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STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury

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World Journal of Gastroenterology 2017年第37期23卷 6833-6844页

作者： Mitsuhiko Abe Takafumi Yoshida Jun Akiba Yu Ikezono Fumitaka Wada Atsutaka Masuda Takahiko Sakaue Toshimitsu Tanaka Hideki iwamoto Toru Nakamura Michio Sata Hironori Koga Akihiko Yoshimura Takuji Torimura Division of Gastroenterology Department of Medicine Kurume University School of Medi-cine Liver Cancer Division Research Center for Innovative Cancer Therapy Kurume University Kurume Clinical pharmacology Clinic Department of Diagnostic pathology Kurume University hospital Department of Microbiology Immun--ology Keio University School of Medicine

AIM To elucidate the role of STAT3 in hepatocarcinogenesis and biliary ductular proliferation following chronic liver injury. METHODS We investigated thioacetamide(TAA)-induced liver injury, compensatory hepatocyte proliferation, and hepatocellular carcinoma(HCC) development in hepatic STAT3-deficient mice. In addition, we evaluated TAAinduced biliary ductular proliferation and analyzed the activation of sex determining region Y-box9(SOX9) and Yes-associated protein(YAP), which regulate the transdifferentiation of hepatocytes to *** Both compensatory hepatocyte proliferation and HCC formation were significantly decreased in hepatic STAT3-deficient mice as compared with control mice. STAT3 deficiency resulted in augmentation of hepatic necrosis and fibrosis. On the other hand, biliary ductular proliferation increased in hepatic STAT3-deficient livers as compared with control livers. SOX9 and YAP were upregulated in hepatic STAT3-deficient *** STAT3 may regulate hepatocyte proliferation as well as transdifferentiation into cholangiocytes and serve as a therapeutic target for HCC inhibition and biliary regeneration.

关键词： Hepatocellular carcinoma Ductular reaction Signal transducer and activator of transcription 3 Yesassociated protein Sex determining region Y-box9 Transdifferentiation

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末端化聚酰胺和交联剂及光酸产生剂所组成的三元负型光敏支化聚酰胺

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高分子学报 2008年第1期18卷 1-7页

作者：肖继君早川晃镜柿本雅明河北科技大学高分子系石家庄050018 东京工业大学日本目黑区大岗山152-8552-S8-26

研究了由未端化支化聚酰胺、交联剂(MBHP)和光酸产生剂(PTMA)所组成的三元负型光敏聚合物体系.其中,不对称ABB′型单体4-(2,4-二氨基苯氧基)苯甲酸3在亚磷酸三苯酯(TPP)和吡啶(Py)的存在下,通过缩合聚合得到支化聚酰胺a,由其1H-NMR数据... 详细信息

研究了由未端化支化聚酰胺、交联剂(MBHP)和光酸产生剂(PTMA)所组成的三元负型光敏聚合物体系.其中,不对称ABB′型单体4-(2,4-二氨基苯氧基)苯甲酸3在亚磷酸三苯酯(TPP)和吡啶(Py)的存在下,通过缩合聚合得到支化聚酰胺a,由其1H-NMR数据计算得支化度(DB)为0.36.接着用肉桂酰氯对支化聚酰胺进行末端化.采用IR,1H-NMR,GPC,TG/DTA对支化聚酰胺和末端化支化聚酰胺b的结构和性能进行了表征.由85wt%末端化支化聚酰胺b、10wt%交联剂(MBHP)和5wt%光酸产生剂(PTMA)所组成的光敏聚合物体系,在100℃预烘10min,采用436nm(g-line)紫外光曝光,随后在25℃于二甲基甲酰胺中显影10s,用水漂洗,110℃后烘3min后,得到负型图案,边界清晰且分辨率达40μm.

