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Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome

World Journal of Gastroenterology 2010年第36期16卷 4532-4540页

作者： Erja Malinen Lotta Krogius-Kurikka Janne Nikkil Airi Palva Anna Lyra Anne Jskelinen Teemu Rinttil terttu vilpponen-salmela Atte Johannes von Wright Department of Veterinary Biosciences Faculty of Veterinary MedicineUniversity of Helsinki00014 HelsinkiFinland Danisco Sweeteners Health and Nutrition02460 KantvikFinland Department of Clinical Nutrition Institute of Public Health and Clinical NutritionFaculty of Health SciencesUniversity of Eastern Finland70211 KuopioFinland Alimetrics Ltd. Koskelontie 19 B02920 EspooFinland Kuopio Harjula Hospital 70101 KuopioFinland Department of Biosciences University of Eastern Finland70211 KuopioFinland

AIM:To investigate the correlations between selfreported symptoms of irritable bowel syndrome(IBS) and the gastrointestinal(GI) microbiota ***:Fecal samples were collected from a total of 44 subjects diagnosed with *** symptoms were monitored with a validated inflammatory bowel disease questionnaire adjusted for IBS *** quantitative real-time polymerase chain reaction assays were applied to evaluate the GI microbiota *** and GI bacterial genera(Bifidobacterium,Lactobacillus and Veillonella),groups(Clostridium coccoides/Eubacterium rectale,Desulfovibrio desulfuricans) and distinct bacterial phylotypes [closest 16S rDNA sequence resemblance to species Bifidobacterium catenulatum,Clostridium cocleatum,Collinsella aerofaciens(***),Coprococcus eutactus(***),Ruminococcus torques and Streptococcus bovis ] with a suspected association with IBS were *** between quantities or presence/absence data of selected bacterial groups or phylotypes and various IBSrelated symptoms were ***:Associations were observed between subjects' self-reported symptoms and the presence or quantities of certain GI bacteria.A Ruminococcus torques(***)-like(94% similarity in 16S rRNA gene sequence) phylotype was associated with severity of bowel ***,among IBS subjects with *** 94% detected,the amounts of *** 88%,***-like and *** 97% phylotypes were significantly *** observations were also made concerning the effect of a subject's weight on GI microbiota with regard to *** like phylotype,Bifidobacterium *** Lactobacillus ***:Bacteria seemingly affecting the symptom scores are unlikely to be the underlying cause or cure of IBS,but they may serve as biomarkers of the condition.

关键词： Irritable bowel syndrome Self-reported symptoms Gastrointestinal microbiota Quantitative realtime polymerase chain reaction

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