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Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism： a multicenter, randomized controlled trial in Japan （EARTH Study）

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Asian Journal of Andrology 2016年第1期18卷 25-34页

作者： Hiroyuki Konaka Kazuhiro Sugimoto Hideki Orikasa teruaki iwamoto Toshinari Takamura Yoshiyu Takeda Kazuyoshi Shigehara Masashi Iijima Eitetsu Koh Mikio Namiki Department of Integrative Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa Ishikawa Japan Division of Biostatistics and Clinical Epidemiology University of Toyama School of Medicine Toyama Toyama Japan Division of Male Infertility Center for Infertility and IVF International University of Health and Welfare Nasushiobara Tochigi Japan Department of Disease Control and Homeostasis Kanazawa University Graduate Schoofof Medical Science Kanazawa Ishikawa Japan Departrnent of Internal Medicine. Division of Endocrinology and Hypertension Kanazawa University Graduate School of Medical Science Kanazawa Ishikawa Japan.

Androgen replacement therapy （ART） efficacy on late-onset hypogonadism （LOH） has been widely investigated in Western countries; however, it remains controversial whether ART can improve health and prolong active lifestyles. We prospectively assessed long-term ART effects on the physical and mental statuses of aging men with LOH in Japan. The primary endpoint was health-related quality of life assessed by questionnaires. Secondary endpoints included glycemic control, lipid parameters, blood pressure, waist circumference, body composition, muscular strength, International Prostate Symptom Scores （IPSS）, International Index of Erectile Function-5 （IIEF-5） scores, and serum prostate-specific antigen levels. Of the 1637 eligible volunteers, 334 patients 〉 40 years with LOH were randomly assigned to either the ART （n = 169） or control groups （n = 165）. Fifty-two weeks after the initial treatment, ART significantly affected the role physical subdomain of the short form-36 health survey （SF-36） scale （P= 0.0318）. ART was also associated with significant decreases in waist circumstance （P = 0.002） and serum triglyceride （TG）（P = 0.013） and with significant increases in whole-body and leg muscle mass volumes （P= 0.071 and 0.0108, respectively）, serum hemoglobin （P 〈 0.001）, IPSS voiding subscore （P = 0.0418）, and the second question on I IEF-5 （P = 0.0049）. There was no significant difference between the groups in terms of severe adverse events. In conclusion, in patients with LOH, long-term ART exerted beneficial effects on Role Physical subdomain of the SF-36 scale, serum TG, waist circumstance, muscle mass volume, voiding subscore of IPSS, and the second question of IIEF-5. We hope our study will contribute to the future development of this area.

关键词： androgen replacement therapy health-related quality of life late-onset hypogonadism randomized controlled trial testosterone

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Current status of sperm banking for young cancer patients in Japanese nationwide survey

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Asian Journal of Andrology 2018年第4期20卷 336-341页

作者： Yasushi Yumura Akira Tsujimura Hiroshi Okada Kuniaki Ota Masahumi Kitazawa Tatsuya Suzuki Tosiyuki Kakinuma Seido Takae Nao Suzuki teruaki iwamoto Reproduction Center Yokohama City University Medical Center Yokohama 232-0024 Japan Department of Urology Juntendo University Urayasu Hospital Chiba 279-0021 Japan Department of Urology Dokkyo Medical University Koshigaya Hospital Saitama 343-8555 Japan Department of Obstetrics and Gynecology Nasu Red Cross Hospital Tochigi 324-8686 Japan Department of Obstetrics and Gynecology Dokkyo Medical University Tochigi 321-0293 Japan Department of Obstetrics and Gynecology Jichi Medical University Tochigi 329-0498 Japan Department of Obstetrics and Gynecology International University of Health and Welfare Tochigi 329-2763 Japan Department of Obstetrics and Gynecology St. Marianna University School of Medicine Kawasaki 216-8511 Japan Division Male Infertility Center for Human Reproduction International University of Health and Welfare Sanno Hospital Tokyo 107-0052 Japan