关键词：负型光敏聚合物支化聚合物支化度肉桂酰氯

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Coil embolization of bronchial artery aneurysm with high flow bronchial artery-pulmonary artery fistula

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World Journal of Cardiovascular Diseases 2013年第1期3卷 14-17页

作者： Yoshiro Matsuo Takuya Okada Masato Yamaguchi Akhamadu Muradi teruaki Okuno Noriaki Sakamoto Koji Idoguchi Koji Sugimoto Department of Radiology and Center for Endovascular Therapy Kobe University Graduate School of Medicine Kobe Japan

We report a case of an asymptomatic 36-year-old man with a bronchial artery aneurysm in the right hilum. Selective angiography revealed a 25mmsaccular aneurysm and an efferent artery of the aneurysm forming a high flow bronchial artery-pulmonary artery fistula. Because of dilatation and tortuosity of the bronchial artery, the microcatheter could reach the efferent artery but not the fistula. Therefore, we embolized the fistula by sending microcoils through the bloodstream from the efferent artery to the fistula (the “flow-dependent” coil embolization technique), and further embolized the aneurysm by coil isolation and packing technique.

关键词： Bronchial Artery Aneurysm Bronchial Artery-Pulmonary Artery Fistula Embolization

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利用枯草杆菌α-淀粉酶分泌载体合成和分泌具有生物活性的鼠β干扰素

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中国生物工程杂志 1985年第4期 29-36页

作者： S.teruaki ,张博润

经BAL31酶消化除去信号序列的鼠β-干扰素（IFN-β）cDNA,引入到用枯草杆菌α-淀粉酶基因的启动子和信号序列所构造的一个枯草杆菌分泌载体中。把得到的嵌合质粒转移进枯草杆菌207-25中。采用菌落杂交和一种新的、用于分泌蛋白质的免疫... 详细信息

经BAL31酶消化除去信号序列的鼠β-干扰素（IFN-β）cDNA,引入到用枯草杆菌α-淀粉酶基因的启动子和信号序列所构造的一个枯草杆菌分泌载体中。把得到的嵌合质粒转移进枯草杆菌207-25中。采用菌落杂交和一种新的、用于分泌蛋白质的免疫印迹方法选出四株卡那霉素抗性转化株。这些转化株把与羊抗-IFN-β血清起交叉反应的蛋白分泌到培养基中去。用L细胞和水泡性口膜炎病毒系统检测,其中一株表达一种高IFN-β活性,而其它三株表现弱的或没有IFN-β活性。基于我们先前的研究[Ohmura等人,*** Res.12（1984）5307-5319],认为这种分泌的IFN分子是杂种蛋白,在这分子中,NH2-末端区域由一部分α-淀粉酶信号肽组成。核苷酸序列分析指出:表达高IFN活性的pTUB502质粒是与来自鼠的成熟蛋白质的密码子位置6的IFN-β基因连接。其它三个质粒,pTUB506、pTUB509和pTUB519分别含有来自密码子位置3,1和5的鼠IFN-β基因。鼠IFN-β的NH2-未端区域似乎与它的生物活性紧密相关。

关键词：质粒基因载体枯草杆菌终止密码子末端密码子基因转化子 α-淀粉酶液化型淀粉酶 IFN 抗原活性菌落杂交格伦斯坦—霍格内斯法 DNA 编码信号转化株抗病毒生物活性分泌

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Intervertebral disc development and disease-related genetic polymorphisms

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Genes & Diseases 2016年第3期3卷 171-177页

作者： Jason W.Ashley Motomi Enomoto-iwamoto Lachlan J.Smith Robert L.Mauck Danny Chan Joseph Lee Martin F.Heyworth Howard An Yejia Zhang Department of Orthopedic Surgery Perelman School of MedicineUniversity of PennsylvaniaUSA Department of Surgery Division of Orthopaedic SurgeryChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA School of Biomedical Sciences The University of Hong KongHong Kong Department of Orthopedic Surgery University of ChicagoChicagoILUSA Corporal Michael J.Crescenz Veterans Affairs Medical Center PhiladelphiaPAUSA Department of Medicine Perelman School of MedicineUniversity of PennsylvaniaUSA Department of Orthopedic Surgery Rush University Medical CenterChicagoILUSA Department of Physical Medicine&Rehabilitation Perelman School of MedicineUniversity of PennsylvaniaUSA

