were followed for 5 weeks, and blood pressure, as well as biochemical markers related to hypertension and atherosclerosis and self-perceived quality-of-life outcomes, was monitored during that period. Group × time interactions on blood pressure changes were examined. For the community dwellers, blood pressure changes did not significantly differ between the UP ingesting and placebo groups. And although studies of students and workers showed subtle differences in blood pressure among the UP and placebo groups, a dose-dependent effect of UP on decreasing blood pressure could not be confirmed. On the other hand, anti-oxidative effects of UP were confirmed especially among male drinkers who were community dwellers. For the community dwellers, self-perceived physical health significantly improved in those who ingested UP. In conclusion, UP might prevent oxidation. A longer monitoring period as well as a higher dose of UP might enable us to confirm effects of UP against hypertension.

关键词： Hypertension Prevention Antioxidants Japanese Plum Polyphenol

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β-内酰胺抗生素的发现的最近进展

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国外医药(抗生素分册) 1984年第6期 469-478页

作者： Kazuaki kitano 陈兆华张玉泉

引言青霉素母核6-APA的发现为研制半合成青霉素铺平了道路,并使化疗取得了惊人的进展。7-ACA制备方法的发现促进了广泛研制半合成头孢菌素。β-内酰胺抗生素选择性抑制细菌细胞壁中肽葡聚糖生物合成的最后一步,给化疗带来一种最适的作... 详细信息

引言青霉素母核6-APA的发现为研制半合成青霉素铺平了道路,并使化疗取得了惊人的进展。7-ACA制备方法的发现促进了广泛研制半合成头孢菌素。β-内酰胺抗生素选择性抑制细菌细胞壁中肽葡聚糖生物合成的最后一步,给化疗带来一种最适的作用机制。因此,半合成头孢菌素类和青霉素类在抗生素生产中占首要的地位,而且对研究新的β-内酰胺抗生素仍有很大兴趣。半合成β-内酰胺抗生素主要来源于青霉素G或头孢菌素C。两者均由发酵产生。多年来,β-内酰胺生物合成局限于这两种化合物。通过各种微生物(如青霉菌和曲霉菌)生

关键词：内酞胺突变株产生菌头抱菌素棒酸青霉素类青霉素结合蛋白抗生素硫霉素链霉菌头霉素

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Pathophysiological Aspects on NOTES

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中国消化内镜 2008年第9期2卷 62-62页

作者： Seigo kitano Department of Gastroenterological Surgery Oita University Faculty of Medicine

Background:NOTES has entered the clinical realmHowever, the healing process of the peritoneal access siteand the physiologic and immunologic impact of NOTESremain unclear.

关键词：病理生理学病症治疗方法临床分析

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Recovery of serum testosterone following neoadjuvant and adjuvant androgen deprivation therapy in men treated with prostate brachytherapy

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World Journal of Radiology 2015年第12期7卷 494-500页

作者： Hideyasu Tsumura Takefumi Satoh Hiromichi Ishiyama Shuhei Hirano Kenichi Tabata Shinji Kurosaka Kazumasa Matsumoto Tetsuo Fujita Masashi kitano Shiro Baba Kazushige Hayakawa Masatsugu Iwamura Department of Urology Kitasato University School of Medicine Department of Radiation Oncology Kitasato University School of Medicine

AIM: To investigate the time course of testosterone(T) recovery after cessation of androgen deprivation therapy(ADT) in patients treated with brachytherapy. METHODS: One-hundred and seventy-four patients treated between June 1999 and February 2009 were studied. Patients were divided into a short-term usage group(≤ 12 mo, n = 91) and a long-term usage group(≥ 36 mo, n = 83) according to the duration of gonadotropin-releasing hormone agonist therapy. Median follow-up was 29 mo in the short-term group and was 60 mo in the long-term ***: Cumulative incidence rates of T recovery to normal and supracastrate levels at 24 mo after cessationwere 28.8% and 74.6%, respectively, in the long-term usage group, whereas these values were 96.4% and 98.8% in the short-term usage group. T recovery to normal and supracastrate levels occurred significantly more rapidly in the short-term than in the long-term usage group(P < 0.001 and P < 0.001, respectively). Five years after cessation, 22.6% of patients maintained a castrate T level in the long-term usage group. On multivariate analysis, lower T levels(< 10 ng/d L) at cessation of ADT was significantly associated with prolonged T recovery to supracastrate levels in the longterm usage group(P = 0.002). CONCLUSION: Lower T levels at cessation of ADT were associated with prolonged T recovery in the longterm usage group. Five years after cessation of longterm ADT, approximately one-fifth of patients still had castrate T levels. When determining the therapeutic effect, especially biochemical control, we should consider this delay in T recovery.

关键词： Androgen deprivation Gonadotropinreleasing hormone agonist Prostate brachytherapy Prostate cancer Testosterone

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Dopamine cannot promote oligomerization of unoxidized α-synuclein

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Journal of Biophysical Chemistry 2013年第3期4卷 110-114页

作者： Sakurako Shimotakahara Mika Matsui Chiseko Sakuma teruaki Takahashi Takashi Fujimoto Kazuo Furihata Masaki Kojima Shohei Seino Tomoya Machinami Yoichi Shibusawa Kenji Uéda Mitsuru Tashiro Department of Chemistry School of Sciences and Engineering Meisei University Tokyo Japan Division of Agriculture and Agricultural Life Sciences The University of Tokyo Tokyo Japan School of Life Science Tokyo University of Pharmacy and Life Science Tokyo Japan School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan

α-Synuclein is the major component of the filamentous Lewy bodies and Lewy neurites that define neuropathological features of Parkinson’s disease and dementia with Lewy bodies. To investigate the oligomerization process of α-synuclein in association with dopamine (DA), the structural propensities to form oligomers were studied using NMR and other biophysical techniques. The1H-15N HSQC spectra indicated that both N- and C-termini interacted with DA. Although interactions with DA were also observed in the presence of glutathione by ESI-MS, the significant suppression of oligomerization was observed in the size exclusion chromatography, suggesting that oxidations of α-synuclein are required for its oligomerization.