This study aimed to ascertain the current status of Japanese sperm banking for young cancer patients. During 2015, we mailed the directors of 695 institutes where sperm cryopreservation might be performed with questionnaires requesting information on the number of patients, age, precryopreservation chemotherapy, semen analyses results and diagnoses, cryopreservation success rate, and causes of unsuccessful cryopreservation. Of these 695 institutes, 92 had cryopreserved sperm before chemotherapy within the study period. In all, 820 cancer patients （237 testicular, 383 hematological, 46 bone and soft tissue, 20 brain, and 134 other malignancy） consulted the responding institutes for sperm cryopreservation. Except for testicular tumor, the number of patients whose sperm was preserved before cancer treatment was low compared to that of young cancer patients. Approximately 20% of patients with malignancies other than testicular tumor underwent chemotherapy before cryopreservation. The success rate of cryopreservation in hematological malignancy was 82.5%, significantly lower than that of both the testicular cancer （93.6%） and other malignancy groups （95.6%）（P 〈 0.05）. The primary reasons for preservation failure were azoospermia and poor semen quality. Patients with hematological malignancies had a higher rate of unsuccessful cryopreservation compared to those in other groups, possibly due to the large number of patients requesting sperm cryopreservation after chemotherapy induction. In Japan, information regarding sperm banking prior to cancer treatment appears to be lacking. Information regarding sperm preservation before chemotherapy should be provided to all Japanese oncologists.

关键词： cancer chemotherapy fertility preservation sperm preservation survey

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Inter/intra investigator variation in orchidometric measure-ments of testicular volume by ten investigators from five insti-tutions

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Asian Journal of Andrology 2006年第3期8卷 373-378,391页

作者： Shinobu Tatsunami KiyomiMatsumiya AkiraTsujimura NaokiItoh TakumiSasao EitetsuKoh YuujiMaeda JiroEguchi KousukeTakehara TakayasuNishida SatetsuMiyano Chisato Tabata teruaki iwamoto Unit of Medical Statistics Faculty of Medical Education and CultureSt.Marianna University School of MedicineKawasaki 216-8511Japan Department of Urology Osaka UniversityOsaka 565-0871Japan Department of Urology Sapporo Medical UniversitySapporo 060-8543Japan Department of Urology Kanazawa UniversityKanazawa 920-8641Japan Department of Urology Nagasaki UniversityNagasaki 852-8501Japan Department of Urology Marianna University School of Medicine HospitalKawasaki 216-8511Japan Ultrasound Center St.Marianna University School of Medicine HospitalKawasaki 216-8511Japan

Aim:To perform quality control studies on testicular volume measurements for a multi-center epidemiological study of male reproductive ***:We constructed a data matrix with a balanced assignment for 2 consecutive days by ten investigators(andrological career:4-21 years)from five institutions and 12 male volunteers aged 20-26 *** volume was measured by Prader's orchidometer.A skilled technician also perfornled an ultrasound estimate of testicular ***:A statistically significant inter-investigator variation was found *'or both testes (P0.05).The difference in experiences of the investigators did not significantly correlate with accuracy of measurements in either ***:The present study revealed significant differences in the results of estimation of testicular volume among the ten investigators,but intra-investigator variation was not *** training and proper standardization of the measurement will be necessary before starting a multi-center study based on an andrological examination,

关键词： testicular volume orchidometer quality control

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A Review of Contact Electrification at Diversified Interfaces and Related Applications on Triboelectric Nanogenerator

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Nano-Micro Letters 2024年第1期16卷 106-130页

作者： Jun Hu Mitsumasa iwamoto Xiangyu Chen CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083People’s Republic of China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Department of Physical Electronics Tokyo Institute of Technology2‑12‑1 S3‑33 O‑OkayamaMeguro‑KuTokyo 152‑8552Japan

The triboelectric nanogenerator(TENG)can effectively collect energy based on contact electrification(CE)at diverse interfaces,including solid–solid,liquid–solid,liquid–liquid,gas–solid,and gas–*** enables energy harvesting from sources such as water,wind,and *** this review,we provide an overview of the coexistence of electron and ion transfer in the CE *** elucidate the diverse dominant mechanisms observed at different interfaces and emphasize the interconnectedness and complementary nature of interface *** review also offers a comprehensive summary of the factors influencing charge transfer and the advancements in interfacial modification ***,we highlight the wide range of applications stemming from the distinctive characteristics of charge transfer at various ***,this review elucidates the future opportunities and challenges that interface CE may *** anticipate that this review can offer valuable insights for future research on interface CE and facilitate the continued development and industrialization of TENG.