The intervertebral disc(IVD)comprises a gelatinous inner core(nucleus pulposus;NP)and concentric rings(annulus fibrosus;AF).The NP,an important structure for shock absorption in the vertebrate spinal motion segment,can be traced back to the notochord in ontogenetic *** vertebrates,the notochord undergoes mucinoid changes,and had been considered vestigial until ***,observed correlations between IVD degeneration and back pain in humans have renewed interest in the IVD in biomedical *** its mechanical contribution to development,the notochord is also an essential signaling center,which coordinates formation of the neural tube and *** pertinent signaling molecules,particularly TGF-b and bone morphogenetic proteins(BMPs),continue to play roles in the adult tissues and have been utilized for tissue *** factors are major determinants of who will develop IVD degeneration and related back pain,and seem to correlate better with disc degeneration and back pain than do external forces on the *** summary,the spinal column is a landmark development in *** directing the development of the IVD may also contribute to its maintenance,degeneration,and ***,structural genes as well as genes responsible for maintenance of the structure are related to IVD ***,genes responsible for inflammation may play a dual role in exacerbating degeneration or facilitating repair responses depending on the context.

关键词： Back pain Development Intervertebral disc(IVD) Notochord Regeneration

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Actual Status of Healthy Lifestyle Habits of Public Health Nurses in Japan

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Health 2018年第2期10卷 189-203页

作者： Yoko Nishida Keiko Koide Reiko Okamoto Saori iwamoto Kayoko Goda Hiroko Seki Yukiko Sugimoto Department of Nursing Faculty of Health and Welfare Kawasaki University of Medical Welfare Okayama Japan Faculty of Education Shitennoji University Osaka Japan Division of Health Sciences Graduate School of Medicine Osaka University Osaka Japan Graduate School of Biomedical Sciences Tokushima University Tokushima Japan Faculty of Nursing and Rehabilitation Konan Women’s University Hyogo Japan Former Graduate School of Health Sciences Okayama University Okayama Japan

Background: The public health nurse should make efforts to keep his/her own mental and physical health good, which is the professional responsibility. However, a variety of challenging issues have been pointed out with regard to well-being of healthcare professionals. Public health nurses are likely to face some difficulties in their habits of leading healthy lifestyles. The purpose of this study was to identify how Japanese public health nurses actually live their healthy lives. Methods: This study covered 1725 public health nurses in the Chugoku/Shikoku Region. We conducted an anonymous self-completed questionnaire survey. As basic attributes, the following 6 categories were set. The health practice indices used in this research consisted of the 7 practices of Breslow’s Health Practice Index (B-HPI), the Morimoto’s 8 practices, and 6 practices related to lifestyle habits that have been developed independently by the authors of this research (Health Lifestyle Index (HLI)), that is, 16 practices in total. The study plan was approved by the Ethics Committee of Okayama University. Results: We analyzed the 960 (55.7%) valid responses. This survey has demonstrated that the healthy life-style practices of public health nurses are generally good. However, there were some practices such as eating between meals, having little physical activity, and not having a good rest/sleep, that need to be improved. None of the assessment tools correlated with the length of experience. Conclusions: This survey has clarified that the healthy lifestyle practices of public health nurses did not correlated with their length of experience, indicating that the healthy lifestyle practices are not intensified by the accumulated career experience as public health nurses.