关键词： α-Synuclein Dopamine Glutathione Oligomerization

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用于通用变频器的DIP-CIB

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电力电子技术 2007年第2期41卷 75-77,80页

作者：長原輝明田畑光晴三菱电机功率器件福岡制作所

针对小功率通用变频器对低成本和小型化的需求,三菱电机开发了集整流、逆变和制动功能于一体的双列直插式封装-整流逆变制动(Dual In Line Package-Converter Inverter Brake,简称DIP-CIB)模块。在此详细介绍了DIP-CIB模块的内部电路、... 详细信息

针对小功率通用变频器对低成本和小型化的需求,三菱电机开发了集整流、逆变和制动功能于一体的双列直插式封装-整流逆变制动(Dual In Line Package-Converter Inverter Brake,简称DIP-CIB)模块。在此详细介绍了DIP-CIB模块的内部电路、半导体硅片技术、封装技术,以及如何配合专用的HVIC来实现通用变频器的小型化设计。

关键词：变频器模块/双列直插式封装-整流逆变制动模块

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腹腔镜辅助远端胃切除术重建方式的比较

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中日友好医院学报 2010年第2期24卷 67-70页

作者：韦佳明黄林平 Seigo kitano Norio Shiraishi 中日友好医院普外一科北京100029 大分大学医学部第一外科

目的:比较早期胃癌患者接受腹腔镜辅助远端胃切除术(LADG)后行Roux-en Y(RY)重建与Billroth Ⅰ(B Ⅰ)重建的短期结果。方法:2002年6月～2007年2月共有96例早期胃癌患者在日本大分大学医院接受了LADG,其中RY重建22例、BⅠ重建74例。比较R... 详细信息

目的:比较早期胃癌患者接受腹腔镜辅助远端胃切除术(LADG)后行Roux-en Y(RY)重建与Billroth Ⅰ(B Ⅰ)重建的短期结果。方法:2002年6月～2007年2月共有96例早期胃癌患者在日本大分大学医院接受了LADG,其中RY重建22例、BⅠ重建74例。比较RY组和BⅠ组患者的临床病理特点、术中情况、并发症、术后经过和血化验结果。结果:2组间术中情况、总并发症率、术后经过和血清学检查结果均无显著性差异(均P>0.05)。2组间手术相关并发症和一般并发症的发生率也无显著性差异(均P>0.05)。RY组有1例吻合口漏和2例胃排空障碍;而BⅠ组有2例吻合口狭窄。结论:LADG术后采用RY重建是安全可行的,具有和BⅠ重建同样的腹腔镜微创手术的优点。

关键词：胃肿瘤远端胃切除术腹腔镜重建

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人参皂甙的吸收、分布、排泄和代谢的研究Ⅰ——大鼠体内人参皂甙Rgl的定量分析

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特产研究 1983年第4期 62-64页

作者： YOSHIO TAKINO TSUTOMU ODANI HISAYUKI TANIZAWA teruaki HAYASHI 常兆生

有关人参皂甙药理学和化学研究的报告很多,但对人参皂甙在动物体内的吸收、分布、排泄和代谢所知尚少。本文报道以大鼠做生物样品,采用薄层扫描法测定人参皂甙Rgl的定量方法。实验实验选用雄性大鼠Sprague—Dawley(JCL:SD,SPF),体重180... 详细信息

有关人参皂甙药理学和化学研究的报告很多,但对人参皂甙在动物体内的吸收、分布、排泄和代谢所知尚少。本文报道以大鼠做生物样品,采用薄层扫描法测定人参皂甙Rgl的定量方法。实验实验选用雄性大鼠Sprague—Dawley(JCL:SD,SPF),体重180～200g。实验前18小时禁食,不限制饮水。人参皂甙Rgl,系通过高效液相层析从红参中分离得到。

关键词：人参皂甙生物样品大鼠 Rgl 定量分析

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基于低聚酰亚胺含氮介孔碳材料的制备

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膜科学与技术 2014年第5期34卷 33-39页

作者：刘圆圆早川晃镜王晓琳清华大学化学工程系膜材料与工程北京市重点实验室北京100084 东京工业大学有机和高分子材料系

以低聚酰亚胺为氮源前驱体、交联酚醛树脂为碳源、嵌段共聚物为软模板剂,通过相分离自组装、交联和高温锻烧处理制备了新型高规整含氮介孔碳材料,并用FT-IR、SEM、TEM、热重分析和小角X光散射等测试方法表征介孔碳材料的组成与结构.结... 详细信息

以低聚酰亚胺为氮源前驱体、交联酚醛树脂为碳源、嵌段共聚物为软模板剂,通过相分离自组装、交联和高温锻烧处理制备了新型高规整含氮介孔碳材料,并用FT-IR、SEM、TEM、热重分析和小角X光散射等测试方法表征介孔碳材料的组成与结构.结果表明,处理温度达350℃时嵌段共聚物模板可被成功移除,进而形成多孔结构;温度达600℃时体系完全碳化,可得到高规整的多孔含氮碳材料.通过调节体系中氮源、碳源及模板剂的相对比例可实现形貌由立方结构向柱状和层状结构的过渡,进而实现对含氮介孔材料形貌的有效调控.

关键词：低聚酰亚胺含氮介孔碳材料高规整形貌调控

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