关键词： Contact electrification Interfaces Triboelectric nanogenerators Diversified applications

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Epigenetic memory of drug exposure history controls neural stem cell quiescence in the adult brain

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Neural Regeneration Research 2024年第4期19卷 711-712页

作者： Masakazu iwamoto Taito Matsuda Department of Stem Cell Biology and Medicine Graduate School of Medical SciencesKyushu UniversityFukuokaJapan

Neural stem cells(NSCs)are the source of all neurons and glial cells(astrocytes and oligodendrocytes)in the central nervous *** adult mammalian brain retains NSCs in the subgranular zone of the dentate gyrus in the hippocampus and ventricular subventricular zone lining the lateral ventricle(Olpe and Jessberger,2022).Adult NSCs in rodents are preserved throughout life and continuously produce new neurons that integrate into the pre-existing neuronal network.

关键词： neural integrate continuously

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A Partial Order in the Knot Table Ⅱ

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Acta Mathematica Sinica,English Series 2008年第11期24卷 1801-1816页

作者： teruaki KITANO Masaaki SUZUKI Department of Information Systems Science Faculty of Engineering Soka University 1-236 Tangi-cho Hachioji-city Tokyo 192-8577 Japan Department of Mathematics Akita University 1-1 Tegata-Gakuenmachi Akita 010-8502 Japan

A partial order on the set of the prime knots can be defined by the existence of a surjective homomorphism between knot groups. In the previous paper, we determined the partial order in the knot table. In this paper, we prove that 31 and 41 are minimal elements. Further, we study which surjection a pair of a periodic knot and its quotient knot induces, and which surjection a degree one map can induce.

关键词： knot partial order surjective homomorphism period degree one map

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Methane, Nitrous Oxide and Ammonia generation in full-scale swine wastewater purification facilities

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Frontiers of Environmental Science & Engineering 2017年第3期11卷 115-122页

作者： Takashi Osada Makoto Shiraishi teruaki Hasegawa Hirofumi Kawahara National Agriculture and Food Research Organization Tsukuba Ibaraki 305-0005 Japan Okayama Prefectural Center for Animal Husbandry Research Misaki Okayama 709-3401 Japan Chiba Prefectural Livestock Research Center Yachimata Chiba 289-1113 Japan Saga Prefectural Higashimastuura Agricultural Development and Extension Center Karatsu Saga 847-0861 Japan

The activated sludge process to remove nitrogen and biochemical oxygen demand （BOD） is reportedly cost-effective for swine wastewater treatment, and it use has thus increased in pig farming. Nitrous oxide （N20） is generated on farms as an intermediate product in nitrification and denitrification, and methane （CH4） is also generated from organic degradation under anaerobic conditions by microorganisms in manure or wastewater. This study was carried out at five activated sludge treatment facilities across Japan between August 2014 and January 2015. Measurements were conducted over several weeks at wastewater purification facilities for swine farms： two in Chiba prefecture （East Japan）, two in Okayama prefecture （West Japan）, and one in Saga （Southern Japan）. Taking several environmental fluctuations into account, we collected measurement data continuously day and night, during both high-temperature and low-temperature periods. The results indicated that CH4 and N20 emission factors were 0.91% （kgCHa·kg volatile solids^-1） and 2.87% （g N2O-N·kg total N^-1）, respectively. Ammonia emissions were negligible in all of the measurements from the wastewater facilities. The N20 emission factor calculated under this experiment was low compared to our previous finding （5.0%; g N2O-N·kg N^-1） in a laboratory experiment. In contrast, the CH4 emission factor calculated herein was rather high compared to the laboratory measurements. There was great variation in daily GHG emission factors measured in the actual wastewater treatment facilities. In particular, the N2O emission rate was affected by several environmental conditions at each facility location, as well as by the management of the wastewater treatment.

关键词： Manure Greenhouse gas Denitrification BOD/NNitrous oxide Methane

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Computationally Efficient Large-Eddy Simulation of Periodic Unsteady Flow using Harmonic Balance Method

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Journal of Thermal Science 2022年第1期31卷 62-71页

作者： YUMA iwamoto SUSUMU Teramoto KOJI Okamoto Department of Aeronautics and Astronautics University of TokyoTokyo 113-8656Japan Department of Advanced Energy University of TokyoTokyo 113-8656Japan