关键词： Public Health Nursing Related Factors Health Practice Breslow’s Health Practice

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最新的单点汽油喷射系统

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小型内燃机 1990年第2期19卷 57-62,6页

作者： Akio iwamoto 黄振球

本文介绍日产Auster CA18i型汽油机上的单点电子喷射系统。它是一种将热线式空气流量计和喷油器组装成一体的简化系统。其特点是用氧传感器实现反馈控制与学习控制,提高了空燃比的控制精度。

关键词：汽油机汽油喷射系统单点

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日本玩具赢得成人欢心

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中外玩具制造 2008年第7期 56-57页

作者： Fumie iwamoto 江南

目前日本玩具市场上,掏钱购买新奇玩具的已经不是孩子的专利。一些原本针对儿童而开发的玩具如今对成人也极具吸引力。没有养宠物的人或许会购买机器动物;机器语音娃娃这类产品也很有市场;而很多男性消费者对价格低于1万日元（约人民币... 详细信息

目前日本玩具市场上,掏钱购买新奇玩具的已经不是孩子的专利。一些原本针对儿童而开发的玩具如今对成人也极具吸引力。没有养宠物的人或许会购买机器动物;机器语音娃娃这类产品也很有市场;而很多男性消费者对价格低于1万日元（约人民币640元），但功能有趣的室内遥控直升机乐此不疲……他们借玩具缅怀童年，为生活增添一丝别样乐趣。

关键词：成人玩具市场日本遥控直升机吸引力人民币消费者机器

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埃德加街塔

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城市环境设计 2010年第11期 244-249页

作者： Lisa iwamoto Craig Scott iwamotoScott建筑事务所

埃德加街塔是iwamoto Scott建筑事务所为格林威治南区设计的,本项目受Beyer Blinder Belleand Architects&Planner sand OPEN建筑研究办公室的领导。同时对项目做出贡献的建筑师和艺术家有

关键词：埃德加建筑混合设计曼哈顿

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Treatment strategies for advanced hepatocellular carcinoma:Sorafenib vs hepatic arterial infusion chemotherapy

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World Journal of Hepatology 2018年第9期10卷 571-584页

作者： Issei Saeki Takahiro Yamasaki Masaki Maeda Takuro Hisanaga Takuya iwamoto Koichi Fujisawa Toshihiko Matsumoto Isao Hidaka Yoshio Marumoto Tsuyoshi Ishikawa Naoki Yamamoto Yutaka Suehiro Taro Takami Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of MedicineYamaguchi 755-8505Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of MedicineYamaguchi 755-8505Japan Department of Medical Education Yamaguchi University Graduate School of MedicineYamaguchi 755-8505Japan Center of Research and Education for Regenerative Medicine Yamaguchi University Graduate School of MedicineYamaguchi755-8505Japan Center for Clinical Research Yamaguchi University HospitalYamaguchi 755-8505Japan Yamaguchi University Health Administration Center Yamaguchi 753-8511Japan

Sorafenib is used worldwide as a first-line standardsystemic agent for advanced hepatocellular carcinoma(HCC) on the basis of the results of two large-scale Phase Ⅲ trials. Conversely,hepatic arterial infusion chemotherapy(HAIC) is one of the most recommended treatments in Japan. Although there have been no randomized controlled trials comparing sorafenib with HAIC,several retrospective analyses have shown no significant differences in survival between the two therapies. Outcomes are favorable for HCC patients exhibiting macroscopic vascular invasion when treated with HAIC rather than sorafenib,whereas in HCC patients exhibiting extrahepatic spread or resistance to transcatheter arterial chemoembolization,good outcomes are achieved by treatment with sorafenib rather than HAIC. Additionally,sorafenib is generally used to treat patients with Child-Pugh A,while HAIC is indicated for those with either Child-Pugh A or B. Based on these findings,we reviewed treatment strategies for advanced HCC. We propose that sorafenib might be used as a first-line treatment for advanced HCC patients without macroscopic vascular invasion or Child-Pugh A,while HAIC is recommended for those with macroscopic vascular invasion or Child-Pugh A or B. Additional research is required to determine the best second-line treatment for HAIC non-responders with Child-Pugh B through future clinical trials.

关键词： Treatment strategy Hepatic arterial infusion chemotherapy Sorafenib Hepatocellular carcinoma

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