To improve the efficiency and fidelity of the numerical analysis for cascade flutter, we propose an efficient scale-resolving simulation method dedicated to time-periodic flows by incorporating the harmonic balance approach into the large-eddy simulation. This method combined convergence calculations of the steady-state problem based on the harmonic balance method for periodic components, and the nonlinear time-marching method for turbulent fluctuations. Using the proposed method, deterministic periodic components and stochastic turbulent fluctuations were calculated simultaneously, and the effect of turbulent fluctuations on deterministic periodic components was directly calculated without using turbulence models. In this paper, we explain the algorithm and feature of this simulation technique and present the results of the computation for channel flow excited in the streamwise direction as an analysis example using the proposed method. In order to validate the proposed method, an analysis of sinusoidally pulsating channel flow at the central friction-velocity Reynolds numbers Rer = 180 was conducted, confirming that the amplitude and phase of the mean velocity oscillation computed by the proposed method were in good agreement with those of the conventional LES. The present calculation achieved an order of magnitude improvement in computational efficiency compared to conventional LES.

关键词： harmonic balance LES turbulent channel flow

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ADAM8 inactivation retards intervertebral disc degeneration in mice

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Genes & Diseases 2024年第3期11卷 91-94页

作者： Zuozhen Tian Frances S.Shofer Mingyue Fan Alec Z.Sandroni Lutian Yao Lin Han Ling Qin Motomi Enomoto-lwamoto Yejia Zhang Department of Physical Medicine&Rehabilitation Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA19146USA Department of Emergency Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Orthopedic Surgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA School of Biomedical Engineering Science&Health SystemsDrexel UniversityPhiladelphiaPA 19104USA Department of Orthopedics/Sports Medicine and Joint Surgery the First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Orthopedics University of Maryland School ofMedicineBaltimoreMD21201USA Section of Rehabilitation Medicine Corporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPA 19104USA

ADAM8 has been identified as the fibronectin-cleaving enzyme in human degenerative intervertebral disc(IVD)tissues.^(1)Increase of the active form of ADAM8 and its cleavage product,fibronectin fragment,correlated with an increased degree of IVD degeneration.1 Furthermore,fibronectin fragments have been shown to accelerate the progression of IVD degeneration.^(2)These findings suggest that ADAM8 may play a role in degenerative disc disease,a clinical problem with tremendous socioeconomic burdens in the United States.

关键词： ADAM8 degeneration intervertebral

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Effect of impact deformation on shape recovery behavior in Fe-Mn-Si shape memory alloy under shape memory training process with cyclic thermo-mechanical loading

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Science China(Technological Sciences) 2021年第7期64卷 1389-1400页

作者： SUN Qian CAO Bo iwamoto Takeshi SUO Tao Graduate School of Engineering Hiroshima UniversityHigashi-Hiroshima739-8527Japan Cluster of Excellence livMatS@FIT-Freiburg Center for Interactive Materials and Bioinspired Technologies University of FreiburgFreiburgD-79110Germany Academy of Science and Technology Hiroshima UniversityHigashi-Hiroshima739-8527Japan School of Aeronautics Northwestern Polytechnical UniversityXi’an710072China

In the past studies, it has been discovered that the shape memory effect(SME) in the Fe-Mn-Si shape memory alloy(Fe-SMA)can gradually be enhanced by a pre-process called as shape memory training process under cyclic thermo-mechanical *** the other hand, it has been shown that the SME of Fe-SMA can also be affected by changing the strain rate. Therefore, it is possible to improve the SME by combining the strain rate sensitivity and shape memory training process. However, the improvement of SME caused by the training process under impact condition is still unclear. For the training process under impact condition, it is difficult to interrupt the test at the desired strain level due to many reflections of stress waves, which reload the specimen from the free ends. In this paper, to obtain reliable experimental results of SME after the training process under impact condition, the stress waves after first loading are eliminated by the double momentum-trap structure introduced into the impact tensile testing apparatus based on the split Hopkinson pressure bar method. In order to achieve an optimum design of the structure used in experiments, the finite element simulation of the structure is performed. Then, tensile tests in the training process of Fe-28Mn-6Si-5Cr alloy at different strain rates including the impact level are conducted and temperature change of the specimen is measured during training and heating process. As a result, the improvement of SME in the alloy after the training process under quasi-static and impact loading is compared with that under quasi-static loading through verification processes.

关键词： Fe-Mn-Si shape memory alloy training cyclic thermo-mechanical process split Hopkinson pressure bar momentumtrap impact deformation

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